Endocrine Abstracts

Contents

• Plenary Lecturers’ Biographical Notes
• • Society for Endocrinology Dale Medal Lecture
  • • Fat, sex hormones and breast cancer

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    • Society for Endocrinology Dale Medal Lecture

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  • Society for Endocrinology Hoffenberg International Medal Lecture
  • • Aldosterone action and the mineralocorticoid receptor

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    • Society for Endocrinology Hoffenberg International Medal Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • GH, GH receptor antagonists, GH receptor 'knock-outs': a story of fat old mice

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • Society for Endocrinology European Medal Lecture 2010
  • • Adrenocortical carcinoma: advance through international cooperation

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    • Society for Endocrinology European Medal Lecture 2010

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  • Society for Endocrinology European Medal Lecture 2011
  • • Genes and adrenal Cushing's syndrome: advance through European and world networks

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    • Society for Endocrinology European Medal Lecture 2011

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  • Society for Endocrinology Medal Lecture
  • • The bare bones of thyroid hormones

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    • Society for Endocrinology Medal Lecture

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  • The British Thyroid Association Pitt-Rivers Lecture
  • • An expanded view on resistance to thyroid hormone

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    • British Thyroid Association Pitt-Rivers Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Genetics of thyroid cancer: clinical and therapeutic implications

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Pituitary tumours: the goal is shrinking!

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    • Clinical Endocrinology Trust Lecture

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• Symposia
• • All you need to know about the genetics of diabetes (types 1 and 2 and MODY)
  • • Immune mechanisms involved in type 1 diabetes: insights from genetics

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    • The diverse phenotypes of KATP channel mutations

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    • How to find all the cases of MODY in your diabetes clinic...

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    • Genome-wide association studies for type 2 diabetes

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  • Novel pathways and treatments in neuroendocrine tumours
  • • Signaling pathways in neuroendocrine tumors

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    • Integrated genome-wide DNA methylation and mRNA expression analysis of pancreatic NETs

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    • Tyrosine kinase inhibitors for neuroendocrine tumours

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    • New horizons in therapy

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  • Fat endocrinology: disorders of adipose tissue and lipids important to the endocrinologist
  • • Can we make more brown adipose tissue to treat obesity?

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    • Familial partial lipodystrophy: an introduction and the importance of diagnosing FPLD

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    • The link between insulin resistance, dyslipidaemia and fatty liver

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    • What you need to know about the genetics of hyperlipidaemia

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  • Endocrine regulation of ageing
  • • The aging process; somatotropic axis and calorie restriction

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    • The ageing process: insulin signalling and mTOR signalling

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    • Cortisol, DHEAS and immunesenescence

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    • Ageing, hormones and cognition in humans

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  • The novel role of primary cilia in endocrine disease and obesity
  • • Making sense: primary cilia in disease and development

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    • Sonic hedgehog signalling and primary cilia in the adrenal

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    • The importance of primary cilium in adipogenic differentiation

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    • The molecular pathophysiology of the human obesity disorder, Bardet Biedl syndrome (BBS)

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  • Novel application of thyroid hormone analogues: thyroid hormones, thinking outside the capsule
  • • Thyroid hormone action: genomic and non-genomic effects

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    • 3-Iodothyronamine: a novel, biologically active thyroid hormone metabolite

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    • The action of thyroid hormone in vascular tissues

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    • Liver: selective TR agonists for the treatment of dyslipidemia

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  • Eat, bond, reproduce – what the hypothalamus dictates
  • • Vasopressin and the olfactory system

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    • The role of tanycytes in the regulation of the reproductive axis

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    • Food or sex: neuropeptides decide

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    • A role for kisspeptin/neurokinin B/dynorphin neurons in initiating and maintaining reproduction

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  • Hormones and bone metabolism
  • • Fracture risk in patients with diabetes

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    • Muscle weakness, falls and vitamin D deficiency

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    • Effects of male hypogonadism on bone metabolism

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    • Protecting bone density during aromatase inhibitor therapy

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  • Doping: performance enhancing substances in sport and their detection
  • • Anabolic steroids in the gym

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    • Compounds enhancing oxygen delivery

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    • Beyond reasonable doubt: catching the GH cheats

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    • Genetic technology in doping and doping detection

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• Clinical Management Workshops
• • The management of difficult Graves’ disease
  • • Autoimmune hyperthyroidism: a spectrum of causes

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    • Thyroid storm, aranulocytosis, vasculitis, hepatitis: what to do next?

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    • The management of Graves' ophthalmopathy and dermopathy

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    • New therapies for Graves' disease

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  • Endocrine problems in pregnancy
  • • Hypothyroidism and euthyroid antibody-positivity in pregnancy

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    • Treatment of hyperthyroidism in pregnancy: risk for the unborn

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    • Management of adrenal disorders in pregnancy

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    • Pituitary disease in pregnancy (including NFPA, prolactinomas, DI)

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  • Pituitary radiotherapy: what are the options?
  • • Focused radiotherapy as primary treatment for pituitary disease

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    • Focussed radiotherapy as primary treatment for pituitary disease

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    • Focused radiotherapy as a salvage treatment for pituitary disease

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    • Radiotherapy, cognition and cerebrovascular disease: what is the evidence?

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  • Management of disorders of sex development (DSD) across the lifespan
  • • The clinical spectrum of DSD

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    • Management of disorders of sex development (DSD) across the lifespan: presentation in adolescence

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    • Transitional care of the young person with DSD

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    • New approaches to molecular diagnosis

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• Applied Physiology Workshop
• • Seeing is believing – cutting edge in vivo cell imaging
  • • Cellular imaging in the pituitary: in vivo confocal microscopy

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    • Dynamic imaging of the tumor microenvironment: impact on invasion and CTL effector function

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    • Quantitative imaging for assessing physical phenotypes in stem cells

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• Clinical Guidelines
• • (1)
  • • Pituitary apoplexy new society guidelines for treatment

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• Special Interest Groups
• • Bone and mineral special interest group
  • • Osteopetrosis and other causes of high bone mass

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    • Patients teaching doctors: hypophosphatemic rickets and the revelation of a novel phosphate homeostatic system

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    • Osteogenesis imperfecta

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    • Osteoporosis

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  • Obesity special interest group
  • • Gut hormone based polypharmacy: same benefits without the surgery?

