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Endocrine Abstracts

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Society for Endocrinology BES 2011

Poster Presentations

Cytokines, growth factors, neuroendocrinology and behaviour

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Clinical biochemistry
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Diabetes, metabolism and cardiovascular

ea0025p109 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Altered corticosterone homeostatsis in hippocampus leads to memory impairment in hypobaric hypoxia

Baitharu Iswar , Deep Satya Narayan , Jain Vishal , Barhwal Kalpana , Hota Sunil Kumar , Prasad Dipti , Ilavazhagan Govindasamy

Hypobaric hypoxia, an environmental condition arising due to the reduced partial pressure of oxygen on ascent to high altitude, is known to cause memory impairment. The mechanism underlying the cognitive dysfunction has been attributed to oxidative stress, glutamate excitotoxicity and Ca2+ mediated death cascade. Though the role of corticosterone in higher order brain function including cognition has been well documented in restrained stress, social stress and other...
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ea0025p110 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Selected adipocytokines serum levels in patients with ischemic stroke

Marek Bogdan , Bienek Radoslaw , Kajdaniuk Dariusz , Nowak Mariusz , Sieminska Lucyna , Glogowska-Szelag Joanna , Kos-Kudla Beata

Adiponectin (ADPN), resistin (RSN) and leptin are proteins that affect insulin resistance and atherosclerosis significantly. Although low levels of adiponectin and high levels of resistin and leptin are associated with coronary heart disease and cardiovascular disease risk factors, it is unclear whether adiponectin, resistin and leptin levels are related to the risk of developing ischemic stroke. The aim of the study was to evaluate the adiponectin, resistin and leptin serum l...
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ea0025p111 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Abstract withdrawn....
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ea0025p112 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Characterisation of the stress--response in BACE1 heterozygous mice

Meakin Paul , Winter Johnathan , Ashford Mike , McNeilly Alison

Alzheimer’s disease (AD) is one of the most common causes of dementia world wide. Accumulation of β-amyloid (Aβ) has been implicated as a causal factor of AD. Beta secretase (BACE1) catalyses the rate limiting step in the production Aβ and has been postulated as a potential therapeutic target for AD treatment. Environmental factors, including psychological stress, accelerate the development of dementia and AD. This study examined hypothalamic–pituitary...
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ea0025p113 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Salivary cortisol monitoring in sheep and cows: evidence for acute activation of the hypothalamo--pituitary--adrenal (HPA) axis using two models of stress

Gibbs Sarah , Green Emma , Stedman Alun , Abayasekara Robert , Renshaw Derek , Fowkes Robert

Inappropriate control of the hypothalamo–pituitary–adrenal (HPA) axis in production animals has serious consequences for animal welfare, and economic consequences in relation to food production. Fertility rates have declined as a consequence of farming practice and selective breeding, which may result in an increased susceptibility to disease and infection. Whilst precise monitoring of HPA status can be achieved through measurement of plasma cortisol levels, obtainin...
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ea0025p114 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

The effects of recombinant human IGF1/IGF binding protein-3 on body composition and physical fitness in recreational athletes

Guha Nishan , Erotokritou-Mulligan Ioulietta , Nevitt Simon , Francis Michael , Woodland John , Bassett Eryl , Sonksen Peter , Holt Richard

Introduction: GH is widely abused by athletes for its anabolic and lipolytic properties. As the tests for detecting GH abuse develop further, it is possible that athletes will exploit IGF1 as an alternative or additional doping agent. There is currently no evidence to suggest that IGF1 administration improves athletic performance.Objectives: To determine the effects of rhIGF1/rhIGFBP3 administration on body composition and physical fitness in recreationa...
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ea0025p115 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

The effects of recombinant human IGF1/IGF binding protein-3 on lipid and glucose metabolism in recreational athletes

Guha Nishan , Erotokritou-Mulligan Ioulietta , Nevitt Simon , Francis Michael , Bassett Eryl , Sonksen Peter , Holt Richard

Introduction: Recombinant human IGF1 (rhIGF1) improves insulin sensitivity and glycaemic control when administered to people with diabetes. The effects of rhIGF1 on lipid metabolism in vivo are unclear.Objectives: To determine the effects of rhIGF1/rhIGFBP3 administration on fasting lipids, non-esterified fatty acids (NEFA) and glucose homeostasis in recreational athletes. This study was part of a randomised, double-blind, placebo-controlled trial...
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ea0025p116 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Hypothalamic tanycytes express nuclear receptor regulating enzymes in the absence of mRNA transcript

Shearer Kirsty , Stoney Patrick , Ransom Jemma , Helfer Gisela , Ross Sandy , Morgan Peter , McCaffery Peter

Tanycytes line the wall of the third ventricle sitting at the boundary between the cerebral spinal fluid (CSF) and the hypothalamus. Tanycytes actively take up substances from the CSF using their villi-like apical projections that extend into the third ventricle. Retinol is one such compound and can be oxidized by these cells to retinoic acid, which can be released to regulate transcription in the hypothalamus via specific nuclear receptors. Two retinal dehydrogenases (RALDHs)...
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ea0025p117 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Differential regulation of the neurotrophins, NGF and BDNF, and their receptors in the myometrium of women affected by adenomyosis

Taylor Anthony , Hawes Michael , Kalathy Vijay , Abbas Muna , Mehasseb Mohamed , Habiba Marwan

Adenomyosis is an oestrogen-dependent uterine disease where ectopic, non-neoplastic endometrium is histologically observed within the myometrium. Its incidence ranges between 5 and 70% and although presenting symptoms; menorrhagia (40–50%), dysmenorrhoea (10–30%) and metrorrhagia (10–12%) are well known, its aetiopathology remains unclear. The neurotrophin, nerve growth factor (NGF), has been implicated in the aetiopathology of adenomyosis, especially in the tam...
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ea0025p118 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Impact of synovial fibroblasts on adipose tissue

Hussain Ahkeb , Hardy Rowan , Patel Pushpa , Ahassan Mohammad , Filer Andrew , Stewart Paul , Cooper Mark

Rheumatoid arthritis (RA) is associated with a loss of lean mass and a corresponding increase in fat mass. How fat accumulation in RA is linked to synovial inflammation is unknown. Wnts comprise a family of secreted glycoproteins that are crucial in regulating adipocyte proliferation, apoptosis and differentiation. Recently we demonstrated that endogenously generated glucocorticoids (GCs) alter the pattern of wnt secretion by synovial fibroblasts (SFs), favouring production of...
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ea0025p119 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Cytokine profiling of pre-diabetic patients

Gupta Saket , Maratha Ashwini , Gajanayake Thusitha , Siednienko Jakub , Natarajan Anandan , Hoashi Shu , Miggin Sinead

Inflammation is a component of obesity-associated insulin resistance. Significant increases in inflammatory mediators such as IL6, TNFa and IL1b have been detected in the serum of diabetic patients. Herein, we investigated whether pre-diabetic patients also exhibited perturbations in circulating pro-inflammatory cytokines. To this end, we recruited 42 healthy non diabetics and subjected them to 75 g OGTT after an overnight fast. We profiled the cytokines that are present in th...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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