Endocrine Abstracts

Contents

• Plenary Lectures
• • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Neuroendocrine regulation of bone mass - GH deficiency and resistance states

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Society for Endocrinology Dale Medal Lecture
  • • How the brain controls appetite

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    • Society for Endocrinology Medal Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • Steroidogenic factor 1, a key mediator of endocrine development

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • British Thyroid Association Pitt-Rivers Lecture
  • • The Na++/I- - symporter (NIS): Physiological and pathophysiological implications

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    • British Thyroid Association Pitt-Rivers Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Growth hormone outgrows growth

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    • Clinical Endocrinology Trust Lecture

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• Symposia
• • Androgens and Prostate Cancer
  • • Androgen action in the prostate

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    • Androgens vs estrogens in prostate cancer

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    • Survey of gene expression during prostate cancer progression using tissue microarrays

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  • Trophic Control of Size
  • • Genes and growth and endocrine diseases

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    • Growth regulation during Drosophila development

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    • The role of the EG-VEGF family in the regulation of angiogenesis in endocrine glands

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  • Apoptosis/Survival Signalling
  • • Building and demolishing cancers in vivo

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    • The role of mitochondria in cell death

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    • Phosphoinositide 3-kinase dependent lipid signals in cellular survival responses

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    • Cell proliferation and death in endocrine glands: The corpus luteum paradigm

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  • Dominant Endocrine Cancer Syndromes
  • • VHL and the genetics of phaeochromocytoma

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    • VHL and HIF, a basis for VHL pathogenesis

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    • Function of menin, product of the MEN1 tumor suppressor gene

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    • Genetics and management of multiple endocrine neoplasia type 1 (MEN1)

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  • The Adipocyte as an Endocrine Organ
  • • The role of adiponectin in carbohydrate and lipid metabolism

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    • Monogenic obesity

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    • Nuclear receptors in metabolic control

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    • Reduced intra-adipose glucocorticoid regeneration: A novel adaptive response to, and therapy for, the metabolic syndrome

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  • Prolactin: Novel Aspects
  • • Regulation of prolactin gene expression

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    • Prolactin receptor expression and prolactin-mediated effects in adipose tissue

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    • Role and regulation of decidual PRL expression: Implications for pregnancy failure

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    • PRL and its antagonist: The yin and yang of growth versus differentiation

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  • Hot Topics
  • • Effects of interleukin-6 (IL-6) deficiency on exercise capacity in mice

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    • Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: A cohort study

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    • A natural product that lowers cholesterol as an antagonist for the bile acid receptor FXR

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  • Radioiodine Biology in the 21st Century
  • • Thyroid eye disease and radioiodine therapy for Graves' hyperthyroidism

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    • NIS and thyroid cancer

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    • The molecular genetics of post Chernobyl thyroid cancer

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• Clinical Management Workshops
• • Fatigue. Is it Endocrinology?
  • • Management of chronic fatigue

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    • The neuroendocrinology of chronic fatigue syndrome

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    • Psychiatry and chronic fatigue

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  • HRT - The Good, the Bad and the Ugly
  • • HRT and the heart

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    • The effect of oestrogen on brain ageing

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    • HRT and fracture prevention

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    • HRT and fracture prevention

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  • Management of Craniopharyngioma
  • • Hypothalamic syndromes: Their investigation and treatment in comparison with craniopharyngiomas

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    • To irradiate or not to irradiate craniopharyngiomas

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    • Quality of survival and prognosis for children with craniopharyngioma

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• Focused Science Session
• • Tissue Engineering in Endocrinology
  • • Tissue engineering

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    • Tissue engineering: The study of human embryonic stem cells

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• Nurses Session
• • Ethical Dilemmas
  • • Understanding the matter of consent

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    • Ethical implications of tissue retrieval

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    • When the results don't match the symptoms ndash the use and abuse of thyroxine medication in hypothyroidism

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• Young Endocrinologists Workshop
• • Alternative Careers for Endocrine Researchers
  • • Clinical biochemistry

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    • Research for clincial paediatric endocrinologists

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    • Sales opportunities in biotech firms

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    • A career in medical education and communication

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• Oral Communications
• • Reproduction and Development
  • • Agonists of peroxisome proliferator-activated receptor-gamma (PPARgamma) regulate steroidogenesis in a human granulosa cell line (HGC-5)

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    • A functional polymorphism in the extrapituitary prolactin promoter has opposing effects on prolactin gene expression in T-lymphocytes and endometrial stromal cells but is not associated with unexplained recurrent miscarriages

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    • Lipocortin-1 is modulated by glucocorticoids in the human endometrium

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    • Early developmental indices of placental growth restriction in the overfed adolescent sheep

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    • Angiotensinogen; the key to programming female hypertension?

