Endocrine Abstracts

Contents

• Society for Endocrinology BES 2017
• • Plenary Lectures
  • Society for Endocrinology International Medal Lecture
  • • Primary hyperparathyroidism: molecular genetic insights and clinical implications

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  • Clinical Endocrinology Trust Lecture
  • • Mechanisms underpinning human insulin resistance

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • What to watch: three breakthroughs that may change our lives in the next 10 years

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  • Society for Endocrinology Starling Medal Lecture
  • • Next generation tools to understand endocrine function in health and disease

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  • Society for Endocrinology Dale Medal Lecture
  • • Abstract unavailable

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  • Society for Endocrinology European Medal Lecture
  • • Corticosteroids and the brain

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Treatment of radioactive iodine refractory thyroid cancer

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  • British Thyroid Association Pitt-Rivers Lecture
  • • Deiodinases and the control of intracellular T3 concentrations

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  • Society for Endocrinology Medal Lecture
  • • Adipose tissue expandability, lipotoxicity and the metabolic syndrome

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  • Society for Endocrinology Jubilee Lecture
  • • Bacteria, steroids and formyl peptide receptors - more twists to the inflammatory response

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• Society for Endocinology Journal Awards
• • Society for Endocrinology Journal Award - Journal of Endocrinology
  • • A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation

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  • Society for Endocrinology Journal Award - Journal of Molecular Endocrinology
  • • MuRF1 mono-ubiquitinates TR[alpha] to inhibit T3 induced cardiac hypertrophy in vivo

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  • Society for Endocrinology Journal Award - Endocrine-Related Cancer
  • • Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk

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  • Society for Endocrinology Journal Award - Clinical Endocrinology
  • • Subcutaneous infusion of kisspeptin-54 stimulates gonadotrophin release in women and the response correlates with basal oestradiol levels

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• Symposia
• • Steroids and the Skeleton
  • • Abstract unavailable

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    • Skeletal actions of glucocorticoids: Molecular mechanism

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    • Skeletal actions of glucocorticoids - in vivo models

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  • When receptors go rogue
  • • Stress and direct targeting of mitochondrial gene expression by the glucocorticoid receptor in the brain

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    • Dissecting thyroid hormone receptor action

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    • Extra-nuclear estrogen receptors in breast cancer

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  • Fat and Fertility
  • • Obesity, fertility and pregnancy

      ea0050s3.1
    • Abstract unavailable

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    • Abstract unavailable

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  • Pituitary disease in adolescents
  • • Hypothalamic and pituitary stalk lesions in adolescents

      ea0050s4.1
    • Abstract unavailable

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    • Prolactinomas in adolescents

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  • Beyond paragangliomas
  • • SDH mutations in tumourigenesis

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    • Identification of novel therapeutic targets in SDH-mutated cancers: tracing dysfunction

      ea0050s5.2
    • Surveillance imaging strategies in SDHx

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  • Sex hormones through the ages
  • • Menopause guidelines: theory to practice

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    • Brain Mechanisms for the Metabolic Control of Puberty

      ea0050s6.2
    • The genetics of delayed puberty

      ea0050s6.3
  • Taking a risk on love - the endocrinology of behaviour
  • • Risky business - when endocrinology takes over...

      ea0050s7.1
    • Abstract unavailable

      ea0050s7.2
    • Kisspeptin and the control of reproductive behaviour

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  • Adrenal - in health and disease
  • • Reshaping the adrenal cortex: the process of adrenarche

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    • ACTH signalling and resistance

      ea0050s8.2
    • Genomic approach to management of adrenal tumours

      ea0050s8.3
  • Obesity for the Endocrinologist
  • • New drug therapies for obesity: Do they work?

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    • Brain control of appetite

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    • Abstract unavailable

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  • Thyroid cancer- whats hot whats not
  • • Game changers in the clinical management of thyroid cancer

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    • Improving radioiodine uptake in thyroid cancer through NIS induction

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    • Molecular mechanism of thyroid tumourigenesis

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  • New developments in adrenal hypertension
  • • ACTH: an underappreciated driver of hypertension

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    • Adrenal vein sampling vs imaging in primary aldosteronism

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    • Mechanisms of salt-sensitive hypertension

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• Early Career Symposia
• • Alternative career pathways
  • • A career in pharma

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    • A career in teaching or lecturing

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    • A career in the charitable sector

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    • A career in publishing

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    • A career in public health - Leaving the lab to influence individual, community and population health at local, national and international levels

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• Clinical Management Workshops
• • Workshop 1: Collateral damage of cancer treatment
  • • Ovarian function after chemotherapy

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    • Abstract unavailable

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    • Bone health in cancer survivors

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  • Workshop 2: Hyper and Hypocalcaemia
  • • Difficult hypercalcaemia

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    • Familial hypocalciuric hypercalcaemia

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    • Abstract unavailable

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  • Workshop 3: How do I. . . (1)
  • • How do I manage . . . . the patient with thyroid dysfunction after immunotherapy?

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    • How do I manage a patient on a bisphosphonate after 5 years?

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    • How do I . . . . reconcile inconsistent results in suspected Cushing's?

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    • How do I . . . . manage thionamide induced leucopaenia

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    • How do I . . . . investigate and manage a patient with Bartter or Gitleman syndrome?

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    • How do I . . . . implement patient safety alerts for adrenal insufficiency across my institution

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  • Workshop 4: Graves orbitopathy: a Thyronet/ TEAMED
  • • Improving outcomes in thyroid eye disease - the TEAMeD 5 programme

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    • Molecular mechanisms of Graves' Orbitopathy

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  • Workshop 5: How do I. . . (2)
  • • How do I follow up a patient with an indeterminate non-functioning adrenal nodule?

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    • How do I manage a postmenopausal woman asking for testosterone replacement

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    • How do I ... approach CVS surveillance in a patient with Turner Syndrome

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    • How do I manage Adipsic Diabetes Insipidus

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    • How do I manage hypercalcaemia during pregnancy?

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    • How do I manage.... myxoedema coma

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• Applied Physiology Workshop
• • Tissue Engineering for Regenerative Medicine in Endocrinology
  • • Reprogramming gastric tissues for insulin production

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    • Reprogramming cells to acquire steroidogenic potential: towards therapy for adrenal insufficiency

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    • 3D-Bioprinting coming of age-from cells to organs

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• Early Career Prize Lecturese
• • (1)
  • • Insights into G-protein coupled receptor (GPCR) trafficking and biased signalling by studies of calcium homeostasis

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    • The role of hypoxia in the physiology and pathology of menstruation

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• Meet the Expert Sessions
• • Pitfalls of testosterone replacement in ment
  • • Pitfalls of testosterone replacement in men: Too much of a good thing?

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  • Metabolomics and Diet
  • • Modernazing dietary assessment by use of metabolic profiling

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  • Autonomous cortisol secretion
  • • Autonomous cortisol secretion

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  • The time is right
  • • Controlling for diurnal variation

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  • Opiate induced endocrinopathy
  • • Opioid-induced Endocrinopathy: 'Endocrinopathy of Trainspotting'

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  • What can next generation sequencing do for you
  • • Abstract unavailable

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  • Growth hormone replacement across the ages
  • • Abstract unavailable

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  • Highlighting management of hyperthyroidism in pregnancy
  • • Highlighting management of hyperthyroidism in pregnancy

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• Skills
• • Skills 1: How to engage with the media
  • • Should we engage with the media?