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    • Gut, hormones, weight loss and metabolic improvement after bariatric surgery

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    • Pre- and post-operative management of patients undergoing bariatric surgery

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    • Bariatric surgery: a cure for diabetes?

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  • Laboratory aspects of clinical endocrinology special interest group
  • • Vitamin D deficiency

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    • Definition of male hypogonadism

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    • The definition of hypothyroidism

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    • Definition of hyperandrogenism

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• Meet the Expert Sessions
• • (1)
  • • Abnormal growth and puberty presenting in late adolescence

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    • Pitfalls in diagnosis and treatment of Cushing's syndrome

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    • The difficult Cushing's or Nelson's patient

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    • Managing Turner Syndrome through childhood and adolescence

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    • Late effects of cancer therapy

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    • Assessing fracture risk and response to therapy in osteoporosis

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    • Managing infertility

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    • Applications of next generation sequencing: what can a key academic service provider offer?

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    • microRNAs - key contributors to endocrinology

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• Nurse Session
• • Turner/Klinefelter’s/Noonan syndrome: case presentations
  • • Turners/Klinefelters/Noonans syndrome

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    • Klinefelter's case presentation

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    • Living with TS: an adult viewpoint

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    • Klinefelter's Syndrome Association

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  • Hyperthyroidism: case presentations
  • • Hyperthyroidism - overview of causes and treatment options

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    • Nurse-led clinic and hyperthyroidism

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    • Hyperthyroidism - Case presentation

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    • Hyperthyroidism - case presentation

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• Young Endocrinologists Session
• • Young endocrinologists’ prize lectures
  • • New insights into glucocorticoid receptor function

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    • Clinical, genetic and molecular characterisation of patients with familial isolated pituitary adenomas (FIPA)

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  • A successful research career
  • • Research in clinical academia

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    • Managing your research career

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    • Postdoctoral research - the things I wish I knew

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    • Commercialisation and IP - translating scientific research

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• Senior Endocrinologists Session
• • (1)
  • • The metamorphosis of testosterone from a sex steroid to a universal health factor

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    • Will we ever discover the mechanism of hormone action?

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    • An exploration of colour theory

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    • Two seminal case reports

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    • The art of medicine

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    • The endocrinology of extramarital affairs

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• Oral Communications
• • Young Endocrinologists prize session
  • • Thyroid hormones in the euthyroid range predict subsequent body mass composition in women: the OPUS study

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    • Does 'mild' primary hyperparathyroidism progress if left untreated? A natural history study

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    • Prolonged exposure to GH impairs insulin signaling in the heart

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    • Developing an in vitro model of tissue expansion in Graves ophthalmopathy: exploring the role of IGF1 receptor targeting as a novel treatment

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    • Atheroprotection by 11[beta]-HSD1 deficiency in ApoE-/- mice: role of both glucocorticoid and 7-oxysterol factors

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    • Evidence for the existence and significance of an alternative pathway towards androgen synthesis during early human life

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    • Mutant cytochrome b5 causing 46,XY disorder of sex development (DSD) due to apparent CYP17A1 17,20 lyase deficiency

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    • TSH levels and thyroid hormone prescribing in primary care in the UK

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  • Steroids
  • • Regulation of 11[beta]-hydroxysteroid dehydrogenase type 1 by NF-[kappa]B in stromal cells: towards tissue specific enzyme inhibition

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    • Anti-inflammatory mechanisms of 5[alpha]-reduced glucocorticoids: potential dissociated steroids

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    • APEX1, a novel, negative regulator of aldosterone synthase activity, differentially binds to a single nucleotide polymorphism in the aldosterone synthase gene and represses transcriptional activity both in vitro and in vivo

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    • Altered miR-125 and miR-134 expression in aldosterone-producing adenoma and post-transcriptional regulation of the CYP11B2 gene

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    • A novel entity of isolated adrenal insufficiency caused by partial inactivation of P450 side-chain cleavage (CYP11A1) enzyme

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    • Novel non-steroidal glucocorticoids that dissociate rapid signalling effects from gene transcription

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    • Depot specific differences in the sensitivity to glucocorticoid and insulin action in human adipose tissue

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    • Metformin increases in vivo 11[beta]-hydroxysteroid dehydrogenase type 1 activity in euglycaemic obese men

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  • Pituitary and thyroid
  • • Development of a novel mass spectroscopy-based method for determining serum IGF1: assessment in a cohort of newly diagnosed subjects with acromegaly

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    • Determination of method-specific normal cortisol responses to the short Synacthen test

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    • miR-107 inhibits the expression of aryl hydrocarbon receptor interacting protein (AIP) and is potentially involved in pituitary tumorigenesis

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    • PTTG promotes mitogenic mechanisms in thyroid cells through autocrine pathways of interaction with growth factors

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    • Metastatic characteristics and radiosensitivity of thyroid carcinoma cells depends on HIF-1 and PI3K signalling in vitro and in vivo

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    • Morbidity in patients with endogenous subclinical hyperthyroidism

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    • Thyroid dysfunction and clot structure: a mechanism for increased thrombotic risk in hyperthyroid individuals?

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    • Assessment of the UK iodine status: a National Survey

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  • Bone and diabetes
  • • A mouse with an ENU-induced mutation (Tyr209Asn) in the natriuretic peptide receptor 3 (Npr3) develops autosomal recessive kyphosis

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    • Is Mepe a novel regulator of growth plate mineralisation?

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    • Rapid bone turnover responses to increased hypothalamic-pituitary-thyroid-axis activity are mediated by thyroid hormones

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    • CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus but not in adipose tissues

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    • Alterations to hypothalamic 5-HT and DA turnover in offspring induced by maternal exposure to a high caloric diet throughout lactation

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    • Dual effect of arachidonic acid on peroxisome proliferator-activated receptor [gamma] (PPAR[gamma])-dependent action in 3T3-L1 adipocytes

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    • Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

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    • Hyperghrelinaemia, hyperphagia, food hoarding and reduced adiposity in an imprinting centre deletion mouse model of Prader-Willi syndrome

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  • Reproduction and fetal programming
  • • The effect of a maternal low protein diet on renal development and function in the offspring

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    • Maternal low protein diet and fetal growth restriction: new insights into the role of placental 11[beta]-hydroxysteroid dehydrogenase-2

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    • Mutations in the gene encoding the fibroblast growth factor 8 (FGF8) are associated with complex midline defects including recessive holoprosencephaly and hypothalamo-pituitary dysfunction

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    • Impaired cardiac function in GR-/- fetal mice

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    • Absence of 11[beta]-HSD2 specifically within the fetal brain alters adult 'depressive' behaviour

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    • Consequence of embryonic exposure to 17[beta]-estradiol on brain asymmetry development and neuroendocrine gene expression in Danio rerio

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    • Plasma biomarkers for early prediction of preeclampsia

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    • Altered fetoplacental growth in monocarboxylate transporter 8 (Mct8) knockout mice

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• Poster Presentations
• • Bone
  • • Does preoperative localisation for total parthyroidectomy in patients with renal failure improve outcome?

