Endocrine Abstracts

Contents

• Plenary Lectures
• • Clinical Endocrinology Trust Lecture
  • • The apple of my eye

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    • Clinical Endocrinology Trust Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • Mechanisms of preterm birth, and influences on disease in later life

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • The neuroendocrinology of Stress

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • British Thyroid Association - Pitt-Rivers Lecture
  • • Molecular genetics of congential hypothyroidism

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    • British Thyroid Association - Pitt-Rivers Lecture

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  • Society for Endocrinology Dale Medal Lecture
  • • Darwin, De Graaf and selection of the ovulatory follicle(s)

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    • Society for Endocrinology Dale Medal Lecture

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• Symposia
• • Hormonal Control of Female Reproduction
  • • Transgenic models to study ovarian folliculogenesis and oogenesis

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    • The generation of the preovulatory LH surge

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    • Role of cofactors for nuclear receptors in reproduction

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    • Role of COX-2 in implantation

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  • Recent Advances in Biological Rhythms
  • • Molecular mechanisms of the circadian clockwork

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    • Photoperiodic regulation of the neuroendocrine system

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    • Human physiological implications of biological timing

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    • Endocrine and other biological rhythms in man

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  • Vascular Risk in Diabetes - Genetic and Environmental Interactions
  • • Diabetes and vascular risk

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    • Genetic basis of type 2 diabetes

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    • From QTL locus to insulin resistance gene

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    • Lifestyle and environmental interactions in type 2 diabetes

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  • Differentiated Thyroid Cancer
  • • Initiating oncogenic events in thyroid follicular cells: Impact on chromosomal instability and disease progression

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    • Improving the utility of fine needle aspiration biopsy of thyroid tumours

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    • Differentiated Thyroid Cancer (DTC): Treatment Outcomes

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    • UK thyroid cancer guidelines

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  • Metalloproteinases and Their Inhibitors: Regulators of Endocrine Activity
  • • The biology of matrix metalloproteinases and their inhibitors

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    • Matrix metalloproteinases, cytokines and bone/cartilage remodelling

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    • Metalloproteinases and the modulation of growth hormone signalling

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    • The functional role of matrix-degrading proteinases and their inhibitors in the female reproduction system

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  • Cell Based Therapies for Treating Neuroendocrine Disease
  • • Embryonic stem cells: Their potential for therapeutics

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    • Human neural stem cells: A therapeutic modality for neurodegenerative disease

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    • Engineering cells to treat diabetes

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    • Repairing and protecting neurones, a dual goal for cell based therapy to the brain

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  • Parturition and Fetal Stress - Hormonal Strategies for Ensuring Life After Birth
  • • New insights into lung maturation - the role of interleukin-1

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    • Parturition and fetal stress: hormonal strategies for ensuring life after birth

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    • Thyroid hormone in the fetal brain

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    • The prolactin receptor and pregnancy

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• Clinical Management Workshops
• • Insulin Resistance and Type 2 Diabetes in Adolescents and Young Adults
  • • Epidemiology of type 2 diabetes in childhood and adolescents in North America: Possible lessons for the UK

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    • Pathophysiology of type 2 diabetes in adolescents and young adults

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    • Management of adolescents and young adults with insulin resistance

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  • New Treatments for Osteoporosis
  • • Prospects for new treatment approaches in osteoporosis

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    • Parathyroid hormone for osteoporosis treatment

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    • Statins for the prevention of postmenopausal osteoporosis

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  • Unconventional Uses of Thyroid Hormones
  • • T3/T4 combination therapy

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    • Unconventional uses of thyroid hormones: Psychiatric indications in mood disorder

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    • Cardiac indications

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  • Why, Why Not and When to Irradiate the Pituitary
  • • Radiotherapy for pituitary disease

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    • Radiobiology, conventional fractionated pituitary radiotherapy and stereotactic LINAC radiotherapy

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    • Gamma-knife radiotherapy of pituitary tumours

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• Oral Communications
• • Genetics: New Insights into Endocrine Disease
  • • All in the family: Site and gender specificity of the genetic control of bone mineral density

