Endocrine Abstracts

The adverse outcomes seen in The Women’s Health Initiative (WHI) combined hormone therapy trial were mainly due to an over-dosage of hormone therapy (HT) in a relatively elderly population. However, fundemental differences exist between conjugated equine estrogens and 17 beta estradiol and between medroxyprogesterone acetate and other progestogens. It is likely that these differences also contributed to the adverse outcomes in WHI, which were contrary to the cardiovascula...

The National Institute of Clinical Excellence (NICE) Menopause Clinical Guidelines, November 2015, has reinstated Hormone Replacement Therapy (HRT) for the average fit & healthy woman in her fifties, the clinical model used. Some women require alternatives for either medical or personal reasons,. Few complementary and alternative treatment options have evidence of efficacy yet several are mentioned by NICE as having possible roles. In symptomatic women with a contra-indica...

Hot flushes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but is not without risk. Neurokinin B signalling is increased in menopausal women, and has been implicated as an important mediator of hot flushes in animals. We carried out a phase 2, randomised, double-blind, placebo-controlled, single-centre, crossover trial assessed the effectiveness of an oral neurokinin 3 rec...