Endocrine Abstracts

Contents

• Plenary Lecturers’ Biographical Notes
• • Society for Endocrinology Dale Medal Lecture
  • • Common metabolic disease: lessons from the extremes

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    • Society for Endocrinology Dale Medal Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • Pathogenesis of pituitary adenomas

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • Society for Endocrinology European Medal Lecture
  • • Adrenal lumps and bumps: progress in the management of adrenal tumours

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    • Society for Endocrinology European Medal Lecture

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  • Society for Endocrinology Hoffenberg International Medal Lecture
  • • Molecular and endocrine mechanism of seasonal reproduction in birds and mammals

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    • Society for Endocrinology Hoffenberg International Medal Lecture

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  • The British Thyroid Association Pitt Rivers Lecture
  • • Thyroid associations

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    • The British Thyroid Association Pitt-Rivers Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Endocrine hypertension: then and now

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Society for Endocrinology Medal Lecture
  • • The hitchhiker's guide to the steroid galaxy

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    • Society for Endocrinology Medal Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Ubiquitination: the 'Kiss of Death' for human growth

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    • Clinical Endocrinology Trust Lecture

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• Symposia
• • Novel mechanistic insights into thyroid diseases
  • • Human mutations causing hypothyroidism

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    • Genetic mechanisms defining the response to thyroid hormone replacement

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    • The clinical spectrum of Pendred syndrome

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    • Novel mechanisms regulating the sodium iodide symporter: implications for thyroid tumourigenesis

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  • New endocrinology of bone
  • • Insight into bone metabolism from human experiments of nature

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    • PPARG osteoporosis and diabetes mellitus

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    • Ghrelin and ghrelin signaling in bone metabolism

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    • FGF23, osteoblasts and phosphate homeostasis

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  • Stem cells - therapeutic potential and endocrine applications
  • • Embryonic stem cells: derivation, propagation and therapeutic potential

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    • Pluripotent stem cells in the testis: restoring fertility

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    • Plasticity of pancreatic duct cells

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    • Reprogramming somatic cell identity: a source for replacement therapy

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  • Glucocorticoid action in inflammation: new insights into old mechanisms
  • • Tissue-specific glucocorticoid action in inflammation and immunosuppression

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    • A novel mechanism of glucocorticoids to block autoimmunity

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    • Role of dual specificity phosphatases in biological responses to glucocorticoids

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    • Selective glucocorticid receptor agonists: control of inflammation without metabolic side effects?

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  • Vitamin D and calcium signalling in the immune system
  • • Vitamin D and calcium signalling in autoimmune disease

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    • Anti-bacterial action of vitamin D

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    • Vitamin D as a risk factor for multiple sclerosis

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    • Vitamin D and regulatory T cells in allergy and asthma

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  • Fit or fat? Mechanisms regulating our metabolic fate
  • • FTO variants are associated with overeating and many long-term health problems associated with obesity

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    • The phenotype of the FTO knockout mouse

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    • Gut-brain circuits controlling glucose homeostasis

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    • Mechanisms of serotonin regulating food intake: the role of the melanocortin pathway

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  • Dilemmas in managing gender identity problems in adolescence
  • • Dilemmas in managing gender identity problems in adolescence: psychological issue

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    • Dilemmas in managing gender identity problems in adolescence: a medical overview

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  • Role of the circadian clock in endocrinology
  • • Molecular basis of the circadian clock: regulation of endocrine rhythms

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    • Circadian clocks in adipose tissue

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    • The adrenal clock: impact on adrenal steroidogenesis

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    • Human clock genes and the metabolic syndrome

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  • Mechanisms and management of ovarian failure
  • • Genetic mechanisms underlying ovarian insufficiency

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    • Mechanisms regulating ovarian reserve

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    • Can ovarian failure be predicted?

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    • Clinical management of ovarian insufficiency

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• Clinical Management Workshops
• • Long-term consequences of endocrine diseases
  • • Subclinical thyroid disease

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    • Mild primary hyperparathyroidism

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    • Long term consequences of Cushing's syndrome

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    • Addisons disease

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  • Endocrine incidentalomas: what to do with lumps and bumps
  • • Thyroid

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    • Pituitary incidentalomas

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    • Adrenal lumps & bumps

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    • Pancreas

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  • Management of congenital adrenal hyperplasia across the lifespan
  • • Prenatal diagnosis and treatment of CAH

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    • Testicular adrenal rest tissue and male fertility in CAH

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    • The adult with CAH: results of the UK congenital adrenal hyperplasia, adult study executive (CaHASE)

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    • Quality of life in CAH: does it differ from adrenal insufficiency?

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  • The management of thyroid cancer
  • • Investigation of thyroid cancer from thyroid lump to surgical referral

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    • Surgical treatment of thyroid cancer

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    • Radioiodine treatment and long-term follow-up of differentiated thyroid cancer

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    • Novel therapies for recurrent thyroid cancer

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• Nurse Session
• • Neuroendocrinology & case presentations
  • • Abstract unavailable

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    • MEN-1 case presentation

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    • Abstract unavailable

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    • Has Carcincioid syndrome given me more than the average number of ears?

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  • Acromegaly – psychological aspects & case presentations
  • • Abstract unavailable

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    • Abstract unavailable

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    • A psychological aspect of acromegaly

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    • McCune-Albright syndrome - case presentation

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• Clinical Debate
• • (1)
  • • This house believes that androgen replacement therapy should be offered to every hypogonadal woman

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    • This house believes that androgen replacement therapy, to get things going, should be offered to every hypogonadal woman

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• Young Endocrinologists Session
• • Alternative careers for basic and clinical scientists
  • • The 'darkside' - pharmaceutical industry for endocrinologists

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    • Clinical biochemistry: one foot in the lab

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    • Scientific communication - medical communication agencies

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    • Government agencies - scientific roles in the civil service

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• Special Interest Group Sessions
• • Andrology Special Interest Group Session
  • • Testosterone and mortality

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    • Testosterone deficiency in metabolic syndrome

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    • Late onset hypogonadism

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    • Assay problems and treatment decisions: when and how to treat?

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  • Pituitary Special Interest Group Session
  • • 'Growth hormone deficiency: a silent epidemic?'

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    • Diagnostic difficulties of GH deficiency

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    • GH: old hormone, new developments: therapeutic dilemmas

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    • Future issues for GH replacement in adults

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  • PCOS Special Interest Group Session
  • • Androgen activation by 5[alpha]-reductase in patients with PCOS

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    • Abstract unavailable

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    • Abstract unavailable

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    • Diagnosis and differential diagnosis of PCOS

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• Systems Biology Session
• • How to access funds and revolutionise your research
  • • System biology: an overview (BBSRC strategy and funding streams)

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    • Integration of live cell imaging and mathematical modelling: how to use systems biology to revolutionise your research

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    • Mathematical modelling and endocrine research

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    • Applications of systems biology for the endocrinologist

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    • Systems biology: a funder's perspective

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• Senior Endocrinologists Session
• • (1)
  • • Will we ever discover the mechanism of hormone action?

