Endocrine Abstracts

Contents

• Plenary Lectures
• • Society for Endocrinology Asia and Oceania Medal Lecture
  • • Ghrelin: discovery and physiological significance

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    • Society for Endocrinology Asia and Oceania Medal Lecture

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  • Clinical Endocrinology Trust Historical Lecture
  • • The history of testosterone

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    • Clinical Endocrinology Trust Historical Lecture

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  • Society for Endocrinology Medal Lecture
  • • The evolution of primary aldosteronism

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    • Society for Endocrinology Medal Lecture

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  • Society for Endocrinology European Medal Lecture
  • • A mouse reporting on ER transcriptional activity to understand the complexities of female physiology in mammals

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    • Society for Endocrinology European Medal Lecture

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• Symposia
• • New frontiers in thyroid cancer
  • • Introduction - chernobyl irradiation and thyroid cancer

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    • Expression arrays in thyroid cancer

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    • Novel molecular markers in thyroid cancer

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  • Non classical sites of action of classical hormones
  • • The sodium/iodide symporter (NIS): recent frontiers

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    • Rapid actions of steroids via non-classical receptors

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    • Direct actions of pituitary hormones on bone

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    • Actions and mechanisms of action of gonadotrophin-releasing hormone (GNRH) in non-pituitary tissue

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    • The hematopoietic system: a new niche for the renin-angiotensin system

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  • The placenta as an endocrine organ
  • • Peri/pre-implantation paracrinology

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    • Paracrynology of the placenta

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    • Human trophoblast syncytialisation: a cornerstone of placental function

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    • Feto-placental 11szlig-hydroxysteroid dehydrogenase type 2 and glucocorticoid programming

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  • Hormone measurements: past, present and future
  • • Ligand assay - origins, present state of the art and ultimate future

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    • Steroid profiling

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    • Detecting growth hormone abuse in athletes

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    • Metabolomics: its value in cancer research

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  • Evolving aspects in the HPA axis
  • • Clinical and genetic aspects of glucocorticoid sensitivity

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    • Update on Cushingaposs of the omentum

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    • Novel therapeutic directions in Cushingaposs

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    • Carney complex, a personal perspective

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• Nurses Session
• • Bone breaking diseases
  • • Parathyroid disease

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    • The clinical use of bisphosphonates

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    • Switching on dead bones

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    • Cushingaposs induced osteoporosis: a case of back pain with a limp

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• Special Interest Groups
• • Big issues in pituitary research
  • • Steroidogenic factor-1 (SF-1) and DAX-1

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    • Folliculostellate cells: what are they?

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    • Lymphocytic hypophysitis

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  • Metabolic, reproductive and cosmetic aspects of PCOS
  • • Cardio-metabolic consequences of PCOS

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    • Reproductive aspects of polycystic ovary syndrome

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    • Cosmetic aspects of PCOS

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  • Endocrinology of bone diseases: recent clinical and basic developments
  • • Thyroid and bone

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    • Understanding the molecular basis of adverse effects of bisphosphonate drugs in the treatment of bone diseases

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    • Hormonal assays for calcitrophic hormones ndash PTH and FGF 23

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    • Vitamin D analogues: pharmacology and therapeutic uses

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• Oral Communications
• • Reproduction, neuroendocrinology and diabetes
  • • Regulation of lysyl oxidase (LOX) and related genes in rat granulosa cells during follicular maturation

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    • Disruption of gap junctional communication within the ovarian follicle induces oocyte maturation

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    • Endogenous opioid inhibition of hypothalamo-pituitary-adrenal (HPA) axis responses to centrally administered neuropeptide y (NPY) during late pregnancy

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    • The 3D cytoarchitecture of the VTA and the size of its dopaminergiccell population are permanently altered by perinatalglucocorticoid exposure

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    • Fasting and postprandial peptide YY response in adolescents with obesity

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    • Ghrelin and cannabinoids increase food intake via stimulation of hypothalamic amp-activated protein kinase (AMPK)

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    • Coronary artery calcium scores in UK subjects with diabetes

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    • Twice-daily biphasic insulin aspart 30 plus metformin compared with once-daily insulin glargine in combination with glimepiride in type 2 diabetes

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  • Thyroid and pituitary
  • • Association of the thyrotrophin receptor gene (TSHR) with Gravesapos disease: evidence from independent UK population based case control and family studies

