Endocrine Abstracts

Thyroid hormone (T3) works through nuclear receptors which are encoded by two genes TRalpha and TRbeta. Each gene encodes several isoforms among which some are not true receptors as they do not bind to DNA or do not bind thyroid hormone. In the absence of T3, thyroid hormone the receptors (apo-receptors) behave as transcription repressors toward target genes. Upon binding the hormone, the apo-receptors are transformed into holo-receptors which work as tanscription activators. ...

Jacques Samarut, Ecole Normale Superieure de Lyon, Université Claude Bernard Lyon, Hospices Civils de Lyon, France Abstract I graduated at the University of Lyon in 1981 working on the development of hematopoiesis in chick embryo. At the same time I started working on retrovirus oncogenes and their transformation of hematopoietic progenitor cells. I then moved to the Rockefeller University (New York) in the Lab...