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    • Science versus the media

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    • How to react to the media

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• Futures
• • Futures 1: Your future in endocrinology and diabetes
  • • Abstract unavailable

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    • Why diabetes?

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    • Clinical academic opportunities in endocrinology

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  • Futures 2: Consultant careers - Escape options
  • • Medical management: the good, the bad and the ugly

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    • How to make a success of private practice

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    • Medico-legal practice: what, why and how?

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• Master Class
• • Masterclass 1: Bone Masterclass
  • • Osteoporosis management: the cutting edge

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    • A comprehensive secondary fracture prevention strategy

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  • Masterclass 2: Delivery of specialist endocrine care
  • • Neuroendocrine tumours and the set up in the UK

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    • Abstract unavailable

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    • Abstract unavailable

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    • Abstract unavailable

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• Debate
• • This house believes that the UK population trend in obesity cannot be reversed without food taxation
  • • Debate: this house believes that the UK population trend in obesity cannot be reversed without food taxation

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    • Abstract unavailable

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• Nurse Session
• • Nurse Session 1: Cushings disease
  • • Abstract unavailable

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    • Cushing's research - Hot topics

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    • Cushing's disease from a patient's perspective

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  • Nurse Session 2: Diabetes Insipidus
  • • Clinical Presentation and Diagnosis of Cranial Diabetes Inspidus

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    • Abstract unavailable

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    • Challenging cases in DI

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• Senior Endocrinologists Session
• • (1)
  • • Reproductive adaptability: Nature's cunning plan

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    • Cancer Survivors-the New Endocrine Epidemic

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    • The mystery of puberty - why it has been such a tough nut to crack?

      ea0050se1.3
    • You think you understand ACTH and Cushing's syndrome?

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• Oral Communications
• • Early Career Oral Communications
  • • Neurokinin 3 receptor antagonism is a highly effective, novel treatment for menopausal hot flushes with rapid onset: a phase 2, randomised, double-blind, placebo-controlled trial

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    • Co-administration of 5[alpha]-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids

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    • Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

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    • An investigation into sodium-iodide symporter (NIS) dimerization and its impact on radioiodide uptake in thyroid cancer

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    • An essential physiological role for MCT8 in bone

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    • Investigating the role of AIP in mouse pituitary adenoma formation

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  • Clinical Highlights
  • • Mild autonomous cortisol excess in adrenal incidentalomas - metabolic disease burden and urinary steroid metabolome in 1201 prospectively recruited patients

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    • Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

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    • A novel IGSF1 mutation in a large Irish kindred highlights the need for systematic familial endocrine screening in the IGSF1 deficiency syndrome

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    • Development of endocrinopathy following treatment of metastatic melanoma with an immune checkpoint inhibitor is associated with better response

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    • Additional value of 4D-CT in patients with primary hyperparathyroidism and negative conventional imaging; a reason to change primary imaging modality in patients over 60?

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    • Reduced early GLP-1 response in gestational diabetes is associated with hyperinsulinaemia and insulin resistance: a prospective case-control study

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  • Obesity, Diabetes Thyroid
  • • Perchlorate exposure affects thyroid function in third trimester pregnant women from South-West England

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    • Hypothyroidism is a risk factor for acquiring diabetes in women with Turner Syndrome

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    • The GLP-1R agonist exendin-4 reduces cerebrospinal fluid secretion and intracranial pressure

      ea0050oc3.3
    • Neutrophil elastase-mediated regulation of adipose glucocorticoid exposure through CBG cleavage

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    • Increased global long interspersed nucleotide element 1 DNA methylation in type 2 diabetes mellitus individuals relates to lower blood pressure and BMI

      ea0050oc3.5
    • Identification of novel sodium iodide symporter interactors which modulate iodide uptake

      ea0050oc3.6
  • Adrenal and Steroids
  • • Predicted benign and silent SNPs in CYP11A1 cause primary adrenal insufficiency through missplicing

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    • Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional pathway involving HDAC6

      ea0050oc4.2
    • Local reactivation of glucocorticoids by 11[beta]-HSD1 mediates their detrimental effects on bone

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    • The role of [ldquo]stress[rdquo] in aldosterone-mediated hypertension: circumstantial evidence from the [ldquo]stress subtraction[rdquo] experiment of adrenal vein sampling

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    • NAD+ availability modulates 11[beta]-HSD1 mediated glucocorticoid regeneration in mouse skeletal muscle

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    • Distinct patterns of glucocorticoid metabolism in patients with HNF1A-MODY have the potential to confer a beneficial metabolic phenotype

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  • Reproduction and Neuroendocrinology
  • • Increased sertoli cell proliferation and sperm production in FSTL3 deleted mice

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    • Kisspeptin modulates resting brain activity to alter responses to negative stimuli in humans

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    • Decoding the functional significance of follicle stimulating hormone glycosylation variants

      ea0050oc5.3
    • Reactive oxygen species as a novel metabolic pathway for sperm DNA damage and Recurrent Pregnancy Loss

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    • Vitamin-D and fetomaternal immunity: next generation RNA sequence analysis reveals unique effects upon uterine natural killer cells

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    • The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF cause congenital hypopituitarism

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  • Bone, Calcium and Neoplasia
  • • Photoperiod-induced central actions of thyroid hormone are essential for medullary bone formation

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    • Glucocorticoids activation by 11beta-hydroxysteroid dehydrogenase type 1 protects against inflammatory bone loss in a murine model of chronic inflammation

      ea0050oc6.2
    • Generation of multiple endocrine neoplasia type 1 and death-domain-associated protein pluripotent stem cell lines to investigate mechanisms of pancreatic neuroendocrine tumourigenesis

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    • G-protein coupled oestrogen receptor mediates Hippo pathway signalling and survival outcomes in colorectal cancer patients

      ea0050oc6.4
    • Tumor immunosuppressive environment and tamoxifen resistance in rats exposed to EE2 in utero can be prevented with HDAC and DNMT inhibitors

      ea0050oc6.5
    • Calcium-sensing receptor (CaSR) mutations in hypercalcaemic and hypocalcaemic patients cluster at the extracellular dimer interface

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• Poster Presentations
• • Adrenal and Steroids
  • • PAPS synthase 2 is the major PAPS-supplying enzyme for DHEA sulfation

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    • ARID1a, a SWI/SNF subunit, is important for the regulation of a subset of glucocorticoid responsive genes

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    • Intra-adrenal cytokine expression during inflammatory stress is immune-dependent

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    • Development of a liquid chromatography tandem mass spectrometry assay for the profiling of salivary androgens and gestagens

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    • 20[beta]-Dihydrocortisol; a weak endogenous agonist of the glucocorticoid receptor but a potent agonist of the mineralocorticoid receptor

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    • Improving the therapeutic index of topical anti-inflammatory steroids: angiostatic effects of 5[alpha]-tetrahydrocorticosterone vs hydrocortisone

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    • Salivary cortisol response to the short Synacthen® test provides a reliable alternative to serum measurement in the assessment of suspected hypoadrenalism

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    • Is renin a useful marker of mineralocorticoid replacement in addison's disease?

