Endocrine Abstracts

Contents

• Plenary Lectures
• • Society for Endocrinology Dale Medal Lecture
  • • A genetic analysis of insulin and diabetes regulated gene expression

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    • Society for Endocrinology Asia and Oceania Medal Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Growth hormone - not only for growth, but for life?

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Thyroid Disease - causes and effects

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    • Clinical Endocrinology Trust Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • Consequences from loss of estrogen receptor activity in endocrine physiology

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • British Thyroid Association Pitt–Rivers Lecture
  • • Essential role of transporters in cellular entry of thyroid hormone

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    • Society for Endocrinology Transatlantic Medal Lecture

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• Symposia
• • Symposium 1: Endocrine complications of systemic disorders
  • • The metabolic effects of antiretrovial therapy

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    • Parathyroid hormone in children with chronic renal failure

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    • The endocrinology of critical care

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  • Symposium 2: The endocrinology of the kidney
  • • Lessons from the genetic hypercalciuric stone forming rat

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    • Regulating PTH responses in the kidney

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    • The WNK Kinases: novel regulators of sodium and potassium transport in the kidney

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  • Symposium 3: Thyroid disease in pregnancy and childhood
  • • Maternal thyroid dysfunction

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    • Maternal and placental control of thyroid hormone availability for the foetus

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    • Neuropsychological consequences of thyroid hormone deficiency

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    • Diagnosis and management of thyroid dysfunction in childhood

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  • Symposium 4: Intracellular transport for steroids
  • • An introduction to lipid rafts and their role in protein targeting

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    • The steroid hormone response element binding proteins

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    • The molecular mechanism of nuclear trafficking

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    • Intracellular trafficking of vitamin D receptors and interacting proteins

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  • Symposium 5: Cardiovascular endocrinology
  • • Adipokines, metabolic syndrome and atherogenesis

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    • Haemostatic and inflammatory markers in coronary heart disease

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    • Endothelial function and atherogenesis

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    • Oxidative stress and cardiovascular disease

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  • Symposium 6: Novel approaches for defining oestrogen action
  • • Imaging of E2 action in vivo

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    • New roles for oestrogens as revealed by models of oestrogen insufficiency

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    • Profiling in endometrium - genomic approaches to defining estrogen action

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    • Oestrogen receptors and growth factor interactions: implications for cancer development and treatment

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  • Symposium 7: The hypothalamic–pituitary–adrenal axis and inflammation
  • • Neuroendocrine and immune changes associated with autoimmune disease

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    • Structure/function of the glucocorticoid receptor and its ligands

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    • Glucocorticoid action in asthma and COPD

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    • Annexin A1 - a unique mediator of glucocorticoid action

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  • Symposium 8: Hyperinsulinism–induced hypoglycaemia
  • • Hypoglycaemia and the brain

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    • Tumour associated hypoglycaemia - mechanisms and treatment

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    • Hyperinsulinism in infancy

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  • Symposium 9: Regulation of ovarian folliculogenesis
  • • Dialogue between oocytes and somatic cells

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    • Anti-mullerian hormone and the dynamics of follicle development

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    • Endocrine and local control of the preovulatory follicle and developing corpus luteum in primates

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• Clinical Management Workshops
• • Clinical Management Workshop 1: Diagnosis and management of steroid deficiency
  • • Why is the management of corticosteroid deficiency still controversial?

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    • Diagnosing the suppressed adrenal

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    • Glucocorticoid resistance

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  • Clinical Management Workshop 2: HRT in women – who should get what?
  • • Current state of HRT in post-menopausal women

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    • Hormone replacement in pre-menopausal pomen

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    • DHEA and its role in women

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  • Clinical Management Workshop 3: Endocrine manipulations in the transsexual
  • • Sexual differentiation of the human brain and gender

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    • Endocrine treatment for the transsexual

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    • Phalloplasty for female to male gender reassignment

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  • Clinical Management Workshop 4: Endocrine sequelae of childhood cancer
  • • Endocrine sequelae of childhood cancer: overview-size of the problem

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    • Growth and puberty after treatment for intracranial neoplasia

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    • Ovarian reserve after chemotherapy

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• Nurses Session
• • Skeletal health
  • • Techniques of bone mass measurement

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    • Steroids and the skeleton

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    • Management of osteoporosis

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    • Osteoporosis and fracture: The role of the endocrine nurse

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• Young Endocrinologists Session
• • Young Endocrinologists Session
  • • Career fellowship schemes for the clinical and non-clinical endocrinologist - where are they and how to succeed

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    • Tricks for success in research: the clinic versus the lab

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    • The BTA (Been to America) Degree: Is it still worth it?

