Endocrine Abstracts

Lesions of the hypothalamus and pituitary stalk are rare in adolescence. Congenital and acquired, benign and malignant lesions occur, and the spectrum of diagnoses differs from that in adults, with inflammatory conditions occurring less frequently.Lesions that develop in the hypothalamus may extend to the pituitary and present with features of pituitary hormone deficiencies, including arrest of growth and puberty in the adolescent age group, or visual di...

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Lactotroph pituitary adenomas (prolactinomas, PRLomas) are the most common form of functioning pituitary tumour. The vast majority can be managed successfully by means of medical (dopamine agonist) therapy; only a small minority require second-line therapy of surgical resection with or without adjunctive radiation. PRLomas occur in adolescent patients, but are unusual. Using a combination of illustrative case presentations and selective reference to informative publications, t...