ea0006s1 | Society for Endocrinology Asia and Oceanic Medal Lecture | SFE2003
Waters M
Growth hormone (GH) is the major regulator of postnatal growth and an important metabolic regulator. It modulates a variety of processes in many tissues, ranging from adipogenesis to neurogenesis and immune function.GH is currently thought to activate its receptor through hormone-induced dimerization, resulting in activation of the Janus kinase, JAK2. However, we find that the receptor exists as a dimer in the plasma membrane before hormone binding, base...