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    • Hypoxia-ischaemia and the insulin-like growth factor (IGF) family at birth

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    • Metformin is more effective than Dianette in the treatment of hirsutism in women with PCOS

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    • Classification of the spectrum of aortic dysmorphology by magnetic resonance imaging in adults with Turner syndrome

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  • Cardiovascular Endocrinology
  • • Use of glucocorticoids and risk of cardiovascular disease in a population-based cohort study of 164,133 participants

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    • Genomic analysis of congenic rat strains identifies a new candidate gene for human hypertension

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    • Characterisation of the metabolic syndrome in the stroke prone spontaneously hypertensive rat and the contribution of the Y chromosome

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    • Corticosteroid effects at the trafficking level on the pathway of key importance in blood pressure control

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    • Assessment of the vasodilatory action of testosterone in isolated human pulmonary and mesenteric arteries and veins

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    • A single nucleotide polymorphism in the p22phox gene affects arterial compliance

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    • A novel PPAR gamma mutation (R357X), associated with partial lipodystrophy, helps define the phenotype of the human PPAR gamma ligand resistance (PLR) syndrome

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    • Identification of novel glucocorticoid receptor isoforms in rat and human lung

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  • Obesity and Diabetes
  • • Autocrine FGF-2 is essential for human preadipocyte differentiation

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    • Expression of adiponectin protein in human fat: the effect of type 2 diabetes and obesity

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    • Obesity reduces resistin immunoreactivity in mouse brain

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    • PYY and decreased appetite following jejunum intestinal bypass in rats

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    • 5alpha-Reduced glucocorticoid metabolites: Novel endogenous activators of glucocorticoid receptors(GR)

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    • Defining the molecular basis for apparent cortisone reductase deficiency reveals a novel redox potential mechanism within the endoplasmic reticulum

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    • Expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 are increased following weight loss

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    • Downstream consequences of increased 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) activity and mRNA in adipose tissue in human obesity

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  • Brain and Behaviour
  • • Novel methods of delivery of neurotrophic growth factor genes to CNS neurons

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    • 11beta-Hydroxysteroid dehydrogenase type 2 (11beta-HSD2), a protector of the developing brain

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    • Adenosine-induced IL-6 expression in pituitary folliculostellate cells is mediated via A2b adenosine receptors coupled to p38 MAPK

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    • Follistatin is secreted from pituitary folliculo-stellate cell lines by an ABCA1 transporter

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    • Decreased anxiety-related behaviour and increased spatial memory retention in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice

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    • Elevated circulating levels of cocaine- and amphetamine regulated transcript (CART) in anorexia nervosa

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    • A role for arcuate cocaine and amphetamine regulated transcript in hyperphagia, thermogenesis and cold adaptation

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    • Localisation and regulation of cocaine- and amphetamine-regulated transcript (CART) in the anterior pituitary gland

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  • Thyroid and Calcium
  • • Contrasting skeletal phenotypes in mice with an identical mutation targeted to either the TRalpha or TRbeta gene

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    • Abnormalities of thyroid function in the POMC-null mouse

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    • Five human thyroid hormone receptor beta1 5'-UTR isoforms differentially regulate levels of gene expression and protein translation in individual tissues

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    • Prophylactic steroids are unnecessary in patients with thyroid-associated ophthalmopathy receiving radioiodine therapy

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    • Sodium-iodide (NIS) gene expression is a potential prognostic indicator for thyroid cancer and is inhibited by pituitary tumor transforming gene (PTTG)

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    • Idiopathic (Normocalcaemic) hypercalciuric nephrolithiasis due to an activating calcium sensing receptor mutation

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    • Parafibromin germline mutations in patients with parathyroid tumours

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    • Matrix metalloproteinase 13 (MMP13) mutation causes spondyloepimetaphyseal dysplasia (SEMD), Missouri variant

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• Poster Presentations
• • Bone
  • • Osteoblastic gene expression in cells of the adipocytic lineage

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    • Effect of active acromegaly on parathormone circadian rhythm and phosphocalcium metabolism

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    • Functional and association studies of calcium sensing receptor polymorphisms and mediators of calcium homeostasis

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    • Hormone replacement treatment (HRT) increases circulating insulin-like growth factor binding protein-4 concentration

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    • Determination of a correlation between release of beta c-terminal telopeptides and area of resorption by recombinant rankl-generated human osteoclasts

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    • Parathyroid responsiveness to parathyroid hormone (1-34) infusion is altered in adult growth hormone deficiency following growth hormone replacement

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    • Effects of thyroid hormone (T3) on fibroblast growth factor signalling in bone

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    • IGF-I reverses dexamethasone induced growth retardation in mouse embryonic metatarsal cultures

