Endocrine Abstracts

At least six major steps are required for secreted thyroid hormone to exert its action on target tissues: thyroid hormone transport into cells, intracellular activation of the prohormone thyroxine, transfer of the hormone from the cytoplasm to the nucleus, intact thyroid hormone receptors and intact nuclear and cytosolic machinery required for the mediation of thyroid hormone action. Mutations interfering with three of these steps have been so far identified and are the subjec...

Samuel Refetoff, University of Chicago, IL, USA. AbstractSamuel Refetoff is known for his discovery (1967) of resistance to thyroid hormone (Refetoff Syndrome) and elucidation of its genetic and molecular basis (1989/92).Devoted to the study of inherited thyroid disorders, his laboratory was first to identify mutations in: serum TH transport proteins [TBG (1989) and albumin (1994)]; the TSH rece...