Endocrine Abstracts

Contents

• Plenary Lectures
• • Society for Endocrinology Transatlantic Medal Lecture
  • • Adipose tissue as an endocrine organ

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Prediction and prevention of autoimmune thyroid disease

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Society for Endocrinology Dale Medal Lecture
  • • Corticotropin releasing factor (CRF) family of ligands and their receptors

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    • Society for Endocrinology Dale Medal Lecture

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  • British Thyroid Association Pitt Rivers Lecture
  • • Are thyroid hormone receptors good or bad for you?

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    • British Thyroid Association Pitt Rivers Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Cycling into trouble

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    • Clinical Endocrinology Trust Lecture

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• Symposia
• • Endocrinology of obesity
  • • Learning from experiments of nature

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    • Uncovering the genetic causes of common obesity

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    • Gut feeling

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    • Current approaches, future therapies

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  • Actions of insulin in non-classical target issues
  • • Insulin signalling through PI 3-kinase

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    • Insulin regulation of pancreatic beta cells

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    • Insulin effects on cell signalling and nitric oxide synthesis in vascular endothelium

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    • Insulin action in the ovary

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  • Pituitary adenomas
  • • Somatostatin and dopamine receptors in vitro

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    • Natural history of prolactinomas: lessons after withdrawal of long-term cabergoline

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    • Clinical markers of aggressive behaviour in non-functioning pituitary adenomas

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  • The extracellular calcium-sensing receptor in endocrine tissues
  • • The calcium-sensing receptor and disorders of calcium-sensing

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    • Extracellular calcium as direct modulator of bone function

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    • Calcium sensing and bone development

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  • Neural migration in neuroendocrine systems
  • • Recent advances in the understanding of GnRH neuronal migration in mammals

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    • GnRH neuronal Ontogeny - lessons from the investigation of Kallmann's Syndrome

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    • Overview of neuronal migration and axonal guidance. The role of the extracellular matrix

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    • Recent advances in pituitary development

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  • Hair: too little, too much
  • • Androgen-dependent human hair growth: a biological paradox

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    • Gene regulation and the developing hair follicle

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    • The clinical management of Hirsutism: evidence based practice

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  • Molecular basis of thyroid disease
  • • Role of cytokines and lymphocytes in Graves' disease

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    • Gene linkage and association studies in autoimmune thyroid disease

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    • Glycoprotein hormone receptors: from disease to structure and function

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    • Thyroid cancer molecular genetics: new oncogenes offer potential therapeutic targets

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  • Joint BES and EFES symposium: Neuroactive steroids: implications for disease and healthy ageing
  • • Effects of neuroactive steroids on myelination

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    • Glial cells as mediators of the neuroprotective effects of oestrogen in the central nervous system

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    • Oestrogen and stroke: the potential for harm as well as benefit

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    • Sexual dimorphism and neuroprotection by sex steroids in an animal model of Parkinson's disease

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• Clinical Management Workshops
• • Electrolyte disturbances
  • • Cerebral salt wasting

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    • Unexplained hyponatraemia - diagnosis strategies

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    • Potassium homeostasis: the renal perspective

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  • Insulin delivery systems
  • • Pancreatic islet transplantation

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    • Continuous glucose monitoring and pump technology

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    • Insulin analogues in diabetes mellitus

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  • When and how to remove the overactive parathyroid
  • • When and how to remove the overactive parathyroid

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    • Imaging and diagnosis in parathyroid disease

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• Focus Session
• • Focused Science Session
  • • Monitoring the dynamic of interaction between the insulin receptor and protein tyrosine phosphatase-1B in living cells using BRET (bioluminescence resonance energy transfer)

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• Nurses Session
• • Congenital adrenal hyperplasia
  • • Congenital adrenal hyperplasia

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    • Assessing the need for an interpreter in families of children with CAH from an ethnic background

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    • Congenital Adrenal Hyperplasia - the nurses' perspective

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• Young Endocrinologists Workshop
• • How to compete for grant funding
  • • How to compete for grant funding

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    • A good academic CV

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    • Experience with applications for fellowships

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• Molecular Endocrinology Workshop
• • Molecular Endocrinology Workshop
  • • Mammalian RNA interference pathways

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• Oral Communications
• • Reproduction
  • • Allopregnanolone is involved in reduced HPA axis responses to immune challenge in late pregnancy

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    • Gonadotrophs in annexin 1 knockout mice demonstrate enhanced secretory activity by structural analysis

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    • Decidual activation of vitamin D3 - a novel immunomodulatory mechanism in early gestation

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    • An anti-inflammatory role for progesterone at the human ovarian surface?