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    • Using mouse adrenocortical cell lines to investigate how glucocorticoid synthesis is dynamically regulated

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    • The impact of a point-of-care rapid cortisol assay on success rate, procedural efficiency and radiation dose in adrenal vein sampling for primary hyperaldosteronism

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    • Does cortisol exposure from the Hydrocortisone day curve predict mortality, type II Diabetes or lipid profiles?

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    • It's a matter of time: the emergence of autoimmune polyendocrine syndrome in autoimmune Addison's disease reaches 100% among those diagnosed more than 50 years ago

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    • Short synacthen test requests may be reduced by considering test indication and identifying a 9am cortisol value that predicts test result

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    • Enteric coating delays the absorption of prednisolone variably and should not be used

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    • How relevant is aldosterone and cortisol co-secretion?

      ea0050p015
    • The potential use of I-131 Norcholesterol scan for large adrenal mass

      ea0050p016
    • Prednisolone should be first line replacement therapy for adrenal insufficiency

      ea0050p018
    • Does higher cortisol exposure during hydrocortisone replacement therapy lead to osteoporosis?

      ea0050p019
    • How accurate are urinary metanephrines in screening for phaeochromocytoma?

      ea0050p020
    • Clinical implications of the short synacthen test: an audit of its rational use in the assessment of adrenocortical insufficiency

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    • The effect of 4,4′ DDT, 4,4′ DDE, 4,4′ DDD, and 2,4′ DDD on dihydrotestosterone binding to and releasing from the androgen receptor

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    • Quality of life in patients with adrenal disease: a systematic review

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    • Hyperandrogenism secondary to congenital portal hypertension

      ea0050p024
    • Epidemiology of PPGLs - A population based approach

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    • Ipilimumab induced hypophysitis

      ea0050p026
    • A comparison between short synacthen and long synacthen results in clinical decision making

      ea0050p027
    • Adrenal Incidentalomas- A Retrospective Analysis

      ea0050p028
    • The 2 year half-life of i.m. Trenbolone

      ea0050p029
    • Influence of vitamin D on outcomes following burn injury: An observational cohort study

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    • Hypoadrenalism, Short Synacthen Test (SST) outcomes and glucocorticosteroid prescribing trend; A large private hospital experience in United Arab Emirates (UAE)

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    • Large functional adrenocortical carcinoma presenting with hyperandrogenism and hypercortisolism

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    • Can your hair tell your secret?

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    • Management of ectopic ACTH syndrome: The birmingham experience

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  • Bone and Calcium
  • • Studies of nuclear factor I/X (NFIX) mutations causing the Marshall-Smith syndrome (MSS)

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    • LC-MS/MS measurement of parathyroid hormone PTH (1-34): Use in studying oral PTH (1-34) administration and possible diagnostic application in pseudohypoparathyroidism

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    • Immunomodulation by vitamin D is associated with regulation of dendritic cell microRNAs

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    • Disruption of the G-protein subunit [alpha]11 (G[alpha]11) interdomain interface causes autosomal dominant hypocalcemia type-2 (ADH2)

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    • Uniparental isodisomy as a cause of the autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) syndrome

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    • Systematic in silico evaluation of rare genetic variants in G-protein alpha 11 (G[alpha]11)

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    • A study on 24 hour urine calcium creatinine ratio in primary hyperparathyroidism (PHPT) and familial hypocalciuric hypercalcaemia (FHH)

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    • Annual incidence of acute severe hypocalcaemia due to hypoparathyroidism: a 3 year consecutive study amongst patients with severe hypocalcaemia presenting to A&E

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    • Predictors of nephrolithiasis, osteoporosis and mortality in primary hyperparathyroidism

      ea0050p049
    • Discontinuation of denosumab-real world experience from a single centre

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    • 1,25-dihydroxyvitamin D deficiency in haemodialysis patients is corrected by vitamin D supplementation

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    • Retrospective audit of the use of cinacalcet for the treatment of primary hyperparathyroidism in adults against the NHS England prescribing criteria

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    • Critical evaluation of biochemical and imaging diagnostic assessment in primary hyperparathyroidism

      ea0050p053
    • Review of denosumab therapy In a Scottish population

      ea0050p054
    • The incidence of Bisphosphonate related Osteonecrosis of the Jaw (BONJ) in patients treated with oral bisphosphonates for osteoporosis

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    • Audit on parathyroid scans in patients with surgically managed primary hyperparathyroidism

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    • Imaging in primary hyperparathyroidism; does it affect our referral pathways for surgery? Results of an audit

      ea0050p057
    • Audit of adjusted calcium and serum 25-OH vitamin D screening and replacement therapy prior to Zoledronic acid infusion at University Hospitals Birmingham

      ea0050p058
    • Spontaneous inpatient parathyroid autoinfarction and remission of primary hyperparathyroidism from a mediastinal adenoma

      ea0050p059
    • Review of parathyroid imaging and subsequent surgical findings in primary hyperparathyroidism - do they correlate?

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    • Prevalence of Kidney Stones and Osteoporosis in Patients with Primary Hyperparathyroidism (PHPT)

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    • Delphi panel to define patients with chronic hypoparathyroidism 'not adequately controlled on standard therapy'

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    • A difficult case of metastatic parathyroid cancer with refractory hypercalcaemia and medication-related osteonecrosis of the jaw

      ea0050p063
    • Milk-alkali syndrome in the post PPI era

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    • Primary hyperparathyroidism - A retrospective review

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    • Bilateral atypical femoral fractures after only 4-years of bisphosphonate therapy

      ea0050p066
    • Playing tennis with off the chart Calcium levels !!

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  • Clinical Biochemistry
  • • Personalized medicine and endocrine disorders: the challenges of interpreting genetic variants

      ea0050p181
    • Clinical evaluation of a multiple-gene sequencing panel for hypoparathyroidism

      ea0050p182
    • The free androgen index in women is inaccurate when the SHBG concentration is low

      ea0050p183
    • Interference of midodrine and desglymidodrine in a plasma metanephrines LC-MS/MS assay

      ea0050p184
    • Development of a sensitive, rapid LC-MS/MS method for detection of oxytocin in human plasma

      ea0050p185
    • Lodotra (delayed release prednisone) is variably absorbed, and should not be used in adrenal insufficiency

      ea0050p186
    • How well can we measure SHBG?