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    • Influence of age and gender on expression of primary hyperparathyroidism

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    • Evaluation of the association between serotonin and bone mineral density in patients with neuroendocrine tumours

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    • Management of hypovitaminosis D in patients with primary hyperparathyroidism

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    • Risk factors for femoral neck fracture in Indian postmenopausal women (BMD, Vitamin D study and Propensity for a fall)

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    • Effect of age and gender on bone turnover markers: relationships with oestradiol and parathyroid hormone

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    • Vitamin D insufficiency in hyperparathyroidism

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    • Thyrostimulin expression and signalling in the skeleton

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    • Bone mineral density in patients with primary adrenal insufficiency compared to patients with congenital adrenal hyperplasia

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    • Serum 25-OH-vitamin D levels in thalassaemia major

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    • Bone turnover markers in patients on aminobisphosphonate therapy for osteoporosis

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    • Lithium-induced hypercalcaemia: 'past, present, and future'

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    • What predicts adverse outcomes in untreated primary hyperparathyroidism?

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    • A gene causing autosomal dominant kyphoscoliosis in an N-ethyl-N-nitrosourea (ENU) mutagenised mouse model is located on a 5 Mb interval on mouse chromosome 4 band A3

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    • Parathyroid hormone concentrations in proton pump inhibitor induced hypomagnesaemia

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    • Radius bone loss with ageing assessed by high-resolution peripheral computed tomography differs in men and women

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    • A 5'-untranslated region mutation of the growth and differentiation factor 5 (Gdf5) gene increases expression and is associated with decreased urinary excretion of the cartilage degradation product, CTX-II: relevance to osteoarthritis

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    • The long-term safety and efficacy of zoledronic acid in the treatment of osteoporosis: a 3-year, randomized extension to the HORIZON-pivotal fracture trial (PFT)

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    • Cervical cord compression in a patient with Paget's disease and primary hyperparathyroidism: a diagnostic challenge

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    • Localisation studies in primary hyperparathyroidism: our experience

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    • Co-existing sarcoidosis, primary hyperparathyroidism and vitamin D deficiency in a patient with hypercalcaemia

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    • Immobility: a rare cause of hypercalcaemia

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    • Ablation of AMP-activated protein kinase (AMPK) [alpha]1 catalytic subunit in mice leads to decreased bone loss after ovariectomy and impaired bone response to intermittent PTH treatment

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    • Management of primary hyperparathyroidism

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    • Comparison of two high dose- bolus vitamin D regimens in women with low vitamin D levels

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    • Audit of local management of hyperparathyroidism and evaluation of vitamin D deficiency in PHPT

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  • Clinical biochemistry
  • • A semi-automated method for measuring salivary cortisol and cortisone by tandem mass spectrometry with sample extraction

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    • 25OH vitamin D analysis by liquid chromatography tandem mass spectrometry: interpret results with caution

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    • Turbulent flow liquid chromatography-tandem mass spectrometry for the analysis of bio-available testosterone in serum

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    • Recurrent phaeochromocytoma?

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    • Seasonal variation of vitamin D level among menopausal and postmenopausal saudi women

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    • Significance of insulin-C-peptide ratio in the diagnostic algorithm for endogenous hyperinsulinaemia

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    • Cross reactivity of Spironolactone with androstenedione immunoassay

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    • An unusual case of leg weakness in a patient with diabetes and Addison's disease (Is there a common link?)

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    • The short Synacthen test (SST): should we be testing at both 30 and 60 min?

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    • Comparison of serum cortisol measurement by immunoassay and liquid chromatography-tandem mass spectrometry in patients receiving the 11[beta]-hydroxylase inhibitor metyrapone

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    • Polycythaemia in men treated with transdermal and intramuscular testosterone

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    • Hypocalcaemia presenting via an acute medical admissions unit is only rarely adequately investigated

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    • Severe hyponatraemia in pregnancy associated with pre-eclampsia

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    • Audit of Causes and Consequences of Hyponatraemia in an Inpatient Cohort at a Tertiary Health Centre: Abstract

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    • Tanned and pregnant-primary adrenal insufficiency during pregnancy

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    • A review of the Endocrine Transition Service over the last 10 years

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    • Tolvaptan in a patient with hyponatraemia and a normal chest X-ray

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    • A case of thyrotropinoma co-secreting FSH and LH

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    • Audit on the management of adrenal incidentaloma

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    • A case of Di George's syndrome presenting in late adulthood

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    • Severe hirsutism of rapid onset in an 81-year-old female

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    • Hypercortisolaemia in congenital adrenal hyperplasia: a diagnostic dilemma

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    • Hyponatraemia: the view from primary care

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    • A clinico-microbiological study of infected diabetic foot ulcers

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    • A calcium sensing receptor mutation associated with hypercalcaemia and recurrent pancreatitis

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    • An unusual goitre

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    • Echocardiogram in prolactinoma patients taking ergot derived dopamine agonists

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    • Management of adrenal incidentaloma: are we getting it right?

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    • Hypoadrenalism then adrenal haemorrhage as manifestation of lymphoma relapse after 3.5 years

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    • Hormone profile of patients referred for Bariatric surgery

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    • Effective use of Cinacalcet in tertiary hyperparathyroidism in a patient with hypophosphataemic rickets

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    • Long-term single centre outcome of phaeochromocytoma/paraganglioma

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    • An analysis of false positive urinary catecholamine and metabolite results in a tertiary endocrine centre

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    • Juxta-adrenal Schwannoma presenting as 'Giant' adrenal adenoma

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    • Life-threatening adverse reaction following pituitary MRI

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    • Audit on colonoscopy screening in acromegaly patients in a tertiary endocrine unit

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    • Adrenal haemorrhage associated with therapeutic Clexane and subtherapeutic warfarin

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    • A case of SIADH and hyponatremia treated successfully with Tolvaptan

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    • Proton pump inhibitor (PPI) therapy in patients admitted to a diabetes and endocrine medical ward: are there clear indications?