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    • GATA3 mutations in the hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome

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    • A molecular deletional-insertion involving chromosomes Xq27 and 2p25 causes X-linked recessive hypoparathyroidism

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    • Analysis of novel mutations in the HSD11B2 gene: Implications for AME and possibly IUGR

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    • Identification of differentially expressed genes in rat chromosome 2 congenic strains

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    • Y chromosome consomic strains and metabolic syndrome in the stroke prone spontaneously hypertensive rat

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    • The vitamin D receptor gene is associated with susceptibility to development of Graves' disease in the UK

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    • Identification and characterization of a novel missense mutation in the growth hormone gene in a child with short stature

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  • Endocrine Neoplasia
  • • Breast cancer cells express the vitamin D activating enzyme 1alpha-hydroxylase

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    • 2-methoxyestradiol sulphamatas induce G2-M arrest and apoptosis in ER-VE MDA-MB-231 breast cancer cells

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    • CYP24 action: An intrinsic mechanism of resistance in breast and prostate cancer cells

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    • Ghrelin inhibits proliferation of breast cell lines acting via the growth hormone secretagogue receptor (GHS-R)

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    • Disruption of the SH3 domain of pituitary tumor transforming gene (PTTG) reveals distinct mechanisms of FGF-induction and cell transformation

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    • Expression and function of vascular endothelial growth factor (VEGF) and its receptor KDR in pituitary tumours

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    • Regional gene expression in the colon of patients with and without acromegaly

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    • BPDZ-154 is a potent activator of ATP-sensitive potassium channels in pancreatic beta-cells

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  • Growth Regulation
  • • The identification of cryptic gene sequences that encode putative ligands: The example of POP1

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    • Overexpression of insulin-like growth factor binding protein-5 (IGFBP-5) induces severe growth retardation in transgenic mice

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    • Thyroid hormone activates fibroblast growth factor receptor-1 in bone

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    • Advanced bone formation in mice with resistance to thyroid hormone due to a targeted mutation in the thyroid hormone receptor beta gene

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    • Decidual matrix metalloproteases MMP-3 and MMP-9 proteolyse insulin-like growth factor binding protein-1

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    • The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits growth of human pituitary cells expressing a mutated form of the EGFR

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    • Follicle-stimulating hormone and transforming growth factor beta superfamily members regulate granulosa cell connective tissue growth factor (CTGF) gene expression in vitro and in vivo

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    • Abnormalities of folliculogenesis in polycystic ovaries start at the primordial stage

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  • Metabolism
  • • Programming of adult adipose tissue metabolism by prenatal glucocorticoids in the rat

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    • Impact of thiazolidinediones on cardiovascular disease risk factors

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    • A digenic basis for severe insulin resistance in a large UK kindred - cosegregation of mutations in PPAR gamma and PPP1R3

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    • Rosiglitazone inhibits insulin-mediated rise in angiotensinogen expression and angiotensin II secretion in human subcutaneous adipocytes

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    • Deleterious effect of non-esterified free fatty acids (NEFAs) on resistance artery endothelial function

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    • Increased muscle oxidation of dietary lipid contributes to oestrogen-induced improvements in postprandial lipid metabolism

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    • An interaction between ghrelin and a species of high-density lipoprotein

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    • Regulation of leptin receptor cleavage

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  • Hormone Action
  • • The role of the PPAR gamma in thyroid eye disease: Possible contra-indication for thiazolidenedione therapy

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    • Iodothyronine deiodinase expression in thyroid responsive fetal tissues

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    • Modification of calcium sensing receptor expression modulates 25-hydroxyvitamin D3-1alpha-hydroxylase activity in a human proximal tubule cell line

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    • Increasing fracture risk with age: Possible role of local corticosteroid generation

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    • Demonstration of progesterone receptor mediated gonadotrophin suppression in men

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    • Autocrine generation of androgens within adipose tissue: Implications for polycystic ovarian syndrome (PCOS)

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    • DHEA, a selective glucocorticoid receptor antagonist, studies in human lymphoblasts and hepatocytes