      ea0050p187
    • The state of glutathione system in patients with type 2 diabetes

      ea0050p188
    • Diagnosis and management of hyponatraemia in patients with cancer

      ea0050p189
    • An unusual case of Gynaecomastia from hCG secreting bladder cancer

      ea0050p190
    • An audit of the management of patients presenting with hyponatraemia

      ea0050p191
    • The investigation of hyponatraemia in hospitalised patients: an audit

      ea0050p193
    • A well recognised but forgotten cause of undetectable Magnesium

      ea0050p194
  • Diabetes and Cardiovascular
  • • Magnesium modulates the expression of INSR and GLUT4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

      ea0050p201
    • Selective expresssion of one specific isoform of the coxsackie adenovirus receptor (CAR) in the human pancreatic beta cells

      ea0050p202
    • Induced maturity affects normal beta cell function

      ea0050p203
    • Effect of vitamin B12 deficiency on the lipid lowering effect of metformin in the liver

      ea0050p204
    • The effect of escalating doses of beta-blockers and ACE inhibitors on mortality in patients with heart failure and diabetes mellitus

      ea0050p205
    • The impact of a dedicated metabolic hepatology clinic for the treatment of non-alcoholic fatty liver disease

      ea0050p206
    • The impact of a dedicated metabolic hepatology clinic for the treatment of non-alcoholic fatty liver disease

      ea0050p207
    • Do glucocorticoids cause mitochondrial substrate switching in fetal cardiomyocytes?

      ea0050p208
    • Assessment of glycated haemoglobin among HIV patients pre and post highly active antiretroviral therapy (HAART) in Kano, Northwestern Nigeria

      ea0050p209
    • The effect of obesity on cardiovascular risk profile and microvascular disease in type 1 diabetes

      ea0050p210
    • Nuclear factor-kappa beta activation and monocyte-endothelial adhesion lead to chemerin induced endothelial cell inflammation

      ea0050p211
    • 'Morning sickness in a 60 year old lady' An unusual presentation of an Insulinoma at a northen DGH.

      ea0050p212
    • Genomic instability in type 2 diabetes mellitus patients from Yucatan, Mexico

      ea0050p213
    • Care processes and intermediate outcomes among patients with diabetes mellitus in a tertiary hospital in Southwestern Nigeria: A retrospective review of records

      ea0050p214
    • A clinical conundrum of euglycaemic ketoacidosis

      ea0050p215
    • The adequacy and effectiveness of inpatient diabetes referrals at University Teaching Hospital

      ea0050p216
    • Audit on management of hyperglycaemia and steroid therapy

      ea0050p217
    • Type 1 or type 3c diabetes: a diagnostic dilemma

      ea0050p218
    • Comparison of laboratory-based and near-patient glucose monitoring in critically ill patients

      ea0050p219
    • The diabetologist as a medical columnist: a 7-year experience

      ea0050p220
    • A rare case of diabetes, hypogonadism and arthritis

      ea0050p221
    • Screening for coeliac disease in type 1 DM - A retrospective observational study in Harrogate District Foundation Hospital

      ea0050p222
    • Frequency of nonalcoholic fatty liver diasease in patients with diabetes mellitus

      ea0050p223
    • UHCW audit on SGLT2 inhibitor (SGLT2-i) use

      ea0050p224
    • Peripheral neuropathy and associated factors among type 2 DM patients in FMC Abeokuta

      ea0050p225
    • Gender differences IN glycaemic target in patient with type 2 DM at the obafemi awolowo university teaching hospitals complex ile-ife South West Nigeria

      ea0050p226
    • Assessing the knowledge of diabetes management within psychiatric crisis resolution teams

      ea0050p227
    • Predictors of hypoglycemia in patients with type 2 diabetes mellitus in South Western, Nigeria

      ea0050p228
    • Antenatal gestational diabetes mellitus care - An audit on follow-up visits and antenatal attendance

      ea0050p229
    • Burden of obesity and hypertension in Nigerians with type 2 diabetes mellitus seen in a tertiary health facility

      ea0050p230
    • Diabetes clinic assessment: lookingout for diabetics' kidneys and toes

      ea0050p231
    • Lifestyle patterns and diabetes risk in second generation South Asians

      ea0050p232
    • The Diabetologist as a Medical Columnist: A 7-year experience

      ea0050p233
    • Transdermal delivery of Syzygium aromaticum-derived oleanolic acid by dermal patches in streptozotocin-induced diabetic rats: effects on some selected metabolic parameters

      ea0050p234
  • Neoplasia, Cancer and Late Effects
  • • Population remodeling in the acquisition of endocrine resistance in breast cancer

      ea0050p241
    • Combination of JQ1, an inhibitor of epigenetic pathways, and everolimus for treatment of pancreatic and bronchial neuroendocrine tumours

      ea0050p242
    • Analysis of the diagnosis, treatment and genetics of 175 cases of phaeochromocytoma and paraganglioma in two ENETS Centres of Excellence

      ea0050p243
    • Identifying linkages between EDCs in personal care products and breast cancer through data integration and gene network analysis

      ea0050p244
    • Assessment of protective factors from the development of radiation induced hypopituitarism: A single centre study

      ea0050p245
    • The course of the endocrine disease in POEMS syndrome

      ea0050p246
    • Check point inhibitor monoclonal antibody therapy - Are there effective markers for endocrine immune-related adverse events?

      ea0050p247
    • In-house method for the detection of miRNA 145 and 21 in plasma samples of breast cancer patients using SYBR green reverse transcription-qPCR

      ea0050p248
    • Multiple endocrine neoplasia type 1 (MEN1) phenocopy due to a P.Leu380Phe cell division cycle 23 (CDC73) mutation

      ea0050p249
    • Immunotherapy and development of endocrine dysfunction: An audit of immune checkpoint inhibitors

      ea0050p250
    • Endocrinopathies are a frequent Consequence of Immune Checkpoint Inhibitor Therapy, with a Low Recovery Rate of both Thyroid and Pituitary Dysfunction

      ea0050p251
    • Primary pulmonary typical carcinoid as a source of ectopic Adrenocorticotropic hormone (ACTH)-dependant Cushing's

      ea0050p252
    • Challenges in diagnosis and management of tumour induced oncogenic osteomalacia

      ea0050p253
    • Giant insulinoma: an unusual cause of hypoglycaemia

      ea0050p254
    • Endocrine adverse effects after immune checkpoint inhibitor therapy in patients with metastatic melanoma: Experience from a single tertiary level centre

      ea0050p256
  • Neuroendocrinology and Pituitary
  • • Morbidity and mortality in patients with hyperprolactinaemia: The prolactin epidemiology, audit, and research study (PROLEARS)

      ea0050p261
    • Establishing the prevalence of pituitary involvement in patients with IgG4-related disease.

      ea0050p262
    • Kisspeptin in the posterodorsal medial amygdala modulates sexual partner preference and anxiety in male mice

      ea0050p263
    • Early post-operative morning serum cortisol measurement as a predictor of remission of Cushing's disease

      ea0050p264
    • Is 11C-methionine PET co-registered with MRI a game changer for persistent acromegaly?

      ea0050p265
    • Patterns of recurrence, response to treatment and mortality in patients with malignant phaeochromocytomas and paragangliomas. - a single centre experience

      ea0050p266
    • 11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing's syndrome in patients with equivocal or negative conventional imaging.

      ea0050p267
    • Disorganised anterior pituitary ultrastructure in choriogonadotrophin-alpha (Cga) null female mice

      ea0050p268
    • Male IGSF1 deficient humans and mice exhibit somatotroph neurosecretory hyperfunction

      ea0050p269
    • Smoke-induced nausea; mediated by the release of the lung tachykinin, endokinin, into the circulation?