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    • Comparison of PTH concentration and phosphocalcium metabolism in treated adult growth hormone deficient patients with normal and reduced bone mineral density

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    • The Short Stature Homeobox containing Gene (SHOX) inhibits alkaline phosphatase (ALP) production by C3H10T1/2 cells treated with retinoic acid (RA)

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    • Effects of growth hormone replacement on parathyroid gland responsiveness to hypo- and hypercalcaemic stimuli in adult growth hormone deficiency

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    • Iranian national osteoporosis prevention plan-1 (inop-1): preliminary report: Relationship between vitamin d deficiency and markers of bone metabolism in urban 20-69 year-olds in Tehran, Iran

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    • Hypophosphatemic rickets as a consequence of pregnancy: A case report

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  • Clinical Case Reports
  • • Combined pituitary hormone deficiency (CPHD) with adult-onset corticotropin deficiency but without evidence for PROP-1 or HESX1 mutations

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    • Rapid enlargement of thyroid neck swelling in two patients with thyroid dysfunction

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    • Recurrent ovulation from an ovo-testis in 46XX/47XXY (mosaic) hermaphroditism: Serial high-resolution ultrasound characterisation

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    • A novel DAX-1 gene mutation with adrenal hypoplasia congenita, differing degrees of hypogonadism and decreased bone mineral density

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    • Gender identity disorder in an Irish population

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    • Addisonian crisis in a patient with a progressive polyneuropathy

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    • Large parathyroid adenomas associated with vitamin D deficiency - quaternary hyperparathyroidism?

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    • The Pituitary Foundation: A national patient support group

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    • A little hard to swallow. A rare cause of dysphagia in scleroderma

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    • Cushing's disease in adolescence

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    • Vanishing bone: Stabilisation of Gorham-Stout disease during antiresorptive therapy

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    • An unusual presentation of hypopituitarism

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    • Abstract unavailable

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    • Delayed carbimazole induced agranulocytosis precipitating thyroid crisis

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    • Fatal cardiac arrest in a woman with thyrotoxic crisis and sarcoidosis

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    • Complimentary hyponatraemia

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    • Failure of metformin and pioglitazone in the treatment of congenital generalised lipodystrophy

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    • Tumour metastases following laparoscopic resection of adrenal cortical carcinoma

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    • Infantile methylmalonic aciduria caused by maternal pernicious anaemia

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    • 80 years of hyperandrogenism

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    • Developing an endocrine nurse specialist post can improve service to patients with endocrine disease

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    • Steroid responsive hypervitaminosis D due to sarcoid myopathy

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    • Clear cell ovarian adenocarcinoma presenting with parathyroid hormone-related protein-dependent hypercalcaemia

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    • A case of ectopic ACTH with severe opportunistic infection

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    • Clinical features of phaeochromocytomas presenting as crises to an intensive care unit

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    • Coexisting struma ovarii and Graves' disease

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    • Testosterone implant therapy- an audit of patients' views

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    • Incidental non secretory pituitary adenoma in a case of ectopic ACTH induced Cushing's syndrome

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    • The use of intravenous etomidate infusion in the acute control of life-threatening hypercortisolaemia in a case of ACTH-dependent Cushing's syndrome

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    • Cortisol producing pheochromocytoma in pregnancy

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    • Cyclical Cushing's syndrome associated with a pituitary gonadotrophinoma

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    • Tumour induced hypoglycaemia

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    • Acromegaly with hyperprolactinaemia - marked response to cabergoline therapy in a patient with a co-secreting tumour

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    • The UK national acromegaly database

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    • An unusual case of gynaecomastia

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    • Pituitary carcinoma presenting as an aggressive non-functioning adenoma

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    • Hirsutism and subclinical Cushing syndrome

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    • Adrenal rest tissue of the testes: A case report

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    • Concurrence of primary hypothyroidism, epilepsy and benign intracranial hypertension in an adult

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    • Vanishing sellar masses: Two case reports

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    • Lymphocytic hypophysitis. A case report

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    • Growth hormone deficiency and pregnancy

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    • An occult cause of hirsutism

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    • Young woman with galactorrhoea

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    • A case of Carney complex with unusual presentation

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    • Calcitonin in nodular thyroid disease

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    • Resolving adrenal insufficiency following haemorrhage into a pituitary adenoma

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    • Androgenisation during pregnancy - A case report

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    • Unexplained profound transient hypocalcaemia in a young male

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    • An unusual case of thyroid enlargement in pregnancy

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    • Persistent hypoglycaemia associated with neoplasia: A case of Doege-Potter syndrome

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    • Empty sella presenting as a syndrome of inappropriate antidiuretic hormone secretion

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  • Comparative
  • • Sheehan's syndrome and non-functioning pituitary adenoma - a comparison of clinical characteristics and response to growth hormone replacement

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    • Prostaglandins modulate the renal actions of antidiuretic hormone in the Pekin duck

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    • Do plasma osmolality methods meet clinical requirements?