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    • Sleep, light and hormones in Antarctica

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    • Is the placenta just a parasitic endocrine organ?

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    • Are salivary hormone measurements a waste of time?

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    • La Mujer Barbuda by Ribera, 1631: a clinical conundrum

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    • Animated enchantment: an investigation of the enduring popularity of Walt Disney's first feature films

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• Oral Communications
• • Diabetes and metabolism
  • • IGF1 receptor and insulin receptor stoichiometry is a critical determinant of nitric oxide bioavailablity

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    • Moderate maternal undernutrition results in epigenetic changes in the fetal hypothalamic feeding centres, but not in the fetal HPA axis

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    • Adipose-specific knockout of androgen receptors in mice results in hyperinsulinaemia without obesity

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    • The impact of saturated fatty acids and glucose on Toll-like receptor activated inflammatory pathways in human adipose tissue, in vitro

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    • The immune-adrenal interface: effects of endotoxin on annexin 1 and formyl peptide receptor expression, cellular morphology and steroidogenesis in the mouse adrenal cortex

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    • Testosterone improves glycaemic control, insulin resistance, body fat and sexual function in men with the metabolic syndrome and /or type 2 diabetes: a Multicentre European Clinical Trial: the TIMES2 Study

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    • Prospective changes in glucocorticoid metabolism predict alterations in metabolic phenotype

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    • Cortisol metabolism and hepatic expression of 11[beta]-hydroxysteroid dehydrogenase type 1 in patients with non-alcoholic fatty liver disease

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  • Neuroendocrine tumours/pituitary
  • • A novel mechanism of effect for somatostatin analogues: the role of AIP

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    • Wnt/[beta]-catenin signalling is down-regulated in pituitary tumours from a multiple endocrine neoplasia type 1 (MEN1) mouse model

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    • 11C-Metomidate positron emission tomography (PET) scanning for Conn's syndrome

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    • Geographical cluster of familial isolated pituitary adenoma kindreds with an identical AIP mutation

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    • Differential effects of oestrogen on hypothalamic GnRH-I and GnRH-II gene expression in female rhesus macaques

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    • Laying the foundation for neuroendocrine control of human reproduction: an investigation into the development of kisspeptin and neurokinin B networks

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    • The spectrum of disease in diazoxide responsive hyperinsulinaemic hypoglycaemia

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    • Diagnosis and localisation of insulinoma: the value of modern MRI in conjunction with calcium stimulation catheterisation

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  • Young Endocrinologists prize session
  • • In patients with primary hyperaldosteronism (PA), careful choice of patients for surgery using a combination of adrenal venous sampling (AVS) data and results of CT scanning, results in excellent post-operative blood pressure and serum potassium responses

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    • [beta]-Cell specific overexpression of 11[beta]-hydroxysteroid dehydrogenase type 1 reverses high fat diet-induced [beta]-cell failure

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    • Development of urinary steroid profiling as a high-throughput screening tool for the detection of malignancy in patients with adrenal tumours

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    • MicroRNAs, let-7 and miR-302, have an altered expression in Men1-null embryos, consistent with abnormal embryonic development

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    • A multisystem selenoprotein disorder with a thyroid signature

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    • Men1 gene replacement therapy using a modified adenoviral vector demonstrates reduced proliferation rates in pituitary tumours from mice deleted for a multiple endocrine neoplasia type 1 allelle

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    • Effects of glucocorticoids on Wnt gene expression in synovial fibroblasts: potential role in inflammatory bone loss

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    • Identification and functional impact of novel mutations in the gene encoding 11[beta]-hydroxysteroid dehydrogenase type 1 in patients with hyperandrogenism

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  • Bone and parathyroid
  • • Multiple endocrine neoplasia type 1 (MEN-1) mutation analysis in patients with primary hyperparathyroidism under the age of 40 years

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    • Intra-cellular availability of T3 in chondrocytes is essential for normal skeletal development and adult bone mass

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    • Mice deleted for the transcription factor Gata3 have fewer parathyroid cells expressing Gcm2, develop hypocalcaemia and have an earlier onset of mortality when challenged with a low calcium-vitamin D diet

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    • Rapid screening for novel bone phenotypes in 100 consecutive lines from the Wellcome Trust Sanger Institute Gene Targeting Programme

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    • Dicer-dependant microRNAs regulate IGF-actions in the human placenta

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    • Impaired osteoblast function in mice lacking the T3-responsive calcineurin inhibitor RCAN2

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    • Persistent symptomatic improvement at more than 12 months after parathyroidectomy for primary hyperparathyrodism

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    • Increased mortality in so-called 'mild' primary hyperparathyroidism: a population-based study

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  • Steroids and thyroid
  • • Familial GC resistance: a novel, naturally occurring mutation which has dominant negative effects on ligand-dependent and -independent GR action

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    • De novo cortisol synthesis by primary human keratinocytes

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    • Differential roles of PAPSS1 and PAPSS2 in the control of androgen synthesis

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    • Induction of hypothyroidism with radioactive iodine therapy is associated with improved survival in patients with hyperthyroidism

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    • Akt activation in a murine thyroid goitre model induced by the tumourigenic factor PBF

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    • Is it safe for patients taking thyroxine to have a low but not suppressed serum TSH concentration?

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    • X chromosome inactivation: the key to the female preponderance in Graves' disease?

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    • The effect of genetic variation in PDE8B and DIO1 on thyroid hormone levels

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• Poster Presentations
• • Bone
  • • Hypercalcaemia following a road traffic accident

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    • Protracted hungry bone syndrome post parathyroidectomy for primary hyperparathyroidism

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    • Hypertrophic pulmonary osteoarthropathy: not all longstanding raised bony alkaline phosphatase is Paget's disease

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    • Vitamin D sufficiency is rare in patients attending the Endocrine Antenatal Clinic even in the Caucasian population

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    • A mouse model, Slip, for an X-linked metaphyseal chondrodysplasia

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    • Bone mineral density in transitional endocrine clinic in a UK Teaching Hospital

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    • Osteoporosis in a young cohort: aetiology and gender differences in referral for DXA

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    • Vitamin D deficiency in primary hyperparathyroidism: prevalence and complications

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    • Osteoporosis in patients with chronic obstructive pulmonary disease

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    • Recurrence of spontaneously resolving hypercalcaemia, an unusual case

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    • Assessment of vitamin D status in patients with primary hyperparathyroidism

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    • Secondary preventative alendronate use in the prevention of fragility fractures in women above 75 years: the implementation of NICE guidance

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    • Is it time to replace the 24 h urine calcium: creatinine clearance ratio in the investigation of PTH-dependent hypercalcaemia?

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    • Mutational analysis of the PHEX gene in three patients with X-linked hypophosphatemic rickets: discovery of a novel point mutation

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    • A study on accuracy of Sestamibi and ultrasound scanning in identifying a solitary parathyroid adenoma in patients with primary hyperparathyroidism

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    • A novel GATA3 mutation, Tyr345Cys, in hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome results in abolished DNA binding

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    • Adenosine A2b receptors induce osteoblastogenesis whereas A1 receptors induce adipogenesis

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    • Management of primary hyperparathyroidism: are we following the guidelines?

