Endocrine Abstracts

Nuclear receptors control developmental and physiological processes by regulating the transcription of gene networks in specific cells. This is achieved by the recruitment of coactivators and corepressors that lead to chromatin remodelling and alterations in gene transcription. RIP140 is a ligand dependant corepressor for nuclear receptors that plays key roles in adipose tissue and muscle to regulate energy homeostasis.RIP140 regulates carbohydrate and l...

The Nuclear Receptor Subfamily 5A member, Steroidogenic Factor 1 (SF-1, Ad4BP, NR5A1), is critical for steroidogenesis, stress responses, sexual differentiation and body weight regulation in mice. Patients with rare mutations in SF-1 have confirmed its role in male sexual differentiation and adrenal response to physiological stress in humans. In contrast, Liver Receptor Homologue 1 (LRH-1, FTF, CPF, NR5A2) is involved in endoderm development, bile acid and lipid metabolism and...

The Liver X Receptors (LXRs) are members of the nuclear hormone receptor superfamily and play a key role as intracellular cholesterol sensors. LXRs control the expression of crucial genes associated with cholesterol absorption, excretion and efflux and are therefore key determinants of atherosclerosis susceptibility. In addition, recent studies have revealed the existence of crosstalk between macrophage inflammatory pathways and LXR signaling. In activated macrophages, LXR ago...

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