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    • Analysis of human renal chloride channel (hCLC-5) mutations based on a three-dimensional model, suggests a structural-functional relationship

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  • Cytokines and Growth Factors
  • • Growth hormone (GH) insensitivity due to a mutation in the cytoplasmic domain of the GH receptor distal to Box 1

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    • A growth hormone receptor (GHR)- glycophosphatidylinositol (GPI) chimera acts as a receptor antagonist

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    • Relationships between IL-6 levels and anthropometric, metabolic and hormonal parameters in women with PCOS and the effect of treatment with metformin

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    • Increased angiogenesis but not lymphangiogenesis in parathyroid proliferative lesions: A possible role for FGF-2

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    • Leptin enhances expression of CD11b by human neutrophils through TNF-alpha

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    • Overexpression of somatostatin receptors 1 and 5, and VEGF and its receptors FLK and FLT in laryngeal carcinoma: Potential targets for anti-tumoral therapy?

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    • Development of a bioassay for leptin agonists and antagonists

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    • Serum concentrations of interleukin-18 and tumour necrosis factor alpha are associated to the features of the metabolic syndrome X in adults

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    • Concentrations of serum Interleukin-18, tumour necrosis factor alpha and plasma malondialdehyde are associated with body mass index in healthy adults

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  • Diabetes, Metabolism and Cardiovascular
  • • Identification of the gene causing familial juvenile hyperuricaemic (Gouty) nephropathy

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    • Influence of the Y chromosome on inter-individual variation in cholesterol serum levels of young men

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    • Effects of the 11beta hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in human obesity

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    • Effect of grape procyanidins on proliferation and apoptosis of pancreas beta cells

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    • Testosterone is a dilator of resistance arteries in men with congestive heart failure

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    • Orlistat use outside of clinical trials: The Irish experience

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    • Adrenomedullin and proadrenomedullin N-terminal 20 peptide have opposing effects on CRLR gene expression in human adrenal cells

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    • Autosomal dominant neurohypophyseal diabetes insipidus associated with a glutatmine47 deletion

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    • Circulating IGFBP-3 concentration is independently associated with insulin resistance and BMI

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    • Mechanisms of splicing inhibition in apolipoprotein B exon 26 (ApoB ex26)

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    • OGIS: An index of insulin sensitivity in a clinical setting

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    • Paradoxical correlation between serum zinc and neutrophil respiratory burst in the resting and stimulated states in type 2 diabetic patients with foot ulcers

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    • Baseline clinical characteristics and response to growth hormone replacement therapy in adults with isolated growth hormone deficiency in comparison with multiple pituitary hormone deficiencies

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    • Cardiovascular risk factors in obese children and their association with insulin resistance

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    • Reduced insulin sensitivity in healthy glucose tolerant first degree relatives of patients with Type 2 diabetes mellitus

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    • Glycaemic control, weight change and treatment : Examining the relationship in Type 2 diabetes

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    • Subcutaneous and visceral preadipocytes from pre-pubertal children show site-specific differences in insulin action

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    • The effect of menopausal status on the biological variation of insulin resistance

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    • Altered insulin sensitivity and secretion in sotos syndrome

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    • The predictive factors for gestational diabetes mellitus and postpartum diabetes mellitus

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    • Hypertension in diabetics and non-diabetics; degree of blood pressure control and antihypertensive agents

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    • Treatment of coronary disease and effects on endogenous testosterone levels

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    • Octreotide LAR - a patient and nurse perspective

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    • Early onset Type 2 diabetes in an Irish population

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    • A 5 year retrospective analysis of diabetes ketoacidosis

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    • Type 2 diabetes in Alstrom syndrome: Targeting insulin resistance with a thiazolidinedione

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    • Polycystic ovary syndrome (PCOS) in Sri Lankans

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    • Metformin. Its effect on weight loss in obese patients with or without polycystic ovary syndrome

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    • Mass screening for diabetes: New horizon with computer aided diagnosis system?

