Endocrine Abstracts

Contents

• Plenary Lecturers’ Biographical Notes
• • Society for Endocrinology Jubilee Medal Lecture
  • • Diamonds are forever

      ea0012s1
    • European Journal of Endocrinology Prize Lecture

      ea0012s1biog
  • Society for Endocrinology Asia and Oceania Medal Lecture
  • • Endocrinology: It’s all about good communication

      ea0012s2
    • European Journal of Endocrinology Prize Lecture

      ea0012s2biog
  • Society for Endocrinology Medal Lecture
  • • Hormone action: Insights from human genetic disorders

      ea0012s3
    • European Journal of Endocrinology Prize Lecture

      ea0012s3biog
  • Society for Endocrinology European Medal Lecture
  • • Assessment of growth hormone levels: Tailor-made assays for specific clinical questions

      ea0012s4
    • European Journal of Endocrinology Prize Lecture

      ea0012s4biog
• Symposia
• • Thyroid at the beginning and end of life
  • • The impact of iodine deficiency even in the 21st century

      ea0012s5
    • Thyroid hormone action on the developing central nervous system

      ea0012s6
    • Management of thyroid disease in pregnancy

      ea0012s7
    • Mortality and morbidity in thyroid dysfunction

      ea0012s8
  • Novel regulation of orphan receptor function
  • • The ups and downs of nuclear receptor action in metabolic tissues

      ea0012s9
    • Repression of NR5A nuclear receptors by SUMO and DEAD-box proteins

      ea0012s10
    • Role of LXRs in lipid metabolism and inflammation

      ea0012s11
    • NRs and circadian rhythm

      ea0012s12
  • New frontiers in steroid hormone metabolism
  • • Molecular mechanisms of electron transfer

      ea0012s13
    • P450 oxidoreductase and androgen metabolism

      ea0012s14
    • Adrenodoxin and cytochromes P450

      ea0012s15
    • Hexose-6-phosphate dehydrogenase and glucocorticoid metabolism

      ea0012s16
  • Cell-cell interactions in the regulation of endocrine cell function
  • • Somatotrophs and lactotrophs: their regulation and communication

      ea0012s17
    • Pituitary-scale organization of functional cell networks

      ea0012s18
    • Germ cell-somatic cell interactions in the ovary: a role for gap junctions in propagating signalling molecules

      ea0012s19
    • Cell-cell interactions in the regulation of testicular endocrine function

      ea0012s20
  • Sexual differentiation
  • • Update on genetic mechanisms of sex determination

      ea0012s21
    • Molecular and phenotypic features of disorders of sex development (DSD) in humans

      ea0012s22
    • Management of disorders of sex development

      ea0012s23
  • AMPK systems
  • • AMPK cascade – new players upstream and downstream

      ea0012s24
    • AMPK in the heart – regulation of energy status

      ea0012s25
    • Central and peripheral effects of leptin on AMP-activated protein kinase

      ea0012s26
    • Role of AMP-activated kinase in the control of insulin secretion and satiety

      ea0012s27
  • Controlling the overactive parathyroid
  • • Consequences of primary and secondary hyperparathyroidism

      ea0012s28
    • Medical management of secondary hyperparathyroidism – lessons from renal disease

      ea0012s29
    • Medical management of primary hyperparathyroidism (PHP)

      ea0012s30
    • Advances in the surgical management of hyperparathyroidism

      ea0012s31
  • Adipocyte tissue and insulin resistance
  • • Adipose tissue and fatty acids as precursors to insulin resistance

      ea0012s32
    • What role for adipocytokines in insulin resistance and diabetes prediction? From genes to epidemiology

      ea0012s33
    • The ins and outs of steroid hormones in human adipose tissue

      ea0012s34
    • Fat mobilisation with insulin sensitising agents: what clues to mechanisms?

      ea0012s35
• Nurse Session
• • Endocrinology of ageing
  • • GH-IGF-1 axis and ageing

      ea0012s36
    • The menopause

      ea0012s37
    • Endocrinology of aging: the andropause and testosterone

      ea0012s38
• Oral Communications
• • Young Endocrinologist prize session
  • • The effects of age and calorie restriction on 24-hour plasma melatonin and activity rhythms in the rhesus macaque (Macaca mulatta)

      ea0012oc1
    • Combinatorial signalling and gene transcription in neuroendocrine cells: does PACAP potentiate hormone-dependent gene transcription?

