Endocrine Abstracts

Contents

• PLENARY LECTURES
• • Society for Endocrinology Jubilee Medal Lecture
  • • Pituitary cells alive: hormone genes pulsing on and off

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  • Society for Endocrinology Medal Lecture
  • • Sex steroids and the endometrium: dynamics and disorders

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Cushing's syndrome as a model of endocrine tumorigenesis

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  • British Thyroid Association Pitt-Rivers Lecture
  • • Thyroid cancer genomics, differentiation state and response to radioiodine

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  • Society for Endocrinology European Medal Lecture
  • • Mechanisms and consequences of endocrine autonomy - lessons learned from the adrenal cortex

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  • Society for Endocrinology International Medal Lecture
  • • The melanocortin microcircuitry and its role in energy homeostasis

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • How is alkaline phosphatase essential for bone? The transatlantic stories

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  • Society for Endocrinology Dale Medal Lecture
  • • From Carney complex to gigantism and Cushing disease: an insight into the genetics of pituitary tumors

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  • Society for Endocrinology Starling Medal Lecture
  • • From its origins to the modern metabolic network

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  • Clinical Endocrinology Trust Lecture
  • • Controlling cortisol in cardiometabolic disease

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• DEBATE: NATURE vs NURTURE
• • This house believes nature not nurture determines our bodyweight
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• SOCIETY FOR ENDOCRINOLOGY JOURNAL AWARDS
• • Society for Endocrinology Journal Award – Journal of Endocrinology
  • • FGF21 acts as a negative regulator of bile acid synthesis

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  • Society for Endocrinology Journal Award – Journal of Molecular Endocrinology
  • • HDAC inhibitors impair Fshb subunit expression in murine gonadotrope cells

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  • Society for Endocrinology Journal Award – Endocrine-Related Cancer
  • • Notch pathway inhibition targets chemoresistant insulinoma cancer stem cells

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  • Society for Endocrinology Journal Award – Endocrine Connections
  • • GH deficiency in patients with spinal cord injury: efficacy/safety of GH replacement, a pilot study

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  • Society for Endocrinology Journal Award – Clinical Endocrinology
  • • Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency

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• EARLY CAREERS AND PLENARY ORALS
• • Early Career Prize Lecture Basic Science
  • • Unravelling of new type 2 diabetes genes with 3D chromatin topology analysis and CRISPR-Cas9 perturbations

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  • Early Career Prize Lecture Translational
  • • From bench to bedside and beyond: a novel therapy to improve wound healing in type 2 diabetes

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  • Clinical Endocrinology Trust Best Abstract Clinical
  • • Urine steroid metabolome analysis allows for metabolic risk stratification in 1309 prospectively recruited patients with benign adrenal tumours and different degrees of cortisol excess

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  • Clinical Endocrinology Trust Best Abstract Basic
  • • Mice harbouring a germline heterozygous AP2S1 mutation, Arg15Leu, are a model for familial hypocalciuric hypercalcaemia type 3 (FHH3)

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• SYMPOSIA
• • Gut hormones physiology, pathology and pharmacology
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  • New insights into PCOS
  • • Fetal antecedents of PCOS: is there a role of AMH?

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  • Phosphate homeostasis physiology, pathology and pharmacology
  • • FGF23 signalling and physiology

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    • Phosphate-sensing update: interplay between FGF23, phosphate, and phosphate-sensors

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    • FGF23-related hypophosphatemic diseases: prospect for new treatment

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  • Thyroid hormone a key regulator in inflammation
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    • Thyroid hormone in inflammation

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    • Myelin repair stimulated by CNS-selective thyroid hormone action

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  • Stress – The rhythm of life
  • • The interplay between stress, biological clocks and metabolic function

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    • Dynamic of the adrenal in health and disease

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  • New horizons in neuro-endocrine disease
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• EARLY CAREER SYMPOSIA
• • Engaging with the public
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• WHAT IS NEW?
• • What is New?
  • • What is new in basic endocrinology research?

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• CLINICAL MANAGEMENT WORKSHOPS
• • Salt & Water
  • • Management of hyponatraemia

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    • Diabetes insipidus - management challenges and pitfalls

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    • Copeptin - a new player in the diagnosis of salt and water balance

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  • Hyperparathyroidism
  • • Management of primary hyperparathyroidism in pregnancy

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    • Genetic testing in hyperparathyroidism - who to test and why

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    • Challenges in recurrent hyperparathyroidism

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• BASIC PHYSIOLOGY WORKSHOPS
• • Modelling endocrinology in vitro, in vivo & in silico
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    • In vitro models of endocrinology: organoids from pituitary and endometrium

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  • Imaging endocrinology from networks to organelles
  • • In vivo imaging of endocrine cell networks

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    • Spatial programming of GPCR signalling

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    • High content imaging for monitoring signalling dynamics in single cells

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• HOW DO I? SESSIONS
• • How do I. . .? 1
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    • How do I decide which patients with gynaecomastia need more detailed evaluation

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    • How do I manage hair loss and hair growth in PCOS

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  • How do I. . .? 2
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    • How do I decide when to initiate dopamine agonist withdrawal?

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• INNOVATION SESSIONS
• • Advances in understanding skeletal disease
  • • Identifying new skeletal disease

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    • Hyponatraemia and osteoporosis

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  • Big data in space and time
  • • Single cell technologies in endocrine systems

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  • NIHR Pathways to clinical impact
  • • From basic science to life changing therapies

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• MEET THE EXPERT SESSIONS
• • Thyroid disease after immune reconstitution
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  • Functional imaging of the adrenal
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  • Updates on DSD genetics
  • • Update on DSD genetics

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  • Fighting liver fat
  • • Fighting liver fat

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  • Novel epigenetic inhibitors
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  • What have we learned from HR-pQCT?
  • • What have we learned from high resolution peripheral quantitative computed tomography (HR-pQCT)?

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• CLINICAL SKILLS
• • Being a consultant – How to get the job and keep it
  • • How to get the consultant post you want

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    • How do I set up a new service?

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• BASIC SKILLS
• • Introduction to teaching
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• TEACHING SKILLS
• • Innovations in teaching
  • • Innovations in teaching

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• NURSE SESSIONS
• • NICE – T3
  • • T3 replacement - What does the evidence suggest?

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    • Health care professional & patient consultation - informed decision making

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    • A Beginners Guide: setting up a Nurse-Led Thyroid Clinic

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  • Management of Hyper and Hypocalcaemia
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    • Patient management of hypercalcaemia and when should the surgeon intervene?

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    • Patient management of hypocalcaemia & the patient perspective

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• ENDOCRINOLOGY IN THE UK
• • Workforce, Standards, and Quality Improvement
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    • Getting it right first time for endocrinology

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    • SfE/ABCD/DUK - diabetes and endocrinology consultant workforce survey: results from 2018

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• SENIOR ENDOCRINOLOGISTS’ SESSION
• • Innovations in teaching
  • • What happened to the adrenal X-zone?

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    • Is the estrogenic component of Premarin all bad?

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    • Potential benefits of adequate vitamin D status for non-bony disorders are large, so why do so many RCTs of supplementation fail?