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    • Hypopituitarism presenting as hypoglycaemia in Type 2 diabetes

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    • Blood stream infections are common in admitted diabetics

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    • Timing of insulin administration amongst diabetic patients

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    • Abnormal immunoglobulin A and D levels in children with type 1 diabetes

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    • The effect of blood glucose in non-diabetic pregnant women on their infants' weight

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    • Unusual causes for hypokalaemia in diabetics

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  • Endocrine Tumours and Neoplasia
  • • Familial isolated primary hyperparathyroidism due to germline multiple endocrine neoplasia Type 1 (MEN1) mutations

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    • Prostate and ovarian cancer cell responses to treatment with 2-substituted oestrogen sulphamates in vitro

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    • Dysregulated extra-renal synthesis of 1,25-dihydroxyvitamin D3: A novel cause of hypercalcemia associated with ovarian dysgerminomas

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    • Parathyroid tumours harbour parafibromin somatic mutations, consistent with the Knudson 'two-hit' hypothesis

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    • Genetic abnormalities in carcinoid tumours

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    • Hyperparathyroidism-jaw tumour syndrome (HPT-JT) in Romany families from Portugal is due to a founder mutation of parafibromin

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    • Clinical and biochemical prognostic indicators at diagnosis in 117 midgut carcinoid tumours

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    • Differential modulation of key steroidogenic enzymes through orphan nuclear transcriptional regulation may control the diverse production of cortisol and adrenal androgens

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    • IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75

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    • Preoperative determination of serum thyroglobulin may identify patients with differentiated thyroid cancer who might recur without increased thyroglobulin

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    • Acromegaly: A study of epidemiological characteristics and treatment outcomes

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    • Dysregulation of the Vitamin D axis in colorectal cancer

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    • Outcomes in acromegaly: A retrospective study of 419 patients from the West Midlands region of the United Kingdom

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    • Proliferative regulation of human breast cancer cells by dietary phytoestrogens: Mechanisms of estrogen receptor-mediated signalling

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    • CYP27b and CYP24 expression combine to determine 1,25 Dihydroxyvitamin D3 insensitivity in breast cancer cells

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    • Stable iodide and radioiodide transport in extrathyroidal tissues

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    • Identification of the ACTH receptor in the human pituitary and its loss of expression in pituitary adenomas

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    • The presence of ghrelin protein in the rat hypothalamus and the effect of ghrelin on corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) release from rat hypothalamic explants pituitary tumours

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    • Pituitary tumor transforming gene upregulates its binding factor PBF in vitro

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    • Insulin-like growth factor binding protein-3 (IGFBP-3) expression in the caecum and rectum of patients with and without acromegaly

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    • Expression of IGF-I in normal and malignant breast tissue and its association with tumour size

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    • Expression of IGFBP-3 mRNA in breast cancer in relation to clinical phenotype

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    • Methylation status and iodide uptake

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    • Prolactinoma volume and serum prolactin level: Evidence for the 'silent lactotroph' tumour

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    • Lipocortin-1 expression within normal and abnormal endometrium

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    • Co-regulators SRC-1 and SMRT interact with ER-alpha and ER-beta in human breast cancer

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    • Pituitary irradiation for recurrent steroid-responsive hypophysitis in three patients

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    • Abnormal expression of 11beta-hydroxysteroid dehydrogenase 2 in primary cultures of human pituitary adenomas

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    • Cell cycle dysregulation in parathyroid adenoma and carcinoma

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    • Transcriptional regulation by PEA3 in human breast cancer

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    • Metaiodobenzylguanidine scintigraghy (MIBG) and familial screening are not useful in phaeochromocytoma

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    • Molecular genetic diagnosis for disorders of calcium metabolism

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    • Expression of somatostatin receptors in proliferating and quiescent endothelial cells

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    • Insulinoma, diabetes and islet cell amyloid polypeptide

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    • A TSH response to a single octreotide test dose predicts a long term response to somatostatin analogue therapy in patients with a TSH-secreting pituitary adenoma

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    • Usefulness of growth hormone response to a test dose of subcutaneous octreotide in predicting longer-term response to the drug. Poor responses predict the need for adjuvant therapy to achieve 'safe' growth hormone levels

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    • Expression of vascular endothelial growth factor and its receptors in human anterior pituitary adenomas

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    • IGF-I inhibits COX-2 function in primary colonic biopsies of patients with acromegaly

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    • Can petrosal sinus ACTH and prolactin responses to CRH help localize the tumour in Cushing's disease due to pituitary microadenomas?

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    • A rapid method for analysing serum pro-insulin-like growth factor-II (pro-IGF-II) in patients with non-islet cell tumour hypoglycaemia (NICTH)

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    • A new role for the endocrine nurse within a multidisciplinary approach to neuroendocrine tumours

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    • Transsphenoidal surgery for acromegaly in Wales: Results based on stringent criteria of remission

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    • Carney complex type 1 gene (PRKAR1A) expression and sequence analysis in sporadic somatotroph and other pituitary tumours

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    • Elevated alpha fetoprotein levels in association with a metastatic neuroendocrine tumour

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    • Retrospective audit of care of patients undergoing pituitary surgery in Plymouth

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    • Lymphocytic adenohypophysitis occurring simultaneously with an ACTH secreting adenoma