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    • Hereditary renal calcification locus, Rcalc1, is associated with altered expression of cell survival genes

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    • Is Vitamin D deficiency a common cause of elevated PTH post-parathyroidectomy?

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    • Transient receptor potential cation channel, subfamily Vanilloid, member 5 (Trpv5) mutation (Ser682Pro) results in loss of apical membrane expression in the distal convoluted tubule, thereby resulting in hypercalciuria

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    • AMP-activated protein kinase (AMPK) regulates in vitro bone formation and bone mass in vivo

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    • A mouse model of early-onset renal failure, tertiary hyperparathyroidism and renal osteodystrophy

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    • The association among bone mineral density (BMD), 24-h mean sex hormone binding globulin (SHBG) concentration and its circadian rhythm

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    • Extra-pituitary expression of the prolactin gene in the bone and cartilage of an hPRL-Luc transgenic rat model

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  • Clinical practice/governance and case reports
  • • Prevelance of various morbidity in North Indian adult obese patients

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    • Intervention to improve the management of diabetes in an academic primary care practice

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    • Are adrenal incidentalomas routinely referred to endocrinology services? An audit of referral pattern and appropriate investigation

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    • Kelp induced thyrotoxicosis

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    • Unusual presentation of a phaeochromocytoma

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    • Severe abdominal pain as presentation of Addison's disease in undiagnosed case of autoimmune polyglandular disease

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    • A case of polyglandular autoimmune syndrome type II and sarcoidosis

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    • The importance of HLA haplotype analysis in the polyglandular autoimmune syndromes

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    • Marked hypercalcaemia in a case of primary hyperparathyroidism

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    • 'Mighty oaks from little acorns grow': a review of the development of Endocrine Nursing in the UK

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    • Altered time-effect profile of insulin glargine in overdose: a case report

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    • The pitfalls of abrupt reduction in glucocorticoid availability: illustrated in the treatment of Cushing's syndrome

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    • A case of microprolactinoma in a young man presenting as obesity despite regular heavy exercise

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    • Insulin induced hypoglycaemia in hospital inpatients

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    • Cushing's disease or pituitary incidentaloma?

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    • Extensive hirsutism, a valuable clue to a sinister pathology

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    • Aetiology of hyperprolactinaemia

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    • Testosterone replacement in the setting of Finasteride therapy: a therapeutic dilemma

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    • Addison's disease unmasking an occult systemic cause for cerebral ischaemic event

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    • Bariatric surgery in renal transplant recipients

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    • Intermittent galactorrhoea due to vacant episodes

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    • Assessment of risk factors given in GP referral letters for DEXA imaging

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    • Forensic endocrinology: a case report of factitious hypoglycaemia

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    • Severe hypoglycaemia leading to death in a patient with type 2 diabetes: insulinoma, sulphonylurea overdose or some other cause?

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    • Hypocalcaemia post total thyroidectomy: a clinical experience

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    • Mass in the median eminence: an unusual cause of confusion

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    • A case of fatal acute severe multi-factorial hyponatraemia

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    • An unusual presentation of polyendocrinopathy

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    • Acute fatty liver due to poor diabetic control

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    • A case of pseudo-carcinoid

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    • Investigating for Cushing's syndrome in a patient with increased BMI on rifampicin

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    • Granulomatous infiltration of the pituitary gland

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    • Audit on the safety of the insulin stress tests in a tertiary endocrine referral centre

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    • The use of insulin stress test as an assessment of tiredness

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    • A case of hypomagnesemia

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    • Hyperandrogenism with an abdominal mass but an ovarian source

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    • Diabetes insipidus secondary to caseating granulomatous disease

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    • Case of post menopausal steroid cell ovarian tumor

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    • A man with short stature and absent testis

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    • A rare case of isolated Cushing's disease from an ACTH and GH staining pituitary adenoma

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    • What a difference a dose makes! Unexpected test results lead to improved communication

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    • Hypercalcaemia due to PTH-related peptide secretion by small cell carcinoma of the ovary

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    • Low sodium and neurological findings: consider the diagnosis

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    • Androgen-producing tumour in a transposed ovary: a diagnostic difficulty

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    • Insulin autoimmune syndrome: a rare case of hypoglycaemia

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    • Improving patient awareness of antithyroid medications

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    • A case of hypogonadotrophic hypogonadism due a pituitary stalk tuberculoma

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    • Recurrent pituitary apoplexy

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    • A case of connective tissue disease complicated by multiple metabolic disorders

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    • The dangers of drinking liquorice tea

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    • A case of functional parathyroid adenoma

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    • A rare cause of a common problem

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    • Chronic lymphocytic infundibulitis with visual field defects, partial hypopituitarism and diabetes insipidus

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    • Misdiagnosed adrenal carcinoma with recurrence of Cushing's syndrome complicated by spontaneous hypoglycaemia

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    • Successful treatment of severe premenstrual dysphoria by a GnRH analogue and hormone add-back

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    • Hypertension in familial adenomatous polyposis (FAP): don't be conn'd!

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    • Pituitary apoplexy in Cushings disease

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    • Audit of hypothyroid management in pregnancy

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    • Severe hypomagnesaemia associated with proton pump inhibitor therapy

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    • Recurrent pregnancy-related hypokalaemia associated with Gitelman's syndrome

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    • An unusual cause of hyperparathyroidism

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    • Cushing's syndrome: a rare cause of hypertension in pregnancy

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    • An unusual case of vitamin D deficiency and Wernicke-Korsakoff syndrome

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    • Phaeochromocytoma/paraganglionoma patients in a joint endocrine genetic clinic setting

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    • Severe primary hyperparathyroidism (PHPT) and osteomalacia in pregnancy complicated by post parathyroidectomy hypocalcaemia related transient congestive cardiac failure (CCF): a case report

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    • Lithium-induced hypercalcemia and parathyroid dysfunction

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    • Failure of renin determined by immunoassay to suppress in a case of adrenocortical carcinoma secreting excess mineralocorticoid

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    • A case of spontaneously resolving occult ectopic ACTH-dependent Cushing's syndrome

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    • Reasons for treatment changes in hypogonadal men undergoing testosterone replacement

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    • An evaluation of the knowledge, motivation and weight-management service needs of obese young people

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    • Addison's disease: a new indication for continuous s.c. insulin infusion (CSII)?

