ea0025pl6 | Society for Endocrinology Medal Lecture | SFEBES2011
Williams Graham R
Hypothyroidism delays bone formation, whilst thyrotoxicosis accelerates skeletal development but is a risk factor for osteoporosis. We characterized mice with mutation or deletion of T3 receptors, TRα and TRβ, in several genetic backgrounds. Delayed ossification and growth retardation were observed in TRα mutants, whereas TRβ mutants had advanced bone age. Adult TRα mutants had high bone mass, whereas TRβ mutants were osteoporotic. Targ...