Endocrine Abstracts

The biggest achievement of bariatric surgery was to demonstrate that obesity co-morbidity improve or even reverse with long-term weight control. This evidence was achieved with the Swedish Obesity Study for mortality and diabetes incidence.Diabetes resolution rates range from 55 to 96% depending on the surgical procedure and length of follow-up. Diabetes improvement or resolution almost reaching the 100%. The type of surgery seems to play a role in diabe...

Harvey Cushing’s work informed us of the deleterious consequences of circulating cortisol excess – hypertension, osteoporosis and obesity that contributes to diabetes and premature mortality. Conversely, Hench, Kendall and Reichstein were Nobel Laureates in Physiology 1950 for the discovery of cortisone and demonstrating efficacy in patients with Rheumatoid Arthritis – in effect the birth of the anti-inflammatory actions of glucocorticoids.<p class="abstext"...

Incretin-based therapies, such as the injectable GLP-1 receptor agonists and orally administered DPP-4 inhibitors, have recently been introduced into clinical practice. At present, the GLP-1 receptor agonists need to be administered once or twice daily. Several once weekly GLP-1 receptor agonists are in phase 3 development. This review examines the efficacy, safety and perspective for the future of the once weekly GLP-1 receptor agonists: exenatide once weekly, taspoglutide, a...