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    • Pituitary thyroid hormone resistance (PTHR)

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    • Status epilepticus in addisonian crisis

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    • Improving communication in clinical care: a re-audit of an Endocrinology and Diabetes GP e-mail advisory service following commissioning

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    • Hyponatraemia in a patient presenting with diabetic ketoacidosis: a case of polyglandular autoimmune syndrome type 2

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    • Sweating is only half the story

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    • Does the glucagon challenge test add to the utility of a 72 h fast for spontaneous hypoglycemia?

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    • Thyroid swelling and tracheal compression: a cautionary tale

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    • Introduction of day-case thyroid and parathyroid surgery has allowed achievement of the shortest length-of-stay in the United Kingdom

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    • Ectopic prolactinoma in a patient with a clivoid mass

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    • Prevalence and prediction of endocrinopathies in thalassaemia major

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    • Significant hirsutism complicating pregnancy with postpartum resolution

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    • A case of cerebral salt wasting syndrome

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    • Milk-alkali syndrome: not to be forgotten

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    • A case of lymphocytic hypophysitis

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    • Targets for improvement of care for thyroid carcinoma patients in the multidisciplinary setting

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    • Use of Tolvaptan in hyponatraemia: how long is treatment required?

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    • The thyroid and the skin

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    • An unusual case of medullary thyroid cancer presented with T3 toxicosis and type 2 diabetes

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    • Tramadol-induced adrenal insufficiency. A case report.

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    • A case of carcinoid syndrome due to medullary thyroid carcinoma

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    • Calcitonin negative medullary thyroid cancer

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    • A case of complete androgen insensitivity syndrome (CAIS), late presentation and difficult management

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    • 'Old Red-Eyes Is Back': a case of calcium-alkali syndrome

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    • Congenital adrenal hyperplasia: spontaneous resolution or cure?

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    • Multiple endocrine dysfunction in the context of psychiatric medication

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    • Primary care records in hospital clinics: implementing two-way communication in Cheshire, UK

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    • Thyroid function monitoring in amiodarone treated patients: the need to increase awareness among prescribing physicians

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    • Psychiatric illness: a cause and hurdle to management of nephrogenic diabetes insipidus

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    • Pseudo-Cushing's syndrome and central pontine myelinolysis

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    • Cyclical Cushing's or poorly controlled diabetes in an insulin resistant patient?

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    • Recreational jaundice

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    • Hypercalcaemia following parathyroidectomy in a pregnant lady with MEN-1

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    • Disappearing adrenal insufficiency

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    • Metastatic insulinoma in a patient with type 2 diabetes mellitus: case report

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    • The beneficial effects of long-acting octreotide in a patient with concomitant metastatic neuroendocrine tumour and anaemia due to lower digestive bleeding

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    • Thyroid storm in a teacup: an unusual presentation of thyrotoxicosis Category: clinical practice/governance and case reports

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    • Hyponatraemia and SIADH as a presenting feature of acquired immunodeficiency syndrome

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    • Testosterone undecanoate has a beneficial effect on lipid profile in men with hypogonadism in routine clinical practice

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    • Unwanted recovery from secondary hypogonadism: paradoxical effect of Zoladex

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    • Review of 125 individuals with adrenal incidentalomas: a single centre cohort

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    • Glucagon like peptide-1 in congestive heart failure cases and type 2 diabetes mellitus cases

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    • Study of serum prolactin and cardiovascular risk in patients with type 2 diabetes mellitus

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    • Identifying patients with familial hypercholesterolaemia and evaluating management locally

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  • Cytokines, growth factors, neuroendocrinology and behaviour
  • • Altered corticosterone homeostatsis in hippocampus leads to memory impairment in hypobaric hypoxia

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    • Selected adipocytokines serum levels in patients with ischemic stroke

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    • Abstract unavailable

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    • Characterisation of the stress-response in BACE1 heterozygous mice

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    • Salivary cortisol monitoring in sheep and cows: evidence for acute activation of the hypothalamo-pituitary-adrenal (HPA) axis using two models of stress

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    • The effects of recombinant human IGF1/IGF binding protein-3 on body composition and physical fitness in recreational athletes

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    • The effects of recombinant human IGF1/IGF binding protein-3 on lipid and glucose metabolism in recreational athletes

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    • Hypothalamic tanycytes express nuclear receptor regulating enzymes in the absence of mRNA transcript

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    • Differential regulation of the neurotrophins, NGF and BDNF, and their receptors in the myometrium of women affected by adenomyosis

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    • Impact of synovial fibroblasts on adipose tissue

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    • Cytokine profiling of pre-diabetic patients

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  • Diabetes, metabolism and cardiovascular
  • • Inflammatory markers are not strongly associated with the metabolic syndrome in type 2 DM

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    • Renal ischemia/reperfusion injury in type II DM: possible role of proinflammatory cytokines, apoptosis, and nitric oxide

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    • Adult patients with congenital adrenal hyperplasia have elevated blood pressure but otherwise a normal cardiovascular risk profile

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    • The effects of Syzygium aromaticum derived oleanolic acid on glycogenic enzymes in streptozotocin induced-diabetic rats

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    • Serum 25-hydroxy-vitamin D is associated with adiponectin and insulin resistance in diabetic Saudi adults

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    • Endoplasmic reticulum oxidoreductases and insulin folding

      ea0025p125
    • Does the effect of non-alcoholic fatty liver disease confer increased cardiovascular risk in patients with polycystic ovary syndrome?