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• ORAL COMMUNICATIONS
• • Metabolism and Obesity
  • • Intracrine activation of 11-oxygenated androgens by AKR1C3 modulates lipid metabolism in human female adipose tissue

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    • Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism

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    • Metabolic and functional effects of fatty acid overload on in vitro tissue engineered skeletal muscle

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    • 5[beta]-reductase (AKR1D1) is downregulated in patients with non-alcoholic fatty liver disease and protects against hepatocellular carcinoma cell proliferation in vitro

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    • Prolyl-hydroxylase 3 maintains [beta]-cell glucose-sensing under metabolic stress

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    • Metabolic surgery reduces kidney SGLT2 expression in mice

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  • Neuroendocrinology, Pituitary and Neoplasia
  • • Differential effects of subcutaneous pulsatile versus oral hydrocortisone replacement therapy on fMRI resting state and task based emotional processing in patients with primary adrenal insufficiency

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    • Investigating the role of AIP in pituitary tumourigenesis

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    • ErbB receptor signalling in MCF7 breast cancer cells: an information theoretic approach

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    • Investigating the role of vagal Y2R in PYY_3-36-mediated appetite suppression

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    • Efnb2 controls pituitary gland development by regulating proliferation of the pituitary stem/progenitor cells and EMT within the pituitary stem cell niche

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    • Post-operative copeptin analysis as a predictor of diabetes insipidus after pituitary surgery

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  • Bone and Calcium
  • • A mouse model generated by CRISPR-Cas9 with a frameshift mutation in the nuclear factor 1/X (NFIX) gene has phenotypic features reported in Marshall-Smith Syndrome (MSS) patients

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    • Hypophosphatasia in adulthood - are patients really 'unaffected'

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    • Generation of a long acting parathyroid hormone hybrid analogue through fusion to a binding protein

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    • Characterisation of rare GNA11 variants reveals 8 novel residues important for signalling by the calcium-sensing receptor: Relevance for FHH and ADH

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    • Mutational analysis of a patient with familial hypocalciuric hypercalcaemia identifies a novel p.Ser182Cys mutation, which is predicted to disrupt the calcium sensing receptor (CaSR) extracellular domain

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    • The role of biased calcium-sensing receptor signalling in urinary calcium excretion and kidney stone disease

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  • Thyroid
  • • A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy

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    • Reduced Length of Hospital Stay with the use of recombinant TSH compared to Thyroid Hormone Withdrawal -A two centre retrospective study

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    • The disturbed thyroid gland homeostasis in conditions of subacute exposure to thyroid-disrupting chemicals: experimental study in Wistar rats

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    • Development of auto-immune thyroid dysfunction in multiple sclerosis patients receiving Alemtuzumab is associated with improved response to treatment

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    • The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility across the United Kingdom

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    • Driver events in thyroid cancer recurrence

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  • Adrenal and Cardiovascular
  • • Central role for corticosteroid-binding globulin in rat HPA axis sexual dimorphism

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    • Subclinical alpha-1 antitrypsin deficiency is associated with increased free cortisol fraction in plasma

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    • Common variants in the gene encoding corticosteroid binding globulin influence cortisol-responsive gene networks in human adipose tissue

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    • Pre-receptor metabolism and signalling of glucocorticoids between macrophages and fibroblasts

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    • Somatic transmembrane domain mutations of a cell adhesion molecule, CADM1, cause primary aldosteronism by preventing gap junction communication between adrenocortical cells

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    • SLC35F1, a potential marker for aldosterone producing cell clusters

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  • Reproductive Endocrinology and Biology
  • • Effect of MVT-602, a potent kisspeptin receptor agonist, on LH levels in healthy pre-menopausal women undergoing a minimal controlled ovarian stimulation protocol

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    • Differential follicle stimulating hormone glycosylation modulates follicle growth and survival rates

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    • Investigating the impact of altered maternal extracellular vesicle miRNAs on placental function in women with gestational diabetes complicated by large for gestational age infants

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    • Kallmann syndrome-associated WDR11 regulates primordial germ cell development

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    • Placental expression of estrogen related receptor [gamma] (ERR[gamma]) is hypoxia-sensitive and is altered in pregnancies complicated by fetal growth restriction

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    • Kisspeptin enhances the brain processing of attraction in men

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• ORAL POSTER PRESENTATIONS
• • Adrenal and Cardiovascular
  • • Betamethasone/GR ChIP-Seq analysis defines a discrete set of canonical GR homodimer binding sites in primary fetal rat lung mesenchymal fibroblasts

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    • Glucocorticoids promote mitochondrial fatty acid oxidation in the fetal heart

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    • Combining 11C-metomidate PET/CT and 18F-FDG PET/CT - a new approach to phenotyping indeterminate adrenal lesions

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    • Global phosphoproteomics links rapidly induced cytoplasmic signals to transcriptional control

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  • Thyroid
  • • Day case radio-iodine for remnant ablation in differentiated thyroid cancer patients is safe and helps reduce bed pressures in a busy tertiary centre hospital

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    • The SH2B3 tryptophan 262 variant is associated with Graves' disease and Addison's disease

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    • Sustained improvements in monitoring and biochemical control of hypothyroidism in primary care with the use of an electronic protocol at two year follow up

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    • The proto-oncogene PBF mediates Src modulation of radioiodine uptake

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  • Metabolism and Obesity
  • • Intermittent cold exposure ameliorates fatty liver disease

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    • Intestinal injury and evidence of increased gut permeability in female AKR1D1 knockout mice

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    • The impact of subcutaneous infusions of three anorexigenic gut hormones glucagon-like peptide-1, oxyntomodulin and peptide YY (GOP) on the psychological health of obese diabetic patients

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    • Mice with a gain-of function G[alpha]₁₁ mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

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  • Bone and Calcium
  • • Oral calcium loading test can predict the progression of hypercalcaemic primary hyperparathyroidism in patients with normocalcaemic hyperparathyroidism

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    • Identification of novel pathogenic variants and phenotypic features in patients with pseudohypoparathyroidism and acrodysostosis, subtypes of the newly defined inactivating PTH/PTHrP signalling disorders (iPPSD) classification system

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    • Mendelian randomization and machine learning to assess the causal association of Type 2 Diabetes with osteoporosis and fragility fractures

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    • The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study

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  • Reproductive Endocrinology and Biology
  • • Hypothalamic-pituitary-gonadal (HPG) axis suppression during basic military training in women despite increased adiposity and insulin resistance

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    • Profiling the expression and function of the truncated oestrogen receptor isoform ER46 in human endometrium

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    • Stress is implicated in programming metabolic disorders in the offspring of fructose-induced diabetic rats

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    • Kisspeptin as a novel biomarker for pregnancy complications

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  • Neuroendocrinology, Pituitary and Neoplasia
  • • Extended TSS (guided by 11C-methionine PET + MRI (Met-PET/MRCR)) can be an effective treatment option for patients with persistent acromegaly due to previously deemed unresectable lateral disease

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    • Transcriptomic analyses reveal deregulation of focal adhesion pathway in Aip KO mice and AIP mutation positive human tumours

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    • JQ1 treatment significantly reduces POMC expression and ACTH secretion from the corticotrophinoma cell line, AtT20

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    • Urine steroid metabolomics as a novel diagnostic tool for recurrent adrenocortical carcinoma detection

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• FEATURED CLINICAL CASE POSTERS
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• POSTER PRESENTATIONS
• • Adrenal and Cardiovascular
  • • Single cell RNA-seq reveals complex processing of glucocorticoid controlled transcriptional programmes

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    • 11[beta]-HSD1 mediates muscle atrophy induced by glucocorticoid therapy in chronic inflammatory disease

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    • A role for salivary cortisol measurement in assessing heat tolerance during exercise

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    • Serum estrogens and the sexual dimorphism in heritable and idiopathic pulmonary arterial hypertension (PAH)

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    • Cardiovascular morbidity is increased in secondary but not primary adrenal failure

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    • Monitoring metyrapone therapy for Cushing's syndrome using salivary glucocorticoid measurement by liquid chromatography tandem mass spectrometry (LC-MS/MS)

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    • ULTRADIAN adrenal steroid metabolodynamics successfully discriminates pituitary Cushing's disease from healthy normal variation

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    • Clinical outcomes in adrenocortical carcinoma: evaluation of single and combined prognostic markers in a UK single centre cohort

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    • Exploring diagnostic thresholds for adrenal insufficiency with the new generation Roche cortisol assay

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    • Thyroid hormone receptors in the mouse kidney in health and chronic kidney disease

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    • Cosyntropin stimulation test post unilateral adrenalectomy for non-steroid secreting lesions: not all who fail require steroids

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    • Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) as an alternative to left sided adrenalectomy in the treatment of primary aldosteronism

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    • Seasonal vaccination and associated steroid management practice in adrenal insufficiency

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    • Adrenal aldosterone and cortisol levels and their concordance with intervention in patients being investigated for primary hyperaldosteronism

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    • A rare case of cardiac phaeochromocytoma with germline mutation

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    • Very high rate of false positive biochemical results when screening for phaeochromocytoma in a large, undifferentiated population with variable indications for testing

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    • A rare presentation of Cushing's syndrome

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    • Support for adopting a pragmatic approach to adrenal incidentalomas

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    • Can short Synacthen tests (SST) be rationalised by establishing a lower baseline cortisol level which will predict SST outcome?

