Endocrine Abstracts

The gut microbiota are becoming increasingly recognised as key players in human health. As such strategies used to alter this microbial community hold the potential to impact on wellbeing. During the ageing process the gut microbiota undergoes changes, these changes are linked with low grade inflammation, sometimes termed inflammageing. Prebiotics and probiotics are two dietary methods used to positively alter our microbial communities. This talk, using in vitro and <...

The gut microbiota is a major component of mammalian biocomplexity exerting a significant influence on the metabolic phenotype of the host. The genetic entourage of these intestinal residents, collectively termed the gut microbiome, encodes a diverse array of metabolic capabilities that far exceed the relatively limited host genome. Cross-talk exists between the microbiome and genome through a variety of mechanisms with implications for both host health and disease. Biochemica...

In Graves’ disease (GD) thyrotropin receptor (TSHR) stimulating autoantibodies cause hyperthyroidism. Many GD patients develop Graves’ orbitopathy (GO) characterized by orbital tissue remodelling including adipogenesis. Whilst progress has been made in understanding the processes causing expansion of orbital tissues, little is known about loss of tolerance to the TSHR target autoantigen. Mechanisms for triggering autoimmunity by microorganisms include molecular mimic...