Endocrine Abstracts

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Pubertal exposure to rising blood concentrations of sex steroids, partly in concert with transiently increased activity of the somatotropic axis, is instrumental in a pubertal acceleration of bone growth and acquisition of bone mass, followed by growth inhibition and closure of the epiphyseal cartilages in late puberty. As is illustrated by experiments of nature, i.e. subjects with aromatase deficiency or lack of functional oestrogen receptor α, and with androgen insensit...

There are increasing numbers of long-term survivors from breast cancer who will have received combination endocrine treatments alone or in addition to cytotoxic chemotherapy. As a result, many of these individuals are at increased risk of osteoporosis, largely because of the endocrine changes induced by treatment characterised by a reduction in the level of bioavailable oestradiol. The associated increase in bone turnover that accompanies cancer treatment induced bone loss (CT...