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    • Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA

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    • Linagliptin induces vasorelaxation via inhibition of Rho-associated protein kinase activity in aortic smooth muscle

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    • Non-adrenal tumours encountered during adrenal surgery

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    • Short Synacthen test; are we getting it right?

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    • A case of severe hypokalaemia and metabolic acidosis

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    • A cross-sectional audit reviewing the management of adults with congenital adrenal hyperplasia in Leicester

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    • Secondary hypertension service in a District General Hospital - the success story

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    • Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test 'Verdict'

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    • Immunoassay interferences and their impact on patient care

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    • A UK national audit of the laboratory investigation of phaeochromocytoma and paraganglioma

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    • The PASS score is not a reliable measure of predicting aggressive potential in phaeochromocytoma - experience over 14 years at our University Teaching Hospital

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    • An unusual case of adrenal cortical carcinoma presenting with hypogonadotrophic hypogonadism

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    • Aldosterone deficiency type 1 due to mutation of the CYP11B2

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    • Hepatocellular carcinoma masquerading as an adrenocortico-carcinoma

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    • Mitiglinide induces vasodilatory through the activation of voltage-gated K+ channels and SERCA pump in aortic smooth muscle

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    • Extensive resection of adrenal tumours requiring complex multidisciplinary approach

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    • Group education clinics for patients with adrenal insufficiency; a DGH experience

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    • Audit of adrenal crisis management at University Hospitals Leicester NHS Trust

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    • Retrospective analysis of the management of adrenal incidentalomas

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    • The peri-operative management of diabetes in elective major vascular procedures: a completed cycle quality improvement project (QIP)

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    • Use of sub-cutaneous pump for continuous hydrocortisone administration in patient with bilateral adrenalectomy and small bowel injury complicated by enterocutaneous fistula

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    • A rare presentation of an androgen-secreting tumour without hyperandrogenic symptoms

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    • An unusual pathology presenting as adrenal incidentaloma

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    • A case of catecholamine induced cardiomyopathy

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    • An audit of the management of adults with Congenital Adrenal Hyperplasia in Newcastle upon Tyne - where are we now?

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    • Primary adrenal failure from bilateral adrenal infiltration by classical Hodgkin's lymphoma

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    • Hypokalaemic cardiac arrest - a rare presentation of primary aldosteronism

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    • Twenty-five years of familial glucocorticoid deficiency: genotypic and phenotypic variability

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    • An interesting case of acute hypoadrenalism following an intervention to treat bleeding splenic artery pseudoaneurysm by thrombin injection

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    • Vildagliptin induces vasorelaxation by activation of SERCA pump and Kv channels in aortic smooth muscle

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    • Heparin-induced hypo-aldosteronism and hyperkalemia

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    • Inpatient pheo crisis in neurofibromatosis type1 (NF 1) 'Triggers and management'

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    • Adrenal suppression following Herbal remedy for Nasal Polyps....not to be sniffed at

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    • A case of adrenal insufficiency due to histoplasmosis

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    • Unexplained adrenal insufficiency after gastric bypass surgery

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    • A case of anaphylaxis in phaeochromocytoma

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    • A case of familial hyperkalemia due to Gordon's syndrome

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    • Safe withdrawal of corticosteroids after prolonged use: a call for a national protocol

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    • Real life experience of 8 people with adrenal insufficiency using subcutaneous hydrocortisone infusion in continuous and pulsatile regimens recruited through hydrocortisone pump support group

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    • Transient diabetes insipidus following aortic valve replacement

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    • Retrospective audit of adrenal incidentaloma

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    • A service evaluation for patients with adrenal incidentalomas

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    • Adrenal medullary hyperplasia mimicking phaeochromocytoma - a case report

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    • Primary aldosteronism (PA) - clinical and hormonal characteristics of a series of patients

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    • Maturity onset diabetes of the young: a first case description of PAX4 mutation in the UAE

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    • Waterhouse-Friderichsen syndrome: an endocrine emergency

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    • New onset paranoid psychosis associated with 'incidental' pheochromocytoma

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    • Unusual case of aldosterone and cortisol co-secreting adrenal adenoma

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    • Adrenal incidentaloma multi-disciplinary investigation and management at University Hospitals of Derby and Burton Foundation Trust

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    • Comparison of adrenal incidentalomas management in single Trust with reference of European society of endocrinology guidelines

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    • Autonomous cortisol secretion in adrenal incidentalomas

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    • Management of adrenal incidentaloma: a DGH experience

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    • Heparin-induced hypo-aldosteronism and hyperkalemia

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    • Symptomatic hyponatraemia due to valerian extract use

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    • Review of the adrenal surgeries at East Sussex Hospitals Trust over 2 years

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    • Factitious Addison's disease in a young adolescent with type 1 diabetes

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    • Impacts and quality of life for people with adrenal insufficiency using Medical Detection Dogs before and after initiation of continuous subcutaneous hydrocortisone infusion (CSHI)

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    • The frustration of endocrine practice in a resource poor, developing country

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  • Bone and calcium
  • • Development of a long-acting parathyroid hormone for the treatment of hypoparathyroidism

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    • Assessing the use of Cinacalcet for conservative management of primary hyperparathyroidism in a regional district general hospital

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    • Relationships between serum calcium and parathyroid hormone levels on effectiveness of parathyroid scintigraphy with Sestamibi

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    • Association between lean mass and bone mass density in patients with inflammatory bowel disease

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    • Estimation of post-surgical hypoparathyroidism incidence following total thyroidectomy in University Hospitals Leicester NHS Trust

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    • A retrospective cohort study evaluating the relationship between the severity of vitamin D deficiency and the clinical and biochemical presentations of patients with primary hyperparathyroidism (PHPT)

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    • The use of 2D-computed tomography scan as a first-line imaging modality in primary hyperparathyroidism

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    • Effect of vitamin D analogue therapy in a patient with autosomal dominant hypocalcaemia type 2 (ADH2) due to GNA11 p.Arg60Leu mutation

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    • Investigations in preparation for surgically managed primary hyperparathyroidism

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    • The prevalence of vitamin D deficiency in patients admitted with low trauma fractures - is pragmatic vitamin D supplementation appropriate?

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    • Bone turnover marker response in patients on second line agents for osteoporosis - what is the significance of non-suppression?