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    • Primary antiphospholipid syndrome presenting as accelerated hypertension and adrenal haemorrhage associated with elevated urinary catecholamines

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    • The relationship between electrolyte disturbance and treatment with proton pump inhibitors

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    • Challenges in management of aggressive GH secreting tumors in adolescents

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    • Vitamin status after gastric bypass and lifestyle intervention: a comparative prospective study

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    • An unusual case of hypercalcaemia in an HIV positive man

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    • Utilising combined treatment modalities in non-islet cell tumour hypoglycaemia (NICTH)

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    • DIPNECH: precursor to pulmonary neuroendocrine tumors

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    • Ghrelin levels in patients with post hepatitis 'C' liver cirrhosis and hepatocellular carcinoma (HCC)

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    • A case of Verner-Morrison syndrome with solitary VIPoma and an incidental serous mucinous adenoma

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    • Risk of metabolic syndrome among Egyptian patients with schizophrenia

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    • Hypocalcaemia following thyroid surgery: impact on length of stay

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    • Audit of the management of metformin treated diabetic patients undergoing i.v. contrast procedures

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    • Hypoparathyroidism treated with Teriparatide and i.m. vitamin D

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    • Primary medical therapy of acromegaly

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    • Severe insulin resistance in hypothyroidism: a case report

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    • An unusual association of primary amenorrhoea and sleep dysfunction

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    • Somatostatin analogues as an alternative treatment for type 1 gastric endocrine tumour: case report

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    • Is a morning serum cortisol a useful screening test to rule out hypoadrenalism?

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    • The endocrine consequences of stem cell transplantation

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    • Endocrinopathy and low bone mineral density in thalassaemia

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    • Unemployment and return to work after the diagnosis of a chronic endocrine condition

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    • The use of the urine calcium/creatinine clearance ratio in patients with hypercalcaemia

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    • Salivary cortisol is a reliable marker to monitor hydrocortisone replacement

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    • Screening for glucose intolerance in young women with polycystic ovary syndrome: what is the optimum strategy?

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    • The role of adrenal vein sampling (AVS) in the diagnosis and management of primary hyperaldosteronism: an audit of 10 years experience at a tertiary referral centre

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  • Cytokines and growth factors
  • • Peripheral blood mononuclear cells from active rheumatoid arthritis patients show a defective induction of adrenomedullin

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    • Impact of adiposity on dynamic changes of serum adipokines after OGTT

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    • Interaction of endothelin, aldosterone and bone morphogenetic proteins on mitotic actions of pulmonary arterial smooth muscle cells isolated from pulmonary arterial hypertension

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    • PTTG promotes mitogenic mechanisms in thyroid cells through autocrine pathways of interaction with TGF-[alpha], EGF and IGF1

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    • Does SOCS2 mediate inflammatory induced growth retardation?

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    • Differential effects of eicosapentaenoic acid (EPA) and palmitate on tumour necrosis factor (TNF-[alpha]) and insulin-like growth factor (IGF1) action in murine skeletal muscle cells

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    • Atrophy or hypertrophy: differential responses of C2 and C2C12 mouse skeletal myoblasts in the absence or presence of tumour necrosis factor-[alpha] (TNF-[alpha])

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    • Blood pressure, renal cytokines and biochemical parameters improve in morbidly obese patients after bariatric surgery

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  • Diabetes and metabolism
  • • Profile of elderly patients with diabetes admitted into Obafemi Awolowo University Teaching Hospital

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    • Factitious hypoglycaemia in a patient without diabetes

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    • Gender and the metabolic syndrome in type 2 DM

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    • Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices

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    • Pancreatic polypeptide: a novel substrate for the endopeptidase neprilysin

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    • Bariatric surgery in renal transplant recipients

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    • Testosterone replacement therapy has no effect on ultrasound assessed carotid artery stiffness and intima-media thickness in men with insulin treated type 2 diabetes

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    • A novel role for neuropeptide Y in the regulation of energy homeostasis

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    • Salicylate induces insulin sensitivity by alleviating endoplasmic reticulum (ER) stress in cultured primary human adipocytes

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    • Herbal remedies as a cause of recurrent hypoglycaemia

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    • The effects of chloroquine on blood glucose and plasma insulin concentrations in male Sprague-Dawley rats

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    • The impact of thiazolidinediones on microalbuminuria in adults with type 2 diabetes mellitus: a systematic review

      ea0021p140
    • Diabetic keto-acidosis in patients with Type 2 diabetes mellitus: a relatively common occurrence, the severity of which correlates with HbA1c

      ea0021p141
    • Healthcare professionals frequently fail to recognise severe obesity

      ea0021p142
    • Starvation ketoacidosis in pregnancy

      ea0021p143
    • Protective effects of annexin A1 in experimental endotoxaemia are mediated by an FPR-dependent mechanism

      ea0021p144
    • Toll-like receptor 2 (TLR2) as a biomarker for cardiovascular diseases in type 2 diabetes mellitus patients

      ea0021p145
    • Regulation of the melanocortin receptor accessory protein (MRAP) in Y1 adrenal cells

      ea0021p146
    • Annexin 1 affords cerebroprotection in sepsis

      ea0021p147
    • The lipoprotein lipase HindIII polymorphism and susceptibility to hypertension

      ea0021p148
    • Intravitreal bevacizumab injection for proliferative diabetic retinopathy

      ea0021p149
    • Diabetic ketoacidosis: a 5-year retrospective analysis

      ea0021p150
    • Effect of rimonabant and metformin on oxidative stress in obese patients with polycystic ovary syndrome (PCOS)

      ea0021p151
    • At high dietary fat levels, dietary fish-oil may enhance metabolic efficiency but may favour a reduction in the deposition of adipose tissue

      ea0021p152
    • A role for aquaglyceroporins in adipogenesis

      ea0021p153
    • Infidelity of ectopic transcription using a pseudo splice site: lessons from HNF-1[beta] mutation causing familial juvenile hyperuricaemic nephropathy

      ea0021p154
    • Patients with Turner syndrome have a high incidence of metabolic abnormalities

      ea0021p155
    • Impact of extra cellular matrix changes on adipogenesis

      ea0021p156
    • The hyperphagic effect of ghrelin is inhibited by diets high in fat in mice

      ea0021p157
    • Nuf mice with an activating calcium sensing receptor mutation, Leu723Gln, have a metabolic acidosis and impaired urinary acidification

      ea0021p158
    • Brain natriuretic peptide shows no response to acute hypobaric hypoxia in humans

      ea0021p159
    • Total pancreatectomy and pancreatic islet autotransplantation in patient with intractable pain caused by chronic pancreatitis

      ea0021p160
    • Weight and glycaemic outcomes following bariatric surgery in people with type 2 diabetes

      ea0021p161
    • Effect of Ramadan fasting on glycaemic control in type 2 diabetic patients on oral hypoglacaemic agents

      ea0021p162
    • An exploration of the predictive factors for the early pleiotropic responses to exenatide therapy in patients with type 2 diabetes mellitus

      ea0021p163
    • Expression of store-operated Orai channels in normal and diabetic kidney

      ea0021p164
    • Metabolic phenotype in brothers' of women with polycystic ovarian syndrome

      ea0021p165
    • Nuf mice with an activating calcium-sensing receptor mutation, Leu723Gln, have impaired glucose tolerance and reduced insulin secretion

      ea0021p166
    • Liraglutide prevents endothelial damage triggered by glucose oscillations

      ea0021p167
    • Glucocorticoid and insulin regulation of lipid metabolism in human adipocytes