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    • Orlistat and metformin are equally beneficial in reducing hyperandrogenaemia in polycystic ovarian syndrome

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    • Effect of a high n-6 polyunsaturated fatty acid (PUFA) diet on COX expression and PGE2 synthesis in the ovine amnion during gestation

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    • Placental endokinins may play a paracrine role on the placental vasculature

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    • Effect of maternal dexamethasone treatment on hepatic and renal type I 5'-monodeiodinase activity and plasma triiodothyronine concentration in fetal sheep

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  • Development and growth
  • • The expression of monocarboxylate transporter 8, as a specific thyroid hormone transporter in human fetal brain and placenta: the effects of intrauterine growth restriction (IUGR)

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    • Key mitotic regulators securin and separase in the human fetal brain

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    • KAL-1 and KAL-2 ontogeny and in vitro function in human GnRH-1 developing system

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    • Alterations of the somatotrophic axis in the obese agouti (Ay/a) mouse

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    • A novel GH variant (Ile179Met) exhibits a decreased ability to activate the ERK pathway

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    • The susceptibility of growth hormone missense variants to proteolytic degradation

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    • Internalization of the GH antagonist pegvisomant

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    • Responsiveness to growth hormone (GH) is increased in obesity

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  • Thyroid
  • • Thyroid hormone (T3) activates fibroblast growth factor (FGF) receptor signalling in bone

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    • Biological consequences of gain-of-function thyrotropin receptor (TSHR) mutant expression in adipose tissue

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    • PBF predicts recurrence in thyroid cancer and potentiates the actions of PTTG in vitro

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    • Steroid modulation of peripheral cytokine expression: increased resistance to dexamethasone and progesterone inhibition of type 1 CD4+ response in autoimmune thyroiditis

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    • Gender, age, goitre type and serum TSH level predict thyroid neoplasia in 1500 patients with thyroid enlargement investigated by FNAC

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    • Defining genetic predictors for the development of Graves' disease in young females

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  • Endocrine tumours
  • • Expression of vitamin D metabolism and signalling components in breast tumours compared to paired normals

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    • Microarray analysis of IGF-I mRNA positive and negative breast tumours

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    • PPAR gamma expression in pituitary tumours

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    • Mechanisms of HER2 resistance in endocrine tumours

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    • Gamma knife sterotactic radiosurgery for acromegaly

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    • Biochemical and genetic screening in isolated and familial MEN1

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    • Clinical experience of intra-arterial calcium gluconate-stimulated hepatic venous sampling in the localisation of insulinomas

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    • Effect of human growth hormone in haemato-oncology patients receiving intensive chemotherapy. A double blind randomized, placebo-controlled study

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  • Diabetes and metabolism
  • • Inducing pancreatic beta cell regeneration; interactions of transcription factors and peptide growth factors

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    • Function of the calcium-sensing receptor in insulin-secreting MIN6 cells and human islets of Langerhans

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    • Dietary intake and the IGF-system: a study in two related populations with a markedly different dietary intake

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    • POMC haploinsufficiency in mice can cause obesity and reduced adrenal function

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    • Continuous subcutaneous administration of ghrelin results in accumulation of adipose tissue, independent of hyperphagia or body weight gain

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    • Tissue-specific alterations of glucocorticoid metabolism in ob/ob mice

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    • Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes

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    • Bacterial and yeast co-expression studies reveal hexose-6-phosphate dehydrogenase to be a crucial regulator of 11beta-hydroxysteroid dehydrogenase type 1 oxoreductase activity

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• Poster Presentations
• • Bone
  • • Failure to normalise PTH during the treatment of osteomalacia

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    • Does leptin regulate bone turnover in adult growth hormone deficiency?

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    • Oral bisphosphonates may reverse the decline in bone mineral density in adults with cystic fibrosis

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    • The role of the growth hormone-insulin-like growth factor-I (GH-IGF-I) axis in the aetiology of male idiopathic osteoporosis

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    • Growth hormone replacement is important for the restoration of PTH circadian rhythmicity in older adult growth hormone deficient patients

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    • Parathyroid hormone and phosphate circadian rhythms are altered in osteopaenic adult growth hormone deficient patients

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    • Transdermal testosterone replacement in men with evidence of borderline gonadal failure

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    • Application of new indices of bone activity for evaluation of the response to treatment of hyperthyroidism and Paget's disease

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    • Outcome of parathyroidectomy for primary hyperparathyroidism in 249 consecutive patients

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    • Inactivating progesterone metabolism in human osteoblasts

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    • Utility of biochemical screening in the context of evaluating patients with a presumptive diagnosis of osteoporosis

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    • Investigation of seasonal reference intervals for 25-Cholecalciferol (Vitamin D)

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    • The role of local corticosteroid generation in inflammation-associated bone loss

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    • Adenosine stimulates IL-6 but inhibits osteoprotegerin secretion by osteoprogenitor cells

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    • Growth retardation following prenatal GC exposure is more pronounced in the female offspring and is associated with raised serum IGF-1

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  • Comparative endocrinology
  • • Developmental changes in gonadal and adrenal steroidogenesis in the blue fox (Alopex lagopus)

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    • An appraisal of biochemical assessment of hypogonadism and bio-available testosterone in adult men

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    • Usefulness of ultrasonography in girls with true precocious puberty before and after two years of treatment with an LH-RH analogue

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    • Changes in bone mineral density in response to growth hormone replacement in adults with isolated growth hormone deficiency compared with multiple pituitary hormone deficiencies

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  • Cytokines and growth factors
  • • Glucocorticoids suppress macrophage migration inhibitory factor (MIF) expression in a cell-type specific manner