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    • Rare case of pseudohypoparathyroidism Type 1b

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    • There is a need to improve care provision for primary hyperparathyroidism - results of a survey of Parathyroid UK

      ea0065p91
    • Hypercalcaemia management in in-patients in a district general hospital

      ea0065p92
    • Lithium induced hypercalcaemia - local review of presentation, management and surgical outcomes

      ea0065p93
    • An audit on the surgical management of patients with asymptomatic primary hyperparathyroidism (PHPT) at University Hospital Birmingham

      ea0065p94
    • A case of successful parathyroidectomy in the third trimester of pregnancy

      ea0065p95
    • Primary hyperparathyroidism in pregnancy - successful pregnancy outcomes in a series of five cases

      ea0065p96
    • Prevalence of PPI usage amongst patients with severe hypomagnesaemia in a London hospital

      ea0065p97
    • Audit into appropriate diagnostic investigation and MDT discussion prior to parathyroidectomy for primary hyperparathyroidism

      ea0065p98
    • Normocalcaemic primary hyperparathyroidism: a diagnostic dilemma

      ea0065p99
    • Management of Familial Hypophosphatemia in Pregnancy

      ea0065p100
    • Four cases of familial hypocalciuric hypercalcaemia presenting with severe hypercalcaemia

      ea0065p101
    • Parathyroidectomy outcomes for primary hyperparathyroidism over a 2 year period at East Sussex Hospitals Trust

      ea0065p102
    • A case of severe hypercalcemia detected in early pregnancy

      ea0065p103
    • Vitamin D Questionnaire Validation and exploration of association with serum 25-hydroxyvitamin D in a UK adult population: a cross-sectional study and pilot study

      ea0065p104
    • Complications at diagnosis in primary hyperparathyroidism

      ea0065p105
    • Are you kidney-ing me? An evaluation of methods to estimate renal function in the Mineral metabolism clinic

      ea0065p106
    • Not all cases of hypercalcemia with calcium above 3.0 mmol/l and raised parathyroid hormone levels are due to primary hyperparathyroidism

      ea0065p107
    • An elusive cause of severe, recurrent hypercalcaemia

      ea0065p108
    • Severe acute 'non-malignant' hypercalcaemia

      ea0065p109
    • Hyperparathyroidism in pregnancy: a case series

      ea0065p110
    • Hypophosphatasia in an infant: a differential diagnosis that should not be overlooked

      ea0065p111
    • Recurrence of hypercalcaemia more than ten years following parathyroidectomy, was it an unfortunate coincidence or should we routinely follow up high risk patients for a longer period following parathyroidectomy

      ea0065p112
    • Sarcoidosis imitating metastatic colon carcinoma

      ea0065p113
    • Intermittent Hypercalcaemia in a Young Man

      ea0065p114
    • Ventricular arrhythmia and cardiac arrest: a dramatic presentation of hypoparathyroidism

      ea0065p115
    • Calcium imbalance in sarcoidosis and renal failure

      ea0065p116
    • An unusual case of symptomatic hypercalcemia from Grave's Disease in a young Filipino female

      ea0065p117
    • Hypercalcaemia secondary to vitamin D deficiency in T.B patients

      ea0065p118
    • Post thyroidectomy and parathyroidectomy: optimizing calcium monitoring and management

      ea0065p119
    • Persistent hypercalcemia in a patient with steroid sensitive sarcoidosis due to coexisting primary hyperparathyroidism

      ea0065p120
    • A case of proton pump inhibitor associated severe hypocalcaemia

      ea0065p121
    • Differential diagnosis of pseudohypercalcaemia by measurement of ionised calcium

      ea0065p122
    • A case report of concomitant diagnosis of multiple myeloma and primary hyperparathyroidism

      ea0065p123
    • The forgotten electrolyte-when hypercalcaemia presents with acute confusion

      ea0065p124
    • Symptomatic hypercalcemia from Graves' disease: a case report

      ea0065p125
    • Hypocalcaemia presentation with HDR syndrome

      ea0065p126
    • Severe hypercalcaemia and acute kidney Injury in a patient with sarcoidosis

      ea0065p127
    • Unusual cause of hypophosphatemia in an adult

      ea0065p128
    • Hyperparathyroidism in pregnancy - a missed opportunity in prenatal management?

      ea0065p129
  • Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer
  • • Nuclear receptor profiling predicts chemical disruptors as risk factors for developing breast cancer

      ea0065p130
    • Inflammatory cytokines dysregulate oestrogen metabolism in colorectal cancer

      ea0065p131
    • Risk stratification of variants of unknown significance (VUS) in monogenic endocrine tumour genes using population-level genetic data and computational analysis

      ea0065p132
    • Tumour detection and outcomes of surveillance screening in SDHB and SDHD mutation carriers

      ea0065p133
    • PLK1 inhibitors as potential new treatment for adrenocortical carcinoma

      ea0065p134
    • The impact of gastrointestinal symptoms on quality of life in people with MEN2B

      ea0065p135
    • Profiling of tissue inflammatory cytokine expression in a pancreatic neuroendocrine tumour mouse model identifies upregulation of the chemokine C-C motif ligand 2 (CCL2)

      ea0065p136
    • Long term outcomes following parathyroidectomy in patients with multiple endocrine neoplasia type 1: A retrospective cohort study

      ea0065p137
    • Targeting oestrogen synthesis and action as a novel therapy for colorectal cancer

      ea0065p138
    • Clinical spectrum of endocrine toxicities of Immune checkpoint therapy: single centre experience

      ea0065p139
    • A cyclin dependent kinase inhibitor 1B missense mutation (Pro69Leu) is associated with familial hypomagnesaemia, but not multiple endocrine neoplasia type 4 (MEN4)

      ea0065p140
    • Predicting hypophysitis in patients treated with immune checkpoint inhibitors: can prolactin be used as a marker of incipient disease?

      ea0065p141
    • Living with and beyond childhood cancer - endocrine impact up to 40 years on

      ea0065p142
    • Ipilimumab-induced hypophysitis: a longitudinal analysis in a cohort of patients with metastatic melanoma

      ea0065p143
    • The yield and cost of radiological screening in von Hippel-Lindau disease

      ea0065p144
    • DI patients vote for a name change to pituitary insipidus to improve safety - a survey

      ea0065p145
    • Frequency of pathogenic germline variants in hereditary endocrine tumour genes in patients with discordant cancer phenotypes

      ea0065p146
    • Lobectomy for thyroid cancer and thyroglobulin as a tumor marker for long term follow up: current controversies and clarification

      ea0065p147
    • An audit on a teenage and young adult (TYA) neuro-oncology and late effects clinic

      ea0065p148
    • Prolonged supervised fast for insulinoma - an experience in a District General Hospital Trust

      ea0065p149
    • Breast cancer in MEN1: coincidence or association?

      ea0065p150
    • A post implementation audit of a local Chromogranin A service - a step towards individualised patient care

      ea0065p151
    • The expression pattern of miR-16, 21, 145, and 375 in plasma of breast cancer patients at different clinical stages

      ea0065p152
    • Ipilimumab-induced hypophysitis with normal pituitary function: a series of 3 cases

      ea0065p153
    • Checkpoint inhibitors and immune related diabetes mellitus: a case series

      ea0065p154
    • Carney's triad due to SDHA gene mutation

      ea0065p155
    • Insulinoma causing remission of diabetes mellitus type 2

      ea0065p156
    • Audit of biochemical screening for multiple endocrine neoplasia type 1 in patients diagnosed with pancreatic neuroendocrine tumours

      ea0065p157
    • Palliative electrochemotherapy treatment in a patient with advanced thyroid papillary carcinoma with cutaneous metastases

      ea0065p158
    • Recurrent hyperparathyroidism in a patient with multiple endocrine neoplasia type 1 (MEN1) after total parathyroidectomy with autotransplantation unmasked by depression and vague abdominal pain

      ea0065p159
    • Irradiation and endocrinopathies: multiple complications in a single patient

      ea0065p160
    • A rare case of Small cell lung carcinoma with dual ADH and ACTH secretion

      ea0065p161
    • Transient adrenal insufficiency in a patient with an insulinoma

      ea0065p162
    • Impact of diabetes education in patients with newly diagnosed diabetes

      ea0065p163
    • Case report on Immunotherapy mediated hypocortisolemia

      ea0065p164
    • A case of pituitary metastatic deposit from breast cancer

      ea0065p165
  • Metabolism and Obesity
  • • Obesity-induced changes in hepatocyte and skeletal myocyte expression of mRNAs encoding islet GPCR peptide ligands