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    • RU486, the glucocorticoid receptor (GR) antagonist, recruits NCoR, but not SRC-1: Explaining type II antagonism

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  • Neuroendocrinology
  • • 11beta-hydroxysteroid dehydrogenase type 1 (11beta HSD1) is expressed in human brain: inhibition with carbenoxolone improves cognitive function in healthy elderly men

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    • A possible role for the melanocortin 3 receptor in the control of the hypothalamo-pituitary gonadal axis

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    • CGRP-alpha inhibits food intake via the paraventricular nucleus (PVN) of the hypothalamus partly through the CGRP-type 1 receptor

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    • MSH precursor peptides in rat cerebrospinal fluid: Evidence that pro-opiomelanocortin (POMC) processing is regulated with respect to energy balance

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    • Evidence for a role of the ATP-binding cassette transporter - A1 (ABC-A1) in the externalisation of annexin I from folliculostellate cells

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    • Chronic CNS administration of Agouti related protein (Agrp) reduces energy expenditure

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    • A2B adenosine receptors mediate the adenosine-induced increase in cell growth and IL-6 expression in pituitary folliculostellate cells

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    • Hypothalamic actions of Neuromedin U

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• Poster Presentations
• • Novartis Award Posters
  • • A molecular deletional-insertion involving chromosomes Xq27 and 2p25 causes X-linked recessive hypoparathyroidism

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    • 11beta-Hydroxysteroid dehydrogenase type 1 (11betaHSD1) is expressed in human brain; inhibition with carbenoxolone improves cognitive function in healthy elderly men

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  • Bone
  • • Bone mineral density in children with insulin dependent diabetes mellitus (IDDM)

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    • Bone mineral density of asthmatic children after long term treatment with inhaled corticosteroids

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    • Investigation into the plasticity of adult human bone marrow adipocytes

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    • Is bone mineral density in women with type 2 diabetes different from nondiabetic women?

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    • Changes in parathyroid hormone sensitivity and rhythmicity and its effects on bone metabolism following growth hormone replacement in adult growth hormone deficient patients

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    • Evaluation of vitamin-D deficiency and other bone biochemical factors in urban population of Tehran - winter 2001

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    • Bone turnover markers after a single intravenous injection of growth hormone in adults with growth hormone deficiency

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    • Availability of a reliable marker of bone resorption in serum, C-terminal cross-linking telopeptide of type I collagen, for evaluation of metabolic bone disease

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    • Development of bone remodelling balance and turnover indices in patients with metabolic bone disease

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    • A comparative study of raloxifen and estrogen on bone strength and cholesterol levels in ovariectomized rats

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    • Effect of rosiglitazone on bone strength in osteoporotic rats

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  • Clinical Case Reports
  • • The perils of low dose locally delivered steroids

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    • Isolated growth hormone deficiency and BPES

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    • Pituitary mass and hypopituitarism with Wegeners granulomatosis

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    • Hyperparathyroidism and polycythaemia

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    • Type 1 diabetes in the elderly

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    • Management of thyrotoxicosis in a non-compliant pregnant woman

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    • Lack of cortisol response using the glucagon stimulation test in diabetic autonomic neuropathy

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    • 'Brittle Addison's disease' but not 'Brittle diabetes' in a young woman with Addison's disease and type 1 diabetes mellitus

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    • A rare cause of intrasellar mass: Cholesterol granuloma

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    • Mitochondrial inheritance of maternal, familial short stature with diabetes mellitus

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    • Prolactin elevation to 16,630 mU/l in a case of a large non-functioning pituitary adenoma

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    • Glucocorticoid remediable aldosteronism. A Northern Ireland experience

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    • Acute polyarticular synovitis complicating Grave's disease

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    • Congenital adrenal hyperplasia: A tale of two enzymes

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    • A new management for congenital adrenal hyperplasia?

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    • A case of pseudohypoparathyroidism with diagnostic dilemmas

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    • Cushing's syndrome of indeterminate origin. Sucessful treatment of a liver abscess after therapy with a block and replacement medical regimen

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    • Self-hypophysectomy - and return to normal

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    • Acute presentation of a ruptured craniopharyngioma

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    • What is the natural history of scalp hairloss in association with the use of somatostatin analogues in the treatment of acromegaly?