      ea0050p270
    • Inpatient prescribed desmopressin nasal spray is omitted three times more often than desmopressin prescribed by other routes

      ea0050p271
    • The severity of obstructive sleep apnoea does not influence ambient IGF-I levels

      ea0050p272
    • Cyclooxygenase-2 is a potential target for the treatment of Adamantinomatous craniopharyngioma

      ea0050p273
    • A comprehensive analysis of the AIP mutation positive pituitary tumour microenvironment: role of stromal cells and the pro-inflammatory cytokine network

      ea0050p274
    • Long-term safety of gamma knife radiosurgery (STRS) for acromegaly

      ea0050p275
    • Adherence to Growth Hormone Therapy in Patients with Growth Hormone Deficiency Following Traumatic Brain Injury

      ea0050p276
    • Copeptin during hypertonic saline infusion in a polyuria/polydipsia syndrome case series

      ea0050p277
    • Pituitary function and quality of life in patients taking oral or transdermal opioid analgesics for non-cancer pain

      ea0050p278
    • Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing's syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

      ea0050p279
    • Pituitary radiotherapy causes increased, cardio- and cerebrovascular morbidity, and high Age Standardized Mortality Ratio (ASMR): single centre experience

      ea0050p280
    • Comparison of Overnight Dexamethasone Suppression Test with Low Dose Dexamethasone Suppression Test for the Diagnosis of Cushing's Syndrome

      ea0050p281
    • Understanding the psychosocial needs of pituitary patients: a survey of Pituitary Foundation members

      ea0050p282
    • Impact of menopause on the natural history of pre-existing prolactinomas

      ea0050p283
    • Non-functioning pituitary macroadenomas: characteristics and outcomes following endoscopic trans-sphenoidal surgery - a single UK tertiary referral centre experience

      ea0050p284
    • Prevalence of paraganglioma at first screen in SDH mutation carriers identified through family screening

      ea0050p285
    • Acromegaly complication screening - are we meeting the guidelines?

      ea0050p286
    • Inpatient endocrinology referrals: does the RCP report 'Referring Wisely' describe who should be referred?

      ea0050p287
    • Post-surgical treatment outcomes of acromegalic patients

      ea0050p288
    • Treating mild central hypothyroidism in postoperative pituitary patients - impact of Endocrine Society guidelines

      ea0050p289
    • An assessment of hypothalamus-pituitary-adrenal axis post-pituitary surgery: can day 8 morning cortisol predict normal SST?

      ea0050p290
    • Predictors of post-operative hypopituitarism following transsphenoidal surgery

      ea0050p291
    • The burden of arthropathy in acromegaly: results from an observational study

      ea0050p292
    • Cannulated prolactin avoids over-diagnosis and unnecessary investigations in normoprolactinaemic patients

      ea0050p293
    • Outcomes of endoscopic, endo-nasal, trans-sphenoidal pituitary adenoma surgery for Acromegaly and Cushing's disease: A single UK centre experience

      ea0050p294
    • Transitoin from paediatric to adult clinic in endocrinology: an assessment of experience at University College Hospital from the prospective of the adult service

      ea0050p295
    • Connected, supported, informed: experiences & benefits of membership of the pituitary foundation

      ea0050p296
    • Recurrence rate of hyperprolactinemia after dopamine agonists withdrawal in macroprolactinoma patients

      ea0050p297
    • Diagnostic challenges in Cyclical Cushing's syndrome presenting with Bilateral Central Serous Retinopathy

      ea0050p298
    • An Insulinoma presenting post bariatric surgery

      ea0050p299
    • Diagnostic challenge of non-invasive and invasive imaging modalities for insulinoma

      ea0050p300
    • Pituitary tumours and bradycardia/complete heart block-an association or incidental findings?

      ea0050p301
    • Unaffected genetic testing in families at risk of phaeochromocytoma or paraganglioma

      ea0050p302
  • Nursing Practice
  • • The value of a holistic needs assessment tool in the care of patients with acromegaly

      ea0050p311
    • Endocrine clinical nurse specialist nurse led clinics - Legal considerations of practice.

      ea0050p312
    • Audit Outcomes of a Nurse Led, Hyperthyroid Telephone Clinic (HTC)

      ea0050p313
    • UK experience with continuous subcutaneous hydrocortisone infusion in patients with adrenal insufficiency

      ea0050p314
  • Obesity and Metabolism
  • • Advanced NAFLD is common in bariatric surgical patients, poorly staged by non-invasive NAFLD biomarkers and is associated with adverse outcome

      ea0050p315
    • Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPAR[gamma] and insulin resistance

      ea0050p316
    • The use of intestinal organoids to investigate nutrient sensing

      ea0050p317
    • 5[beta]-reductase (AKR1D1) is a potent regulator of carbohydrate and lipid metabolism and inflammation in human liver

      ea0050p318
    • The adverse metabolic phenotype associated with obstructive sleep apnoea is not driven by activation of the hypothalamo-pituitary-adrenal axis

      ea0050p319
    • Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

      ea0050p320
    • Rectal and oral administration of L-Phenylalanine supresses food intake and modulates neuronal activation in appetite-regulating brain regions in rodents

      ea0050p321
    • Cholestatic pregnancy alters the gut incretin response to diet, affecting GLP-1, PYY and FGF19 secretion, with reversal of changes associated with ursodeoxycholic acid treatment

      ea0050p322
    • A randomised controlled trial of vitamin D treatment on markers of liver fibrosis in obese women with Polycystic Ovary Syndrome

      ea0050p323
    • Leptin receptors localise to [beta]-cells in the fetal ovine pancreas, but do not appear to influence [beta]-cell mass in utero

      ea0050p324
    • Evaluating the role of testosterone in cerebrospinal fluid secretion

      ea0050p325
    • Low vitamin B12 induces de novo lipogenesis in human hepatocytes

      ea0050p326
    • Male sexual dysfunction and hypogonadism improves following bariatric surgery

      ea0050p327
    • DNA methylation differs between lean and obese placenta and is influenced by maternal environment and fetal sex

      ea0050p328
    • Vitamin B12 deficiency triggers adipocyte dysfunction by enhancing triglyceride biosynthesis and pro-inflammatory cytokine production: a new agonist in metabolic disease?