      ea0065p166
    • Sarcopenic phenotypes are associated with an increased risk of type 2 diabetes: findings from the Korean Genome and Epidemiology Study (KoGES)

      ea0065p167
    • Long term impact of sleeve gastrectomy on metabolic parameters in morbidly obese patients

      ea0065p168
    • Intravascular subcutaneous adipose tissue blood flow measured with Doppler ultrasound for experimental medicine studies

      ea0065p169
    • Chronic disruption of endothelial Insulin/IGF1 signaling pathway enhances whole body insulin sensitivity

      ea0065p170
    • 5[beta]-reductase (AKR1D1) isoforms differentially regulate natural and synthetic glucocorticoid clearance and glucocorticoid receptor activation in vitro

      ea0065p171
    • Physicochemical optimization of dermal insulin patches: effects on selected metabolic parameters in STZ-induced diabetic rats

      ea0065p172
    • Effect of maternal obesity on offspring metabolic indices

      ea0065p173
    • Impact of free fatty acid 4 receptor internalization on signalling

      ea0065p174
    • The effect of tumour necrosis factor-alpha on myogenesis in immortalised human myoblasts

      ea0065p175
    • Brain derived neurotrophic factor (BDNF) methylation in patients with impaired glucose regulation: implications progression to type 2 diabetes mellitus (T2DM)

      ea0065p176
    • Investigating the role of GPR119 in the vagus nerve

      ea0065p177
    • Glycaemic response to a mixed meal challenge: does camel milk preload confer an advantage?

      ea0065p178
    • Continuous subcutaneous insulin infusion (CSII): a trust-wide audit

      ea0065p179
    • Very low calorie diet (VLCD) in obese patients with longstanding type 2 diabetes mellitus: real-world outcomes with twelve months follow-up

      ea0065p180
    • The progesterone metabolite epiallopregnanolone sulphate induces glucose-stimulated insulin secretion from human and mouse islets and is reduced in gestational diabetes mellitus

      ea0065p181
    • Oral chenodeoxycholic acid increases post-prandial anorectic gut hormone levels and increases indices of insulin sensitivity

      ea0065p182
    • Hepatic effects of new anti-diabetic drugs: real world data from a retrospective study

      ea0065p183
    • Vitamin B12 deficiency leads to fatty acid metabolism dysregulation and increased pro-inflammatory cytokine production in human adipocytes and in maternal subcutaneous and omental adipose tissue

      ea0065p184
    • Endotoxin and adiposity as mediators of down-regulating the BRITE fat phenotype

      ea0065p185
    • AKR1D1 (5[beta]-reductase) deletion drives hepatic inflammation, fibrosis and tumour development in vivo

      ea0065p186
    • Low B12 is associated with increased de novo synthesis of 'unsafe' fatty acids in the liver

      ea0065p187
    • Insulin signalling in kidney podocytes: an information theoretic approach

      ea0065p188
    • The FreeStyle libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes (T1DM) in Eastern Cheshire, UK

      ea0065p189
    • Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes - a 14-year follow up study

      ea0065p190
    • Male testosterone levels and laboratory practice: a need for a standardised approach to measurement and reporting

      ea0065p191
    • Lipoprotein(a) as a predictive biomarker for subclinical coronary atherosclerosis

      ea0065p192
    • Modulation of vagal afferent signalling by the amino acid metabolite sensor GPR35

      ea0065p193
    • Efficacy of liraglutide in weight management post bariatric surgery patients: data from an Emirati cohort

      ea0065p194
    • ISX-9 preferentially induces enterochromaffin and I-cell enteroendocrine lineages in human small intestinal organoids

      ea0065p195
    • The differential effects of weight loss by RYGB versus very-low calorie diet (VLCD) on gut hormone levels and appetite: potential contribution to sustained weight loss

      ea0065p196
    • Immature [beta]-cells are required for normal islet function and insulin release

      ea0065p197
    • Modulation of EGFR expression to increase islet transplantation success

      ea0065p198
    • Systemic and femoral adipose tissue-specific nontargeted plasma metabolome during acute hypercortisolaemia

      ea0065p199
    • A role for kisspeptin in long-term islet function in females

      ea0065p200
    • Vitamin D-binding protein is required for the maintenance of [alpha]-cell identity and function

      ea0065p201
    • Endoplasmic reticulum stress directly impacts mitochondrial function in human adipocytes

      ea0065p202
    • The track-pump study

      ea0065p203
    • Glucocorticoid regulation of the PEPITEM pathway

      ea0065p204
    • The American lifestyle induced obesity syndrome diet (ALIOS) in rodents recapitulates the clinical features and sexual dimorphism of NAFLD and NASH

      ea0065p205
    • Role of palmitoylation on GLP-1 receptor responses in pancreatic beta cells

      ea0065p206
    • Visfatin and resistin as predictors of poor pain outcome in total hip and knee joint replacement in patients with osteoarthritis

      ea0065p207
    • Assessment of cardiovascular disease risk in subjects with pre-diabetes

      ea0065p208
    • Maternal diet-induced cholestasis programmes murine offspring metabolic impairment on feeding a Western diet, with altered intestinal metabolites and microbiota in the female offspring

      ea0065p209
    • All cause and cardiovascular mortality in adults with schizophrenia and diabetes - a retrospective matched study

      ea0065p210
    • Glycated haemoglobin and obstetric outcomes among patients with gestational diabetes mellitus: a single center study

      ea0065p211
    • An audit of SGLT2-inhibitors in the management of type 2 diabetes in Sligo University Hospital Ireland: metabolic and haemodynamic outcomes

      ea0065p212
    • Determinants for developing foot ulcer among persons with diabetes mellitus attending outpatient clinic in a tertiary hospital in Nigeria

      ea0065p213
    • Hypoglycaemia screen (hypopak) quality improvement audit

      ea0065p214
    • Bariatric surgery outcomes amongst older obese patients: data from an Emirati cohort

      ea0065p215
    • Risk of sleep apnoea among Emirati patients with type 2 diabetes

      ea0065p216
    • A novel method for analysis of 11 oestrogens using high-throughput liquid chromatography tandem mass spectrometry

      ea0065p217
    • Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) prevents cytokine-mediated beta cell dysfunction

      ea0065p218
    • Predicting mortality in both diabetes and open-source clinical datasets from free text entries using machine learning (natural language processing)

      ea0065p219
    • GLP-1/Glucagon dual agonist affects amino acid metabolism

      ea0065p220
    • A digital lifestyle programme to support outpatient treatment of type 2 diabetes: a randomised controlled trial

      ea0065p221
    • FSH levels are adversely associated with markers of regional adiposity in postmenopausal women

      ea0065p222
    • Untreated pre-operative mental illness is associated with poorer bariatric surgery outcomes

      ea0065p223
    • Regulation and role of MiR-125b in [beta]-cells

      ea0065p224
    • Refeeding syndrome induced hypertriglyceridemia

      ea0065p225
    • Are PCSK9 inhibitors delivering as promised?

      ea0065p226
    • Bariatric surgery outcomes in super obese Emirati patients

      ea0065p227
    • Investigating mesenchymal stromal cell mediated support of islets after exposure to transplantation related stressors

      ea0065p228
    • Steroid deconjugation by helix pomatia - can we overcome snail speed?

