Focused Science Session

ea0007s43 | Focused Science Session | BES2004

Monitoring the dynamic of interaction between the insulin receptor and protein tyrosine phosphatase-1B in living cells using BRET (bioluminescence resonance energy transfer)

Boute N , Boubekeur S , Lacasa D , Issad T

Objective: PTP1B is a protein tyrosine-phosphatase, predominantly localized on the endoplasmic reticulum, which plays a major role in the regulation of the tyrosine-kinase activity of the insulin receptor (IR). A better understanding of the dynamics of the interaction between the IR and PTP1B constitutes a major task for the development of compounds that will improve insulin sensitivity.Methods: The BRET methodology represents a major advance for the stu...

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Endocrine Abstracts

23rd Joint Meeting of the British Endocrine Societies with the European Federation of Endocrine Societies

Focus Session

Monitoring the dynamic of interaction between the insulin receptor and protein tyrosine phosphatase-1B in living cells using BRET (bioluminescence resonance energy transfer)

BiosciAbstracts