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    • Responsiveness to growth hormone throughout the menstrual cycle

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    • The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men

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    • Effects of estrogen on leptin signalling and leptin-induced TNF-alpha production

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    • Excessive daytime sleepiness associated with hypercytokinaemia in POEMS

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    • Effects of long term growth hormone replacement on leptin and body composition in adult growth hormone deficiency

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    • GHR-GPI insertion into target CHO cell membranes

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    • Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour

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    • Adrenomedullin mRNA and peptide content are increased in skin following wounding

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    • Basic fibroblast growth factor (FGF2) in hypothalamus, neurohypophysis and choroid plexus: dehydration supports a putative linkage with arginine vasopressin and fluid balance

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    • Comparison of IL-1 alpha induced gene expression in normal human ovarian surface epithelial cells and ovarian cancer cells

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    • Thyroid hormone regulates heparan sulphate proteoglycans in the growth plate

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    • Urinary human chorionic gonadotrophin (hCG) associated proteins: isolation and characterisation by peptide identification mass spectrometry

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  • Diabetes, metabolism and cardiovascular
  • • Non-alcoholic fatty liver disease among Saudi type-2 diabetics attending medical outpatient clinic

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    • The effect of DHT on the regulation of the renin angiotensin system in human abdominal subcutaneous adipocytes: implications for PCOS

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    • The effect of body mass index on duration of intensive care stay and in-hospital mortality after cardiac surgery in an Irish centre

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    • A7r5 rat aortic vascular smooth muscle cell apoptosis is reduced by testosterone

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    • Mitogen-induced apoptosis in A7r5 rat aortic vascular smooth muscle cells is not effected by testosterone

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    • Reduced insulin content and secretory capacity in the adult offspring of rats exposed to a high fat diet in pregnancy

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    • A randomised controlled trial of laser treatment among hirsute women with polycystic ovary syndrome

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    • Understanding the fetal origins of the metabolic syndrome and its amplification by obesity; high fat feeding potentiates the programming of hepatic insulin resistance by antenatal dexamethasone in rats

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    • The N363S polymorphism of the glucocorticoid receptor in South Asians in the North East

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    • PYY deficiency may reinforce obesity

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    • Improvements in glucose utilisation immediately following exercise in patients with and without type 2 diabetes seem to be independent of improvements in insulin sensitivity

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    • Effect of size at birth on glucose tolerance in pigs at 5 months of age

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    • Transcriptional interference by novel human PPARgamma mutants associated with lipodystrophic insulin resistance

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    • Single nucleotide polymorphisms within oxidative stress genes affect arterial compliance: gene function relationships

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    • A novel non-steroidal inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 improves features of metabolic syndrome in murine disease models

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    • Mechano-receptors and cell-to-cell communication in the human collecting duct: functional involvement of TRPV4 and connexin-43

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    • Increased C-jun N terminal kinase (JNK) activity may link insulin resistance and inflammation in human central obesity

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    • Circulating pro-inflammatory cytokines and epicardial expression of resistin and TNF-alpha are increased in patients with cardiovascular disease

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    • Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients

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    • The IGF system influences prevalence of the metabolic syndrome in a population with high rates of cardiovascular disease

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    • Investigation and management of severe hyponatraemia - cause for concern?

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    • TLR mediated activation of the innate immune response in human adipocytes with associated down-regulation of adiponectin secretion and elevated TNF-alpha and IL-6 levels

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    • Expression of mineralocorticoid effector mechanisms in renal biopsies of patients with severe proteinuria

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    • Testosterone regulates renal expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC)

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    • Protective effects of phytoestrogens against oxidative stress in human endothelial cells

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    • Targeted RNA interference to selectively modulate expression of PPARgamma2 and 1 isoforms

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    • Quantitative analysis of glucose and insulin sensing genes in the hypothalami of Zucker Diabetic Fatty (ZDF) rats

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    • Increased aromatase expression in human subcutaneous adipose tissue in obesity

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    • PPARgamma2 and RXRalpha are required for the transcriptional activation of the melanocortin 2 receptor during adipocyte differentiation

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    • Physiological concentrations of testosterone inhibit extracellular calcium entry via voltage-gated calcium channels in A7r5 vascular smooth muscle cells

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    • Testosterone inhibits Ca2+ currents in A7r5 vascular smooth muscle cells, and in HEK293 cells stably expressing the alpha1C subunit of L-type Ca2+ channels (CaV1.2) and alpha1H T-type Ca2+ channels (CaV3.2)

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    • High prevalence of low testosterone in men with type 2 diabetes and an association with glycaemic control and obesity

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    • Leptin increases lipid peroxidation in the mouse brain

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    • Testosterone-induced vasodilatation of isolated human mesenteric and pulmonary resistance arteries is independent of the vascular endothelium

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    • Evaluation of the in-house radioimmunoassay method for peptide YY (PYY)

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    • Diastolic blood pressure, waist circumference and cardiovascular disease in patients with obesity and type 2 diabetes

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    • Diabetes risk in Turner syndrome - a unique metabolic defect?