      ea0012oc2
    • Co-administration of SR141716 with peptide YY or oxyntomodulin has additive effects on food intake in mice

      ea0012oc3
    • Antral follicle count (AFC) is related to serum anti-Mullerian hormone (AMH) independent of age, FSH and body mass index (BMI) in candidates for assisted conception

      ea0012oc4
    • Restoration of glucocorticoid receptor expression causes apoptotic cell death of human small cell lung cancer cells

      ea0012oc5
    • Subcellular distribution of thyroglobulin (Tg) and sodium-iodine-symporter (NIS) in normal thyroid, Graves’ and thyroid carcinomas using confocal microscopy

      ea0012oc6
    • T3 stimulation of MAP kinase and cell proliferation in human osteoblast-like cells is initiated at integrin α_Vβ₃

      ea0012oc7
    • Caveolin-1: A regulator of the IGFIR/Akt pathway mediating cellular proliferation but not survival

      ea0012oc8
  • Placenta, bone and genetics
  • • IGF acts through the IGF1R mediated PI3K pathway in first trimester human placenta to rescue cytotrophoblasts from apoptosis

      ea0012oc9
    • The expression and regulation of the tachykinin (TAC) genes in the placenta

      ea0012oc10
    • Effect of leptin on hepatic carbohydrate metabolism and insulin signalling proteins in fetal sheep

      ea0012oc11
    • Physiological blockade of gut hormones increases food intake

      ea0012oc12
    • A kindred with Carney Complex due to a novel PRKAR1A gene mutation (c1067_1070 del AACG ins GCCCA)

      ea0012oc13
    • The metabolic basis of a severe rickets-like deformity in Nigerian children

      ea0012oc14
    • Preliminary results from the PRISM study: a multicentre randomised controlled trial of intensive vs. symptomatic management for Paget’s disease of bone

      ea0012oc15
    • Symptomatic improvement after parathyroidectomy for primary hyperparathyroidism

      ea0012oc16
  • Pituitary, ovary and steroids
  • • Prolactinomas: all in the family?

      ea0012oc17
    • Adult onset diabetes insipidus due to congenital midline defects of the brain

      ea0012oc18
    • Metformin stimulates AMP kinase activity and increases lactate production in human granulosa cells

      ea0012oc19
    • Novel activation of MAPK family proteins in pituitary GH3 somatotrophs and alphaT3-1 gonadotrophs by C-type natriuretic peptide (CNP)

      ea0012oc20
    • Macroprolactinoma with progressive resistance to high-dose cabergoline

      ea0012oc21
    • Coupling of cell cycle progression to GR cellular distribution

      ea0012oc22
    • Metformin inhibits ovarian aromatase and anti-Müllerian hormone (AMH) production

      ea0012oc23
    • Influence of C-type natriuretic peptide (CNP) on cell proliferation in αT3-1 gonadotrophs and GH3 somatotrophs

      ea0012oc24
• Poster Presentations
• • Bone
  • • Primary hyperparathyroidism – a great masquerader

      ea0012p1
    • The effect of bisphosphonates on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism over 2 years

      ea0012p2
    • Growth hormone stimulates osteogenesis activity of alveolar bone derived-osteoblasts from adolescents

      ea0012p3
    • Audit on the efficacy of intravenous Pamidronate in the treatment of osteoporosis

      ea0012p4
  • Clinical case reports/Governance
  • • Adrenoleukodystrophy presenting with hypoadrenalism: can it occur at any age?

      ea0012p5
    • Delayed onset hungry bone syndrome following parathyroidectomy in a patient taking high dose cinacalcet for primary hyperparathyroidism

      ea0012p6
    • Anaplastic astrocytoma co-existing with acromegaly: the first report

      ea0012p7
    • An audit on the management of severe hyponatremia in a hospital population

      ea0012p9
    • The investigation and management of critical hyponatraemia

      ea0012p10
    • Sporadic pancreatic somatostatinomas: 3 cases

      ea0012p11
    • Milk-Alkali Syndrome without milk

      ea0012p12
    • An androgen secreting ovarian tumour presenting in second trimester of pregnancy

      ea0012p13
    • Hirsuitism and amenorrhoea – not always “PCOS”

      ea0012p14
    • Once weekly thyroxine as a treatment strategy in non-compliant hypothyroid patients

      ea0012p15
    • Successful management of hypercalcaemia and hypertension in pregnancy

