Endocrine Abstracts

Introduction: Follicle-stimulating hormone (FSH) and its corresponding receptor (FSHR) are essential factors for regular gonadal development, sexual maturation at puberty and gamete production during the fertile period in both sexes. The FSHR encoding gene was mapped to the short arm of chromosome (CR) 2 in 2p16.3.3 In females, inactivating mutations result clinically – depending on the degree of inactivation – in primary amenorrhea, sec...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

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Sertoli Cell Only Syndrome (SCOS) is a rare cause of male infertility in which the cause is often unknown. Here, we report an unusual presentation of SCOS in a 32 year old man with severe fatigue, flushing, aches and hypothyroidism. These symptoms did not improve despite correcting hypothyroidism with thyroxine replacement. There have been no features of depression and he has been investigated thoroughly as predominant fatigue has been...

Introduction: The polycystic ovary syndrome is the commonest cause for hyperandrogenism in young women. However, in older women, adrenal and ovarian tumours are more common, particularly if (a) hyperandrogenism is of short duration, (b) causes significant clinical androgenisation, and (c) is biochemically severe. We present an elderly woman who presented diagnostic and therapeutic challenges on account of her comorbidities.Case Present...

During menopause, plasma lipids change in an unfavourable way to a more atherogenic pattern with, increased total and LDL-cholesterol and decreased HDL cholesterol concentrations. Women with POI show increased cardiovascular morbidity and mortality regardless of the cause of the ovarian insufficiency. The treatment of premature ovarian failure in patients presenting extremely low HLD-C is a real challenge.We present the case of a 29 ye...