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    • The metabolic syndrome is common in type 2 but uncommon in type 1 diabetes mellitus

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    • Diabetes knowledge deficits in adolescents and young adults with type 1 diabetes mellitus

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    • Maternal serum hCG binding to immobilised wheat germ agglutinin in women with and without type 1 diabetes mellitus

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    • A comparison of the impact of exercise in Asian and Caucasian women with Polycystic Ovary Syndrome

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    • Exercise instruction in patients with type 2 diabetes and obesity: a randomised controlled trial

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    • Characteristics and outcome of severe hyponatraemia - a case control study

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  • Endocrine tumours and neoplasia
  • • Galectin-3 staining of benign and malignant thyroid lesions - is it a useful diagnostic tool?

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    • A case of severe Cushing's disease in a treated non-functioning pituitary adenoma with difficult medical management

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    • Proliferation of colon cancer cell line and parathyroid hormone-related peptide gene

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    • Is there an ultra-short loop feedback of ACTH on itself?

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    • FSH-secreting pituitary gonadotroph adenoma producing ovarian hyperstimulation

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    • Deacetylating agents as mediators of iodide uptake and efflux in thyroid and breast

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    • Over-expression and over-activation of protein kinase B/Akt in human pituitary tumours

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    • An audit of acromegaly in North-East Scotland: increased use of medical therapy enables preservation of pituitary function

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    • The cyclin E specific F-box protein archipelago is over-expressed in pituitary tumours

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    • Urinary free metadrenalines provide the best diagnostic biochemical test for phaeochromocytoma; experience in a tertiary care centre

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    • A clinic for multiple endocrine neoplasia highlights needs for greater family awareness of type 1 MEN and for genetic testing of other family members

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    • Association between serum insulin-like growth factor-1 and serum growth hormone levels across an oral glucose tolerance test in assessing disease activity in acromegaly

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    • Ovarian stromal luteoma - a rare cause of postmenopausal virilization diagnosed by selective ovarian venous sampling

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    • The GnRH test in the assessment of patients with pituitary and parapituitary lesions. Results of a 5-year retrospective study

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    • Adrenal incidentalomas and insulin resistance - a simple coincidence or a complex syndrome?

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    • Should post hypophysectomy patients be discharged on steroids? The use of 0900h-cortisol measurements as a screening test for pituitary-adrenal dysfunction

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    • Inhibition of cell proliferation, but lack of antiangiogenic effect on GH-secreting pituitary adenomas treated with Lanreotide

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    • A new operation for adrenal pathology: laparoscopically-assisted mini-adrenalectomy

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    • Somatostatin and VEGF expression within the larynx

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    • The effects of surgery and tamoxifen on serum IGF-I and IGFBP3 levels in breast cancer

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    • Results of different primary treatment procedures for acromegalic patients

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    • Transcriptional silencing of the IGF-I receptor inhibits proliferation of MCF-7 breast cancer cells

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    • Diagnosis - 'query acromegaly'

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    • Factors determining remission of microprolactinomas after dopamine agonist withdrawal

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    • Pituitary tumor transforming gene (PTTG) regulates downstream angiogenic genes in thyroid cells

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    • Clinical studies of patients with neuroendocrine tumours (NETs)

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    • IGF-I and IGFBP-3 mRNA expression in tamoxifen-resistant, recurrent breast cancers

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    • IGF-I and IGFBP-3 mRNA expression in tamoxifen-resistant, recurrent breast cancers

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    • A somatostatin analogue and octreotide exert anti-proliferative effects on colonic cancer cells

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    • Imbalance between separase and securin levels in thyroid and other malignancies

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    • The effects of ghrelin on IGF-I expression in normal and malignant breast tissue explants

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    • Prevalence of hypopituitarism in patients with prolactin-secreting pituitary microadenomas

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    • Systemetic dose extension of octreotide LAR - the importance of individual tailoring of treatment

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    • Investigation into the efficacy of routine octreotide scanning in post-operative acromegalics with refractory disease

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    • Octreotide dependency: a cautionary tale

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    • Expression of SSTR subtypes (1-5) in normal and malignant colonic tissue

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    • Metastatic glucagonoma de-differentiated to an insulinoma: response to embolization

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    • Long acting somatostatin analogues administered by practice nurses: an audit

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    • Long-term remission following withdrawal of dopamine agonist therapy in subjects with microprolactinomas

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    • The effects of pituitary tumours on cognitive function

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    • Novel actions of the anti-estrogen faslodex at the estrogen receptor

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    • Managing prolactinomas: our experience at Preston

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    • Expression and localisation of BAD and Akt in human breast cancer cell lines pre- and post-irradiation

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    • Bilateral laparoscopic adrenalectomy for ACTH-dependent Cushing's syndrome

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    • BIM-23244, a somatostatin analogue with high affinity for somatostatin receptors 2 and 5, inhibits endothelial proliferation in vitro

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    • Discrepancies between current consensus criteria for cure after transsphenoidal surgery for acromegaly

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    • Retrospective audit of bilateral adrenalectomies with reference to the occurrence of Nelson's syndrome

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    • Parathyroid imaging: which modality best inform surgical treatment?