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    • Double trouble. Dual pathology and false positive as well as false negative imaging in a man with phaeochromocytoma and hypogonadism

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  • Growth and Development
  • • Testosterone enhances the effect of growth hormone (GH) to increase IGF-I but exerts an anabolic effect that is independent of GH action

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    • GATA3 missense mutation disrupts interaction with Friend of GATA 2 (FOG2) and causes the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome

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    • Identification of GATA3 zinc finger 1 residues that are important for interactions with friend of GATA 2 (FOG2)

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    • A potential role for human securin/PTTG in the developing human fetal brain

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    • A unique sequence element that silences the growth hormone receptor (GHR) pseudoexon

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    • A novel mutation within the conserved eh-1 domain of HESX1 causes evolving CPHD due to the loss of interaction with the co-repressor TLE1

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    • The use of a specific questionnaire to assess quality of life in growth hormone deficient adults

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    • Differential regulation of the ghrelin promoter in WRL68 and HEK293 cells

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    • Expression and distribution of the prolactin-receptor in healthy, fibrotic and cirrhotic liver in rats and humans

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    • Regulation of Wolffian duct development in patients with complete androgen insensitivity syndrome

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    • The effect of chronic administration of recombinant (human) leptin on leptin and uncoupling protein (UCP) 2 mRNA in neonatal pigs

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    • Adults with partial growth hormone (GH) deficiency have an adverse body composition

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    • The effect of chronic administration of recombinant (human) leptin on the growth performance of neonatal pigs

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    • The effect of maternal dietary supplementation during late gestation on the growth performance of intra-uterine growth restricted (IUGR) pigs

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    • The use of combined GHRH and arginine test in the diagnosis of growth hormone deficiency in successfully treated acromegalics

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    • Cessation of growth hormone (GH) results in loss of lean body mass and reduced accrual of bone mass in adolescents with severe GH deficiency- 2 year follow up

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  • Neuroendocrinology and Behaviour
  • • Galanin-like peptide interactions with leptin and GnRH

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    • Insulin sensitivity improves in patients with acromegaly converted from depot octreotide (Sandostatin LAR) to pegvisomant

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    • Intracerebroventricular ghrelin injection acutely stimulates food intake and inhibits luteinising hormone secretion in sheep

      ea0005p179
    • Intra-hypothalamic gene transfer of cocaine and amphetamine regulated-transcript results in increased food intake and weight gain

      ea0005p180
    • A randomised double-blind cross-over study of GH treatment in patients over 60 years

      ea0005p181
    • Hypopituitarism following cranial irradiation for non-pituitary brain tumours

      ea0005p182
    • Serum leptin, insulin, IGF-1 levels and body composition in partially and fully recovered patients with anorexia nervosa

      ea0005p183
    • Differential effects of the route of testosterone administration on GH sensitivity and bone mineral density in hypopituitarism

      ea0005p184
    • Abnormal endocrine tests in chronic pain require investigation and are not the result of opioid analgesia

      ea0005p185
    • Effect of the novel somatostatin ligand, SOM230, on rat amp human anterior pituitary hormone secretion

      ea0005p186
    • Pituitary apoplexy: A review of presentation, management and outcome

      ea0005p187
    • Treating hyperprolactinaemia: Where to draw the line?

      ea0005p188
    • Treatment outcome in acromegaly: Results from the Beaumont Hospital pituitary database

      ea0005p189
    • Single centre audit of surgical outcome in acromegaly

      ea0005p190
    • Problematic development of an immunometric assay for cocaine and amphetamine regulated transcript (CART) (55-102) peptide fragment

      ea0005p191
    • Audit of quality of life in individuals who have undergone treatment for pituitary tumours over the past ten years at a single neurosurgical centre

      ea0005p192
  • Reproduction
  • • Maternal and neonatal outcomes after conception during cabergoline therapy for hyperprolactinaemia

      ea0005p193
    • Insulin sensitivity in polycystic ovary syndrome-influence of peroral versus transdermal estrogen treatment

      ea0005p194
    • Oxygen tension regulates placental 11beta-hydroxysteroid dehydrogenase type 2

      ea0005p195
    • Clinical features of patients with macroprolactinaemia

      ea0005p196
    • Hypoxia influences steroid and nitric oxide production in swine granulosa cells

      ea0005p197
    • Effect of aroclor 1242 (PCB) on the reproductive function of adult male rhesus monkey (Macaca mulatta)

      ea0005p198
    • Treatment of hypogonadotropic hypogonadism in women with neuroendocrine disorders

      ea0005p199
    • Biological variation of free androgen index and bioavailable testosterone in PCOS: Implications for estimation of hyperandrogenaemia

      ea0005p200
    • Screening for iron deficiency and anaemia in adults with Turner syndrome

