Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Previous issue | Volume 10 | SFE2005 | Next issue

196th Meeting of the Society for Endocrinology and Society for Endocrinology joint Endocrinology and Diabetes Day

Poster Presentations

Cytokines, growth factors, growth and development

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Clinical case reports/Governance
Table of contents
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Diabetes, metabolism and cardiovascular

ea0010p24 | Cytokines, growth factors, growth and development | SFE2005

Effect of maternal cold exposure on hepatic glycogen content, peroxisome proliferator-activated receptor alpha and insulin-like growth factor-II mRNA expression in the neonate

Butt E , Pearce S , Stephenson T , Symonds M

Maternal cold exposure induced by winter shearing promotes fetal growth, particularly that of the liver by increasing maternal glucose supply to the fetus. A major component of the fetal liver is glycogen which is rapidly mobilized at birth in order to provide an endogenous energy source. Hepatic glyocgen content is regulated in part by the lipid activated transcription factor, peroxisome proliferator-activated receptor alpha (PPARα), whilst insulin-like growth factor (IG...
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ea0010p25 | Cytokines, growth factors, growth and development | SFE2005

A simple colorimetric cell-based bioassay for interferon alfa 2a

Silva M , Jones C , Robinson C

Biopharmaceuticals are complex molecules and can show variation between production batches. Physicochemical tests and biological activity measurements contribute complementary data to the characterisation of these products.As part of a project to correlate physicochemical and bioassay data, under the Department of Trade and Industry’s Measurements for Biotechnology programme, we have developed a simple, robust cellbased bioassay protocol for interfe...
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ea0010p26 | Cytokines, growth factors, growth and development | SFE2005

Ahmed Z , Mazibrada G , Dent R , Berry M , Logan A

Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...
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ea0010p27 | Cytokines, growth factors, growth and development | SFE2005

Vascular endothelial growth factor (VEGF): modulation of heparin-binding activity and bioactivity by site-directed mutagenesis

Stammers R , Robinson C , Forster M , Mulloy B , Rafferty B

VEGF is an endothelial-cell specific mitogen and is a critical regulator of developmental and reproductive angiogenesis. VEGF165 is the most abundant isoform, with the N-terminal 110 aa domain containing the receptor binding site and the C-terminal 55 aa domain containing a heparin-binding site. The activity of the molecule is mediated through its interaction with two main receptors, VEGFR-1 and VEGFR-2, the binding to which is modulated by both cell surface-associated glycosa...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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