      ea0065p229
    • Acute changes in steroid biosynthesis in patients following severe trauma: the golden hour study

      ea0065p230
    • Mammary adipose tissue steroid activation and its relevance for breast cancer prognosis

      ea0065p231
    • Anti thrombin activity in newly diagnosed Type 2 diabetes subjects in a Tertiary Hospital in Calabar, Nigeria

      ea0065p232
    • L-Phenylalanine simulates the secretion of pancreatic hormones via vagal CaSR

      ea0065p233
    • Adhesion G-protein coupled receptors as novel players in islet development

      ea0065p234
    • Insights into the mechanisms underpinning the physiological effects of biased GLP-1 receptor agonists

      ea0065p235
    • Case reports of immunosuppression therapy for anti-insulin receptor and anti-insulin antibodies in patients attending the national severe insulin resistance service

      ea0065p236
    • Obesity induces cardiac hypertrophy without functional or fibrotic alterations

      ea0065p237
    • Idiopathic gigantomastia: newer mechanistic insights implicating the paracrine milieu

      ea0065p238
    • Weight loss and change in obesity related comorbidities in patients undergoing laparoscopic adjustable gastric banding at UHCW between 2009 and 2012

      ea0065p239
    • Safe use of variable rate intravenous insulin infusion: a trust wide audit

      ea0065p240
    • Investigating the role of microRNA-7 in pancreatic islet development

      ea0065p241
    • Glucocorticoid treatment is associated with dose-dependent effects in healthy male volunteers

      ea0065p242
    • Mass spectrometric characterisation of circulating proinsulin-derived peptides in insulin autoimmune syndrome

      ea0065p243
    • Hepatic steatosis in rats with dexamethasone-induced metabolic syndrome: a role for Ocimum gratissimum leaf extract

      ea0065p244
    • Glycaemic control in patients with diabetes mellitus in a Tertiary Hospital in South-West, Nigeria

      ea0065p245
    • Presentation, investigations and management of suspected Gitelman syndrome in pregnancy

      ea0065p246
    • Audit on initial investigation and management of hyponatraemia in inpatients

      ea0065p247
    • Using problem-based learning (PBL) to engage undergraduate medical students in endocrinology at Edinburgh Medical School

      ea0065p248
    • 'H' syndrome; a rare case with novel symptoms

      ea0065p249
    • Abstract unavailable

      ea0065p250
    • Five-year review of diabetic foot ulcer admissions at Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigera

      ea0065p251
    • Molecular interactions of cashew leaf (Anacardium occidentale) derived compounds with anti-diabetic targets: in silico and in vivo studies

      ea0065p252
    • Juvenile type 2 diabetes and Klinefelter syndrome

      ea0065p253
    • St James's Hospital intensive care unit insulin discharge policy - A quality improvement project

      ea0065p254
    • Ten years type 2 diabetes risks among doctors in Ondo State, South West Nigeria

      ea0065p255
    • Diabetic lipemia − acute pancreatitis and new diagnosis of diabetes

      ea0065p256
    • Life threatening hypoglycaemia associated with illicit benzodiazepines

      ea0065p257
    • Severe peri-partum hyponatraemia: is oxytocin always the culprit?

      ea0065p258
    • Effectiveness of bariatric surgery - impact and metabolic outcome in different co-morbidities - a single center study in UK

      ea0065p259
    • Diabetes-related knowledge, attitude and practice among patients attending a Tertiary Hospital in Kano, Northwestern Nigeria

      ea0065p260
    • Challenges in management of hypoglycemia presented post bariatric surgery

      ea0065p261
    • Audit on sodium glucose cotransporter-2 inhibitors (SGLT2) at Nottingham University Hospitals

      ea0065p262
    • BMI concordance in the United Arab Emirates (UAE): a study of 200 twin pairs

      ea0065p263
    • Dapsone-induced discordant glycated haemoglobin values in a patient with type 1 diabetes

      ea0065p264
    • Emphysematous pyelonephritis − medical management, a viable option

      ea0065p265
    • Cushing's or not − a diagnostic dilemma

      ea0065p266
    • Social support and medication adherence among type 2 DM (T2DM) patients attending a public hospital in Lagos, Nigeria

      ea0065p267
    • Social support and health-related quality of life among type 2 DM (T2DM) patients attending a public hospital in Lagos, Nigeria

      ea0065p268
    • Severe symptomatic hyponatraemia following a minor surgical procedure

      ea0065p269
  • Neuroendocrinology
  • • Antisense oligonucleotides as a novel medical therapy for Cushing's disease

      ea0065p270
    • Increased clot density in patients with acromegaly: the role of the adverse metabolic profile and disease activity to the increased thrombotic potential

      ea0065p271
    • Developing a pyrosequenicng based assay for the detection of SDHC epimutations in clinical practice

      ea0065p272
    • Tissue responsiveness to cortisol: a novel clinical biosignature for the prediction of Nelson's syndrome

      ea0065p273
    • Heat shock protein profiling of Non-functioning pituitary adenomas

      ea0065p274
    • Predictive power of ACTH and cortisol in the early post-operative period following pituitary surgery: relationship to long term glucocorticoid requirement

      ea0065p275
    • The effect of tumor staining pattern on secondary hormonal deficiency in nonfunctioning pituitary adenomas

      ea0065p276
    • Secondary hormonal deficiency patterns vary among different types of sellar masses despite similar size at presentation

      ea0065p277
    • Distinct methylation patterns in sparsely and densely granulated growth hormone-secreting pituitary tumours provide clues to different underlying tumorigenic mechanisms

      ea0065p278
    • CACNA1C genotype does influence CACNA1C methylation and the association with cortisol release/potential mental health resilience

      ea0065p279
    • Prognostic indicators of metastatic neuroendocrine tumour of unknown primary site: a single centre retrospective study

      ea0065p280
    • Clinical PhenClinical phenotypes of GNAS gene mutations in Korean Acromegalic Patientsotypes of GNAS gene mutations in Korean acromegalic patients

      ea0065p281
    • Onset of radiation-induced hypopituitarism in pituitary adenomas

      ea0065p282
    • Review of acromegaly management and outcomes in Imperial College Healthcare NHS Trust over eleven years

      ea0065p283
    • Silent somatotroph pituitary neuroendocrine tumours (PitNETs): systematic review of cases from a Pituitary Centre

      ea0065p284
    • The argument for growth hormone day curve testing in acromegaly; significant discrepancy between mean growth hormone and random growth hormone levels

      ea0065p285
    • Efficacy and safety of Temozolamide therapy as a part of multimodality treatment in patients with pituitary adenomas: experience from a single pituitary centre of excellence

      ea0065p286
    • Cannulated prolactin as a diagnostic tool for true hyperprolactinaemia

      ea0065p287
    • Modalities to overcome resistance to dopamine agonists in patients with macroprolactinomas

      ea0065p288
    • Does volumetric MRI (3D-SGE sequence) imaging enhance diagnostic rates in Cushing's disease?

      ea0065p289
    • The prevalence of acromegaly in the sleep apnoea clinic

      ea0065p290
    • ACTH producing pancreatic NET

      ea0065p291
    • Cabergoline in the treatment of acromegaly: experience from a large pituitary centre

      ea0065p292
    • Frequency and timing of hypopituitarism as a consequence of pituitary directed radiotherapy; a retrospective cohort study

      ea0065p293
    • A rare case of a malignant prolactinoma presenting with skull metastasis after two years of a masked diagnosis

      ea0065p294
    • Review of pituitary metastases diagnosed in a large pituitary centre

      ea0065p295
    • In-hospital endocrinology consultation (IHEC) for patients undergoing transsphenoidal resection of sellar masses - is it always necessary?

      ea0065p296
    • Outcomes in patients undergoing transsphenoidal surgery for non functioning pituitary macroadenomas at Lancashire Teaching Hospitals NHS Foundation Trust

      ea0065p297
    • Review of microarray, RNA sequencing and next-generation sequencing data reveals key pathways involved in pituitary tumorigenesis

      ea0065p298
    • Use of serial Short Synacthen tests (SST) in determining failure of hypothalamic-pituitary−adrenal (HPA) axis in patients with pituitary disorders

      ea0065p299
    • Oxaliplatin/raltitrexed-associated nephrogenic diabetes insipidus − a new finding

      ea0065p300
    • The natural history of pituitary apoplexy: long term follow-up study

      ea0065p301
    • Macroprolactinoma resistant to cabergoline: effective use of quinagolide

      ea0065p302
    • Thyrotropic adenoma requiring transphenoidal surgery in a young female with congenital hypothyroidism

      ea0065p303
    • Pituitary imaging in mild hyperprolactinaemia

      ea0065p304
    • Can a hypernatraemia alert system protect inpatients with diabetes insipidus?