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    • The efficacy of an octreotide test dose to predict the outcome of treatment for acromegaly with somatostatin LAR

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    • The changing patterns of presentation and treatment of acromegaly in the UK as reflected by the UK National Acromegaly Database

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    • Improved quality of life (QOL) with normalisation of IGF-I in patients with acromegaly

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    • 24-hour ambulatory blood pressure monitoring (ABPM) in patients with acromegaly and the value of clinic blood pressure measurements

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    • Regional variations in colonic neoplasia in acromegaly

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  • Growth and development
  • • The effect of nutritional deprivation in late gestation on uncoupling protein-2 mRNA abundance in the ovine neonatal lung

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    • Possible factors determining individual sensitivity to GH replacement therapy; a KIMS database analysis

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    • Do prolonged courses of testosterone affect final height in extreme maturational delay?

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    • The hydration fraction of lean body mass (LBM) does not change during six months physiological GH replacement in adults with severe GHD

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    • The relationship between maternal thyroid status in the antenatal period and new born growth measurements: a cohort study

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    • Quality of life (QOL) improvement, during physiological GH replacement in severely GHD adults, is not explained by favourable changes in body composition

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    • Leptin and leptin receptor localisation in endocrine glands of fetal sheep

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    • The value of the TRH test in the assessment of hypothalamic-pituitary disorders in children

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    • Frequency of single nucleotide polymorphisms in the GHRH receptor gene in short children

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    • A dominant negative thyroid hormone receptor (TR) beta1 mutant enhances N-Tera-2 (NT2) cell proliferation

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    • Transdermal testosterone application: pharmacokinetics and effects on pubertal status, short-term growth and bone turnover

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    • Long-term association of the Y chromosome and blood pressure in boys at the pre- and post-pubertal periods

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    • Growth hormone replacement reduces circulating inflammatory markers, blood pressure and large artery compliance but does not affect resistance artery function in adult hypopituitary patients

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    • Regulation of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1) paracrine pathway by thyroid hormone (T3) during bone development

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    • Pregnancy-induced plasticity in rat pituitary: a morphological and endocrine study of somatotroph and lactotroph function

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    • Gene expression in peripheral blood mononuclear cells: the effect of GH in a GH-deficient child

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  • Neuroendocrinology and behaviour
  • • The insulin tolerance test (ITT) in clinical practice: the experience of a busy pituitary unit

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    • Cardiovascular risk burden in adult patients with hypopituitarism

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    • Incorporating social preferences in the measurement of QoL outcomes in growth hormone deficiency (GHD) in adults

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    • Neuroendocrine abnormalities in the acute phase of traumatic brain injury

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    • Investigating the potential role of melanocortin receptor 5 in the rodent adrenal gland

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    • Quality of life deficit in hypopituitary adults with growth hormone deficiency (GHD): comparison of age-sex matched patient data and a UK population survey

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    • Downward resetting of the osmotic threshold for thirst in patients with syndrome of inappropriate antidiuretic hormone

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    • Nephrogenic diabetes insipidus in the mouse does not deplete vasopressin neurons or activate oxytocin neurons

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    • Comparison of anterior pituitary annexin 1 expression in male/female and old/young Long Evans and Brattleboro rats

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    • Prevalence of hypopituitarism in survivors of traumatic brain injury

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    • The effect of oestrogen replacement therapy (ORT) on growth hormone (GH) dose; KIMS database perspective

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    • Metastatic glucagonoma transforming to an insulinoma

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    • Investigation of the hypothalamo-pituitary-adrenal axis in patients with irritable bowel syndrome

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    • DNA microarray analysis of NECA action in a pituitary folliculostellate cell line

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    • Imaging of the pituitary is indicated in marginal hyperprolactinaemia (lt1000 milliunits per litre) to detect microadenoma

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    • Effects of melatonin on catecholaminergic neurotransmitters in brain areas regulating food intake in the male rat

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    • The acute octreotide suppression test is useful in predicting long-term responses to depot somatostatin analogue injections in patients with active acromegaly

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    • Effects of melatonin on the regulation of leptin production in rat anterior pituitary cells

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    • Primary therapy with somatostatin analogues in acromegaly does not restore orderly GH secretion

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    • Down-regulation of neurotrophin receptor expression limits the regenerative potential of injured CNS neurons

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    • Functional interactions between anosmin-1, heparan sulphate and urokinase-type plasminogen activator and the pathogenesis of X-linked Kallmann's Syndrome

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    • Are cortisol responses to psychological stress related to size at birth in humans?