      ea0021p168
    • MOPDII and Alstrom syndrome: two centrosomopathies featuring severe insulin resistance and impaired adipogenesis

      ea0021p169
    • A novel syndrome of IGF1 and insulin supersensitivity

      ea0021p170
    • Biomarkers of the hypothalamic-pituitary-adrenal (HPA) axis for analysis of in vivo 11[beta]-hydroxysteroid dehydrogenase 1 inhibition

      ea0021p171
    • Aldosterone production by the mouse adrenal gland is compromised by a high fat diet and 11[beta]-hydroxysteroid dehydrogenase type 1 deficiency

      ea0021p172
    • Transdermal delivery of insulin using amidated pectin hydrogel patches

      ea0021p173
    • Low testosterone level is associated with significant increase in mortality in patients with type 2 diabetes

      ea0021p174
    • The effects of plant derived oleanolic acid bioactive compound on glycogenic enzymes in streptozotocin-induced diabetic rats

      ea0021p175
    • Testosterone replacement may be beneficial in hypogonadal men with cardiovascular disease

      ea0021p176
    • Mice harbouring the familial juvenile hyperuricaemic nephropathy disease-causing uromodulin (Tamm-Horsfall glycoprotein) mutation Cys125Arg, have a urine concentrating defect, progressive renal failure, and altered uric acid handling

      ea0021p177
    • Investigating the role of ventromedial hypothalamic glucose-sensing neurones in the response to hypoglycaemia

      ea0021p178
    • Functional muscarinic acetylcholine receptors are expressed in white and brown adipose tissue

      ea0021p179
    • Impact of glucocorticoids upon lipogenesis and [beta]-oxidation in skeletal muscle

      ea0021p180
    • The influence of HIV status and antiretroviral (ARV) therapy on expression of genes related to mitochondrial metabolism in human adipose tissue (AT)

      ea0021p181
    • Deficiency in 11[beta]-hydroxysteroid dehydrogenase type 1 reduces systemic inflammation and inflammatory cell infiltration in atherosclerotic lesions of ApoE-/- mice

      ea0021p182
    • Short sleep duration is independently associated with obesity in with Type 2 diabetes

      ea0021p183
    • Vitamin D status relates to premature aortic sclerosis in South Asians -- a novel risk factor for cardiovascular disease?

      ea0021p184
    • Diet-induced obesity in C57Bl/6 mice is associated with sex-specific changes in glucocorticoid metabolism

      ea0021p185
    • Circadian rhythmicity is altered in hepatic corticosterone-related genes from diet induced obese mice

      ea0021p186
    • Down-regulation of adipose 11[beta]HSD1 mediates the insulin sensitising effects of salicylate in obesity

      ea0021p187
  • Endocrine tumours and neoplasia
  • • Ovarian Leydig cell tumour in a peri-menopausal woman with severe hyperandrogenism and virilisation

      ea0021p188
    • Laparoscopic versus open adrenalectomy and adjuvant mitotane in adrenocortical carcinoma

      ea0021p189
    • An unusual presentation of insulinoma with postabsorptive hypoglycaemia?

      ea0021p190
    • A family with functional extraadrenal paragangliomas and positive SDHB gene mutation

      ea0021p191
    • Medical management of an insulinoma - a safe long-term alternative to surgery?

      ea0021p192
    • Two cases of meningitis as a complication of pituitary adenoma

      ea0021p193
    • A case of phaeochromocytoma mimicking an acute ischemic limb: an unusual presentation

      ea0021p194
    • Ectopic Cushings complicated by paraneoplastic cerebral vasculopathy requiring high-dose steroid therapy

      ea0021p195
    • Cranioplasty for extensive skull deposit in the management of differentiated thyroid cancer

      ea0021p196
    • Pseudophaeochromocytoma syndrome associated with Modafinil

      ea0021p197
    • An unusual case of rapidly progressing pituitary lesion

      ea0021p198
    • Cinacalcet treatment of resistant hypercalcaemia due to MEN1-associated primary hyperparathyroidism in pregnancy

      ea0021p199
    • A case of Carcinoid syndrome without liver metastasis

      ea0021p200
    • Choroidal malignant melanoma in a patient with Carney complex

      ea0021p201
    • A rare case of steroid responsive non-islet cell tumour hypoglycemia (NICTH) secondary to metastatic haemangiopericytoma

      ea0021p202
    • Adrenal venous sampling for catcholamines- a normal value study

      ea0021p203
    • Temozolomide-induced regression of hepatic metastases in a pituitary corticotroph carcinoma with low O6-methylguanine-DNA methyltransferase expression

      ea0021p204
    • Secretory glomus jugulare tumour treated with steriotactic radio surgery

      ea0021p205
    • Case report: multiple endocrine neoplasia type 2a and hereditary haemorrhagic telangiectasia presenting consecutively in a single patient

      ea0021p206
    • Parathyroidectomy has no impact on haemoglobin levels on patients with primary hyperparathyroidism

      ea0021p207
    • Low incidence of hypocalcaemia after thyroidectomy in patients administered routinely oral calcium supplements

      ea0021p208
    • Utilization of various imaging modalities in the localization of tumours in MEN-1 and insulinoma

      ea0021p209
    • Functional characterisation of aryl hydrocarbon receptor interacting protein (AIP) promoter and silent mutations

      ea0021p210
    • Investigating the role of HIF-1[alpha] in tumour growth and metastasis in an in vivo model of thyroid cancer

      ea0021p211
    • Routine central compartment lymph node dissection for papillary thyroid cancer has minimal impact on early postoperative parameters

      ea0021p212
    • Concordance between thyroglobulin antibody assays

      ea0021p213
    • Mutations of the transcription factor, GATA3, in oestrogen receptor positive breast cancers

      ea0021p214
    • Receptor-based scintigraphic imaging of insulinoma and glucagonoma in MEN-1

      ea0021p215
    • Expression and regulation of oestrogen sulfotransferase (EST) in human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC)

      ea0021p216
    • Is the anti-proliferative effect of AIP (aryl hydrocarbon receptor interacting protein) via ZAC transcription factor?