      ea0050p329
    • Blunt response to a stress test and higher prevalence of risk polymorphism of glucocorticoid receptor gene (NC3C1) in obese patients

      ea0050p330
    • Alterations in concentration and characteristics of circulating extracellular vesicles in morbid obesity

      ea0050p331
    • Reverse cholesterol transport and other functions of high density lipoprotein are enhanced after bariatric surgery

      ea0050p332
    • Genes involved in zinc homeostasis are associated with metabolic syndrome and insulin resistance in Romanian and French populations

      ea0050p333
    • Low iliac skinfold thickness predict mortality in a prospective cohort of white males

      ea0050p334
    • Investigating the role of Annexin A1 in Adipogenesis and its ability to dampen Obesity associated Inflammation

      ea0050p335
    • Metabolic phenotype of Male Obesity-associated Secondary Hypogonadism pre- and post-replacement therapy with intra-muscular Testosterone undecanoate therapy

      ea0050p336
    • Effect of Roux-en-Y bariatric surgery on lipoproteins, insulin resistance, and systemic and vascular inflammation in obese patients with and without diabetes

      ea0050p337
    • Body fat distribution by dual energy x-ray absorptiometry (DXA) and metabolic risk factors in intravenous glucose tolerance test (IVGTT)-defined high and low insulin sensitivity normoglycaemic, overweight men

      ea0050p338
    • The Prevalence of Obstructive Sleep Apnoea in women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis

      ea0050p339
    • Vitamin D status before and after bariatric surgery during 4 years of follow-up

      ea0050p340
    • Resistant Hypertriglyceridemia in pregnancy

      ea0050p341
    • Anthropometric changes associated with antiretroviral therapy in nigerians infected with human immunodeficiency virus

      ea0050p342
    • The challenges of reducing calorie intake in everyday life- a pilot study

      ea0050p343
    • Metabolic profile in a semi urban community in South western Nigeria

      ea0050p344
    • The challanges faced in managing gycogen storage disease

      ea0050p345
  • Reproduction
  • • Mass spectrometry-based assessment of androgen excess in 1205 consecutive patients over 5 years: PCOS most common diagnosis, but severe androgen excess indicates other ovarian and adrenal pathology

      ea0050p351
    • A comparison of Ovarian Hyperstimulation Syndrome (OHSS) parameters following different triggers of oocyte maturation during IVF Treatment

      ea0050p352
    • Polycystic ovary syndrome is associated with adverse mental health and neurodevelopmental outcomes: a retrospective, observational study

      ea0050p353
    • Metformin improves oestrous cycle, ova count and expression of oestrogen receptors in diabetic female Sprague-Dawley rats.

      ea0050p354
    • RNA-Sequencing reveals a downregulation of cholesterol metabolism pathways in granulosa cells from women with PCOS

      ea0050p355
    • Impact of delayed pubertal induction and route of estrogen administration on health parameters in adults with Turner Syndrome

      ea0050p356
    • Metabolic syndrome reduce gravid uterine contractility in female sprague-dawley rat

      ea0050p357
    • Pregnancy, pre-eclampsia and vitamin D: a multi-scale mathematical approach

      ea0050p358
    • Is serial urinary progesterone measured via automated chemiluminescent assay a valid alternative to pregnanediol via manual ELISA for the detection of ovulation?

      ea0050p359
    • Aberrant fetal development precipitated by genistein is accompanied with disruption in the Giant Trophoblast cell histomorphometry, and alteration in the serum, placenta and the amniotic fluid oxidation-reduction system

      ea0050p360
    • Non-cardiac maternal and fetal outcomes in Turner Syndrome pregnancies.

      ea0050p361
    • Kisspeptin-leptin interplay in assisted reproductive techniques

      ea0050p362
    • Effects of myoinositol and D-chiro inositol on hyperandrogenism and ovulation in women with polycystic ovary syndrome: a systematic review

      ea0050p363
    • Aortic dissection in Turner syndrome: a single centre experience

      ea0050p364
    • Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

      ea0050p365
    • Audit of endocrine investigations undertaken in females with elevated testosterone

      ea0050p366
    • Turner syndrome management. Are we going along with the new clinical guidelines?

      ea0050p367
    • Polycystic Ovarian Syndrome (PCOS): Social situation influences Cardiometabolic Outcome

      ea0050p368
    • Polycystic Ovarian Syndrome: Assessment of approaches to diagnosis and cardiometabolic monitoring in UK primary care

      ea0050p369
    • High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

      ea0050p370
    • Standardisation of care: a quality improvement project in Polycystic Ovary Syndrome (PCOS) clinic

      ea0050p371
    • A rare case of Gestational Hyperandrogenism

      ea0050p372
    • Successful stimulation of spermatogenesis in a man with hypogonadotrophic hypogonadism, azoospermia, previous right orchidectomy and a remaining small left testicle

      ea0050p373
    • Clinical and biochemical evaluation of a 32 year old patient with hypogonadism.

      ea0050p374
  • Thyroid
  • • Genetic variants modify susceptibility to AF in patients on thyroid hormone replacement therapy

      ea0050p381
    • A population-based study of the Epidemiology of Chronic Hypoparathyroidism

      ea0050p382
    • Novel driver mutations in thyroid cancer recurrence

      ea0050p383
    • Urinary Iodine to Creatinine ratio (UI/C) during pregnancy is not associated with adverse obstetric outcomes

      ea0050p384
    • Marked increases in levothyroxine prescribing and laboratory testing following a reduction in the upper end of the TSH reference range

      ea0050p385
    • Prevalence of and factors predicting thyroid dysfunction at the time of ST- and non-ST- elevation myocardial infarction - the ThyrAMI 1 study

      ea0050p386
    • The Oxford Multidisciplinary Thyroid Eye Disease Clinic: Can short waiting times and use of Steroid Sparing Agents reduce total glucocorticoid dose and requirement for surgery/radiotherapy?

      ea0050p387
    • An electronic protocol replicating QOF thyroid alerts improves monitoring but does not help optimise levothyroxine replacement in hypothyroidism in primary care

      ea0050p388
    • Morbidity and Mortality in patients with Chronic Hypoparathyroidism

      ea0050p389
    • Thyrotrophin receptor antibodies (TRAb) and other autoantibodies after treatment of Graves' disease

      ea0050p390
    • Iodine status on the Island of Ireland

      ea0050p391
    • The relationship between free T4 and thyrotropin receptor antibodies is log-linear and negatively influenced by age and smoking in patients with Graves' disease

      ea0050p392
    • Long-term relapse rates following thionamide withdrawal in Graves' thyrotoxicosis and the predictive role of TRAbs

      ea0050p393
    • Investigating the utility of diffusion weighted magnetic resonance Imaging as an adjunct to clinical assessment in Graves' Orbitopathy (GO)

      ea0050p394
    • Recent liothyronine price increases have changed primary care prescription practice, with increased referrals to specialist care

      ea0050p395
    • Association of a promoter BAFF polymorphism in Graves' disease

      ea0050p396
    • Primary versus tertiary care follow-up of low risk well differentiated thyroid cancer

      ea0050p397
    • Predictors of thyroid autoimmunity in Maltese individuals

      ea0050p398
    • Autoantibodies to the thyrotropin receptor in Alemtuzumab-induced thyroid autoimmunity: determination of their biological activity, and possible role as predictive marker of disease

      ea0050p399
    • Activating germline TSHR mutations are rare in adult hyperthyroid patients without autoimmunity and showing diffuse uptake on radionuclide thyroid scintigraphy

      ea0050p400
    • Does presence of 'Coexisting Thyroiditis' affect Radioiodine Uptake in Thyroid Cancer Ablation Doses?

