Endocrine Abstracts

The cell-cell interactions that occur within the breast tumor microenvironment are critical determinants of cancer cell fate. In the face of treatment, the theory of clonal evolution dominates current thinking. Thus, individual cells may acquire a mutation(s) that provides a selection advantage, i.e., Darwinian selection acts at the single cell level. We studied the effect of antiestrogen treatment on the population remodeling ...

Current treatments, including surgery, medical therapy, radiotherapy, and radionuclide therapy for neuroendocrine tumours of the pancreas (PNETs) and bronchus (BNETs) are often unsatisfactory, leading to a 5-year survival of <50% and 5%, respectively. PNETs and BNETs frequently have mutations in chromatin-remodelling genes and the protein encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, menin. Menin binds the...

Background: Phaeochromocytomas (PCC) and paragangliomas (PGL) are tumours derived from neural crest cells within the adrenal medulla or extra-adrenal ganglia, respectively. Over 20 known genes are implicated in at least 30% of cases. Experience with these tumours in individual centres is limited due to their rarity.Objective: To describe the demographics, genetics, treatment and progression-free survival (PFS) in ...

Abstract withdrawn....

Pituitary irradiation is a known risk factor for the development of subsequent hormonal dysfunction. However, it has been noted that some patients do not appear to be affected after many years of follow up. The aim of this retrospective study was to identify protective factors from developing radiation induced hypopituitarism (RIH).Methods: This is a single center study of patients attending the late effects of ch...

Introduction: POEMS syndrome is a rare multisystem disorder characterised by polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma-proliferative disorder and skin changes among other features. We describe the course of the endocrine disease in the context of this paraneoplastic syndrome.Methods: Of the 60 patients with POEMS care in hospital, data are available for 43 patients who attended the Joint POEM...

Introduction: Whilst effective, targeted checkpoint inhibitor monoclonal antibodies are associated with immune-related adverse events including endocrinopathies. Increased licensed oncological indications for these agents raise the need for effective screening, monitoring and ongoing treatment of endocrinopathies. The aim of our study was to investigate potential predictive factors that may identify patients at risk of endocrinopathies....

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid tumours, and neuroendocrine tumours (NETs) of the pituitary and pancreas. MEN1 is caused by mutations of the tumour suppressor gene MEN1, and MEN1 germline mutations are found in >75% of MEN1 patients. The remaining 25% of patients may have mutations involving as yet unidentified gene...

Introduction: Immune checkpoint inhibitors such as CTLA 4 inhibitors (Ipilimumab) and PD1 inhibitors (Nivolumab/ Pembrolizumab) are being increasingly used for treatment of malignant melanomas and other solid tumours. Despite clinical benefits, they have been known to cause certain Immune related adverse effects (IrAEs) which may be dermatological, gastrointestinal, endocrine, or other immune phenomenon.The endocr...

Background: Immune checkpoint (CTLA-4, PD-1) inhibitors are increasingly used to treat cancers including advanced melanoma. Although endocrine immune related adverse events (IRAEs) are now well reported, the frequency and type of thyroid and pituitary dysfunction reported varies considerably, with hypophysitis after CTLA-4 inhibitors reported in 2–16%, and thyroid dysfunction after PD-1 inhibitors in 2–39%. In addition, recove...

Ectopic ACTH is rare and represents about 10% of causes of Cushing’s syndrome. Associated tumours are neuroendocrine in origin and include small cell lung cancer, carcinoid tumours, and medullary carcinoma of the thyroid. In this report, we describe a rare case of ectopic ACTH due to a primary pulmonary carcinoid tumour.A 29 years old male was diagnosed with hypertension 18 months prior to presentation. On ex...

The combination of hypophosphataemia and hypercalcaemia has numerous aetiologies, which can be challenging in the clinical setting. Careful early biochemical identification will facilitate appropriate further imaging and management. We report a case of a gentleman who presented in his ninth decade with deteriorating cognition, proximal muscle weakness and reduced mobility on a background of hypertension, type 2 diabetes with associated ...

Abstract withdrawn....

Abstract withdrawn....