Endocrine Abstracts

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Steroid bioavailability is delineated by the “free hormone hypothesis” and its underlying tenet that only steroids not bound by plasma proteins enter cells. Steroid hormones, as well as their unconjugated precursors and metabolites, circulate bound by several unrelated plasma proteins, including albumin, orosomucoid, sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), while the more water soluble sulphated steroid conjugates are bound large...

In 1547 Henry VIII died, and was succeeded by his young son from his marriage to Jane Seymour; the boy was only 9 years old, and became Edward VI. However, he was a sickly child, and only survived to the age of 15 years, probably dying of TB. With no living male heir, there was an attempt at continuing with a Protestant monarch, but this lasted only 9-days with the unfortunate Lady Jane Grey. The crown then fell to Mary, the child of the marriage of Henry to Catherine of Arago...