Endocrine Abstracts

Nuclear receptors control gene expression by recruiting transcriptional coactivators (or corepressors). The coactivators are ‘master regulators’ that coordinately activate multiple distinct transcription factors and target genes and pathways to control major physiologic processes such as reproduction, development, inflammation, metabolism and growth. Because of their central role as regulatory ‘nodes’, coactivators are major targets in the development of nu...

Bert W O’MalleyBert W O’Malley, MD is the Tom Thompson Distinguished Service Professor of Molecular and Cellular Biology at Baylor College of Medicine. A native of Pittsburgh, he has a bachelor’s degree from the University of Pittsburgh (1959) and an MD from their School of Medicine (1963). He completed his residency at Duke University and spent four years at the National Institute of Health followed by four years serving as the Luscious B...