      ea0025p126
    • Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

      ea0025p127
    • Safety profile of Vildagliptin in clinical practice: 2-year data from 2 Tertiary hospitals

      ea0025p128
    • Sound mind, but sweet blood: olanzapine induced hyperglycaemia

      ea0025p129
    • Cabergoline prevents weight gain in patients evaluated for hyperprolactinaemia

      ea0025p130
    • Interactions between glucagon and GLP-1 in neuronal pathways affecting food intake

      ea0025p131
    • The effect of environmental enrichment on food intake, body weight and the HPA axis in laboratory rats

      ea0025p132
    • Plasma Annexin A1 (AnxA1) is inversely correlated with waist to hip ratio in healthy males

      ea0025p133
    • Abstract unavailable

      ea0025p134
    • Characterisation of IGFBP1 molecular forms in healthy persons and patients with diabetes mellitus type 2 or hypoglycemia

      ea0025p135
    • The Megalin-Cubilin receptor-mediated endocytic pathway is impaired in Dent's disease renal proximal tubule cell-lines

      ea0025p136
    • Influence of metabolic decompensation in children with diabetes mellitus type 1 on changes of QT interval

      ea0025p137
    • Hypogonadism with subsequent multi-organ involvement: a mystery solved

      ea0025p138
    • Pomegranate juice consumption influences urinary glucocorticoids, attenuates blood pressure and exercise-induced oxidative stress in healthy volunteers

      ea0025p139
    • Insulin sensitivity and cytokine response to different exercise modalities in hypoxia in type 2 diabetics

      ea0025p140
    • Audit of short synacthen tests in patients with type 2 diabetes mellitus

      ea0025p141
    • Retinal screening in pregnant women with diabetes: 'are we doing enough'

      ea0025p142
    • Insulin-mediated pseudoacromegaly

      ea0025p143
    • Brain natriuretic peptide rises with exercise at high altitude and is associated with acute mountain sickness scores

      ea0025p144
    • Diet-induced obesity with metabolic dysfunction does not alter vascular function or remodelling in young C57Bl/6 mice

      ea0025p145
    • Postprandial hypertriglyceridaemia in patients with polycystic ovary syndrome

      ea0025p146
    • Abstract unavailable

      ea0025p147
    • Continuous feeding in rats: a novel paradigm for inducing hypocaloric obesity?

      ea0025p148
    • Improvement of cardiovascular risk factors 12 months after Roux-en-Y surgery

      ea0025p149
    • The prevalence of non alcoholic fatty liver disease in GH deficiency and the effect of GH replacement

      ea0025p150
    • Serum erythropoietin levels in patients with acute myocardial infarction

      ea0025p151
    • Low testosterone and severity of erectile dysfunction (ED) are independently associated with poor health related quality of life (HRQoL) in men with type 2 diabetes

      ea0025p152
    • Glucagon like peptide-1 in congestive heart failure cases and type 2 diabetes mellitus cases

      ea0025p153
    • Over-expression of iodothyronine deiodinase III in the hypothalamic VMN as a potential model of local hypothyroidism

      ea0025p154
    • The effect of glucose on hypothalamic neuropeptide Y release investigated using static incubation of hypothalamic explants

      ea0025p155
    • Attenuated atherosclerosis in 11[beta]-hydroxysteroid dehydrogenase type 1 deficient ApoE-/- mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

      ea0025p156
    • Study of serum prolactin and cardiovascular risk in patients with type 2 diabetes mellitus

      ea0025p157
    • Effect of diet/lifestyle advice on weight change in an unselected polycystic ovary syndrome (PCOS) population

      ea0025p158
    • Investigating the effects of testosterone on inflammatory markers of early aortic atherosclerosis in the testicular feminised mouse (Tfm) model

      ea0025p159
    • Study of the adipocytokine visfatin in obesity and type 2 diabetes mellitus

      ea0025p160
    • Study of lipoprotein phospholipase A2 as a biomarker for cardiovascular events in type 2 diabetes mellitus

      ea0025p161
    • Serum 25-hydroxyvitamin D3 concentrations and cardiovascular risk among type 2 diabetic patients

      ea0025p162
    • Low testosterone predicts increased mortality and testosterone replacement therapy improves survival in men with type 2 diabetes

      ea0025p163
    • Chronic GH excess is associated with adenosine monophosphate-activated protein kinase (AMPK) threonine-172 phosphorylation changes that do not lead to changes in AMPK activity

      ea0025p164
    • Differential effects of olanzapine and risperidone on plasma adiponectin levels over time: results from a 3-month prospective open-label study

      ea0025p165
    • Lack of beneficial metabolic profile in liver-specific 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) knockout mice

      ea0025p166
    • Defining multipotent progenitors in the human fetal pancreas by expression and ChIP-seq

      ea0025p167
  • Endocrine tumours and neoplasia
  • • Ectopic ACTH syndrome: experience of a tertiary referral centre: from diagnosis to outcome

      ea0025p168
    • Ovarian steroid cell tumour in association with Von Hippel--Lindau disease

      ea0025p169
    • Simplified minimally invasive parathyroidectomy: a series of 100 cases and a review of the literature

      ea0025p170
    • 'Uterine neuroendocrine tumour: an unusual cause of hyponatraemia' and the role of tolvaptan, a vasopressin V2 receptor antagonist

      ea0025p171
    • Toll receptor-mediated inflammatory system is present in tumour cells from endocrine-related tissues

      ea0025p172
    • Adenosine receptors modulate chromogranin A secretion and growth of neuroendocrine tumours: potential targets for therapy

      ea0025p173
    • Low rate of recurrence after excision of non-familial phaeochromocytomas

      ea0025p174
    • Phaeochromocytoma presenting as polycythaemia

      ea0025p175
    • Development and validation of a LC-MS/MS method for the measurement of plasma renin activity using on-line solid phase extraction

      ea0025p176
    • Clinical and biochemical features of sporadic and hereditary phaeochromocytomas and paragangliomas: an analysis of 47 cases investigated in a single centre

      ea0025p177
    • Metastatic insulinoma treated by transhepatic arterial embolisation

      ea0025p178
    • Pro-opiomelanocortin is a marker of liver and brain metastases from small cell lung cancer xenografts

      ea0025p179
    • Prevalence of functionality in adrenal incidental masses

      ea0025p180
    • Laparoscopic adrenalectomy for Conn's syndrome benefits is beneficial to patients and to health finances

      ea0025p181
    • A rare case of calcitonin and carcinoembryonic antigen negative medullary thyroid cancer

      ea0025p182
    • Endocrine disorders in adults treated for Hodgkin lymphoma in childhood

      ea0025p183
    • Parathyroid carcinoma: an important differential diagnosis in primary hyperparathyroidism

      ea0025p184
    • A patient with adrenal carcinoma

      ea0025p185
    • Adrenal incidentaloma: how frequently do adrenal incidentalomas cause problems in terms of hormone hypersecretion or tumour growth?