      ea0021p217
    • The role of PBF in NIS and MCT8 cellular trafficking

      ea0021p218
    • MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation

      ea0021p219
    • First report of SOX2 loss of function associated with a large hypothalamo-pituitary tumour; further insights into the role of SOX2 in pituitary development

      ea0021p220
    • Pro-opiomelanocortin is a novel biomarker for small cell lung cancer

      ea0021p221
    • Parafibromin, a tumour suppressor protein, interacts with transforming acidic-coiled coil protein 3 and kinesin family member 5B

      ea0021p222
    • Open or laparoscopic surgery for phaeochromocytoma

      ea0021p223
    • PBF is induced by ionising radiation and functionally inactivates p53 in thyroid cancer

      ea0021p224
    • Mitotane treatment has profound effects on cortisol catabolism

      ea0021p225
    • The microRNA let-7a is downregulated in pituitary tumours from a multiple endocrine neoplasia type-1 mouse model

      ea0021p225.1
  • Growth and development
  • • Klinefelter's syndrome often remains undiagnosed or diagnosed late

      ea0021p226
    • Altered responses to GH and IGF1 in children born small for gestational age without post-natal catch up growth

      ea0021p227
    • Delayed puberty in children with inflammatory bowel disease may be associated with gonadotrophin resistance

      ea0021p228
    • Familial growth hormone deficiency - response to growth hormone therapy and analysis of the GH-1 and GHRH-R genes

      ea0021p229
    • The impact of IBD on pubertal growth is most marked in boys with Crohn's disease

      ea0021p230
    • Phenotypic presentation of P450 oxidoreductase deficiency during puberty

      ea0021p231
    • Loss of the Golgi localised E3 ubiquitin ligase containing Cullin 7 in the growth disorder 3-M syndrome leads to reduced cell proliferation and reduced IGF1 mediated activation of Akt

      ea0021p232
    • A novel dominant-negative Glial Cells Missing B (GCMB) mutation (Asn502His) is associated with autosomal dominant hypoparathyroidism and results in reduced transactivation activity

      ea0021p233
  • Neuroendocrinology and behaviour
  • • Sleep is frequently disordered in patients irradiated for brain tumours

      ea0021p234
    • Intra-cerebral haemorrhage in a young woman with phaeochromocytoma

      ea0021p235
    • The endocrine and behavioural effects of high fat feeding

      ea0021p236
    • Profiling the metabolic clearance and enzymatic degradation of the gut hormone Peptide YY as a tool to design long-acting PYY3-36 analogues in treating obesity

      ea0021p237
    • Characterising the role of 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) in viral meningitis

      ea0021p238
    • Alarin stimulates food intake and the hypothalamo-pituitary-gonadal axis in male rats

      ea0021p239
    • Transgenic disruption of 5alpha-reductase 1 in mice results in a blunted stress response

      ea0021p240
  • Pituitary
  • • Stress hormone response in men at high altitude: effect of ethnicity

      ea0021p241
    • Hypopituitarism secondary to pituitary apoplexy- is it due to high dose Aspirin?

      ea0021p242
    • Not every pituitary apoplexy is caused by pituitary haemorrhage

      ea0021p243
    • Management of non-functioning pituitary adenomas in a University Hospital: aretrospective analytical audit

      ea0021p244
    • Lymphocytic hypophysitis or Sheehan's syndrome?

      ea0021p245
    • Management of diabetes insipidus during pregnancy

      ea0021p246
    • Thyrotropin-secreting pituitary tumour causing high output cardiac failure

      ea0021p247
    • Is it pituitary adenoma or metastasis?: an unusual presentation of carcinoma prostate

      ea0021p248
    • Sub-optimal testosterone replacement in acromegaly

      ea0021p249
    • TSH-secreting pituitary adenoma: potential benefits of pre-operative octreotide

      ea0021p250
    • An uncommon cause of hypopituitarism

      ea0021p251
    • Herpes encephalitis causing hypopituitarism

      ea0021p252
    • The effects of 3 year growth hormone replacement on the lipid profile of adults with growth hormone deficiency using a fixed graded initiation, followed by a titration phase method: 3-year retrospective analysis

      ea0021p253
    • Adverse prognosis in breast cancer patients who develop pituitary metastases

      ea0021p254
    • High incidence of survivors of childhood malignancy in an endocrine transition service

      ea0021p255
    • Hypopituitarism following Russell's Viper bite: a case report

      ea0021p256
    • Carcinomatous change in a craniopharyngioma: a case report

      ea0021p257
    • Outcome of treatment for patients with acromegaly in a single referral centre

      ea0021p258
    • An interesting case of intrasellar cavernous carotid aneurysm mimicking pituitary adenoma

      ea0021p259
    • Solitary pituitary metastasis from carcinoma of the prostate: a case report

      ea0021p260
    • Glucocorticoid replacement therapy and fibrinolysis in hypopituitarism

      ea0021p261
    • Prolonged remission of acromegaly after cessation of somatostatin analogue treatment

      ea0021p262
    • Spontaneous remission of Cushing's disease: apoplexy of a pituitary microadenoma?

      ea0021p263
    • Both acetylcholine and choline stimulate externalisation of annexin 1 from S100-positive folliculo-stellate cells of the pituitary gland

      ea0021p264
    • Gender differences in presentation and response to treatment for prolactin-secreting adenoma

      ea0021p265
    • Cabergoline therapy is associated with successful abolition of abnormal cycles of excess steroid excretion in a case of pituitary dependent Cushing's disease

      ea0021p266
    • Endocrine outcomes of pituitary surgery

      ea0021p267
    • Recurrent meningitis secondary to an invasive TSHoma

      ea0021p268
    • When should an MRI pituitary scan be performed in hypogonadal men with low or low normal LH?

      ea0021p269
    • Hypothalamic resistance to signals of energy reserve, rather than excess appetite stimulation, may contribute to obesity in CP patients

      ea0021p270
    • The effect of pituitary surgery on VEGF, MMP 2 and MMP 9 levels in acromegaly and non-functioning pituitary adenomas

      ea0021p271
    • Obesity and cardiovascular risk factors in adult patients with acquired structural hypothalamic damage

      ea0021p272
    • The R304X mutation of the Aryl hydrocarbon receptor interacting protein (AIP) gene in familial isolated pituitary adenomas: mutational Hot-Spot or founder effect?

      ea0021p273
    • Rathke's cleft cysts in need of regular follow-up in case of recurrence

      ea0021p274
    • Recurrence rates in patients with non-functioning pituitary adenomas presenting with acute apoplexy: a long-term follow-up study

      ea0021p275
    • Pituitary gonadotrophinoma and ovarian-hyperfunctioning: link or coincidence?

      ea0021p276
    • Somatotroph adenoma subtype and responsiveness to somatostatin analogues in patients with acromegaly

      ea0021p277
    • Remission rate in microprolactinomas treated with dopamine agonists

      ea0021p278
    • Echocardiography in patients with hyperprolactinaemia treated with dopamine agonists: what happens in daily clinical practice and what are the findings?

      ea0021p279
    • Treatment experience in 11 patients with gigantism

      ea0021p280
    • The actions of long-term opioids for persistent pain on anterior pituitary hormones

      ea0021p281
    • Cortisol but not GH responses are dependent on symptoms during the glucagon stimulation test

      ea0021p282
    • Presentation, management and outcomes in acute pituitary apoplexy: a single centre experience from the United Kingdom

      ea0021p283
    • Validity of the new pituitary apoplexy guideline group scoring system (PAGGS) in the management of pituitary apoplexy: a large retrospective review of 46 patients with classical pituitary apoplexy

      ea0021p284
    • Electrocardiographic features in Cushing's disease: are there specific EKG changes associated with hypercortisolemia?