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• Workshop
• • Molecular Endocrinology Workshop
  • • Protein chip technology

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• Oral Communications
• • Oral Communication 1: Diabetes and metabolism
  • • Improving insulin resistance: role of Akt isoforms in type II diabetes

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    • The relationship of beta-cell function with age: effect of population migration

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    • Depot specific glucocorticoid regulation of key components of the insulin signalling cascade in human adipose tissue

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    • Effect of cholesterol depletion on IGF-induced cell survival: the role of caveolar and non-caveolar domains

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    • Changes in gut hormones after Roux-en-Y gastric bypass for morbid obesity favour an anorectic state

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    • Analysis of post-translational processing and trafficing of agouti-related protein

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    • Calcitonin Gene Related Peptide (CGRP)II mRNA in human subcutaneous adipose tissue is altered by menopausal status

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    • Blockade of the Neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous Peptide YY (3-36) on food intake

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    • Testosterone improves funtional capacity and symptoms in men with chronic heart failure: a double blind placebo controlled trial

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  • Oral Communication 2: Reproduction and growth
  • • Glucocorticoid-induced apoptosis in human decidua: a novel role for 11 beta-hydroxysteroid dehydrogenase in late gestation

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    • A defect in the DHEA-DHEAS shuttle defines a novel cause of polycystic ovary syndrome

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    • Direct inflammatory action of triiodothyronine on human ovarian surface epithelial cells in vitro

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    • A novel autocrine/paracrine inside-out signalling pathway that cross-talk the prostanoid and GnRH receptors in pituitary cells

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    • Pathophysiology and genetics of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency

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    • Early preantral follicle development in polycystic ovaries (PCO) differs according to ovulatory status

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    • A densitometric and architectural analysis of the skeleton in adults with varying degrees of GH deficiency

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    • Disruption of intramembranous and endochondral bone development in TRalpha 2 null mice

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  • Oral Communication 3: Neuroendocrinology
  • • Genetic ablation of the AgRP neuron leads to a lean, hypophagic phenotype

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    • The nadir growth hormone after an octreotide test dose predicts the long term efficacy of somatostatin analogue therapy in acromegaly

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    • Transcriptional activation of the prolactin gene by TNF-alpha is mediated via NFkB

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    • Adenosine expression and function in the anterior pituitary gland

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    • Modulators of the SUR2B/Kir6.1 ATP-sensitive K+ channel regulate annexin 1 release in the TtT/GF folliculostellate cell line

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    • Ghrelin and cannabinoid interactions on food intake

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    • Feeding effects of the gut hormones ghrelin, peptide YY3-36 and oxyntomodulin in lean and obese mice

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    • Does GH replacement increase the risk of recurrence in patients with craniopharyngioma?

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  • Oral Communication 4: Steroids
  • • Identification of a defective gene in Familial Glucocorticoid Deficiency type 2 as a ACTH receptor accessory factor responsible for cell surface trafficking

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    • Interaction of the ACTH receptor C-terminal tail with a nuclear envelope protein

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    • Impact of dietary chenodeoxycholic acid on the hypothalamic-pituitary-adrenal axis in rats

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    • Characterisation of a novel protein interacting with the glucocorticoid receptor

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    • Cortisol, DHEA and DHEAS in severe sepsis - a paradigm revisited

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    • Functional effects of mutations in the 11beta-hydroxylase (CYP11B1) gene

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    • Differential induction of fibroblast 11beta-HSD1: a mechanism for tissue-specific regulation of inflammation

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    • Generation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase isozymes in the perfused mouse hindlimb

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  • Oral Communication 5: Thyroid
  • • Association between serum TSH and fT4 concentrations and occurrence of atrial fibrillation in a large community-based population of elderly subjects. The Birmingham Elderly Thyroid Study (BETS)

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    • Risk of second cancers among people with thyroid cancer - treatment effects or common aetiology?