      ea0065p305
    • Long term effects of cranial radiotherapy on hypothalamic-pituitary-adrenal axis in patients with established pituitary diseases

      ea0065p306
    • A case of SIADH post-brain injury presenting in pregnancy

      ea0065p307
    • Making best use of clinical genetic testing in the diagnosis of Neurohypophysial Diabetes Insipidus with significant family history - a case for early access

      ea0065p308
    • Post trans-sphenoidal pituitary surgery outcomes: single centre, single surgeon outcome data

      ea0065p309
    • An audit of Acromegaly patients managed in a large district general hospital

      ea0065p310
    • Intrasellar cyst masquerading as empty sella syndrome: history repeating itself

      ea0065p311
    • A case of retroperitoneal fibrosis on low dose Cabergoline

      ea0065p312
    • Prolactinoma causing visual disturbance in pregnancy - a multidisciplinary management conundrum

      ea0065p313
    • Resolution of symptoms of acromegaly in pregnancy

      ea0065p314
    • The spectrum of testosterone levels in males with functioning gonadotroph adenomas: report of three cases

      ea0065p315
    • Hypopituitarism and patterns of hormonal replacement in an endocrinology clinic

      ea0065p316
    • Severe hyponatraemia in hospitalised patients - an endocrine problem?

      ea0065p317
    • Giant functional gonadotroph adenoma - case report

      ea0065p318
    • Panhypopituitarism secondary to hypothalamic involvement in Isolated Langerhans cell Histiocytosis

      ea0065p319
    • Sheehan's syndrome in a sickle cell disease patient

      ea0065p320
    • A suprasellar germ cell tumour presenting with cranial diabetes insipidus

      ea0065p321
    • Pituitary incidentalomas: are we getting it right?

      ea0065p322
    • Testosterone replacement exacerbating hyperprolactinaemia in a male patient with macroprolactinoma: A rare complication

      ea0065p323
    • Prevalence of peripheral neuropathy, hyponatraemia and hypotension in patients admitted to hospital following a fall

      ea0065p324
    • Non anorectic functional amenorrhea in young women

      ea0065p325
    • A rare pituitary tumour mimicking an adenoma - spindle cell oncocytoma

      ea0065p326
    • Normocytic anaemia and fatigue can have unifying endocrine cause: Think outside the box: Think hypopituitarism: Think growth hormone

      ea0065p327
    • Normocytic anaemia and fatigue can have unifying endocrine diagnosis: Think outside the box: Think Hypopituitarism: Think growth hormone

      ea0065p328
    • CNS lymphoma masquerading as pituitary macroadenoma

      ea0065p329
    • An unusual case of orthostatic hypertension likely secondary to dysautonomia

      ea0065p330
    • I would love to remove my head= pituitary apoplexy

      ea0065p331
    • Recurrent pregnancy induced pituitary apoplexy in a patient with a macro-prolactinoma

      ea0065p332
    • A rare case of metastatic insulinoma

      ea0065p333
    • Co-secreting TSH and growth hormone pituitary adenoma

      ea0065p334
  • Nursing practice
  • • The role of microbiological cultures in managing diabetic foot osteomyelitis

      ea0065p335
    • Effectiveness of a nurse-led adrenal incidentaloma (AI) clinic at the University Hospital of Wales, Cardiff

      ea0065p336
    • A pituitary problem in pregnancy

      ea0065p337
    • Cortisol alert dog: Improving patient outcomes?

      ea0065p338
    • Use of a holistic needs assessment questionnaire to inform 'late effects' clinic appointments for childhood cancer survivors

      ea0065p339
    • A simple tool to assess the self-care management knowledge and skill needs of people with adrenal insufficiency (AI) before their adrenal education

      ea0065p340
    • One-week biochemical investigations in Cushing's disease - from the endocrine specialist nurse perspective

      ea0065p341
    • More than just tea and cake. The benefit of patient to patient peer support

      ea0065p342
  • Reproductive Endocrinology and Biology
  • • Neuroendocrine control of puberty in primates: differential involvement of two distinct populations of GnRH neurons?

      ea0065p343
    • Defining the impact of paternal diet on testicular morphology and apoptosis

      ea0065p344
    • Placental expression of progesterone receptor is down regulated in fructose-induced diabetic rats

      ea0065p345
    • Islet adaptations to pregnancy: a role for Urocortin 2

      ea0065p346
    • Vitamin D binding protein (DBP) is required for pro-invasion effects of vitamin D on placental trophoblastic cells

      ea0065p347
    • Impact of a FSHR positive allosteric modulator on FSH glycosylation variant-dependent FSHR homomerisation and signal pathway activation

      ea0065p348
    • miR-1-3p and miR-133-3p are altered in maternal serum EVs and placenta in pregnancies complicated by gestational diabetes with large-for-gestational age babies

      ea0065p349
    • Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

      ea0065p350
    • Igf2 regulates placental endocrine capacity in the mouse placenta

      ea0065p351
    • Oxytocin as a new target in treating ejaculatory disorders?

      ea0065p352
    • Differential expression in granulosa-lutein (GL) cells from polycystic ovaries of genes implicated in assembly and modification of extracellular matrix (ECM)

      ea0065p353
    • Maternal cardiovascular risk and pregnancy outcomes in turner syndrome - new evidence supports current guidance

      ea0065p354
    • Identifying placental hormones regulating maternal physiology during pregnancy - potential diagnostic and treatment markers for pregnancy complications

      ea0065p355
    • Are all kisspeptins equal? The effect of kisspeptin 10 and kisspeptin 54 on kisspeptin-mediated signalling

      ea0065p356
    • Deciphering the effects of testosterone on FSH glycosylation variant-dependent ERK/MAPK activation

      ea0065p357
    • Effects of the endocrine disrupting chemical bisphenol A (BPA) in human placentation in vitro

      ea0065p358
    • Normosmic idiopathic hypogonadotrophic hypogonadism in two homozygous siblings with a familial novel GnRH1 gene mutation

      ea0065p359
    • Pirimiphos-methyl modulates the timing of puberty and ovarian functions in female rats

      ea0065p360
    • Options for childbearing and pregnancy outcomes in Turner syndrome

      ea0065p361
    • Placental GLUT9 expression is associated with altered fetal growth in pregnancies complicated with GDM

      ea0065p362
    • Placental expression of progesterone receptor is down regulated in fructose-fed rats

      ea0065p363
    • Retrospective analysis of pulmonary venous drainage in 90 patients with Turner syndrome demonstrates abnormalities are common; Is it time to review the guidelines?

      ea0065p364
    • Derivatisation of 5[alpha]-dihydrotestosterone enhances sensitivity of analysis of human plasma by liquid chromatography tandem mass spectrometry

      ea0065p365
    • The effects of peptide-YY (PYY) on the reproductive axis in humans

      ea0065p366
    • GC-MS-based quantitative steroid signatures reveal different androgenic pathways between fetal and adult mice

      ea0065p367
    • A comparison of follow-up rates of women with gestational diabetes before and after the updated National Institute for Health and Care Excellence guidance advocating routine follow-up, and the association with neighbourhood deprivation

      ea0065p368
    • Investigating placental endocrine dysfunction in a translationally relevant mouse model of fetal growth restriction

      ea0065p369
    • Hyperprolactinaemia resistant to dopamine agonist due to an ectopic source of prolactin arising from a Uterine Tumour Resembling Ovarian Sex Cord Tumours (UTROCST)

      ea0065p370
    • Polycythaemia in a Klinefelter syndrome population on testosterone

      ea0065p371
    • Turner syndrome and fertility discussion: food for thought from patients

      ea0065p372
    • Should SHBG be measured in every patient before diagnosing hypogonadotrophic hypogonadism?