      ea0012p16
    • A case of thoracic cord ependymoma in neurofibromatosis type 1

      ea0012p17
    • Acromegaly with normal pituitary

      ea0012p18
    • Raised alpha-subunit does not always predict gonadotrophinoma in secondary hypergonadism

      ea0012p19
    • Systemic manifestations of inhaled corticosteroids- Case reports of Cushing’s syndrome and Adrenal suppression

      ea0012p20
    • An illustration of the potent anti-natriuretic effect of growth hormone

      ea0012p21
    • Management of occult virilizing ovarian tumours in postmenopausal women

      ea0012p22
    • A rare cause of self-neglect

      ea0012p23
    • Perforated duodenal ulcer may predict disease progression in subclinical Cushing’s syndrome

      ea0012p24
    • Infertility and osteopenia in a male patient with thyroid hormone resistance

      ea0012p25
    • Unusual causes of hypercalcaemia in a DGH

      ea0012p26
    • Interfering antibodies can cause diagnostic confusion – a case report

      ea0012p27
    • Abdominal pain……don’t miss the endocrine case!!

      ea0012p28
    • Life threatening hypocalcemia after use of fleet phospho-soda in bowel preparation for routine colonoscopy – a case report

      ea0012p29
    • A case of Gitelman’s syndrome, a variant of Bartter’s syndrome

      ea0012p30
    • Severe hyponatremia and subsequent extra-pontine myelinolysis as a presentation of addison’s disease

      ea0012p31
    • Problems in the diagnosis of disorders of sex development

      ea0012p32
  • Cytokines, growth factors, growth and development
  • • Effects of recombinant human insulin-like growth factor binding protein-3 (rhIGFBP-3) on human malignant pleural mesothelioma cell growth

      ea0012p33
    • Quantitative RT-PCR (qRT-PCR) as an early stage bioassay for vascular endothelial growth factor (VEGF)

      ea0012p34
    • Effects of androgens on differentiation of human skeletal muscle-derived cells in vitro

      ea0012p35
  • Diabetes, metabolism and cardiovascular
  • • The effects of Sclerocarya birrea [(a. rich.) hochst.] [Anacardiaceae] stem-bark aqueous extract on blood glucose, kidney and cardiovascular function in rats

      ea0012p36
    • Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin (stz)-induced diabetic rats

      ea0012p37
    • Relationship between insulin resistance and adipokines with body composition and glucose tolerance

      ea0012p38
    • Principal component analysis for the assessment of metabolic syndrome features following gestational diabetes among women of three ethnic groups

      ea0012p39
    • Lipoatrophy can happen with any subcutaneous insulin

      ea0012p40
    • Type II diabetes mellitus presenting with diabetic ketoacidosis in a young obese Caucasian male

      ea0012p41
    • Cannabinoid receptors in proliferation and differentiation of white and brown adipose tissues

      ea0012p42
    • What is the relationship between testosterone and fat mass in young male cancer survivors and healthy controls?

      ea0012p43
    • Redox status of a hyperglycaemic cell culture model of osteoblasts supplemented with bacterial LPS and minocycline

      ea0012p44
    • Oxidative stress induced by TNF-alpha and glucose in an osteoblastic model and therapeutic implications of minocycline

      ea0012p45
    • A novel syndrome of extreme insulin resistance, primordial dwarfism, and gonadal failure

      ea0012p46
    • Women gain weight and fat mass despite lipectomy at abdominoplasty and breast reduction

      ea0012p47
    • Assessment of foot problem in patients with diabetes in primary care clinics

      ea0012p48
    • Relation of free and bound leptin and the soluble leptin receptor to metabolic and inflammatory responses in patients with liver cirrhosis

      ea0012p49
    • Evidence for a safe switch from human premixed insulin to BIAsp 30 in twice-daily regimens – data from the REACH study

      ea0012p50
    • High glucose regulates SGK1 and alpha-ENAC expression in a human cortical collecting duct cell line

      ea0012p51
    • Screening for HNF1α mutations in women with gestational diabetes and established diabetes in the diabetes antenatal clinic

      ea0012p52
    • Proglucagon processing can be altered to produce GLP-1 in pancreatic alpha cells

      ea0012p53
    • Prospective analysis of benefits of orthotic interventions in diabetic foot ulcers

      ea0012p54
  • Endocrine tumours and neoplasia
  • • Audit of adrenal incidentaloma in Sunderland Royal Hospital

      ea0012p55
    • Dopamine-secreting paraganglioneuroma – maintain high index of suspicion

      ea0012p56
    • Parathyroid carcinoma - consider it in a subset of presumed adenomas

      ea0012p57
    • Conn’s syndrome: should all patients undergo adrenal vein sampling?