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    • PTTG Induces Genomic Instability in Thyroid Cells

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    • PTTG Binding Factor (PBF) - a novel transforming gene in thyroid tumorigenesis which represses iodide uptake

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    • Anti-TNFa therapy inhibits TNFa-dependent ICAM1 up-regulation in orbital fibroblasts from patients with thyroid associated ophthalmopathy

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    • Thyrotropin receptor (TSHR) activation in preadipocytes stimulates the early but inhibits the terminal stages of adipogenesis

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    • Development of novel thyroid stimulating monoclonal antibodies from an experimental model with potencies equivalent to those in Graves' disease patients, including full agonistic activity but also differential blocking properties

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• Poster Presentations
• • Diabetes and metabolism
  • • Study of catecholamine secretion in obstructive sleep apnoea

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    • Rosiglitazone increases testosterone levels in hypogonadal men with Type 2 diabetes

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    • Low insulin-like growth factor-II (IGF-II) concentration predicts weight gain in normal weight subjects with type 2 diabetes

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    • Silencing of leptin and resistin gene expression by RNA interference in vitro

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    • A study of obesity awareness in obese patients attending a District General Hospital

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    • A comparison study between the new ADA criteria for the diagnosis of dysglycemia to the old ADA/WHO criteria

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    • Cystic fibrosis-related diabetes in adults in Ireland

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    • Hyperinsulinaemia associated endotoxaemia and its relationship to Type 2 diabetes mellitus

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    • Assessment of angiogenic factors, microalbuminuria and electroretinography in type 1 diabetes mellitus

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    • Assessment of subclinical neuropathy in children with insulin dependent diabetes mellitus

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    • The risk of vascular complications in patients with newly diagnosed type 2 diabetes mellitus.

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    • Refractory hypertension can often be helped by the use of the potent vasodilator minoxidil: results in 13 patients, 12 of whom were already receiving angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists

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    • A comparative analysis of clinical outcomes in a multidisciplinary weight management clinic

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    • Effects of hormone replacement therapy and raloxifene on C-reactive protein in healthy postmenopausal women

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    • Prostaglandin synthesis in adipose tissue from women with simple obesity - differences between omental and subcutaneous depots

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    • Hypothalamic expression of the glucose sensing KATP channel component Kir 6.2 is altered in animal models of obesity and diabetes

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    • Targeted inactivation of hexose-6-phosphate dehydrogenase (H6PDH) results in impaired reactivation of glucocorticoids and endorses a pivotal role for H6PDH in regulating 11beta-hydroxysteroid dehydrogenase type 1

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    • Murine expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and hexose-6-phosphate dehydrogenase (H6PDH)

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    • Cholesterol feeding induces fatty streak formation in the testicular feminised mouse

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    • Is ghrelin involved in BMI determination in patients with type 2 diabetes?

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    • Fatty liver disease is associated with both endotoxaemia and sub-clinical inflammation which is further aggravated by diabetes

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    • The effect of a high fat, high cholesterol diet on blood glucose in pigs

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    • Upregulation of adiponectin receptors in human adipose tissue from women with the polycystic ovary syndrome(PCOS)

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    • Glucocorticoid-induced mineralisation of vascular pericytes

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    • Lys-gamma3-MSH stimulated lipolysis in the 3T3-L1 adipocyte cell line may be mediated through a novel melanocortin receptor

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    • Physiological concentrations of testosterone inhibit extracellular calcium entry via voltage-gated calcium channels in the A7r5 vascular smooth muscle cell line

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    • Maternal consumption of a high-meat, low carbohydrate diet during pregnancy impairs glucose tolerance in the adult offspring

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    • Expression of adiponectin receptors in fetal and adult human adrenal cortex

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    • Differential modulation of orexin receptors by hyperglycaemia in the mouse heart