      ea0021p285
    • Oral and transdermal oestrogen treatments have differing effects on GH sensitivity in hypopituitary women receiving GH replacement

      ea0021p286
    • Patients with pituitary disease are at risk of under-replacement with levothyroxine

      ea0021p287
    • Anti-allergic cromolyn drugs facilitate annexin 1 secretion from pituitary folliculo-stellate cells

      ea0021p288
    • A fall in serum prolactin level after a 2-h rest predicts a normal MRI in patients using dopamine antagonist treatment

      ea0021p289
    • Adult GH replacement and risk of tumour recurrence: 15 years experience from a large single centre

      ea0021p290
    • Fish and chicks: C-type natriuretic peptide and the development of the pituitary gland in Gallus gallus and Danio rerio

      ea0021p291
    • Circadian and pulsatile secretion of copeptin, an arginine vasopressin (AVP) marker, argues against a physiological role of AVP in cortisol release

      ea0021p292
    • Long-term unsynchronised transcriptional cycles in individual living pituitary cells

      ea0021p293
    • Can we ever stop imaging in surgically treated and radiotherapy naive patients with non-functioning pituitary adenoma?

      ea0021p294
    • Effects on insulin action of dehydroepiandrosterone sulphate replacement in hypopituitary females

      ea0021p295
    • Cabergoline suppression test: assessment tool for management of hyperprolactinemia

      ea0021p296
    • Should we take macroprolactinoma patients off dopamine agonists at 3 or 5 years as they almost invariably recur?

      ea0021p297
    • Onset of prolactin gene transcription in nascent pituitary lactotroph cells

      ea0021p298
    • Immuno-modulatory role of prolactin in immune tissues driven by the alternative promoter

      ea0021p299
    • Genetic screening for variability in regulatory regions of SOX2 and implications for hypothalamo-pituitary development

      ea0021p300
    • Adults with partial GH deficiency (GHD) show phenotypic dichotomy related to the timing of onset of the deficiency

      ea0021p301
    • The effect of the familial pituitary adenoma gene AIP on apoptosis

      ea0021p302
    • Oncogene-induced senescence occurs in human pituitary adenomas

      ea0021p303
    • Pituitary tumours of mice deleted for a multiple endocrine neoplasia type 1 allele have alterations in apoptotic pathway components

      ea0021p304
    • MicroRNAs, miR-15a and miR-16-1, are implicated in pituitary tumourigenesis via regulation of cyclin D1

      ea0021p305
  • Reproduction
  • • Direct control of ovarian functions by ghrelin

      ea0021p306
    • Androsterone glucuronide does not differ between nonobese and obese Caucasian women with polycystic ovary syndrome despite a higher DHEAS in nonobese subjects

      ea0021p307
    • In vivo validation of potential natural products' abortifacient property mediated through modulation of uterine protein and vascular endothelial growth factor-C expression in foetal-maternal interface in albino rats

      ea0021p308
    • Alteration of uterine receptivity and modulation of uterine protein expression during periimplantation by natural product from Piper species leads to pregnancy disruption in albino rats

      ea0021p309
    • Factors that influence the decision to perform a karyotype in suspected disorders of sex development: lessons from The Scottish Genital Anomaly Network Register

      ea0021p310
    • A possible cardioprotective role for metformin in PCOS: a study of clot structure and fibrinolysis

      ea0021p311
    • Clinical experience of Nebido: monitoring the efficacy and safety of testosterone undecanoate in men over 60 years of age

      ea0021p312
    • A simple modification of a commercial RIA to enable the more accurate measurement of serum testosterone in women

      ea0021p313
    • GLUT4 expression and translocation in immortalised mouse granulosa cells

      ea0021p314
    • The role of thyroid hormone transporters MCT8 and MCT10 in the EVT-like cell line HTR8-SVneo

      ea0021p315
    • The tyrosine phosphatase, SHP-1, acts on multiple tyrosine kinase receptors to negatively regulate human cytotrophoblast proliferation

      ea0021p316
    • Localisation of adiponectin receptors in normal and polycystic ovaries

      ea0021p317
    • Expression of adhesion molecules in preantral mouse follicles

      ea0021p318
    • Establishment of an in vitro model to study oocyte regulation of gene expression in granulosa cells of preantral follicles

      ea0021p319
    • Activation of testicular melanocortin 3 receptors (MC3-R) inhibits LH-stimulated testosterone production

      ea0021p320
    • Study of serum visfatin in Egyptian women with polycystic ovary syndrome

      ea0021p321
    • Interaction between fibroblast growth factor-8 and bone morphogenetic proteins in regulation of ovarian steroidogenesis by rat granulosa cells

      ea0021p322
    • Kiss1 mRNA and kisspeptin immunoreactivity are differentially regulated in hypothalamus and visceral fat in a rat model of polycystic ovary syndrome (PCOS)

      ea0021p323
    • Apparent under-reporting of polycystic ovary syndrome in primary care

      ea0021p324
    • Pregnancy adversely affects ability to recall previously seen spatial locations

      ea0021p325
    • Female mice expressing constitutively active FSH receptor present with a phenotype of premature follicle depletion, premature aging and teratomas

      ea0021p326
    • Sexual dimorphism in experimental endotoxaemia

      ea0021p327
    • Twice-weekly administration of kisspeptin leads to long-term stimulation of reproductive hormone release in infertile women with hypothalamic amenorrhoea

      ea0021p328
  • Steroids
  • • Metyrapone interference in serum cortisol immunoassay

      ea0021p329
    • Cyclical epilepsy associated with testosterone replacement

      ea0021p330
    • Group education improves patient confidence in managing steroid sick day rules

      ea0021p331
    • Steroid analysis in patients receiving metyrapone therapy

      ea0021p332
    • Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay

      ea0021p333
    • A rare cause of massive bilateral adrenal enlargement complicating management of congenital adrenal hyperplasia

      ea0021p334
    • Diagnostically difficult Cushing's syndrome in a pharmacy student

      ea0021p335
    • Post-traumatic hypoadrenalism case report

      ea0021p336
    • Determination of tandem mass spectrometry specific reference ranges for testosterone, androstenedione and DHEAS

      ea0021p337
    • A sensitive and specific tandem mass spectrometry assay for the measurement of salivary testosterone

      ea0021p338
    • Analysis of cortisol by stable isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS): pitfalls of rapid LC-MS/MS analysis of clinical samples

      ea0021p339
    • Steroid replacement: an unusual alternative to oral therapy via 24-h s.c. infusion device

      ea0021p340
    • Moderate liquorice consumption enhances salivary DHEA and testosterone levels in healthy volunteers

      ea0021p341
    • Is a raised DHEAS significant when analysed as part of an androgen profile

      ea0021p342
    • Application of a highly specific and sensitive ELISA for the estimation of cortisone in biological fluids

      ea0021p343
    • Successful fecundity with addition of night-time dexamethasone to hydrocortisone in a patient with congenital adrenal hyperplasia (CAH) and testicular adrenal rest tumours (TART)

      ea0021p344
    • Dexamethasone testing and visceral:subcutaneous fat ratios in patients with adrenal incidentalomas

      ea0021p345
    • Salivary aldosterone is a useful marker of serum aldosterone in normotensive individuals

      ea0021p346
    • Regulation of glucocorticoid receptor activity by cellular stress

