Endocrine Abstracts

Thyroid disease - hyper- and hypothyroidism, together with goitre and thyroid cancer - is extremely common. The familial clustering of autoimmune diseases such as Graves' hyperthyroidism illustrates the genetic contribution to susceptibility; we have described advances in understanding of the role of the CTLA4, HLA and other immune response genes in this susceptibility. We have shown that hyperthyroidism results in increased mortality, especially from vascular disease. Develop...

Jayne A Franklyn, Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK AbstractJayne Franklyn qualified in medicine with honours at the University of Birmingham in 1979. After basic training in medicine and endocrinology, she was appointed Sheldon Research Fellow and MRC Training Fellow to pursue studies of thyroid hormone receptor binding, leading to MD in 1985. After appointment as Clinical Lecturer ...