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    • Gene polymorphisms related to metabolic and cardiac complications in patients with primary aldosteronism

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    • Elevated endotoxin levels as a mediator of consistent chronic sub-clinical inflammation in CABG patients

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    • Rosiglitazone and phenformin, but not metformin activate AMP-activated protein kinase and stimulate nitric oxide release in human aortic endothelial cells

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    • Testosterone does not promote A7r5 rat aortic vascular smooth muscle cell growth

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    • Control of MC2-R expression during adipogenesis

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    • Study of the effect of testosterone upon apoptosis in the rat aortic A7r5 vascular smooth muscle cell line

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  • Growth and development
  • • SOCS proteins inhibit leptin signalling in MCF-7 cells

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    • Internalization of the melanocortin 2 receptor is required for erk activation by ACTH in H295R adrenocortical cells

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    • Modulation of somatostatin receptors expression by genistein in human umbilical vein endothelial cells

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    • Expression of Somatostatin receptors in normal human kidney

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    • Purifying growth hormone on an affinity column using his-tagged growth hormone receptor

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    • Nuclear FactorkappaB signalling in the folliculo-stellate Cell Line TtT/GF

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    • Hyperinsulinaemia and insulin resistance in an animal model of Polycystic Ovary Syndrome (PCOS)

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    • Kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis in adult male rats following central and peripheral administration

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    • The regulation of neurokinin B and its preferred NK3 receptor during pregnancy

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    • Bioactivity of macroprolactin in vitro

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    • Differential effects of CREB (cAMP responsive element binding) protein expression between normal ovarian surface epithelial cells and cell lines derived from ovarian cancers

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    • In vitro effects of prolactin and bromocriptin on seminal vesicle contractions in rat

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    • Fertilization in superovulated sheep is disturbed by oestrogenic anovulatory follicles

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    • Expression of iodide transporters in human placental tissue

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    • Nebivolol inhibits spontaneous and oxytocin-induced contractions in the rat uterus

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    • Radioimmunoassay (RIA) method for Salivary Testosterone: Reference ranges in children, adult men and adult women

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    • The value of ultrafiltration in the detection of macroprolactin

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    • Adult growth hormone replacement therapy and neuroimaging surveillance in brain tumour survivors

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    • A new sustained-release preparation of human growth hormone: pharmacokinetic, pharmacodynamic and safety profile

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    • Constitutional delay of growth and puberty (CDGP)is associated with the GPR54 gene but not with Leptin (L), Leptin Receptor (LR) and Cocaine and Amphetamin Regulated Transcript (CART) genes

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    • Obese subjects have lower satiety

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    • Partial GH deficiency is associated with an adverse serum lipid profile

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    • Growth hormone replacement in patients with hypopituitarism and severe growth hormone deficiency

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    • In vitro demonstration of the effect on RNA splicing of a novel growth hormone receptor mutation

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    • PTTG and PBF in human placenta: the effects of intra-uterine growth restriction

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    • The effects of modifying the fatty acid composition of lipids used in total parenteral nutrition (TPN) on the growth and development of the preterm piglet

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    • Separase and Securin; their roles in the developing human fetal brain

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    • The effect of maternal dietary fat supplementation on the immunoglobulin status of their offspring

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    • Epigenetic programming of the human endothelial nitric oxide pathway

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    • Effect of active and treated acromegaly on PTH concentration, PTH target-organ sensitivity and phosphocalcium metabolism

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    • The circadian rhythm of osteoprotegerin and its association with parathyroid hormone secretion

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    • Assessment for osteoporosis in patients with primary hyperparathyroidism- audit

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    • Effect of phosphate supplementation on PTH target-organ sensitivity during growth hormone replacement in adult growth hormone deficiency

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    • Effects of raloxifene and oestradiol on bone turnover parameters and histology in female rats

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    • Modulatory effects of Aroclors 1221 and 1254 on bone turnover and vertebral histology in intact and ovariectomized rats

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    • Effect of grape procyanidins on free radical-induced oxidative damage in MC3T3-E1 Osteoblast-like cells in vitro