      ea0065p373
    • Diagnostic evaluation of polycystic ovarian syndrome: how the biochemistry stacks up against subsequent ultrasound scan evaluation

      ea0065p374
    • Audit of premature ovarian insufficiency management at University Hospitals Leicester NHS Trust

      ea0065p375
    • Too much of a good thing - two cases of severe dilutional peripartum hyponatraemia with lessons to learn

      ea0065p376
    • A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

      ea0065p377
    • Role of risk factors for gestational diabetes mellitus in determining newborn outcomes in a Nigerian teaching hospital

      ea0065p378
    • Infertility in a man with Sertoli cell-only syndrome and 47,XYY karyotype

      ea0065p379
    • Seeing is believing - is that always true?

      ea0065p380
    • Effect of endocrine disrupting chemicals on male reproductive health

      ea0065p381
    • An evaluation of the current clinical care pathway of patients referred to a large UK Tertiary Centre with suspected PCOS

      ea0065p382
    • A retrospective analysis of side effects of testosterone replacement therapy (TRT)

      ea0065p383
    • Its not just the baby that grows in pregnancy

      ea0065p384
    • Osteoporosis with hypergonadism-2nd time lucky

      ea0065p385
    • Female hyperandrogenemia, Think beyond the common: A rare case of ovarian Sertoli-Leydig cell tumour

      ea0065p386
    • Analysis of efficacy of different formulations of testosterone replacement therapy (TRT)

      ea0065p387
    • When dehydration cured Conn's !

      ea0065p388
    • Late presentation of 46 XX male - a case report

      ea0065p389
    • A rare case of hyperprolactinaemia

      ea0065p390
    • Non-classical congenital adrenal hyperplasia: a case report in a developing country

      ea0065p391
    • Investigations on reproductive hormones associated - effects of contraception in women

      ea0065p392
  • Thyroid
  • • Investigating the mechanism behind sodium-iodide symporter trafficking by the small GTPase ARF4

      ea0065p393
    • Correlation of hormonal analysis in pregnant women with subclinical hypothyroidism and comparison of pregnancy outcome in hypothyroid pregnant women with euthyroid pregnancies

      ea0065p394
    • Thyroid dysfunction is common in hospitalised patients with pre-existing levothyroxine treated hypothyroidism

      ea0065p395
    • A link between thyroid eye disease (TED) and diabetes?

      ea0065p396
    • Thyroid dysfunction in patients with type 1 diabetes: a 10-year retrospective study

      ea0065p397
    • Thyroid function testing in the first trimester of pregnancy - no role for screening?

      ea0065p398
    • Factors involved in the relapse of autoimmune thyrotoxicosis following first line treatment with anti-thyroid medication

      ea0065p399
    • An abnormal TSH can persist throughout pregnancy following gestational transient thyrotoxicosis and is not associated with increased maternal or foetal risk: a single centre retrospective cohort study

      ea0065p400
    • Management of thyroid disease in pregnancy - a national survey

      ea0065p401
    • Rates of maternal complications from TRAb positive pregnancies are low, but strongly positive TRAb in later pregnancy is associated with adverse neonatal outcomes

      ea0065p402
    • Iopanoic acid safely, quickly and effectively induces euthyroidism in resistant thyrotoxicosis

      ea0065p403
    • Thyroid eye disease (TED): patient demographics across three multi-disciplinary (MDT) clinics in London, UK

      ea0065p404
    • Weekly thyroxine administration to aid diagnosis and improve treatment compliance

      ea0065p405
    • Radioiodine therapy for Grave's disease: does post treatment block and replace therapy reduce the incidence of biochemical hypothyroidism?

      ea0065p406
    • Fixed 600 Mbq radioiodine activity is more effective than variable dose in treatment of benign thyroid disease

      ea0065p407
    • Weight trajectory during treatment for hyperthyroidism

      ea0065p408
    • Patients with hypothyroidism of differing aetiologies are often inadequately treated without appropriate dose adjustment: a retrospective cohort study based in primary and secondary care

      ea0065p409
    • Simultaneous occurrence of Graves' disease in a monozygotic twin with type 1 diabetes

      ea0065p410
    • Levothyroxine dosage in hypothyroid pregnancies - our experience in a tertiary care hospital T Balafshan, T S Purewal, E Finch, A Tang, D Kalathil Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool Women's NHS Foundation Trust

      ea0065p411
    • Health utility of people with treatment-resistant hypothyroidism as measured with the EQ-5D-5L quality of life questionnaire

      ea0065p412
    • A prospective clinical trial on the efficacy of lithium as adjuvant therapy to radioiodine in the treatment of hyperthyroidism (RAILIT study)

      ea0065p413
    • Place of elastography in the diagnostic of intermediary cytology thyroid nodules

      ea0065p414
    • Thyroid dysfunction in adult hematopoietic stem cell transplant patients treated with Alemtuzumab based conditioning

      ea0065p415
    • Outcomes of Liraglutide as treatment for weight regain after bariatric surgery: A 2-year retrospective study

      ea0065p416
    • An audit of the use of liothyronine (LT3) in the East Sussex Health Care Trust

      ea0065p417
    • 'Toxic adenoma; biopsy or not to biopsy?'

      ea0065p418
    • Postoperative hypoparathyroidism in patients after total thyroidectomy - experience of a tertiary center in Romania

      ea0065p419
    • Achievement and maintenance of euthyroidism in patients with Graves' disease: How well do we do?

      ea0065p420
    • Analysis of the outcome of repeat Fine Needle Aspiration Cytology for Thy3a thyroid nodules - a retrospective study of 4 year data in a district general hospital

      ea0065p421
    • Propylthiouracil causing pulmonary haemorrhage and glomerulonephritis

      ea0065p422
    • Thyrotoxicosis and post RAI hypothyroidism in someone with thyroid hormone resistance: A conundrum

      ea0065p423
    • Clustering of papillary thyroid carcinoma, familial hypocalciuric hypercalcemia and parathyroid adenoma in members of the same family-Case report

      ea0065p424
    • Severe proximal myopathy with high creatine kinase levels secondary to Hashimoto's thyroiditis

      ea0065p425
    • A reversible cause of pulmonary hypertension

      ea0065p426
    • Managing hypothyroidism without oral levothyroxine

      ea0065p427
    • Myxoedema coma with severe hypoxia

      ea0065p428
    • Audit of the use of TRAb testing first-line in the evaluation of hyperthyroidism

      ea0065p429
    • Iododerma following radioiodine treatment for Graves' thyrotoxicosis

      ea0065p430
    • Macro TSH in a case of 'poorly controlled' hypothyroidism

      ea0065p431
    • Value of thyroid fine needle aspiration and cytology in clinical practice

      ea0065p432
    • Discordant thyroid function tests due to immunoassay interferance - case report

      ea0065p433
    • Concomitant Graves' & (?) ectopic parathyroid adenoma

      ea0065p434
    • Early diagnosis and prompt treatment of severe thyrotoxicosis in patients with congestive cardiac failure is critical: lessons from a case of type 1 amiodarone induced severe thyrotoxicosis

      ea0065p435
    • Amiodarone induced thyroiditis in congenital heart disease - how long should we continue steroids?

      ea0065p436
    • Radioactive iodine therapy dose for recurrent thyrotoxicosis

      ea0065p437
    • A rare complication of thyrotoxicosis: diabetic ketoacidosis

      ea0065p438
    • Large Pericardial Effusion due to Primary Hypothyroidism

      ea0065p439
    • Thyroiditis in a returning traveller

      ea0065p440
    • Inhibitory actions of diketopiperazines within the thyroid gland, and their system-wide presence

      ea0065p441
    • Multiple Mieloma associated with Graves disease - case presentation

      ea0065p442
    • The need to update patient safety information on carbimazole

      ea0065p443