Endocrine Abstracts

Sertoli-Leydig cell tumours are rare comprising 0.2–1.2% of all primary ovarian cancers. Virilisation is seen in 30–50% of cases. Heterologous Sertoli-Leydig cell tumours with dominant cystic component are even rarer and mainly affect females aged 20 to 30 years. A 66-year-old lady was referred to the Endocrine Department with a one year history of rapid severe hirsutism involving the limbs, abdomen, chest, face and thinning of hair on the scalp. Blood pressure of 15...

Erythrocytosis is classified as either primary or secondary. Polycythemia vera (PV), a myeloproliferative neoplasm, is often caused by a mutation in exon 12 of the Janus kinase 2 (JAK2) tyrosine kinase gene which phosphorylates erythropoietin receptor (EPO-R) at multiple sites. Secondary erythrocytosis mainly results in conditions with increased erythropoietin (EPO) production. We report a 21-year-old man with metastatic medullary thyroid carcinoma (MTC) at diagnosis. The tota...

Hypoglycaemia is a common and potentially life threatening presentation to Emergency Departments across the UK.It is often a result of medications for treatment of diabetes but other differentials include rarer reactive and fasting causes.This case report describes a 69 year old man who initially presented with right upper quadrant pain and weight loss which then lead to a diagnosis of inoperable hepatic sarcoma. He later presented with hypoglycaemia and Whipples triad in the ...

A 79-year-old female patient, with a background history of hypertension and ischaemic heart disease was brought by ambulance to hospital with near collapse episode associated with capillary blood glucose (CBG) of 2.1 mmol/l. Her regular medications include Ramipril, clopidogrel and atorvastatin. She had no history of diabetes. While inpatient, it was observed that majority of low capillary blood glucose readings (CBG) were late night or early mornings. At venous glucose of 1.9...

MEN2A is an autosomal dominant inherited syndrome, caused by a gain of function germline mutation in the RET proto-oncogene, with multiglandular tumoral development. Although the presence of MTC is very high and 50% of patients present with pheochromocytoma, the penetrance of hyperparathyroidism is estimated to be between 9 and 34%. The clinical presentation of the syndrome varies widely even in members of the same family, because of the difference of gene penetration (1). In ...