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    • IL-1 and glucocorticoids synergistically enhance 11beta-hydroxysteroid dehydrogenase expression in osteoblastic MG-63 cells: a novel mechanism for steroid induced bone loss

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    • Effects of raloxifene on serum cytokine concentrations in healthy postmenopausal women

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    • Two novel missense mutations in GPR54 in a subject with hypogonadotropic hypogonadism

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    • A comparison of vascular reactivity in postmenopausal women receiving testosterone and conventional HRT versus conventional HRT

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    • Intercellular adhesion molecule 1, ICAM-1, in polycystic ovary syndrome: relationship to insulin resistance or obesity

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    • UCP1 (A-3826G) and PPARG2 (Pro12Ala) polymorphisms in women with polycystic ovary syndrome

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    • Testogel - An effective and acceptable androgen replacement

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    • A 2 year audit of the polycystic ovary syndrome (PCOS) clinic at the Royal Berkshire Hospital

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    • The biological variation of the LH/FSH ratio in normal women and those with Polycystic Ovarian Syndrome

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    • Testogel - Improves well being and libido in hypogonadal men

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    • Assessment and diagnostic workup of male hypogonadotrohic hypogonadism

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    • Differential effects of pregnancy on different high molecular mass forms of serum prolactin

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  • Endocrine tumours and neoplasia
  • • DNA array analysis of a vitamin D-resistant variant of MCF-7 breast cancer cells

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    • Tissue specific regulation of IGF-1 expression by GH

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    • Adiponectin receptor expression in human prostate cancer cell lines

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    • Expression and role of 'steroid superfamily' receptors in meningioma

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    • Long term culture of MCF-7 breast cancer cells with siRNA to the IGF-I receptor causes continued transcriptional silencing of the IGF-I receptor and decreased cell proliferation

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    • Cell cycle dysregulation in breast cancer - the roles of Jab1 and Archipelago

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    • The effect of somatostatin analogues on p27 and on mitogen-activated protein kinase (MAPK) in different human pituitary tumour cells

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    • Superoxide dismutase expression in human uterine cervix carcinoma cells (HeLaS3) treated with cytostatics or nucleoside drug

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    • Is survivin regulated by c-Myc?

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    • Associations and interactions between the co-regulatory protein SRC-1 and Ets-2 in breast cancer

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    • Development of a tamoxifen resistant breast cancer cell line

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    • Diagnostic mutation testing in multiple endocrine neoplasia type 1 (MEN1): Support for the current referral criteria

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    • Experience of intrarterial calcium stimulation in the localisation of insulinomas

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    • External pituitary irradiation normalizes serum insulin like growth factor-1 levels in a significant percentage of patients with acromegaly

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    • What is the final outcome in patients with macroprolactinoma resistant to dopamine agonists?

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    • Natural history of non-functioning pituitary adenomas managed conservatively at a single neuroendocrine unit

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    • BRAF mRNA is over-expressed in pituitary adenomas, but the oncogenic BRAF mutation V5999E is not a frequent finding

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    • Patients with hypothalamic-pituitary disease: prevalence of diabetes, hypertension, dyslipidemia and other cardio-vascular risk factors

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    • Localisation of unilateral aldosterone secreting tumours in hypokalaemic hypertensive subjects

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    • Peripituitary tumour surveillance imaging in patients receiving growth hormone replacement

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    • Acromegaly outcomes: the Exeter experience

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    • Clinically mute adrenal tumours - study of 63 cases

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    • Selective parathyroid venous sampling in patients with complicated primary hyperparathyroidism

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    • Hypercalcaemia in acromegaly is not always due to MEN-1

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    • Attenuation of vasopressin-induced antidiuresis in poorly-controlled type 2 diabetes

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    • Leptin and the diurnal rhythm of blood pressure

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    • Symptomatic Rathke cleft cysts: systematic review of 10 cases with long follow-up

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    • Dehydroepiandrosterone (DHEA) replacement enhances IGF-I generation in hypopituitary patients on growth hormone replacement

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    • Implications of severe hyponatraemia in neurosurgical patients

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    • Late endocrine effects after treatment for nasopharyngeal cancer

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    • How useful is IGF-I in adults with GH deficiency?

