Endocrine Abstracts

Bariatric surgery, in particular, Roux-en-Y gastric bypass (RYGB), is the most effective treatment for morbid obesity. The restricted gastric capacity and reduced absorption of nutrients cannot account for all the metabolic benefit we observe post-operation. Therefore, we applied metabolic and microbial profiling approach to investigate the potential mechanisms of RYGB surgery. Metabolic profiling strategy is widely applied in the discovery and development of metabolic biomark...

Prospective studies and clinical trials have repeatedly demonstrated that high intake of dietary fibre reduces the incidence of metabolic diseases and their risk factors. An increased intake of dietary fibre raises the amount of undigested material available for fermentation by the gut microbiota and the production of short chain fatty acids (SCFA). SCFA have been shown to regulate energy homeostasis through various metabolic pathways and receptor-mediated mechanisms. The majo...

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