Adrenal 1

ea0085p1 | Adrenal 1 | BSPED2022

Recommendations for hydrocortisone doses for emergency management and peri-operative care for childhood adrenal insufficiency. BSPED consensus guidelines

Mushtaq Talat , Ali Salma , Boulos Nabil , Boyle Roisin , Cheetham Tim , Davies Justin , Elder Charlotte , Gan Hoong-Wei , Hindmarsh Peter , Katugampola Harshini , Kerr Stephanie , Krone Nils , Salomon Estebanez Maria , Shenoy Savitha , Tollerfield Sally , Choong Wong Sze , Regan Fiona

Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands which is treated with replacement doses of hydrocortisone. At times of physiological stress there is an increased requirement for exogenous glucocorticoids, which if untreated can lead to an adrenal crisis. Currently there are no unified guidelines for those <18 years old in the UK; this can lead to a substantial variation in the management of AI in both an emergency and peri...

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ea0085p2 | Adrenal 1 | BSPED2022

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Park Julie , Jones Lily , Dliso Silothabo , Bright Orla , Walker Laura , Grasim Ionela , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Saliva is ideal for measuring free, biologically active hormones. Measurements of salivary androgens may be valuable in diagnosis and monitoring of adrenal disorders, however the diurnal profile and robust reference ranges in healthy children are currently undefined. We report salivary testosterone, androstenedione (A4), 11-ketotestosterone (11-KT), 11-β hydroxyandrostenedione (11β-OHA4) concentrations measured throughout the day in healthy children.<...

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ea0085p3 | Adrenal 1 | BSPED2022

Mean glucose concentrations are increased, and cardiovascular risk factors are common in children and young people with secondary adrenal insufficiency (GRACE2)

Park Julie , Jones Lily , Dliso Silothabo , Hawcutt Daniel , Shantsila Alena , Lip Gregory , Blair Joanne

Background: Hypoglycaemia, possibly due to non-physiological hormone replacement, and poor cardiovascular outcomes are described in patients with adrenal insufficiency (AI), particularly in the adult population. In this study, we describe glucose profiles and risk factors for premature cardiovascular disease (CVD) in children with secondary AI (SAI).Methods: Participants underwent continuous glucose monitoring (CGM), for seven days (blinded Dexcom G6 mon...

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ea0085p4 | Adrenal 1 | BSPED2022

Establishing the utility of the 60-minute serum cortisol sample in a standard synacthen test in a tertiary paediatric centre

Tollerfield Sally , Ridout Deborah , Atterbury Abigail , Wadey Hannah , Amin Rakesh , Gan Hoong-Wei , Katugampola Harshini

Background: The standard synacthen test (SST) is commonly utilised to interrogate the hypothalamo-pituitary-adrenal (HPA) axis in children. It comprises baseline and 30-minute serum cortisol concentrations (SCC), after injecting synthetic adrenocorticotropic hormone (ACTH)[124]. There is debate regarding the utility of a 60-minute SCC in the SST protocol with most studies to date conducted in adults.Aim: To assess the utility of a 60-minute SCC in ...

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ea0085p5 | Adrenal 1 | BSPED2022

Abstract Withdrawn...

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ea0085p6 | Adrenal 1 | BSPED2022

Abstract Unavailable...

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Endocrine Abstracts

49th Annual Meeting of the British Society for Paediatric Endocrinology and Diabetes

Poster Presentations

Recommendations for hydrocortisone doses for emergency management and peri-operative care for childhood adrenal insufficiency. BSPED consensus guidelines

Salivary adrenal biomarkers differ depending on age and sex in healthy children: preliminary data

Mean glucose concentrations are increased, and cardiovascular risk factors are common in children and young people with secondary adrenal insufficiency (GRACE2)

Establishing the utility of the 60-minute serum cortisol sample in a standard synacthen test in a tertiary paediatric centre

BiosciAbstracts