Endocrine Abstracts

The observation that acquired GnRH deficiency and estrogen deficiency leadsto decreased bone mass in young women was critical evidence thathypothalamic/pituitary disorders could impact on bone metabolism in adults.A three-fold risk of fractures in adults with growth hormone deficiency(GHD) has led to the investigation of the role of the GH/IGF-I axis in bonemetabolism. Two human experimental models, acquired GHD and acquired GHresistance due to severe w...

Anne Klibanski, Massachusetts General Hospital, Boston, MA, USA AbstractAnne Klibanski, M.D, is Professor of Medicine, Harvard Medical School and Chief, Neuroendocrine Unit and Director of the Neuroendocrine Clinical Center at Massachusetts General Hospital, Boston. A leader in the field of neuroendocrinology, Dr. Klibanski's research interests include the pathogenesis of hypogonadal osteoporosis, neuroendocrine contro...