Endocrine Abstracts

Thyroid hormone (TH) is essential for the development of tissues, in particular the brain, and for their metabolic function throughout life. The thyroid secretes mostly the prohormone T4 and a small amount of the active hormone T3. Most T3 is generated by outer ring deiodination of T4 in peripheral tissues, and both T4 and T3 are degraded by inner ring deiodination to inactive metabolites. This involves three di...