Endocrine Abstracts

Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum haemorrhage. It is characterized by varying degrees of anterior pituitary dysfunction and GH is one of the earliest hormones lost. We have compared patients with Sheehan's syndrome (n=189) and with non-functioning pituitary adenoma (NFPA; n=117) to determine whether adult GH deficient patients with Sheehan's syndrome have different baseline characteristics and whether they respond in ...

Past studies in Pekin ducks have indicated that the sensitivity of the avian kidney to the antidiuretic action of arginine vasotocin (AVT), the avian antidiuretic hormone, differs with the osmotic status of the birds (1). The objective of this study was to determine whether this modulation involves an interaction with prostaglandins (PG's).The study was carried-out in vivo, using 8 unanaesthetized Pekin ducks given an intravenous maintenance infusion of either 200 mosmolal...

IntroductionPlasma osmolality is used to investigate fluid and electrolyte abnormalities. The objective of this study was to investigate the degree of agreement between 2 routinely used osmometers and to compare this to clinical requirements.Methods49 plasma specimens were analysed once using the Advanced Micro-osmometer model 3MO and the Advanced Micro-osmometer plus model 3MO. These freezing-point depression based osmometers were calibrated using the same calibra...

Dent's disease is an X-linked renal tubular disorder characterised by low molecular weight proteinuria, hypercalciuria, and nephrolithiasis. The disease is caused by inactivating mutations of a renal-specific chloride channel, hCLC-5, that belongs to the family of mammalian voltage-gated chloride channels (CLCs). Heterologous expression of wild-type CLC-5 in Xenopus oocytes results in chloride (Cl-) conductance, which is markedly reduced or abolished by the m...