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    • A novel finding of activation of the hypothalamic-pituitary-adrenal axis with increased cortisol production rates and circulating cortisol concentrations in 24-hour profiling study in cranially irradiated adult cancer survivors

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    • The dynamics of GH secretion in adult cancer survivors with severe radiation-induced GH deficiency

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    • The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage

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    • The natural history of post-traumatic hypopituitarism: Implications for assessment and treatment

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    • Comparison of long term psychological health in patients with treated Pituitary Cushing's and Nelson's syndrome vs. Adrenal Cushing's

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    • GH, ACTH and cortisol responses to insulin induced hypoglycaemia and exercise in healthy young men

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    • Absence of specific effect of DHEA-S deficiency on mood and quality of life in Addisons disease

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    • Lymphocytic hypophysitis: What is the long-term outcome?

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    • Screening and prevalence of endocrine and radiological pituitary abnormalities in adult-onset Langerhans cell histiocytosis

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    • Central Relaxin-3 administration causes hyperphagia in male Wistar rats

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    • Oestrogen interacts with TNFalpha signalling pathways to stimulate human prolactin gene transcription

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    • Complement C5a receptors are expressed throughout the anterior pituitary gland

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    • Does Annexin-1 have a biological function in the adrenal gland?

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    • PYY3-36 inhibits food intake in both fed and fasted states

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    • Telomerase-mediated immortalisation of human embryonic olfactory GnRH neuroblasts

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  • Steroids
  • • Refolding and purification of recombinant human hexose-6-phosphate dehydrogenase from bacterial inclusion bodies

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    • Identification of the sites of expression of the Triple A syndrome mRNA in the rat using in situ hybridisation

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    • Immunomodulatory 1,25dihydroxyvitamin D3 synthesis by dendritic cells and macrophages is highly dependent on the availability of inactive substrate 25D3 levels

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    • Modulation of glucocorticoid sensitivity by retroviral gene transfer

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    • Haplotype analysis of the aldosterone synthase (CYP11B2) and 11beta-hydroxylase gene (CYP11B1) locus

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    • ACTH stimulates mitogenic signalling pathways but does not affect cell division in the human adrenal H295R adrenal cell line

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    • Establishment of physiological and supra-physiological testosterone dosing regimen in mice

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    • Development of a cortisol binding capacity assay for use in the newborn

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    • WNK kinases; a novel pathway regulating electrolyte balance and blood pressure, which is mutated in Pseudohypoaldosteronism type II

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    • Profiling aldosterone and salt responsive pathways in an inducible hypertensive mouse model

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    • N-POMC peptides activate adrenal ERK signaling pathways

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    • Chronic glucocorticoid excess does not cause fatty liver disease in mice

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    • Medication management and quality of life in patients with primary adrenal insufficiency

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    • Salivary testosterone measurement for monitoring treatment of children with congenital adrenal hyperplasia (CAH)

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    • Increased 5alpha-reductase activity during the luteal phase of the normal menstrual cycle

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    • The aldosterone/renin ratio using renin concentration compared to renin activity in a healthy population

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    • Natural history of metabolic progression for autoimmune Addison's disease in subjects with adrenal autoantibodies

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  • Thyroid
  • • Seaweed - a marine thyroid?

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    • Gene regulation by the c-terminal pxxp motif of pituitary tumor transforming gene (PTTG)

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    • Thyroid hormone (T3) activates GH/IGF-1 signalling during skeletal development

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    • Antisense chemoradioimmunotherapy consisting of antiEGFscFv linked onto high energy radioisotopes,vinorelbine and 21-nucleotide double stranded siRNA targeted to DNMT1 induce apoptosis in anaplastic thyroid CCCa characterised by hypermethylated oncosuppressor Gadd45 promoter CpG islands and overexpression of bcl-2,VEGF and Raf-1

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    • Psychometric validation of new measures of hypothyroid-dependent quality of life (QoL) and symptoms

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    • Thyroid follicular cells express receptors for vascular endothelial growth factors which have an autocrine role

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    • Plasminogen activators in human thyrocytes: regulation and role

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    • Can deacetylation promote radioiodide uptake in thyroid cancer?