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    • Treatment of subclinical hypothyroidism with L-thyroxine improves endothelial function due to increase in free T4 levels

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    • Mortality and vascular outcomes in the thyroid population: an observational study comparing relative levels of mortality and morbidity using the record linkage of patient level datasets

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    • High frequency of abnormal GH suppression and subclinical acromegaly in a series of patients with thyrotropin-secreting pituitary adenoma

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    • Effect of dopamine agonists on prolactinomas and normal pituitary, assessed by dynamic contrast enhanced magnetic resonance imaging

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    • Comparison of random growth hormone and mean growth hormone on oral glucose in patients with acromegaly

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    • Prolactin secretion in the female annexin 1 knockout mouse: effects of ovariectomy and oestrogen replacement

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    • Expression and function of NR5A1, NR5A2 and NR0B1 in mediating gonadotrophin-releasing hormone (GNRH) function in gonadotroph cell lines

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  • Young Endocrinologist session
  • • Stem cells: therapeutic prospects for diabetes mellitus

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    • Functional SNPs involved in NF-kappaB signalling and binding pathways and their contribution to the pathogenesis of gravesapos disease

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    • Characterisation of a novel glucocorticoid-interacting protein expressed in human cancers that modulates glucocorticoid sensitivity

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    • Investigating the role of abca1 in the externalisation of annexin 1 in the anterior pituitary

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    • Neuroendocrine response to ghrelin in patients with anorexianervosa (AN)

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    • Antioxidants enhance the adrenocortical response to stress in the fetus

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    • The effect of the hormonal milieu on the response of the isolated human myometrium to PGE2

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    • Bovine endometrial cells express toll-like receptor 4 (TLR4) and secrete prostaglandins in response to lipopolysaccharide

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• Poster Presentations
• • Bone
  • • Vitamin D deficiency and renal-nonresponsive, bone-responsive pseudohypoparathyroidism (PHP-1b)

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    • Investigation and management of hypophosphataemic rickets in infancy

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  • Clinical case reports/Governance
  • • Scleromyxedema, a cause for primary hypogonadism?

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    • Persistent partial hypopituitarism following an episode of cerebral oedema caused by diabetic ketoacidosis

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    • Autoimmune Addisonaposs disease in identical twins

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    • Lest an lsquooldrsquo diagnosis be forgot ndash a case of disseminated osteolytic lesions and thyroid calcification

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    • A rare cause of hypokalaemia

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    • Unusual case of proliferative retinopathy in a newly diagnosed 27 year old type 2 diabetic

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    • Ethics and pragmatism versus DoH guidelines: what to do?

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    • Krukenberg tumour with virilization: A case report

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    • Ectopic thyroid tissue in the lower cervix with a coexisting normally located multinodular goiter

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    • Cushingaposs syndrome without the cortisol

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    • An unusual postpartum headache

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    • Cardiac transplantation for undiagnosed acromegalic cardiomyopathy

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    • Is Gravesapos disease severity influenced by genes: a tale of two identical twins

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    • Hyperemesis gravidarum causing malnutrition related glucose intolerance: a clinical vignette

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    • The challenge of managing unresponsive thyrotoxicosis in pregnancy

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    • A charcot joint without evidence of a clinical neuropathy

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    • Informed consent for thyroxine replacement?

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    • New onset diabetes associated with the atypical antipsychotic olanzapine

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    • Non-alcoholic steatohepatitis (NASH) in a patient with Type 1 diabetes

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    • Poems from the endocrinologist

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    • Kawasaki disease in young adult with concomitant new onset of type I diabetes and autoimmunethyroiditis

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  • Cytokines, growth factors, growth and development
  • • Effect of maternal cold exposure on hepatic glycogen content, peroxisome proliferator-activated receptor alpha and insulin-like growth factor-II mRNA expression in the neonate

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    • A simple colorimetric cell-based bioassay for interferon alfa 2a

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    • Regulated intramembrane proteolysis (RIP) of p75NTR and ectodomain shedding of NgR disables growth cone signalling and disinhibits DRG neurite outgrowth

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    • Vascular endothelial growth factor (VEGF): modulation of heparin-binding activity and bioactivity by site-directed mutagenesis

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  • Diabetes, metabolism and cardiovascular
  • • Ghrelin enhances gastric emptying in diabetic gastroparesis

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    • Circulating alanine aminotransferase (ALT) is elevated in obese women with PCOS, and is reduced by protracted metformin treatment

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    • How empowered are patients with type II diabetes?