      ea0012p58
    • Pheochromocytoma presenting as type-I diabetes mellitus

      ea0012p59
    • Rare presentation of neuroendocrine tumour

      ea0012p60
    • Difficulties in management of hypercalcaemia in MEN1

      ea0012p61
    • A case of non-islet cell tumour hypoglycaemia

      ea0012p62
    • Spindle epithelial thyroid tumour with thymus-like differentiation (SETTLE) in a six year old boy: a case report

      ea0012p63
    • A probable PTH- secreting metastatic breast carcinoma

      ea0012p64
    • Adrenal Rest Tumours in 11-β hydroxylase deficiency

      ea0012p65
    • Colocalisation of GH and FSH in the human fetal pituitary by confocal immunofluorescence microscopy

      ea0012p66
  • Neuroendocrinology and behaviour
  • • Salivary alpha-amylase: a potential surrogate marker for sympathetic activity

      ea0012p67
    • High cocoa polyphenol rich chocolate improves the symptoms of chronic fatigue

      ea0012p68
    • Quinelorane activates oxytocin neurones in the hypothalamus during penile erection

      ea0012p69
    • Development of an automated blood sampling system for undisturbed blood sampling in humans

      ea0012p70
    • The role of twenty four hours of daylight on sleep, appetite and cortisol: is it a hard day’s night?

      ea0012p71
    • Evidence of a possible role for Lys-γ3-Melanocyte Stimulating Hormone in the regulation of adipocyte function

      ea0012p72
    • Adrenomedullin in a rat model of multiple sclerosis

      ea0012p73
  • Pituitary
  • • Anaemia: A rare presenting feature of pituitary tumour

      ea0012p74
    • Suprasellar arachnoid cyst: a surgically reversible cause of hypothalamo-pituitary dysfunction

      ea0012p75
    • Effect of dietary iron deficiency anaemia on peripartum pituitary hormones

      ea0012p76
    • An unusual case presentation of acromegaly

      ea0012p77
    • Upregulation of Id1 and Id3 in response to BMP2 stimulation in LβT2 cells

      ea0012p78
    • Combining GHRH/Arginine with a synacthen test diminishes the cortisol response

      ea0012p79
    • Long term follow-up of patients treated with Yttrium-90 implants for pituitary adenomas

      ea0012p80
    • Long term follow-up of patients with a non-functioning pituitary adenoma

      ea0012p81
    • Combined pituitary hormone deficiency secondary to suspected PIT-1 mutation

      ea0012p82
    • Pituitary macroadenomas: are combination antiplatelet and anticoagulant therapy contraindicated?

      ea0012p83
    • Cinderella’s story: the psychosocial impact of pituitary conditions

      ea0012p84
    • “Cinderella’s Unhappy”: an objective measure of the psychological impact of pituitary conditions

      ea0012p85
    • Growth hormone deficiency and complex congenital abnormalities: a further case of Stratton-Parker syndrome?

      ea0012p86
    • ACTH hyperplasia and prolactinoma in MEN 1

      ea0012p87
    • Massively elevated serum prolactin without galactorrhoea in man with a giant prolactinoma

      ea0012p88
    • Assessment of subjective daytime sleepiness using the Epworth Sleepiness Scale in acromegalic patients

      ea0012p89
    • Cabergoline is an effective and well tolerated primary and adjunctive treatment for acromegaly

      ea0012p90
    • Metastatic lung carcinoma presenting as hypopituarism

      ea0012p91
  • Reproduction
  • • Continuous administration of kisspeptin-54 leads to desensitisation of the hypothalamo-pituitary-gonadal axis and testicular degeneration

      ea0012p92
    • Continuation rate and reasons of early removal of the levonorgestrel-releasing intrauterine system

      ea0012p93
    • Patient satisfaction with the levonorgestrel-releasing intrauterine system

      ea0012p94
    • Characterisation of 11β-hydroxysteroid dehydrogenase (11βHSD) expression and activity in the pre- and post-pubertal porcine (sus scrofa) testis and male reproductive tract

      ea0012p95
    • Adult survivors of haematological malignancies with premature ovarian failure (POF) secondary to multimodality cancer therapy have normal bone mass

      ea0012p96
    • The effect of oestrogens on BMD of patients with premature ovarian failure (POF) resulting from multi-modality cancer therapy

      ea0012p97
    • Polyunsaturated fatty acids in vivo and in vitro affect expression of steroidogenic acute regulatory protein in steroidogenic tissues

      ea0012p98
    • Are anti-Müllerian hormone levels and antral follicle count related to lifestyle factors, demographics and reproductive history in subfertile women?

