Endocrine Abstracts

INTRODUCTIONOsteopenia has been demonstrated in type I diabetes (insulin dependent diabetic patients)at some time during the course of the disease. The purpose of the present study was to assess any possible longitudinal changes in bone mineral density in children with I.D.D.M. whose duration ranged from 3 to 14 years.SUBJECTS AND METHODSBone mineral density was studied in 14 children with I.D.D.M. (8 boys an...

INTRODUCTIONTwelve prepubertal children (7 boys and 5 girls) who had been continuously using I.C.S. for at least 3 to 5 years in a prescribed dose of at least 500-800 micrograms per day were included in the study. Age ranged from 4 to 11 years. Duration of I.C.S. treatment ranged from 3 to 5 years. 20 children of the same population were used as controls. Bone mineral density (B.M.D.) of the lumbar spine (L2-L4) was measured by Dual Energy X-ray Absorpti...

Osteoblasts and adipocytes are derived from the same stem cell in adult marrow and plasticity exists between the two lineages. In Osteoporosis there are reduced osteoblast numbers and increased adipocyte numbers suggesting a disturbance in the normal balance of the cells' differentiation pathways, leading to defective osteoblastogenesis and favouring adipogenesis. The stage of adipocytic differentiation at which plasticity is lost and commitment is established is not known. We...

In this controlled study the BMD of Proximal femur in postmenopausal diabetic women were assessed in comparison to healthy postmenopausal controls.BMD results from 65 postmenopausal women, aged 45-65 years old, with diabetes type 2, were compared with 65 age-matched controls. Bone densitometry from proximal femur (neck, Ward, trochanter) was performed using Dual X-ray Absorptiometry (DEXA). Subjects were categorized as 'osteopenic-osteoporotic' if their...

BACKGROUND: Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports have suggested target cell insensitivity to PTH as a contributor to the changes in bone turnover seen in AGHD. Although growth hormone replacement (GHR) increases BMD, the underlying mechanisms remain unclear.OBJECTIVES: To determine the effect of GHR on 24-hour PTH profiles, phosphocalcium ...

Osteoporosis is one of the most common bone diseases whose complications, morbitidy and mortality impose direct and indirect expenses. Vitamin-D is one of the most important factors in calcium absorption for bone formation. In this study we have evaluated vit-D level and other calcium metabolism indicators in urban population of Tehran.In a cross-sectional study in winter 2001, 1231 normal persons; 20-69 years, 502 male and 724 female, among urban popula...

Growth hormone (GH) is thought to have a dual effect (direct and indirect) on bone metabolism. We sought to explore the inter-relationships and potential determinant factors of several markers of bone turnover in GH deficient adults (GHD), as well as possible acute changes arising from GH.24 GHD subjects [14 M, 10F; age (range, 24-74 yrs)] were studied after consent and ethical approval. They were randomised into three groups (GP) of 8 subjects, each to ...

In contrast to bone formation biomarkers, reliable bone resorption biomarkers have not been available in serum. Recently, automated measurement of C-terminal cross-linking telopeptide of type I collagen (CTX-I), has been promoted as a reliable indicator of bone resorption. The objective of the study was to examine the correlation of CTX-I, with the traditional urinary markers, N-telopeptide of type I collagen (NTX-I) and deoxypyridinoline (DPD) in a series of patients with Pag...

Measurement of the various available bone formation and resorption markers provide insights into different aspects of the bone metabolism process. Interpretation of bone biomarkers in a clinical setting is complex. Analysis of formation markers including bone alkaline phosphatase, procollagen type 1 propeptide and intact osteocalcin and resorption markers including free deoxypyridinoline and N-terminal cross-linking telopeptide of type 1 collagen were performed. From the inter...

Objective: Estrogen or raloxifen prevent estrogen deficiency-induced bone loss animals and humans. There is a medical need for agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects tissue. So, we investigated the effects of raloxifen on bone strength and cholesterol levels in osteoporotic rats and compared them with estrogen treatment.Methods: Thirty-one ovariectomized (OVX) Sprague-Dawney ra...

Objective: Thiazolidinediones offer promise as oral insulin-sensitizing agents. Peroxisome proliferator-activated receptor-g (PPARg), a member of the steroid receptor superfamily, play a pivotal role in the differentiation of adipocytic cells. Osteoblasts and adipocytes are derived from common bone marrow stromal cells that play crucial roles in the generation of osteoclasts. Activation of peroxisome proliferator-activated receptor-g (PPARg) induces adipogenic differentiation ...