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    • Expression of connective tissue growth factor in human thyroid tissue

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    • Regression mapping of the HLA association with Graves' disease

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    • The Birmingham Elderly Thyroid Study (BETS): TSH and fT4 values in 5784 community-living subjects aged 60 and over

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    • Pegylated-liposomal formulation of chimeric LNA/DNA antisense oligonucleotides against DNA MeTase and vinorelbine induces apoptosis in anaplastic thyroid cancer characterised by 5'CpG island methylation of TSGs Gadd45,p53 and Rb

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    • Effects of maternal hyperthyroidism during early gestation on neonatal and obstetric outcome

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    • Abnormalities in basal and stimulated TSH secretion in cranially irradiated euthyroid adult cancer survivors: Does 'hidden' central hypothyroidism exist?

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    • The titration regimen is as effective and better tolerated than the block-replace regimen in the medical therapy of Graves' hyperthyroidism

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    • Screening thyroid function in early pregnancy

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    • Left ventricular functional reserve and central arterial stiffness in subclinical hypothyroidism

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    • Health status is impaired in people with sub-clinical hypothyroidism

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    • Physical examination in thyroid diseases, should it be relied on?

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    • Triiodothyronine and glucose insulin potassium individually improve cardiovascular performance post coronary artery bypass graft surgery without increasing systemic oxygen consumption

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    • Evaluation of thyroid hormone replacement therapy with two different thyroid preparations

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    • Pseudomembranous gastritis, hepatitis and iritis complicating carbimazole therapy for Graves disease

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    • Early response to high dose intravenous steroids in thyroid associated ophthalmopathy

      ea0009p169
    • Thyroid stimulating hormone (TSH) levels predict relapse of Graves' disease following carbimazole treatment

      ea0009p170
    • Quality of Life is impaired in people on Levothyroxine therapy and untreated people with sub-clinical hypothyroidism

      ea0009p171
    • Changes in thyroid function in survivors of brain tumours followed longitudinally

      ea0009p172
    • Incidence of Selenium deficiency in thyroid disease

      ea0009p173
    • Clinical outcome and implications for training in thyroid surgery in a district general hospital

      ea0009p174
    • An audit of the outcome of a fixed dose (555Mbq)of radioidine for hyperthyroidism

      ea0009p175
    • Iodine deficiency goitre in the United Kingdom - the result of a vegan diet

      ea0009p176
    • Thyroid dysfunction alters NT-proBNP concentrations

      ea0009p177
    • Dietary factors in Thyrotoxicosis management: case report on excessive lsquoBrassicarsquo intake

      ea0009p178
    • Are urgent thyroid referral proformas successful enough in detecting thyroid cancers?

      ea0009p179
  • Clinical
  • • Pituitary Apoplexy. Retrospective review of 28 patients: is surgical intervention always necessary?

      ea0009p180
    • Pituitary macroadenoma: is IGF-I measurement enough to exclude growth hormone excess? 3 case reports

      ea0009p181
    • Familial expansile osteolysis (FEO): a rare cause of tooth loss

      ea0009p182
    • A novel calcium-sensing receptor gene mutation in a family with an extensive history of familial hypocalciuric hypercalcaemia

      ea0009p183
    • Refeeding Blaine: studies following a 44 day fast

      ea0009p184
    • Appropriate management of CAH requires detailed mutational analysis to be interpreted within the context of family history and biochemistry

      ea0009p185
    • Isolated thyroid stimulating hormone (TSH) deficiency: A rare condition? Three case reports

      ea0009p186
    • Pituitary mass due to lymphocytic hypophysitis presenting in late pregnancy with spontaneous post-partum resolution

      ea0009p187
    • Graves' disease and Struma Ovarii

      ea0009p188
    • Myelinolysis following the treatment of Addisonian crisis

      ea0009p189
    • A case of insulin sensitivity

      ea0009p190
    • Ulcerative colitis presenting after bilateral adrenalectomy

      ea0009p191
    • Antibodyless, painless, steroid responsive thyrotoxicosis

      ea0009p192
    • Coexistent acromegaly and thyroid-associated ophthalmopathy: chance or association?