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    • Addition of dopamine agonists to somatostatin analogue therapy improves biochemical control of acromegaly

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    • Variability in GH assays undermines the value of consensus criteria for the diagnosis of adult GH deficiency and acromegaly

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    • The role of the melanocortin 5 receptor in the hypothalamic regulation of appetite and pituitary function

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  • Reproduction
  • • Leptin, inhibin B and LH levels in patients with anorexia nervosa

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    • Regulation of ovine placentome morphology by cortisol in late gestation

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    • The effect of insulin-like growth factor I (IGF-I) on initiation of follicle growth in normal and polycystic ovaries in vitro

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    • Specificity and clinical utility of methods for the detection of macroprolactin

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    • New approach in treatment of hyperandrogenism with triiodothyronine

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    • Effect of supplementing the maternal diet with excess energy during late gestation on body fat deposition, reproductive performance and plasma insulin concentration in pigs

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    • The effects of thyroid hormone on cytokine-induced proliferation in human trophoblast cells

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    • Oral tibolone combined with testosterone as a potential male contraceptive: pharmacodynamic study examining additive effects in suppression of pituitary-testicular axis

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    • Routine screening for macroprolactin

      ea0007p178
    • Microarray studies of human ovarian surface epithelium exposed to an inflammatory stimulus

      ea0007p179
    • Peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists increase glucose metabolism in a human granulosa cell line (HGL-5)

      ea0007p180
    • The CAM technique and follicle development

      ea0007p181
    • Paint thinner exposure inhibits testosterone synthesis and secretion in a reversible manner in the rat

      ea0007p182
    • Ultrastructural and immunohistochemical examination of effects of leptin on testis in mice

      ea0007p183
    • Stimulatory effects of ghrelin on spontaneous contractions in the rat myometrium

      ea0007p184
    • The expression of somatostatin receptors in human granulosa cells

      ea0007p185
    • Anti-Mullerian hormone (AMH) protein expression in normal and polycystic human ovaries

      ea0007p186
    • Effects of oral nomegestrol acetate, a 19 norprogesterone-derived progestin on the reproductive axis and lipids in men

      ea0007p187
    • Follow up of women with Turner's syndrome in an adult endocrine clinic

      ea0007p188
    • TGFbeta signaling pathways in LHRH neurons

      ea0007p189
    • Mullerian Inhibiting Substance is elevated in obese women with PCOS and is suppressed by metformin treatment

      ea0007p190
    • Protein kinase (PKA)-independent but cAMP-dependent regulation of progesterone secretion by luteinizing human granulosa cells

      ea0007p191
    • Intramuscular testosterone (T) undecanoate for the treatment of male hypogonadism: a parallel-group randomised open-label pharmacokinetic study

      ea0007p192
    • Neurokinin B-like immunoreactivity can be detected in peripheral tissues in the non-pregnant rat

      ea0007p193
    • Biochemical evidence for follicular maturation (1): changes of inhibins and activin-A levels in follicular fluid from matched follicles

      ea0007p194
    • Analysis of hCG beta core fragment glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry

      ea0007p195
    • Biochemical evidence for follicular maturation (2): production of progesterone, inhibins and activin-A by granulosa cells from size matched follicles

      ea0007p196
    • Clinical interpretation of macroprolactin reports

      ea0007p197
  • Steroids
  • • Conventional corticosteroid replacement therapy may overtreat adult hypopituitary patients with partial ACTH deficiency

      ea0007p198
    • Glucocorticoids contribute to the heritability of leptin in Scottish adult female twins

      ea0007p199
    • Patients' knowledge and satisfaction on the management of steroid replacement therapy

      ea0007p200
    • The origin of 18-hydroxycortisol and 18-oxocortisol in man

      ea0007p201
    • Sweat patch cortisol - a new screen for Cushing's syndrome

      ea0007p202
    • Dehydroepiandrosterone sulphate (DHEAS) inhibits growth of human vascular endothelial cells

      ea0007p203
    • Inhibition of steroid 5beta-reductase by bile acids

      ea0007p204
    • Adequacy of patient understanding about glucocorticoid replacement

      ea0007p205
    • Regulation of 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat adrenal gland and central nervous system by ACTH and dexamethasone

      ea0007p206
    • Local inflammation activates the renal vitamin D hormonal system in human kidneys

      ea0007p207
    • The testicular feminised mouse: physiological testosterone replacement

      ea0007p208
    • The effect of adrenalectomy on 11beta-hydroxylase(CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the hippocampus

      ea0007p209
    • Quantitative analysis of plasma 17-hydroxyprogesterone using isotope dilution mass spectrometry

      ea0007p210
    • Spironolactone interference in the immunoassay of androstenedione

      ea0007p211
    • Role of PPAR-gamma receptor agonist therapy in two patients with newly diagnosed pituitary-dependent Cushing's syndrome

      ea0007p212
    • Local regeneration of glucocorticoids by 11betaHSD-1 within the vessel wall modulates angiogenesis

      ea0007p213
    • Lipopolysaccharide (LPS) stimulates cortisol secretion via toll-like receptors and COX-2 activation

      ea0007p214
    • An AP-1-like site is required for basal activity of the murine ACTH receptor (MC2-R) promoter in Y1 cells

      ea0007p215
    • The inhibition of human hair growth by 17beta-oestradiol using whole follicle organ cultures

      ea0007p216
    • Molecular basis of a new form of congenital adrenal hyperplasia

      ea0007p217
    • The impact of endogenous cortisone on bone and fat: demonstration of in vivo 11beta-hydroxysteroid dehydrogenase type 1 activity

      ea0007p218
    • Hexose 6-phosphate dehydrogenase expression confers reductase activity upon 11 beta-HSD1 in adipose tissue