      ea0025p186
    • Phaeochromocytoma, paraganglioma and tumour genetics: clinical practice lagging theory?

      ea0025p187
    • Clinical outcomes of adrenal incidentalomas over a 3 year period: a retrospective analysis to evaluate a new referral pathway

      ea0025p188
    • Pituitary apoplexy: headache and beyond

      ea0025p189
    • Adrenal incidentalomas: should we be doing PET scans?

      ea0025p190
    • Endocrine neoplastic manifestations of neurofibromatosis type 1 (NF1): a case and discussion

      ea0025p191
    • Familial adrenocortical carcinoma associated with HNPCC

      ea0025p192
    • Prevalence and follow-up of adrenal incidentalomas after CT renal colic

      ea0025p193
    • Bowel obstruction can be the presenting symptom of phaeochromocytoma

      ea0025p194
    • PBF is induced by ionising radiation and functionally inactivates p53 in thyroid cancer

      ea0025p195
    • MEN-1 mosaic: the founder of a family

      ea0025p196
    • Rare association of simultaneous adrenal Cushing's and primary hyperparathyroidism in patient with previous Graves disease

      ea0025p197
    • PTTG and PBF: targets for enhancement of radioiodine uptake in thyroid tumours

      ea0025p198
    • A case of phaeochromocytoma of the urinary bladder

      ea0025p199
    • An atypical presentation of primary hyperparathyroidism

      ea0025p200
    • Insulinoma presenting as post-prandial hypoglycaemia

      ea0025p201
    • Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a precursor to pulmonary carcinoid

      ea0025p202
    • Five year experience of investigation and management of histologically proven chromaffin cell tumours

      ea0025p203
  • Growth and development
  • • Association between plasma steroid hormone level, growth and obesity in adolescent girls

      ea0025p204
    • Identification of turner syndrome specific mRNA expression profiles that correlate with clinical response to growth hormone

      ea0025p205
    • Effects of the prenatal environment on haematological and skeletal muscle parameters in one-week-old piglets: a role for glucocorticoids?

      ea0025p206
    • Genetic characterisation of primary GH Insensitivity (GHI) presenting as growth failure: 10 years experience at the Centre for Endocrinology, William Harvey Research Institute, Barts and the London

      ea0025p207
    • The use of a novel injection delivery system to address compliance in patients receiving GH replacement therapy

      ea0025p208
  • Nursing practise
  • • Audit of low dose dexamethasone suppression test to exclude androgen secreting tumours in hyperandrogenic women

      ea0025p209
    • Care of cancer survivors: the role of endocrinologists

      ea0025p210
    • Nebido (testosterone undecanoate) in patients over 60 years of age: a time to reduce dose frequency?

      ea0025p211
    • Diagnosis denial exacerbated by thyrotoxicosis

      ea0025p212
    • Cushing's syndrome due to ectopic ACTH secretion from a hepatic neuroendocrine tumour

      ea0025p213
    • An unusual complication in a patient with Graves' disease

      ea0025p214
    • What is the appropriate time for radioactive iodine re-dosing to achieve cure of persistent hyperthyroidism?

      ea0025p215
    • A comparison between post-radioiodine outcomes following the use of two different fixed-dose regimes

      ea0025p216
    • Use of plasma metanephrine estimation in the diagnostic work-up of phaeochromocytoma: an audit of local practice

      ea0025p217
    • Bilateral testicular tumours, a case of mistaken identity?

      ea0025p218
    • Low bone mass is an infrequent long-term sequelea of pituitary disease

      ea0025p219
    • Joint radioiodine clinic - patient satisfaction survey

      ea0025p220
    • Assessment of bone density in patient with adrenal insufficiency

      ea0025p221
  • Pituitary
  • • Has you appearance changed over the last few years? Oh I'm really ugly now!

      ea0025p222
    • Mortality in cushing's disease: stoke-on-trent data and meta-analysis

      ea0025p223
    • Negotiating with a pea-sized hormone factory: the mediatory role of pituitary formyl peptide receptor (FPR) ligands in times of stress

      ea0025p224
    • Pituitary dysfunction is uncommon in pituitary incidentalomas

      ea0025p225
    • A case of lymphocytic hypophysitis with spontaneous remission

      ea0025p226
    • An unusual cause of a sellar mass presenting as a pituitary adenoma

      ea0025p227
    • An audit of 220 insulin tolerance tests

      ea0025p228
    • 20 year experience in the surgical management of cushing's disease in a UK tertiary referral centre

      ea0025p229
    • Suspected spontaneous resolution of pituitary cushing's disease

      ea0025p230
    • Tri-phasic changes in sodium levels post pituitary surgery

      ea0025p231
    • Rare case of disseminated adenocarcinoma prostate metastasising to the pituitary, with a normal PSA

      ea0025p232
    • An unusual case of extremely high prolactin due to stalk disconnection hyperprolactinaemia

      ea0025p233
    • The risk of cardiac valvulopathy in cabergoline-treated endocrine patients in a district general hospital

      ea0025p234
    • Cancer stem cells with a stabilising mutation in beta-catenin are implicated in the aetiology of human adamantinomatous craniopharyngioma

      ea0025p235
    • Long term morbidities in a large series of patients with Cushing's disease

      ea0025p236
    • Molecular and functional characterisation of an endocannabinoid system in L[beta]T2 gonadotrophs

      ea0025p237
    • Assessment of the feasibility of early hospital discharge following trans-sphenoidal pituitary surgery

      ea0025p238
    • A debilitating case of cushing's disease?

      ea0025p239
    • Cranial nerve palsy related to previous radiotherapy in a treated case of acromegaly

      ea0025p240
    • Worsening of thyroid functions following surgical removal of a combined GH/TSHoma

      ea0025p241
    • Pitfalls in transphenoidal surgery: a 10 years experience

      ea0025p242
    • Pituitary apoplexy is a rare endocrine emergency, historically confused with other acute medical conditions, which delayed the diagnosis, however with advances in brain imaging, diagnosing this condition is much easier

      ea0025p243
    • BAC recombineering to understand the role of the alternative promoter in the regulation of prolactin expression

      ea0025p244
    • Evaluation of the interaction of phosphodiesterases 2A and 4A5 with the aryl hydrocarbon receptor interacting protein in pituitary cells

      ea0025p245
    • SIADH of cancer: rapid diagnostic evaluation using copeptin as a marker of AVP

      ea0025p246
    • Hypopituitarism: is it due to bacterial meningitis?

