ea0026s16.1 | TSH Receptor and thyroid disorders | ECE2011
Sanders J
TSHR autoantibodies with stimulating (agonist) activity cause the hyperthyroidism of Graves disease, while the rarer blocking (antagonist) type TSHR autoantibodies are responsible for hypothyroidism in some patients. We have isolated four human monoclonal autoantibodies (MAbs) which bind the TSHR with high affinity. Two antibodies, M22 and K1-18 have potent thyroid stimulating activity, one MAb K1-70 has strong antagonist (blocking) activity and the fourth MAb 5C9 has st...