      ea0012p99
    • Peripheral plasma thyroid hormone concentrations during pregnancy in Black Bengal goats

      ea0012p100
    • The effects of feeding an n-3 polyunsaturated fatty acid (PUFA) rich diet on ovarian function in the Welsh mountain ewe

      ea0012p101
    • The effect of leptin on maturation of the ovarian follicles of albino rats – An electron microscopic study

      ea0012p102
    • Leptin accelerating effect on the puberty of female albino rats – immunohistochemical and cytological data

      ea0012p103
    • Population reference ranges for plasma testosterone and calculated free testosterone in older men

      ea0012p104
    • Effect of ghrelin on mean plasma concentrations of luteinizing hormone, insulin and glucose in male goat

      ea0012p105
    • Preliminary investigation on the effects of prostaglandin EP₂ and EP₄ agonists on isolated uterus from non-pregnant and pregnant mice

      ea0012p106
    • Prevalence of assay interference in women with high serum testosterone levels

      ea0012p107
    • The effect of smoking on prostaglandin (PG) biosynthesis and responsiveness in isolated human umbilical artery

      ea0012p108
    • Altered natural anti-microbial expression in the uterine decidua of ectopic compared to intra-uterine pregnancy

      ea0012p109
    • The effect of different exogenous hormone regimens on body weight in female hooded-Lister rats

      ea0012p110
    • Endocrine evaluation of gynaecomastia

      ea0012p111
    • Functional pharmacology of prostaglandin EP agonists in isolated human myometrium from term pregnant donors

      ea0012p112
    • Comparison of metformin, orlistat and pioglitazone in treatment of polycystic ovarian syndrome

      ea0012p113
    • Effect of serum testosterone concentrations on outcome of induction of ovulation by low-dose FSH in women with polycystic ovary syndrome (PCOS)

      ea0012p114
    • Does metformin act via AMPK in the human ovary?

      ea0012p115
  • Steroids to include Cushing's
  • • Cushing’s syndrome secondary to recurrent olfactory neuroblastoma

      ea0012p116
    • An audit of diagnosis and management of Cushing’s syndrome in a district general hospital

      ea0012p117
    • Current practice regarding the diagnosis of Cushing’s disease: Survey at the European Congress of Endocrinology 2006

      ea0012p118
    • Determination of xenobiotic glucocorticoids by gas chromatography–mass spectrometry for clinical purposes

      ea0012p119
    • Fluticasone-induced adrenal suppression in an HIV positive patient is reversed by substitution with Beclomethasone

      ea0012p120
    • Role of glucocorticoids and AMPK in the regulation of lipogenesis and glycerogenesis in mesenteric adipose tissue

      ea0012p121
    • The diverse manifestations of impaired androgen biosynthesis

      ea0012p122
  • Thyroid
  • • Effect of dietary iron deficiency anaemia on TSH and peripartum thyroid function

      ea0012p123
    • Hypothyroid associated deafness

      ea0012p124
    • Red ears and blue hands in thyroid clinic – anti-thyroid medication causing rare connective tissue diseases

      ea0012p125
    • Identifying risk factors for relapse in Graves’ disease: a retrospective study

      ea0012p126
    • Diagnosing hypopituitarism from suggestive thyroid function tests

      ea0012p127
    • Pulverised thyroxine could be the answer

      ea0012p128
    • Does lithium administered with radioiodine therapy improve the cure rate for thyrotoxicosis?

      ea0012p129
    • Use of a telephone clinic to follow up patients treated with radioactive iodine for thyrotoxicosis

      ea0012p130
    • Two cases of thyrotoxic hypokalaemic periodic paralysis

      ea0012p131
    • Thyroid eye disease in patients treated with radio-iodine

      ea0012p132
    • Does L-thyroxine reduce weight in people with subclinical hypothyroidism?

      ea0012p133
    • MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) and thyrotoxicosis

      ea0012p134
    • Tri-iodothyronine, how does it get in? What if it goes wrong?

      ea0012p135