      ea0025p247
    • Thyroid function in patients with pituitary disease: difficulties of individualisation

      ea0025p248
    • Prospective assessment of pituitary function in patients with macroprolactinoma treated with cabergoline

      ea0025p249
    • Delivery of anti-POMC siRNA using a novel polymer

      ea0025p250
    • Structure and function of lactotrophs in the anterior pituitary of TPC1 null mice

      ea0025p251
    • An uncommon cause of panhypopituitarism

      ea0025p252
    • Associations of overall GH and IGF1 exposure with ischaemic heart disease and cardiomyopathy in patients with treated acromegaly

      ea0025p253
    • Overall GH exposure is raised in acromegalic patients with type 2 diabetes and impaired glucose tolerance, when compared with euglycaemic acromegalic patients

      ea0025p254
    • Morphological analysis of lactotrophs in pregnant and lactating mice

      ea0025p255
    • Hypertrophic pachymeningitis and pituitary pathology: lymphocyctic hypophysitis or cabergoline related fibrosis?

      ea0025p256
    • Thyroid function in patients with pituitary disease: difficulties of individualisation

      ea0025p257
    • An unusual presentation of thyrotroph adenoma

      ea0025p258
    • Wide range of eye abnormalities in patients with hypopituitarism; implications for diagnosis and treatment

      ea0025p259
    • Abstract unavailable

      ea0025p260
    • Lymphocytic hypophysitis-extrapancreatic manifestation of autoimmune pancreatitis

      ea0025p261
    • Elusive ectopic ACTH source

      ea0025p262
  • Reproduction
  • • Endocrine disruptors and their association with male reproductive disorders and testicular dysgenesis syndrome: establishing a xenografting model of human fetal testis development

      ea0025p263
    • Distinct expression pattern of Dicer1 correlates with ovarian-derived steroid hormone receptors in human Fallopian tubes during the ovulatory process and in the mid-secretory phase.

      ea0025p264
    • The effect of atorvastatin on adrenal and ovarian hyperandrogenemia in patients with polycystic ovary syndrome.

      ea0025p265
    • Abstract unavailable

      ea0025p266
    • Placental iodothyronine deiodinase activity across the placental bed in normotensive (NT) and pre-eclamptic (PE) pregnancies.

      ea0025p267
    • In support of the 'Rotterdam' PCOS criteria: Identical LH responses to GnRH stimulation in women with oligo-/amenorrhoea and polycystic ovaries regardless of androgen status

      ea0025p268
    • Kisspeptin-54 injection stimulates activity of the human GnRH pulse generator in healthy women

      ea0025p269
    • Expression and functional activity of thyroid hormone transporters in microvillous plasma membranes from human term placental syncytiotrophoblasts

      ea0025p270
    • Increased epididymal Rnase9 expression in Rnase10 (-/-) mice

      ea0025p271
    • Is age of vaginal opening an indicator of leptin sensitivity in female Sprague Dawley rats?

      ea0025p272
    • A case of severe refractory hypercalcaemia in pregnancy caused by hypersecretion of parathyroid hormone related peptide (PTHrP) by the placenta.

      ea0025p273
    • Comparison of cardiovascular markers and variability of insulin resistance in women with anovulatory and ovulatory polycystic ovary syndrome

      ea0025p274
    • Male germ cell activity during perinatal reproductive development in the mouse

      ea0025p275
    • Defining insulin signalling pathways in granulosa-lutein (GL) cells in women with polycystic ovary syndrome (PCOS)

      ea0025p276
    • Increased intensity of P450c17 protein expression in theca cells from polycystic ovaries

      ea0025p277
    • Neuromedin B stimulates the hypothalamo-pituitary-gonadal axis in male rats

      ea0025p278
    • Nesfatin stimulates the hypothalamic-pituitary-gonadal axis in male rats

      ea0025p279
    • Study of role of retinol-binding protein 4 in women with polycystic ovary syndrome

      ea0025p280
    • HRPE773 (ZG16B) expression is elevated in human endometrium during the early secretory phase of the menstrual cycle and in uterine decidua following miscarriage

      ea0025p281
    • Case-control study of 5-alpha reductase type 2 Val89Leu polymorphism in Romanian PCOS patients

      ea0025p282
  • Steroids
  • • GPs say they rely on endocrinologists to manage adrenal crisis and patient education for Addison's disease

      ea0025p283
    • Dehydroepiandrosterone (DHEA) supplementation improves cognitive function in perimenopausal rhesus monkeys

      ea0025p284
    • Measurement of salivary testosterone in female samples using a highly sensitive LC-MS/MS assay

      ea0025p285
    • Steroid Replacement Education: Impact on Patients and their Carers

      ea0025p286
    • How reproducible are LC-MS testosterone results? A calibration exercise

      ea0025p287
    • The effect of prednisolone on different cortisol methods

      ea0025p288
    • Glucocorticoid receptor antagonism as a decision making tool in patients with adrenal incidentaloma and low-grade excess cortisol secretion: a pilot study

      ea0025p289
    • Urinary tetrahydroaldosterone excretion is determined by rising urinary sodium excretion in patients with chronic kidney disease

      ea0025p290
    • Urinary tetrahydrodeoxycorticosterone excretion is a significant independent predictor of LV mass in patients with chronic kidney disease

      ea0025p291
    • Glycyrrhetinic acid disrupts the synthesis of adrenocorticosteroid hormones at multiple sites

      ea0025p292
    • Clinical outcomes of 250 [mu]g short synacthen tests in a tertiary referral centre

      ea0025p293
    • Cortisol decreases lipogenesis in human hepatocytes

      ea0025p294
    • Systems biology reveals a novel mechanism regulating glucocorticoid action

      ea0025p295
    • Spitting out the issues: Identifying optimal procedures for saliva collection and storage

      ea0025p296
    • Effects of endocrine disruptors in adult rats: integrative evaluation from gonadal steroidogenic gene expression profiles to hormonal balance

      ea0025p297
    • An unusual case of hypoadrenalism presenting with hypercalcaemia following severe Legionella sepsis

      ea0025p298
    • A retrospective analysis of Short Synachthen Tests to assess the effect of a change in the normal reference range

      ea0025p299
    • Concurrent analysis of 10 serum steroids by mass spectrometry: investigation of the viability of the Perkin-Elmer CHS[trade] MSMS steroids kit on a waters xevo mass spectrometer with acquity UPLC system

      ea0025p300
    • An atypical case of familial glucocorticoid deficiency without pigmentation caused by coexistent homozygous mutations in MC2R (T152K) and MC1R (R160W)

      ea0025p301
    • Cushing's syndrome in a patient with two lung tumours

      ea0025p302
    • Accidental long-term ingestion of androgenic steroid in a young female: a case report

      ea0025p303
    • Exogenous Cushing's syndrome due to topical corticosteroid application

      ea0025p304
    • Is there a threshold morning cortisol level at which to perform the short synacthen test?