      ea0021p347
    • -344 C/T polymorphism of aldosterone synthase gene (CYP11B2) and cortisol synthesis in heart failure patients

      ea0021p348
    • Urinary steroid metabolite profiling in 11[beta]-HSD1 and H6PDH transgenic mice

      ea0021p349
    • Epitopes of pterin-dependent hydroxylases in autoimmune polyendocrine syndrome type 1

      ea0021p350
    • Responses of putative adrenocortical stem/progenitor cells and transiently amplifying cells to ACTH

      ea0021p351
    • Assessing adrenal status in patients before and after coronary artery bypass graft surgery

      ea0021p352
    • Ongoing symptoms in treated Addison's disease significantly impair health-related quality of life

      ea0021p353
    • Low testosterone and androgen receptor insensitivity results in decreased AMP-activated protein kinase activity (AMPK) in the liver in the testicular feminised (Tfm) mouse

      ea0021p354
    • Salivary annexin 1 has a diurnal rhythm but does not share an awakening response with cortisol at 30 min

      ea0021p355
    • Use of bioluminescence resonance energy transfer to reveal the structural dynamics of the ACTH receptor complex

      ea0021p356
    • 6-Phosphogluconate dehydrogenase: an NADPH-generating enzyme in the lumen of the endoplasmic reticulum

      ea0021p357
    • Hepatic vein cannulation and stable isotope tracer infusion reveals that liver cortisol regeneration by 11[beta]-HSD1 is sustained in obese men with type 2 diabetes mellitus, providing a target for enzyme inhibition

      ea0021p358
    • Variation in the aldosterone synthase gene may alter gene transcription via altered transcription factor binding

      ea0021p359
    • Replicated association of regions at CYP11B1/B2 locus with hypertension in Caucasians

      ea0021p360
    • Anti-inflammatory effects of SGRMs: are they dependent on DUSP1?

      ea0021p361
    • MicroRNA expression profiling of non-tumorous adrenal tissue and modulation of 11[beta]-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes by miR-24

      ea0021p362
    • Is increased 11[beta]-HSD1 expression a key factor underpinning intrinsic and extrinsic skin aging?

      ea0021p363
    • Functional characterisation of 21-hydroxylase gene mutations is a valuable tool for genetic counselling: in vitro and in silico analysis of six novel CYP21A2 sequence variants

      ea0021p364
    • Chronic glucocorticoid treatment causes de novo methylation of Tpit and causes continued reduction in POMC expression after glucocorticoid withdrawal

      ea0021p365
  • Thyroid
  • • Spectrum of thyroid disorders in Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife

      ea0021p366
    • Expensive but unreliable: Wayne's index to the rescue!

      ea0021p367
    • A case of severe hypothyroidism treated with supervised weekly thyroxine

      ea0021p368
    • A difficult case of very aggressive thyroid eye disease

      ea0021p369
    • A case of non-Graves thyroid eye disease

      ea0021p370
    • The unrestricted use of baseline thyroid function tests in elderly and female patients is justified in the diagnosis of thyroid dysfunction

      ea0021p371
    • Technetium pertechnetate scanning in the differential diagnosis of benign thyroid disease

      ea0021p372
    • Audit on fine needle aspiration of thyroid

      ea0021p373
    • The many faces of hyperthyroidism in primary care

      ea0021p374
    • A case of spousal abuse secondary to thyrotoxicosis

      ea0021p375
    • A 10-year retrospective analysis of variable-dose radioactive iodine therapy for hyperthyroidism

      ea0021p376
    • An unusual presentation of hyperthyroidism

      ea0021p377
    • Incidence and predictors of transient hypothyroidism or euthyroidism following radioactive iodine therapy for hyperthyroidism

      ea0021p378
    • The safety and efficacy of iopanoic acid in the pre-surgical management of thyrotoxicosis

      ea0021p379
    • Audit of TSH-receptor antibodies and 99m technetium pertechnetate scintigraphy in the diagnosis of thyrotoxicosis aetiology

      ea0021p380
    • Do we warn patients about the risk of neutropenia associated with the use of anti-thyroid drugs?

      ea0021p381
    • Severe thyrotoxicosis due to metastatic differentiated thyroid carcinoma

      ea0021p382
    • Pancytopenia and nephrotic syndrome related to autoimmune hypothyroidism: a case report

      ea0021p383
    • Radioactive-iodine therapy: a patient satisfaction survey

      ea0021p384
    • Atypical presentation of Riedel's thyroiditis: multifocal nodular fibrosis and resolution with levothyroxine

      ea0021p385
    • Interpreting adrenal status in thyrotoxicosis

      ea0021p386
    • Bulbar myopathy as a rare presenting feature of severe thyrotoxicosis in an elderly man

      ea0021p387
    • Radioactive iodine (RAI) therapy for benign thyroid disease: joint RAI clinic

      ea0021p388
    • TSH receptor antibody assay: its use in a tertiary centre

      ea0021p389
    • Thyrotoxicosis presenting as intussusception

      ea0021p390
    • Practical value of 131I whole body scan in follow up of patients with differentiated thyroid cancer

      ea0021p391
    • An audit of the management of all patients with thyroid cancer treated with 131I for remnant ablation or persistent disease at a tertiary referral hospital between 2003 and 2008

      ea0021p392
    • Radioiodine for Graves' disease: what do patients really think?

      ea0021p393
    • Treated Grave's disease? think again!

      ea0021p394
    • An evidence based protocol for the early identification and management of hypocalcaemia following total thyroidectomy

      ea0021p395
    • A case of thyroid hormone resistance in a family with three generations of thyroid disease

      ea0021p396
    • The use of district-wide laboratory database to identify new patients with persistent hyperthyroidism

      ea0021p397
    • Dilated cardiomyopathy and atrial fibrillation secondary to resistance to thyroid hormone

      ea0021p398
    • Iopanoic acid: a bridge to surgery when all else fails in complicated hyperthyroidism

      ea0021p399
    • Selective malabsorption of thyroid hormone or selective intake?

      ea0021p400
    • Management and follow up of post-operative hypocalcemia after thyroidectomy: a pilot study

      ea0021p401
    • Clinical management and outcomes of anti-TSH receptor antibody positive pregnancies

      ea0021p402
    • 123I uptake scanning after radioiodine treatment for thyrotoxicosis prevents delayed diagnosis of radioiodine induced hypothyroidism

      ea0021p403
    • Sunitinib induced hypothyroidism: a retrospective analysis

      ea0021p404
    • Screening and management of thyroid dysfunction in pregnancy

      ea0021p405
    • Diagnostic and financial benefits of checking TSH receptor antibodies in patients with thyrotoxicosis

      ea0021p406
    • Should the cytological finding of Thy 3 mandate surgical excision?

      ea0021p407
    • Characteristics of patients requiring more than one dose of radioactive iodine to induce cure of hyperthyroidism

      ea0021p408
    • Screening of six novel candidate genes for association with Graves' disease

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    • The physiological role of thyroid hormone in the hypothalamic ventromedial nucleus

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