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    • Hyponatraemia: ignored or ignorance?

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    • Is the mother always to blame?

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    • Spontaneous non-traumatic muscle pain in diabetes

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    • Hypoglycaemic effects of Hypoxis hemerocallidea (Fisch. and C. A. Mey.) [Hypoxidaceae] corm ethanolic extract in rats

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    • Programming of insulin sensitivity in lean and obese sheep

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    • Is the variation in insulin sensitivity related to the variation in docosahexaenoic acid composition in red blood cell membrane?A pilot study

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    • Assessment of glucose tolerance and pregnancy outcome in pregnant women with polycystic ovarian syndrome

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  • Endocrine tumours and neoplasia
  • • Pre operative localization of 28 consecutive parathyroid adenomas. A prospective imaging/surgical outcome correlation study

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    • Bilateral laparoscopic adrenalectomy offers good palliation for medullary thyroid cancer associated with ectopic acth secretion

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    • The RET mutation E768D confers a late onset FMTC-only phenotype with incomplete penetrance

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    • An audit on hypercalcaemia. Tools of the trade

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    • Octreotide in the treatment of pthrp related hypercalcaemia in neuroendocrine tumours: a case report and literature review

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  • Growth and development
  • • Plasma cortisol and methyl group metabolism in lean and obese sheep before and after feeding

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    • Differential effects of maternal cold exposure on mRNA abundance for the growth hormone secretagogue receptor (1a) and glycerol-3-phosphatase in adipose tissue of the newborn sheep

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    • Maternal nutrient restriction (MNR) lowers offspring blood pressure (BP) despite raised plasma corticosterone levels

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    • Testosterone effect on immature prostate gland growth in dogs associated with suppression of TGF-beta mRNA expression

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    • Leptin in sow milk: impact on offspring plasma concentrationsand growth

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  • Neuroendocrinology and behaviour
  • • Effect of third ventricle infusuion of ghrelin on plasma GH, T3 T4, milk amount and constituents in the dairy goats

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    • Comparative study of gender differences in cognitive performance

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    • A preliminary investigation into the effects of gender on cognitive performance in the rat using the novel object recognition task

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    • Pituitary adenylate cyclase activating polypeptide (PACAP) and histone H2AZ: novel SF-1 target gene in the ventromedial hypothalamus (VMH)?

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  • Pituitary
  • • A prospective follow up study of cognitive function in patients with pituitary tumours requiring surgery

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    • Is screening for colonic cancer in acromegaly fruitful?

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    • Long-term review of 21 acromegalic patients with yttrium-90 implants

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    • Challenges of colonoscopy in patients with acromegaly

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    • Regulation of anterior pituitary Anx-1 during the estrus cycle of the rat

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    • The low dose dexamethasone suppression test with CRH is not reliable following pituitary surgery

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    • Pituitary tumour, yes or no? ndash A DGH experience

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    • Inhibitors of the ABCA1 transporter affect annexin 1 release in the TtT/GF folliculostellate cell line

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    • Bone morphogenetic protein-2 and Smad signalling in clonal gonadotrophs

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    • Reproducibility of the growth hormone response to resistance exercise in humans

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    • Growth hormone and ghrelin responses to very intense exercise in humans

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  • Reproduction
  • • Male hypogonadism caused by isolated LH deficiency: from pathology to physiology

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    • Hormonal male contraception: serum epitestosterone quantification by mass spectrometry to assess testicular steroidogenesis

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    • PCOS responsive to metformin therapy despite very low BMI

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    • 11beta-hydroxysteroid dehydrogenase (11betaHSD) activities in the testis and reproductive tract of post-pubertal boars

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    • VEGF signalling: integration and multi-tasking in endothelial cell biology

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    • Intra-follicular cortisol:cortisone (f:e) ratios in porcine antral follicles and ovarian cysts; relationship to ovarian modulators of type 1 11beta-hydroxysteroid dehydrogenase (11betaHSD1) activity

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    • Matrix metalloproteinases and angiogenesis