      ea0025p305
    • Why does MRAP2 fail to save familial glucocorticoid deficiency type 2 patients?

      ea0025p306
    • Epidemiology of Addison's disease in the area of banbury, oxfordshire

      ea0025p307
    • Derivatisation of estrogens enhances sensitivity of analysis by liquid chromatography tandem mass spectrometry

      ea0025p308
    • Utility of basal DHEAS measurement in the detection of subclinical autonomous glucocorticoid hypersecretion in adrenal incidentaloma

      ea0025p309
    • Effects of topical betamethasone and calcipotriol therapy in improving the tolerogenic potential of a 'vaccine' for type 1 diabetes

      ea0025p310
    • Hepatic 11[beta]-hydroxysteroid dehydrogenase type 1 expression is dynamically related across the liver lobule and is linked to metabolic status

      ea0025p311
  • Thyroid
  • • Prevalence of overt and subclinical hypothyroidism among Saudi pregnant women attending tow referral hospitals in Saudi Arabia and associated maternal and fetal complications

      ea0025p312
    • Hashimoto's encephalopathy: an unusual cause for coma

      ea0025p313
    • Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy

      ea0025p314
    • Outcomes of radioactive iodine treatment for hyperthyroidism: 1 year follow up survey in subjects attending a general hospital endocrine clinic

      ea0025p315
    • The mystery of persistent thyrotoxicosis

      ea0025p316
    • Anaplastic thyroid carcinoma presenting with stridor after ablative radioiodine therapy for Graves' disease

      ea0025p317
    • Serum phosphate predicts temporary hypocalcaemia following thyroidectomy

      ea0025p318
    • Audit on follow up of thyroid function tests done during osteoporosis screening

      ea0025p319
    • Serum homocysteine concentrations in hypothroid, euthyroid and hyperthyroid patients

      ea0025p320
    • PTTG-binding factor (PBF) induces hyperplastic lesions in thyroids of aged mice

      ea0025p321
    • Does the introduction of a pregnancy-specific TSH reference range improve the increases in management of treated hypothyroidism during pregnancy?

      ea0025p322
    • Spectrum of thyroid dysfunction in interferon-[alpha] treated hepatitis C-positive patients

      ea0025p323
    • Effect of weight loss through gastric bypass on thyroid function in euthyroid people with morbid obesity

      ea0025p324
    • Iodine induced thyrotoxicosis: the danger of over the counter slimming aids

      ea0025p325
    • The effect of parathyroidectomy on neuropsychological symptoms in patients with asymptomatic primary hyperparathyroidism

      ea0025p326
    • Management of hyperfunctioning thyroid malignancy with psychiatric co-morbidity

      ea0025p327
    • Thyrotoxic crisis: a stormy period on intensive care

      ea0025p328
    • Hypothyroidism and adrenaleukodystrophy, a rare association

      ea0025p329
    • Should individuals with a Thy 3 result always undergo surgery?

      ea0025p330
    • The natural history of endogenous subclinical hyperthyroidism

      ea0025p331
    • A case of amiodarone induced thyrotoxicosis, type II followed by subsequent hypothyroidism

      ea0025p332
    • Audit of thyroid function testing in patients on amiodarone

      ea0025p333
    • Depot specific differences in regulation of hyaluronan production of relevance to Graves' orbitopathy

      ea0025p334
    • The use of tandem mass spectrometry to identify binding partners of PBF in thyroid cells

      ea0025p335
    • Variation in levels of skewed X chromosome inactivation represents a shared pathogenic pathway for the common autoimmune thyroid diseases

      ea0025p336
    • Seasonal variation in thyroid autoimmunity as assessed by anti-thyroid peroxidase antibodies is related to temperature

      ea0025p337
    • A case of Graves' disease associated with severe hypercalcaemia

      ea0025p338
    • Thyroid hormone receptor alpha is a permissive factor that regulates osteoclastogenesis indirectly

      ea0025p339
    • Targeted hPTTG overexpression in vivo induces reduced cellular proliferation and p53 stabilisation resulting in decreased thyroid size

      ea0025p340
    • What is the influence of rheumatologic conditions on response to medical therapy of Graves' disease?

      ea0025p341
    • Hashimoto's thyroiditis with associated neurological deficits (Hashimoto's encephalopathy)

      ea0025p342
    • Optimal use of thyroid antibody assays in the identification of auto-immune thyroid disease

      ea0025p343
    • Thyroid hormone changes and psychological response to high altitude stress: effect of ethnicity

      ea0025p344
    • Study of serum adiponectin and leptin in a cohort of Egyptian women with thyroid dysfunction

      ea0025p345
    • Changes in urinary fractional excretion (FE) of calcium and phosphate following treatment of hyperthyroid cats

      ea0025p346
    • Retrospective analysis of thyroid fine needle aspiration (FNA) in a tertiary hospital

      ea0025p347
    • Weight gain following treatment of hyperthyroidism depends on gender and disease severity but not on the treatment administered

      ea0025p348
    • A novel prospective ocular manifestation of Graves' disease

      ea0025p349
    • Sialorrhoea: an uncommon symptom of Graves' disease

      ea0025p350
    • Thyroid dysfunction in patients receiving interferon treatment for hepatitis C: an audit

      ea0025p351
    • Variation in free T3 (fT3) within the reference range is associated with bone development in children, and mediated via alteration in body mass indices

      ea0025p352
    • Langerhans cell histiocytosis of the thyroid gland -does it needs prophylactic thyroidectomy?

      ea0025p353
    • Generalised anxiety disorder following thyroidectomy

      ea0025p354