      ea0009p193
    • Challenges of treating hyperthyroidism

      ea0009p194
    • Phaeochromocytoma in pregnancy: medical or surgical management?

      ea0009p195
    • A case of an angry old man

      ea0009p196
    • Cushing's syndrome in pregnancy: a case report

      ea0009p197
    • Bromocriptine-sensitive acidophil-stem-cell adenoma co-secreting growth hormone and prolactin - A case report

      ea0009p198
    • Pituitary failure as a presentation of previously undiagnosed metastatic lung cancer

      ea0009p199
    • Hyperthyroidism as the cause for lsquobrittle' Addison's disease

      ea0009p200
    • Controversial issues in the management of hypercalcaemia in a young patient

      ea0009p201
    • Interpretation of the short synacthen test in the presence of low cortisol binding globulin

      ea0009p202
    • An incidental phaeochromocytoma

      ea0009p203
    • Langerhans cell histiocytosis and auto-immune thyroiditis presenting as a thyroid mass with progressive hypothalamic-pituitary dysfunction

      ea0009p204
    • Antineutrophil cytoplasmic antibody positive inflammatory athropathy during long term propylthiouracil treatment in a patient with Graves hyperthyroidism

      ea0009p205
    • Thionamide resistant thyrotoxicosis - three illustrative cases

      ea0009p206
    • Autoimmune thyroid disease following treatment of multiple sclerosis with Campath-1H

      ea0009p207
    • A somatostatin responsive, ACTH-secreting bronchial carcinoid- a diagnostic and therapeutic challenge

      ea0009p208
    • Late change in immunohistochemical staining in a non-functioning pituitary adenoma following treatment with GnRH analogue

      ea0009p209
    • Young woman with alopecia, short stature and recurrent fractures

      ea0009p210
    • Evolving tumour behaviour in a patient with combined Conn's and Cushing's syndrome

      ea0009p211
    • Management of a macroadenoma in pregnancy

      ea0009p212
    • A case of transient hypopituitarism and hyponatraemia

      ea0009p213
    • Use of etomidate for control of severe hypercortisolism

      ea0009p214
    • Pituitary tumours coexisting with meningioma and astrocytoma - description of 4 cases in unirradiated patients

      ea0009p215
    • Genuine carcinoid syndrome but spurious adrenal carcinoma - deception by heterophile antibodies

      ea0009p216
    • The association of thyroid cancer with Graves' disease: potential cost implications

      ea0009p217
    • Cushing's syndrome in evolution

      ea0009p218
    • Pitfalls in the biochemical assessment of acromegaly

      ea0009p219
    • Unusual presentation of multiple endocrine neoplasia 2A

      ea0009p220
    • Adrenal crisis in an individual with panhypopituitarism and new-onset Graves' disease

      ea0009p221
    • Hypothalamo-pituitary axis in chronic fatigue syndrome amp incidentaloma

      ea0009p222
    • Effect of timing of prolactin sampling on the incidence of spurious hyperprolactinaemia

      ea0009p223
    • lsquoTired all the Time' - a positive diagnosis

      ea0009p224
    • Management of hyponatraemia, are we doing enough?

      ea0009p225
    • An audit on the type and amount of specialist education that newly appionted endocrine nurses receive; educational needs unmet?

      ea0009p226
    • An audit of the management of primary hyperparathyroidism

      ea0009p227
    • An audit of insulin stress tests performed by an individual endocrine specialist nurse - a safe and reliable procedure

      ea0009p228
    • The TRH test at South Tyneside, lsquoshould it be confined to the dustbin?rsquo

      ea0009p229
    • Differential regulation of Urocortin 3 mRNA expression in the central nervous system by stress and glucocorticoids

      ea0009p230
  • Novartis Award Posters
  • • Genetic ablation of the AgRP neuron leads to a lean, hypophagic phenotype

      ea0009np1
    • Characterisation of a novel protein interacting with the glucocorticoid receptor

      ea0009np2