Endocrine Abstracts

Obesity is a chronic disease associated with a number of co-morbidities. Management options include lifestyle changes, pharmacotherapy and bariatric surgery. European guidelines recommend the use of pharmacotherapy for BMI ≥30 kg/m2 or BMI ≥27 kg/m2 with comorbidities in adjunct to lifestyle modification. Until 2015, orlistat was the only available medication for the treatment of obesity in Europe. Since then, further pharmacological agents ha...

Obesity has emerged as one of the key health concerns of this century due to its prevalence and resistance to treatment. Specifically, more than 60% of people within the UK are currently overweight or obese. Recently, significant progress has been made in clarifying brain neurochemicals and regions regulating energy intake and energy expenditure. Among these neurochemicals is the precursor polypeptide pro-opiomelanocortin (Pomc) localised within the homeostatic brain region th...

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