Endocrine Abstracts

Estrogen receptors (ER) play a crucial role in development, reproduction and normal physiology. Even though the concept of ER gene mutations was thought to be lethal. Gene targeting allowed us to produce lines of mice with disrupted ER-alpha (alpha-ERKO) and ER-beta genes (beta-ERKO) as well as a compound alpha/beta-ERKO. Comparable levels of ER-beta mRNA in tissues of alpha-ERKO mice suggesting that ER-beta expression is not dependent on ER-alpha. Estrogen, EGF or IGF-1 treat...

Kenneth S Korach, National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA AbstractKenneth S Korach is the Program Director of the Environmental Disease and Medicine Program, Chief of the Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health...