Endocrine Abstracts

Primary hyperparathyroidism in pregnancy is rare, with a reported incidence of 1%. It is often asymptomatic with the majority of cases in case-series identified incidentally. Published case series report dramatic maternal complications including nephrolithiasis, pancreatitis, hyperemesis gravidarum, pre-eclampsia and hypercalcaemic crises with fetal complications including intrauterine growth restriction, preterm delivery and neonatal hypocalcaemic tetany. Severity of complica...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder with a prevalence of 0.86% in Europe. Approximately 10% of cases are hereditary. Syndromic PHPT occurs as part of multiple endocrine neoplasia (MEN)1, MEN4, MEN2A and hyperparathyroidism jaw tumour syndrome. Non-syndromic causes include familial hypocalciuric hypercalcaemia. Establishing the underlying genetic cause allows for targeted, cost effective management. Current guidelines recommend that genetic testing...

Success following initial parathyroid surgery is high at approximately 95%. Developments in preoperative imaging techniques and subtle variations in parathyroid surgical approach have marginally improved already high success rates. However, failed initial neck exploration or true later recurrence of primary hyperparathyroidism (PHPT) can be difficult to manage. The initial consideration is always to ensure that the diagnosis of PHPT is secure and it is prudent to re-evaluate t...