Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is one of the most prevalent conditions facing the clinical endocrinologist, affecting 5–10% of all women. The condition is characterized in part, by clinical and / or biochemical androgen excess. Despite its prevalence, the molecular mechanisms that contribute to its pathogenesis remain relatively poorly understood. Whilst androgen excess forms part of the diagnostic criteria, the source of the androgen excess is unclear, and ovarian, adr...

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Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory infertility, menstrual disturbances and hirsutism. In its classic form the presentation is of amenorrhoea or oligomenorrhoea associated with clinical and/or biochemical evidence of hyperandrogenism. However, it is clear that the spectrum of presenting symptoms of women with polycystic ovaries is wide, including anovulation without hirsutism (androgen levels are usually raised) and hirsutism with regular cyc...