      ea0005p201
    • Complications of testosterone replacement in men with primary and secondary hypogonadism

      ea0005p202
    • A more rigorous laboratory definition of macroprolactinaemia with clinical significance

      ea0005p203
    • The effect of insulin-like growth factor-I (IGF-I) on initiation of human follicle growth in vitro

      ea0005p204
    • Effects of CAG repeat expansion of the androgen receptor and its truncation on neural and non-neural cells

      ea0005p205
    • Sexual dimorphism in fetal testosterone output in the silver fox

      ea0005p206
    • Polycystic ovary syndrome (PCOS) has a significant negative impact on health-related quality of life (HRQoL)

      ea0005p207
    • Pharmacokinetics and tolerability of a new a bioadhesive buccal testosterone tablet in testosterone deficient men

      ea0005p208
    • Immunopurification of gonadotrophin surge-attenuating factor (GnSAF) bioactivity

      ea0005p209
    • Comparison between azoospermic responders and oligozoospermic non-responders to sex steroidal contraception: A pharmacogenetics study examining the androgen receptor, CYP17, LHbeta and 5alpha-reductase-2 genes

      ea0005p210
    • 1,25-Dihydroxyvitamin D3 has a direct effect on steroid production from human theca cells

      ea0005p211
    • Evidence for the use of metformin in women with polycystic ovary syndrome

      ea0005p212
    • Testosterone pellet implants - an acceptable mode of androgen replacement

      ea0005p213
    • Investigating germ cell development and differentiation in the human fetal testis

      ea0005p214
  • Steroids
  • • 11Beta-hydroxysteroid dehydrogenase in human fibroblasts: Expression and regulation depends on tissue of origin

      ea0005p215
    • Adipocyte size increases with BMI, but is unrelated to 11 beta-hydroxysteroid dehydrogenase type 1 expression

      ea0005p216
    • Interactions between 11beta-hydroxysteroid dehydrogenase type 1 and 5beta-reductase

      ea0005p217
    • Studies on functional activity of human ERbeta wild type and variant isoforms

      ea0005p218
    • Mutagenesis studies on recombinant human 11beta-hydroxysteroid dehydrogenase type 1

      ea0005p219
    • The relationalship of on-admission plasma cortisol to outcome in critical illness: a longitudinal prospective study

      ea0005p220
    • CYP7B catalyses the 7alpha-hydroxylation of dehydroepiandrosterone in human prostate

      ea0005p221
    • In vitro expression of human aldosterone synthase and 11-beta hydroxylase

      ea0005p222
    • Excretion of the urinary metabolite of deoxycortisol is heritable and influenced by polymorphic variation at the CYP11B2 (aldosterone synthase) locus

      ea0005p223
    • Differential regulation of vitamin D receptor and its ligand in human dendritic cells: A paracrine mechanism for regulation of antigen presentation

      ea0005p224
    • High prevalence of low testosterone levels in men with coronary heart disease and an association with hypertension and obesity - The South Yorkshire study

      ea0005p225
    • Identification of glucocorticoid target genes in human subcutaneous and omental adipose tissue using microarray analysis

      ea0005p226
    • The 5' untranslated region of the rat glucocorticoid receptor contains elements important for cell-specfic promoter activity and glucocorticoid regulation

      ea0005p227
    • Activation of the hypothalamic-pituitary-adrenal axis in adult women with low birthweight

      ea0005p228
    • Regulation of aldosterone synthase (CYP11B2) gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II

      ea0005p229
    • Beneficial affects of regular exercise: Is it all in the hormones?

      ea0005p230
    • Development of a mouse hypertension model induced by aldosterone excess

      ea0005p231
    • Urinary 18-hydroxycortisol: diagnostic utility of three methods compared

      ea0005p232
    • In vitro synthesis of 18-hydroxycortisol (18-OH-F) and 18-oxocortisol (18-oxo-F); clues to their origin in normal human subjects

      ea0005p233
    • Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) gene expression in the normal and failing rat heart

      ea0005p234
    • Cardiovascular risk assessment in bodybuilders abusing anabolic steroids

      ea0005p235
    • Regulation of the human 11beta-hydroxysteroid dehydrogenase gene by glucocorticoids

      ea0005p236
    • Cortisol metabolite excretion and 11-hydroxysteroid dehydrogenase type 1 activity are strongly heritable in man

      ea0005p237
    • Contrasting acute and chronic changes in glucocorticoid action during high fat feeding in rats

      ea0005p238
    • Effect of dietary sodium manipulation on aldosterone synthase (CYP11B2) gene expression in the rat cardiovascular system

      ea0005p239
    • Is the cortisol day curve a useful tool?