      ea0007p219
    • Secretogogues induce transcription factor, SF-1 and co-activator, SRC-1 activity in the human adrenal gland

      ea0007p220
    • Mineralocorticoid replacement in patients with primary hypoadrenalism; does plasma renin concentration help in practice

      ea0007p221
    • A model for evaluating 11beta-hydroxysteroid dehydrogenase type 1 activity in ocular and orbital tissues

      ea0007p222
    • 11beta-hydroxysteroid dehydrogenase type 1 and the production of cerebrospinal fluid

      ea0007p223
    • Reproducibility of cortisol day curve in monitoring patients on long-term Hydrocortisone Replacement Therapy

      ea0007p224
    • Gene expression responses induced in kidney by aldosterone excess and salt

      ea0007p225
  • Thyroid
  • • Outcome of atrial fibrillation complicating hyperthyroidism

      ea0007p226
    • No association of a polymorphism in the kozak sequence of the CD40 gene and Graves' disease in a UK Caucasian population

      ea0007p227
    • Congenital hypothyroidism (CH) in the United Arab Emirates (UAE) - past, present and future

      ea0007p228
    • Twenty-four hour hormone profiles of TSH, free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy

      ea0007p229
    • Thyroid hormones and TPO-antibodies in the cord blood of newborns

      ea0007p230
    • Pretibial myxoedema as the first manifestation of Graves disease

      ea0007p231
    • Thyroxine replacement monitoring using a computerised register: the North Trent experience

      ea0007p232
    • Estimators of number- and volume-weighted mean volume of colloid in the thyroid gland of rats

      ea0007p233
    • Adjunctive lithium improves outcome in patients given radioiodine for hyperthyroidism

      ea0007p234
    • Evaluation of thyroid function in patients with chronic active HCV and HBV hepatitis treated with interferon-alpha

      ea0007p235
    • Hypothyroidism is less frequent following radioactive iodine treatment for toxic nodular goitre than Graves' disease

      ea0007p236
    • Seaweed as a model for iodide uptake and retention in the thyroid

      ea0007p237
    • Multiple thyroid tumours

      ea0007p238
    • Specific effect of thyrotropin on thyroglobulin and on the polypeptides distribution in cultured human thyroid cells

      ea0007p239
    • Defining aetiological variants within the HLA class II region that lead to the development of Graves' disease

      ea0007p240
    • The evaluation of arterial stiffness in subclinical hypothyroidism

      ea0007p241
    • Premature birth and fetal growth retardation in nonautoimmune hyperthyroidism due to activating thyrotropin receptor gene mutation

      ea0007p242
    • Controlled anti-natal thyroid screening study (CATS) - early results

      ea0007p243
    • The expression of mRNA for thymidine kinase 1 (TK1), deoxycytidine kinase (dCK), and thymidine phosphorylase (dThdPase) in the tissue of papillary thyroid carcinoma (PTC) and of medullary thyroid carcinoma (MTC) in humans

      ea0007p244
    • Does thyroidectomy exacerbate or relieve the throat symptoms of globus pharyngeus?

      ea0007p245
    • Electrocardiographic changes in patients with hypothyroidism

      ea0007p246
    • Regulation of the angiopoietins in thyroid follicular cells

      ea0007p247
  • Clinical case reports
  • • X-linked hypopituitarism: clinical and biochemical features of a rare cause of short stature

      ea0007p248
    • Cocaine use a risk factor for DKA

      ea0007p249
    • Osteomalacia precipitated by growth hormone treatment in the adult: increased bone turnover unmasking occult vitamin D deficiency

      ea0007p250
    • Adrenal insufficiency as the second clinical manifestation of the primary antiphospholipid antibody syndrome

      ea0007p251
    • Paradoxical urine and plasma cortisol response to dexamethasone: probable Carney Complex with micronodular adrenal hyperplasia

      ea0007p252
    • Myocardial infarction due to coronary artery spasm in a patient with thyrotoxicosis

      ea0007p253
    • Puerperal hypoglycaemia in a young woman with type 1 diabetes mellitus

      ea0007p254
    • Coeliac disease as a cause for delayed presentation of hypopituitarism

      ea0007p255
    • Thyrotoxicosis due to Graves' disease in a patient on immunosuppressive therapy for psoriasis

      ea0007p256
    • Transformation of a micro-prolactinoma to a macro-prolactinoma during pregnancy without symptoms or signs of pituitary enlargement: two case reports

      ea0007p257
    • Severe hypercalcaemia in Graves' disease

      ea0007p258
    • Diagnostic difficulty in differentiating between meningioma and pituitary adenoma

      ea0007p259
    • Pitfalls in the management of hypocalcaemia: refractory hypocalcaemia after thyroidectomy not caused by postoperative hypoparathyroidism

      ea0007p260
    • Hypothalamic cavernous haemangioma presenting with hypothalamic syndrome and secondary hypogonadism

      ea0007p261
    • Acquired von Willebrand's disease secondary to autoimmune hypothyroidism

      ea0007p262
    • A case of the pituitary resistance to thyroid hormone successfully treated with bromocriptine

      ea0007p263
    • Hyponatremia and recurrent abdominal pain

      ea0007p264
    • Cushing's disease and coexistent craniopharyngioma - report of a case

      ea0007p265
    • Is there an association between serum calcium concentrations and endoscopic diagnosis in patients with dyspeptic symptoms?