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    • The biological variation of Cndashreactive protein in polycystic ovarian syndrome

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    • The effect of prostaglandin E2, sulprostone and isoprenaline on isolated mouse uterine tissue taken during labour

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    • Effect of weight loss on hyperandrogenism and oligomenorrhoea in a woman with polycystic ovarian syndrome

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    • Serum concentrations of anti-mullerian hormone (AMH) and inhibin b, in regularly cycling and anovulatory women with polycystic ovaries (PCO)

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  • Steroids to include Cushing's
  • • Detection of endogenous nandrolone in the urine of healthy volunteers by utilising a sensitive ELISA

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    • Effect of meal fat content on salivary testosterone and cortisol levels in healthy female volunteers

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    • Free testosterone calculation: critical comparison of three equations and establishment of reference limits

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    • Does the dexamethasone-suppressed CRH test improve diagnostic accuracy in Cushingaposs syndrome?

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    • Induction of pigmentation up regulates ERalpha and aromatase in epidermal melanocytes and melanoma cells

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    • Hydrocortisone suppress DNA fragmentation in isolated thymocyte nuclei

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    • Oestrogens and wound healing: migration, proliferation and secretion of paracrine factors by human dermal fibroblasts in vitro

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    • Association of an FC receptor-like 3 haplotype with autoimmune Addisonaposs disease suggests an alternative pathogenic allele at the locus

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    • Cortisol circadian rhythm in critically ill patients ndash can we modulate it?

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    • A proliferative role for liver X receptors within human skin

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    • Comparison of salivary and serum cortisol values during hydrocortisone day curves in hypocortisolaemic patients

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    • Adrenalectomy for hypercortisolism

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    • The selective inhibition of human hair growth by oestrogenic compounds in vitro

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    • Rapid glucocorticoid effects: novel signalling protein interactions

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    • Non-genomic effects of the glucocorticoid receptor - the effect of glucocorticoids on activation of c-src and PKB/Akt

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  • Thyroid
  • • The effect of high calcium on activity of thyroid gland in rat

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    • Results of surgery in patients with medullary thyroid carcinoma

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    • Lack of association of interleukin-13 polymorphisms with Gravesapos disease

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    • Acute intermittent porphyria associated with inappropriate ADH secretion and hyperthyroidism

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    • Thyrotoxic periodic paralysis in a caucasian man

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    • A UK wide survey of post-operative thyroid surgical practice and life threatening complications

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    • Thyroid dysfunction in HIV

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    • Comparison of radioiodine with radioiodine plus lithium in the treatment of hyperthyroidism

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    • Recurrent thyrotoxicosis refractory to repeated radioactive iodine ndash a case report

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• Society for Endocrinology joint Endocrinology and Diabetes Day
• • Beta cell growth: implications for Type 1and Type 2 diabetes
  • • The onset of type 2 diabetes - controlling the balance between szlig-cell life and death

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    • Islet mitogens ndash role in the maintenance of beta-cell mass

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    • beta-cell death in type 2 diabetes: a link to type 1 diabetes

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    • Gain and loss of function strategies for directing human embryonic stem cell differentiation

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• Lecture
• • Cell therapy to cure
  • • Cell therapy to cure

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• Poster Presentations (1)
• • Diabetes, metabolism and cardiovascular
  • • Stimulation of insulin secretion by an aqueous extract of Gymnema sylvestre: role of intracellular calcium

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    • Oxidative effects of advanced glycation end products (AGE) in a gingival fibroblast cell culture model

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    • Modulation of nicotine and advanced glycation end product (AGE) mediated effects by the antioxidant glutathione (G) in fibroblasts

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    • Familial diabetes in Asian families; remember MODY

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    • A transgenic mouse system for conditional ablation and regeneration of pancreatic beta cells

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    • Triple oral therapy in diabetes ndash a case

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    • Ghrelin enhances gastric emptying in diabetic gastroparesis

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    • Circulating alanine aminotransferase (ALT) is elevated in obese women with PCOS, and is reduced by protracted metformin treatment

      ea0010dp8
    • How empowered are patients with type II diabetes?

      ea0010dp9
    • Hyponatraemia: ignored or ignorance?

      ea0010dp10
    • Is the mother always to blame?

      ea0010dp11
    • Spontaneous non-traumatic muscle pain in diabetes

      ea0010dp12