      ea0005p240
    • Urinary steroid hormone metabolites in patients with porphyrias

      ea0005p241
    • Functional analysis of the N/C interactions in the AR

      ea0005p242
    • Insulin sensitivity and hypoglycaemic susceptibility in children with endocrinopathies reflects the underlying hormone deficiency and treatment regimen

      ea0005p243
    • Bilateral massive adrenal enlargement in a poorly treated adult patient with salt losing congenital adrenal hyperplasia

      ea0005p244
    • Audit of adrenal vein sampling for primary aldosteronism

      ea0005p245
    • Testosterone reduces free radical release from human monocytes

      ea0005p246
    • Can random urine samples substitute for 24 hour collections for steroid profiling?

      ea0005p247
    • A non-invasive test of mild glucocorticoid resistance

      ea0005p248
    • Mutations in the HSD11B2 gene causing AME in the Oman population

      ea0005p249
    • Isolated ACTH deficiency precipitated by silent thyroiditis presenting as acute metabolic acidosis

      ea0005p250
    • Macroprolactinoma and pituitary dependent Cushing's syndrome: An unusual combination with response to dopamine agonist therapy

      ea0005p251
    • The influence of anticoagulant preservatives, time and posture in renin measurements and estimation of aldosterone to renin ratio (ARR)

      ea0005p252
    • Assessment of antiandrogenic activity in a range of environmental contaminants

      ea0005p253
  • Thyroid
  • • Thyroid hormone receptor (TR) activity is modulated by TRdeltabeta3 in a cell-, response element-, and TR isoform-specific manner

      ea0005p254
    • Preliminary evidence for genetic heterogeneity in the autoimmune polyendocrinopathy and enteropathy syndrome (IPEX)

      ea0005p255
    • The type II and III iodothyronine deiodinase enzymes are expressed in differentiating growth plate chondrocytes

      ea0005p256
    • Does iodide modulate the biological outcome of activating thyrotropin receptor mutations?

      ea0005p257
    • The W546X mutation of the thyrotropin receptor gene: Potential major contributor to thyroid dysfunction in a caucasian population

      ea0005p258
    • The expression of apoptotic genes in autoimmune thyroid diseases

      ea0005p259
    • Iodide effects on iodide transport and organification in human thyroid cells in vitro

      ea0005p260
    • The epidemiology of thyroid cancer in Scotland, 1960 - 1999

      ea0005p261
    • The controlled antenatal thyroid screening study (CATS) - first observations

      ea0005p262
    • Cardiac autonomic function in hyperthyroidism

      ea0005p263
    • Is the thyroglobulin gene a susceptibility locus for autoimmune thyroid disease in the UK?

      ea0005p264
    • Assessment of UK caucasian allele frequencies of known TNF-alpha polymorphisms and their association with Graves' disease

      ea0005p265
    • Psychological well-being in patients on 'adequate' doses of L-Thyroxine

      ea0005p266
    • Does HLA-DRB1-DQA1-DQB1 genotype contribute to chronic autoimmune thyroiditis development in adult patients with diabetes mellitus Type 1?

      ea0005p267
    • A managed clinical network for thyroid disease

      ea0005p268
    • Somatostatin receptor expression in thyroid disease

      ea0005p269
    • Adequacy of information delivered to patients during consultation for thyrotoxicosis

      ea0005p270
    • Serum TSH and thyroid autoantibodies in thyroidal and extrathyroidal disease

      ea0005p271
    • Comparison of simultaneous ultrasonography and radio-isotope scanning in hyperthyroid patients as compared with radio-isotope scanning alone

      ea0005p272
    • Conventional withdrawal of thyroid suppression in differentiated thyroid carcinoma: How frequently are adequately raised TSH levels attained?

      ea0005p273
    • High prevalence of ANCA in patients with Graves' disease treated with thionamides

      ea0005p274
    • Lack of association of the interleukin 4 receptor gene with Graves' disease in the UK

      ea0005p275
    • Does an eosinophil/monocyte ratio help to differentiate between types of thyrotoxicosis?

      ea0005p276
    • Acute metabolic effects of high dose intravenous methylprednisolone therapy in patients with thyroid-associated ophthalmopathy

      ea0005p277
    • Graves' disease presenting in the third trimester of pregnancy

      ea0005p278
    • Outcome of carbimazole, radioactive iodine and subtotal thyroidectomy in the treatment of Graves' disease at Alnour Hospital in Saudi Arabia

      ea0005p279
    • Homocysteine in subclinical hypothyroidism, a risk factor for atherosclerosis?

      ea0005p280
  • Novartis Award Posters
  • • Expression of adiponectin protein in human fat: the effect of type 2 diabetes and obesity

      ea0005np1
    • Abnormalities of thyroid function in the POMC-null mouse

      ea0005np2