      ea0050p401
    • Evaluation of normal reference range for thyroid uptake of technetium-99 m in a single centre UK population

      ea0050p402
    • Use of glucocorticoids in subacute thyroiditis

      ea0050p403
    • The impact of a profoma introduction on the accuracy and appropriateness of Synacthen testing

      ea0050p404
    • Metoprolol succinate is associated with better quality of life in treatment of grave's disease

      ea0050p405
    • Radioiodine treatment for thyrotoxicosis in a district hospital: a re-audit

      ea0050p406
    • Clinical outcomes following radioiodine therapy in Graves' thyrotoxicosis

      ea0050p407
    • Thyroid Nodules (n=400): Correlation of TI-RADS' score with cytological results

      ea0050p408
    • Orbital decompression surgery for graves' ophthalmopathy

      ea0050p409
    • Adoption of the British Thyroid Association guidelines for the investigation of thyroid nodules: a district general hospital experience

      ea0050p410
    • Audit of Fine Needle Aspiration Cytology in the Management of Thyroid Nodule: 3-year experience from Scunthorpe General Hospital

      ea0050p411
    • A rare case of Moyamoya disease in association with Graves Disease in a Caucasian female

      ea0050p412
    • Radioiodine treatment phone clinic for benign thyroid disease: A service audit and quality improvement project in a large tertiary hospital

      ea0050p413
    • Pitfalls in the diagnosis of TSHoma vs Resistant Thyroid Hormone Syndrome.

      ea0050p414
    • A rare case of carbimazole-induced acute liver failure

      ea0050p415
    • Myopathy and dyshagia cause by Severe Hyperthyroidism

      ea0050p416
    • Results of the Liothyronine audit looking at the improvements seen in over all physical well being, mental concentration & somatic symptoms in patients before & after starting T3+T4 combination

      ea0050p417
    • Thyroid related adverse effects of Alemtuzumab in patients with multiple sclerosis- Experience from a single tertiary level centre

      ea0050p418
• ePoster Presentations
• • Adrenal and Steroids
  • • Transient adrenal insufficiency secondary to chronic opioid drug therapy

      ea0050ep002
    • A challenging case of primary aldosteronism presenting in pregnancy

      ea0050ep003
    • An unusual case of acute adrenal insufficiency

      ea0050ep004
    • A rare occurence of adrenal leiomyosarcoma

      ea0050ep005
    • Rare case of bilateral massive adrenal myelolipoma in association with congenital adrenal hyperplasia

      ea0050ep006
    • Respiratory muscle weakness and diaphragmatic failure secondary to cushing's syndrome

      ea0050ep007
    • Glucocorticoid and mineralocorticoid Insufficency on treatment with tramadol

      ea0050ep008
    • Pitfalls in the management of indeterminate adrenal masses

      ea0050ep009
    • Idiopathic spontaneous adrenal haemorrhage in pregnancy

      ea0050ep010
    • Isolated DHEAS elevation causing Hirsutism and Oligomenorrhea - A case report

      ea0050ep011
    • A rare cause of hypertension in pregnancy

      ea0050ep012
    • Puzzling adrenal masses in a patient with hypertension

      ea0050ep013
    • Delayed diagnosis of neurofibromatosis type 1 associated phaeochromocytoma and intussuscepting sigmoid adenocarcinoma

      ea0050ep014
    • A case series of metastatic adrenocortical carcinoma at a tertiary care hospital in UK

      ea0050ep015
    • 'Connshing syndrome' as a cause of hypertension: case report

      ea0050ep016
    • Abstract unavailable

      ea0050ep017
    • Iatrogenic cushings syndrome precipitated by fluticasone nasal drops in HIV infected patient

      ea0050ep018
    • Two cidental lesions: a benign adrenal schwannoma and cerebral meningioma

      ea0050ep019
    • The challenge of gender re-assignment in a female pseudohaemaphrodite in a resource poor setting: a case report

      ea0050ep020
    • Shortcomings of the short Synacthen test; a near miss case of Addison's disease

      ea0050ep021
    • When One Diagnosis Reveals Another...

      ea0050ep022
  • Bone and Calcium
  • • MEN -1 with Primary hyperparathyroidism in pregnancy: a report of two cases

      ea0050ep023
    • An Unusual Case of Hypercalcaemia Whilst Severely Hypomagnesaemic

      ea0050ep024
    • Ribbing Disease: An Unusual Cause of Leg Pain in a Young Woman

      ea0050ep025
    • Parathyroid Cysts - An Unusual Cause for Primary Hyperparathyroidism

      ea0050ep026
    • Resistance to 1 hydroxyvitamin D? A challenging case

      ea0050ep027
    • A rare case of hypercalcaemia: Double trouble, with a twist

      ea0050ep028
    • A rare clinical presentation of osteomalacia mimicking bony metastatsis in adult

      ea0050ep029
    • Hypercalcaemic crisis secondary to a large cystic parathyroid adenoma

      ea0050ep030
    • Presenting with hypercalcaemia: 'chicken' or 'egg'?

      ea0050ep031
    • Systemic Mastocytosis: A Rare but Important Cause of Osteoporosis

      ea0050ep032
    • Vitamin D Toxicity & Undetectable Serum Levels - A Conundrum

      ea0050ep033
    • A rare case of combined hyperparathyroidism and thymoma

      ea0050ep034
    • Parathyroid Perils: Efficiently Investigating Hypercalcaemia for Malignancy

      ea0050ep035
    • Intracranial Calcification

      ea0050ep036
    • When remedy becomes toxin-rare cause of hypercalcaemia

      ea0050ep037
    • Calcimimetic effect of alfacalcidol in a patient with unusual occurrence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism - Case Report

      ea0050ep038
    • Sclerotic Bone Metastases Diagnosed on DXA

      ea0050ep039
    • Case report on symptomatic hypocalcemia associated with acute severe malaria - need for vigilance

      ea0050ep040
  • Clinical Biochemistry
  • • Sertraline-induced non-hyperinsulinemic hypoglycaemia in a non-diabetic patient : A case report

      ea0050ep041
    • A rare cause of acute severe hyponatraemia secondary to the syndrome of inappropraite anti-diuretic hormone (SIADH) secretion

      ea0050ep042
    • A Case of Hypoglycaemia

      ea0050ep043
    • Investigating an isolated serum alkaline phosphatase: an incidental mediastinal seminoma

      ea0050ep044
    • A curious case of recurrent episodes of multiple-electrolytes derangement

      ea0050ep045
    • Blood glucose control in a pregnant female with Type 1 diabetes and Medium-chain acyl-CoA dehydrogenase deficiency (MCADD)

      ea0050ep046
    • A rare metabolic condition presenting to Ophthalmology

      ea0050ep047
    • Pre-eclampsia as a rare cause of severe hyponatraemia

      ea0050ep048
    • '2' much of a problem with hypoglycaemia

      ea0050ep049
    • Starvation ketoacidosis - a rare but significant metabolic condition

      ea0050ep050
    • Primum Non Nocere - the need for appropriate assessment before starting testosterone therapy

      ea0050ep051
  • Diabetes and Cardiovascular
  • • Hypoglycaemia manifested as transient cardiac arrhythmias in a non-diabetic: a case report

      ea0050ep053
    • Significant improvement in response to the GLP1-agonist 'Liraglutide' following change in injection site

      ea0050ep054
    • Diabetes presenting as spontaneous hypoglycemia. Is it possible?

