Endocrine Abstracts

The glucocorticoid receptor (GR) is a ligand activated transcription factor, serving to regulate both energy metabolic and immune functions. The natural endogenous glucocorticoid in humans is cortisol, but a variety of synthetic molecules have been developed to treat inflammatory disease. These synthetic ligands offer new insights into how the GR works, and how it can be manipulated. Novel, non-steroidal GR agonists specifically alter the GR LBD structure at the HSP90 binding ...

Professor David RayDavid Ray graduated in Medicine from University of Manchester in 1987. He trained in medicine and endocrinology in the North West, before doing a PhD with Anne White and Julian Davis, again in Manchester. Towards the end of his PhD he was offered a post with Shlomo Melmed at UCLA, and, attracted by the lab, and the adjacent coast, headed west. This research post stimulated an ...