      ea0007p266
    • A vicious cycle of profuse diarrhoea, hypokalaemic renal failure and elevated gut hormone levels unmasking a neuroendocrine pancreatic tumour

      ea0007p267
    • The pituitary lesion that escaped the knife

      ea0007p268
    • Primary and secondary hypogonadism in systemic sarcoidosis: indications for corticosteroid therapy

      ea0007p269
    • Truly rare - a true hermaphrodite

      ea0007p270
    • Normoprolactinaemic galactorrhoea in a male-to-female transsexual

      ea0007p271
    • Myxoedema coma with pericardial effusion and respiratory arrest in a 59-year-old woman

      ea0007p272
    • Development of GH secretion and malignant change in a giant prolactinoma

      ea0007p273
    • Crooke Cell Adenoma: case report of a rare but aggressive tumour

      ea0007p274
    • Bilateral laparascopic adrenalectomy as a palliative procedure for resistant ectopic ACTH producing small cell carcinoma of the lung: a case report

      ea0007p275
    • The evolution of diabetes insipidus in a man with multiple pathology in the sacrum

      ea0007p276
    • A diagnostic pitfall: concomitant occurrence of macroprolactinaemia and a non-secreting pituitary adenoma

      ea0007p277
    • Primary hypopituitarism as a first presentation of sarcoidosis - 2 case reports

      ea0007p278
    • A novel 17 alpha hydroxylase mutation (CYP 17) associated with a pelvic germ cell tumour

      ea0007p279
    • Surgical treatment of children with neonatal severe hyperparathyroidism

      ea0007p280
    • Recognition of Smith Lemli Opitz syndrome by characteristic steroids

      ea0007p281
    • Pituitary sarcoidosis with disappearing mass: case report

      ea0007p282
    • A case of undiagnosed multiple endocrine neoplasia type 2B (MEN 2B)

      ea0007p283
    • Late recovery of pituitary function following traumatic brain injury

      ea0007p284
    • Hypocalcaemia and hypomagnesaemia as a complication of Cronkhite-Canada syndrome

      ea0007p285
    • Porphyria cutanea tarda complicated by primary hepatocellular carcinoma

      ea0007p286
    • Post menopausal virilisation

      ea0007p287
    • Testosterone-replacement stimulated hyperprolactinaemia

      ea0007p288
    • A case of non-classical 11-beta hydroxylase deficiency

      ea0007p289
    • Spontaneously resolving hypopituitarism followed by primary adrenal lymphoma-related phenomena?

      ea0007p290
    • A case of adrenal failure secondary to metastasis from a breast angiosarcoma

      ea0007p291
    • A case of severe congenital adrenal hyperplasia treated successfully with laparoscopic bilateral adrenalectomy

      ea0007p292
    • Ectopic pancreas presenting as dyspepsia

      ea0007p293
    • Ectopic ACTH syndrome presenting with epistaxis and hypertension: a case report

      ea0007p294
    • Tuberculous thyroiditis - a rare cause of hyperthyroidism

      ea0007p295
    • Multiple endocrine disturbances in a 15-year old girl with intranial tuberculomas

      ea0007p296
    • Gestational diabetes insipidus, severe hypernatremia and hyperemesis gravidarum in a primigravid pregnancy

      ea0007p297
    • The use of 17 hydroxyprogesterone and short synacthen tests in patients diagnosed with polycystic ovarian syndrome

      ea0007p298
    • Human chorionic gonadotrophin responsive adrenal cortical carcinoma and Cushing's Syndrome in pregnancy

      ea0007p299
    • Severe reactive hypoglycaemia alleviated by acorbose administration

      ea0007p300
    • Complete right vocal cord paralysis: a very rare complication of radioiodine therapy for hyperthyroidism

      ea0007p301
    • Radiotherapy is more effective than growth hormone in treating haemangiopericytoma induced hypoglycaemia

      ea0007p302
    • Short stature in thalassemia major: multiple aetiologies

      ea0007p303
  • Clinical practice
  • • An audit to evaluate the second radioiodine challenge scan in patients with thyroid cancer

      ea0007p304
    • Audit of follow-up for patients on long-term amiodarone and the incidence of amiodarone induced thyrotoxicosis

      ea0007p305
    • Audit of thyroid surgery in a district general hospital

      ea0007p306
    • Incidence and prevalence of thyroid dysfunction in the general population of Tayside, Scotland

      ea0007p307
    • A change in role for the endocrine nurse specialist - a survey

      ea0007p308
    • Mutation testing in multiple endocrine neoplasia (MEN1): an audit

      ea0007p309
  • Novartis Award Posters
  • • KAL-1 and KAL-2 ontogeny and in vitro function in human GnRH-1 developing system

      ea0007np1
    • Bacterial and yeast co-expression studies reveal hexose-6-phosphate dehydrogenase to be a crucial regulator of 11beta-hydroxysteroid dehydrogenase type 1 oxoreductase activity

      ea0007np2