      ea0050ep055
  • Neoplasia, Cancer and Late Effects
  • • Cardiac Paraganglioma associated with SDHB mutation and elevated 3-methoxytyramine levels

      ea0050ep057
    • A Novel cause of non-islet cell tumour hypoglycaemia

      ea0050ep058
    • Pneumocystis pneumonia in Cushing's syndrome due to ectopic ACTH

      ea0050ep059
    • A rare case of MEN 4 presenting with hypercalcaemia in a patient with microprolactinoma 6 years after the diagnosis

      ea0050ep060
    • Hypertestosteronemia and primary infertility from a mediastinal extragonadal germ cell tumor

      ea0050ep061
    • Parathyroid adenoma, pituitary macroadenoma and raised gastrin levels in a patient with negative genetic testing for Multiple Endocrine Neoplasia Type 1: a mere coincidence?

      ea0050ep062
    • Synchronous endocrine malignancies (adrenocortical carcinoma and metastatic papillary thyroid cancer) - case report

      ea0050ep063
    • Case report of adrenocortical carcinoma in a nigerian woman

      ea0050ep064
  • Neuroendocrinology and Pituitary
  • • A rare case of primary suprasellar meningeal melanocytoma associated with nonfunctional pituitary adenoma

      ea0050ep065
    • Case report: Indolent IgG4 hypophysitis with partial anterior pituitary failure

      ea0050ep066
    • A case of plurihormonal TSHoma presenting as meningitis

      ea0050ep067
    • A mysterious pituitary adenoma

      ea0050ep069
    • Tolosa hunt syndrome: a rare cause of hypopituitarism

      ea0050ep070
    • Cushing's disease caused by pituitary macroadenoma exhibiting Crooke's hyaline changes and immunoreactivity for adrenocorticotrophic hormone and growth hormone

      ea0050ep071
    • Multi-drug resistant hyperprolactinaemia - a rarity or a rising entity?

      ea0050ep072
    • Distracting spontaneous refractory hypoglycaemia

      ea0050ep073
    • Recurrent lymphocytic hypophysitis during two pregnancies: a very rare case

      ea0050ep074
    • A rare case of SDHB mutation in a male individual with pituitary adenoma, and paraganglioma/phaeochromocytoma syndrome

      ea0050ep075
    • Secretory Head and Neck Paraganglioma - A rare entity

      ea0050ep076
    • AIP mutation causing familial pituitary tumours

      ea0050ep077
    • A partial hypopituitarism case that resolved following bariatric surgery

      ea0050ep078
    • Siadh associated with neuromyelitis optica involving hypothalamus

      ea0050ep079
    • Paraneoplastic Cushing's syndrome associated with neuroendocrine tumour of the pancreas: A case report and review of literature

      ea0050ep080
    • A rare case of a functioning retroperitoneal paraganglioma in a patient with recurrent Phaeochromocytoma/Paraganglioma (PPGL)

      ea0050ep081
    • Ipilimumab induced hypophsitis. A new cause for a rare disease

      ea0050ep082
    • Secondary adrenocortical insufficiency and renal impairment in a patient presenting with Hyperprolactinaemia

      ea0050ep083
    • Aggresive Ectopic ACTH production causing Cushing's

      ea0050ep084
    • Severe hypoglycaemia in a woman with secondary hypoadrenalism and an abnormal pituitary stalk, complicating metastatic breast carcinoma

      ea0050ep085
    • Cushing's disease - Case report

      ea0050ep086
    • A 32 Year old Nigeria Male with Azoospermia Who Presented with Bilateral Gynecomastia at The State Specialist Hospital Akure - A Case Report and Review of Literature

      ea0050ep087
    • Was it Growth hormone deficiency?

      ea0050ep088
  • Obesity and Metabolism
  • • Successful use of canagliflozin for treatment of post-bariatric surgery hypoglycaemia unresponsive to other therapy

      ea0050ep090
    • The importance of the lows, and not the just the highs, of glycaemia in critical illness

      ea0050ep091
    • Case Series; Experience of the Management of 2 Patients with Severe Anorexia Nervosa in Sligo University Hospital using the MARSIPAN protocol

      ea0050ep092
    • An unsual case of erectile dysfunction with high total testosterone levels

      ea0050ep093
  • Reproduction
  • • Secondary amenorrhea due to abnormalities of the autosomal chromosomes - Case report

      ea0050ep094
    • Oligo-amenorrhoea - a triple whammy?

      ea0050ep095
    • Triple X syndrome and premature ovarian insufficiency - A case report

      ea0050ep096
    • Unusual presentation of sertoli cell only syndrome with extreme tiredness

      ea0050ep097
    • Siginificant hyperandrogenism in a postmenopausal woman from a likely ovarian source

      ea0050ep098
    • Extremely low HDL-C in a patient with premature ovarian failure: case presentation

      ea0050ep099
  • Thyroid
  • • Thymic hyperplasia in Graves' disease - wait and see, or intervene?

      ea0050ep100
    • Persisting biochemical thyrotoxicosis due to biotin supplementation in a patient with Graves' disease

      ea0050ep102
    • Severe thyroid-associated orbitopathy manifesting two years post total thyroidectomy for follicular carcinoma variant of the thyroid

      ea0050ep103
    • Thyroid FDG-PET positivity; Pattern and implications

      ea0050ep104
    • A case of Graves' disease refractory to radioactive iodine

      ea0050ep105
    • Hyperthyroidism secondary to weight loss supplements

      ea0050ep106
    • A case of clinical parotitis following radioiodine treatment for toxic multinodular goitre

      ea0050ep107
    • Development of Graves' ophthalmopathy post-thyroidectomy: Important lessons for clinical practice

      ea0050ep108
    • Thymic hyperplasia associated with Graves' disease: could thymic surgery be deleterious?

      ea0050ep109
    • Challenges in management of a severe case of Amiodarone induced thyroiditis type 2

      ea0050ep110
    • Nivolumab induced thyroid dysfunction in a 61 year old male with non-small cell lung cancer (NSCLC)

      ea0050ep111
    • Delayed diagnosis of severe secondary hypothyroidism in a patient presenting with mixed hyperlipidaemia and metabolic myositis

      ea0050ep112
    • A case of thyrotoxic hyperemesis

      ea0050ep113
    • An interesting case of cryptogenic stroke in the setting of Graves' disease

      ea0050ep114
• Featured Clinical Cases
• • Featured Clinical Cases
  • • Novel ABCC9 mutation with Cantu syndrome-associated phenotype of hypertrichosis with acromegaloid facial features (HAFF) with coexisting familial pituitary adenoma

      ea0050cc01
    • A case of giant prolactinoma with JAK 2 positive mutation

      ea0050cc02
    • A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome

      ea0050cc03
    • Renin assay interference may conceal the diagnosis of primary aldosteronism

      ea0050cc04
    • Mutational analysis and SDHB immunostaining in bladder paraganglioma

      ea0050cc05
    • Activating mutation in the arginine vasopressin receptor AVPR2 resulting in nephrogenic syndrome of inappropriate antidiuresis in a female

      ea0050cc06
    • Case report of MAX mutation causing bilateral phaeochromocytoma

      ea0050cc07
    • Pseudohypervitaminosis D due to assay interference

      ea0050cc08
    • Deteriorating course of a cystic pituitary lesion during pregnancy

      ea0050cc09
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