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    • Fish oil and antacids: A cautionary tale

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    • Primary hyperaldosteronism in association with primary hyperparathyroidism and prolactinoma - a case report

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    • A case of Gitelman's syndrome

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    • Iatrogenic Acromegaly

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    • Efficacy and safety of high dose testosterone therapy in partial androgen insensitivity

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    • Xanthoma Disseminatum: A rare cause of hypopituitarism

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    • Sustained improvement in vision in a recurrent growth hormone secreting macroadenoma during treatment with octreotide in the absence of marked tumour shrinkage. A reason for cautious optimism ?

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    • Hyperprolactinaemia in a patient taking the herbal remedy Agnus Castus

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    • Differentiated thyroid carcinoma with large bony metastases - what is the best approach?

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    • An unusual presentation of sarcoidosis

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    • A spontaneously resolving mediastinal parathyroid adenoma with no previous Tc-99m pertechnetate uptake

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    • A patient with Turner's syndrome, type 2 diabetes and primary biliary cirrhosis

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    • A case of polyuria, thirst and weight loss

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    • Growth hormone deficiency in salt-losing congenital adrenal hyperplasia

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    • Steroid responsiveness in a case of Riedel's thyroiditis and retroperitoneal fibrosis

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    • Thromboembolism in patients with Cushing's disease - a retrospective case review

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    • Multidisciplinary management of Cushing's syndrome due to a malignant thymic carcinoid tumour

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    • Li-Fraumeni syndrome with adrenocortical tumours producing oestrogens in the father and testosterone in his 18-month-old daughter

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    • Cushing's disease and nasal obstruction from a large biochemically 'silent' corticotroph adenoma

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    • Cushing's syndrome presenting with weight loss and type II diabetes mellitus

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    • Extremely long effects of vitamin D therapy: A near-fatal complication of thyroid surgery

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    • Severe thyroid eye disease associated with stable primary hypothyroidism

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    • Apparent mineralocorticoid excess caused by Barnips cough tablets

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    • Bilateral adrenal histoplasmosis

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    • Cranial diabetes insipidus and possible prolactinoma-an interesting case

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    • The use of the domperidone test in differentiating macroprolactinaemia from true hyperprolactinaemia

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    • A case report of hungry bone syndrome in the course of Graves disease

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    • Anaplastic carcinoma of the thyroid presenting with hyperthyroidism

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    • A case of Addison's disease caused by the antiphospholipid syndrome

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    • Acute adrenal insufficiency and encephalomeningitis with cerebral haemorrhage: A case of secondary lupus anticoagulant syndrome?

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    • Pituitary carcinoma - a pain in the head and a pain in the neck

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    • A case of false immunoassay results due to assay interference

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    • Prolactinoma and macroprolactin

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    • Is the Endocrine nurse too accessible?

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    • Ghanaian influenza

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    • Seizures as first manifestation of catch 22 syndrome in adulthood

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    • An androgen-secreting tumour presenting with resistant hypertension and an 'incidentaloma'

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    • A near fatal case of haematuria

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    • An unusual case of secondary amenorrhea

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    • A diagnostic trilemma of primary adrenal failure, sepsis and HITTS

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  • Cytokines and Growth Factors
  • • Studying of e-selectin in patients with diabetes type 1 amp microangiopathy

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    • The universal expression of ghrelin in normal and malignant breast tissue and its association with tumourigenic genes

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    • Antiangiogenic effect of lanreotide on GH-secreting pituitary adenomas

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    • Ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon: Importance of P-selectin, CXC chemokines

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    • Expression of the membrane interleukin-6 receptor (mIL6R) but absence of shedding of soluble IL6R (sIL6R) in human pituitary tumour cells

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    • Inhibitory effects of interleukin1-alpha, interleukin-6 and leptin on growth of HP75 human pituitary tumour cells

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    • Leptin increases expression of CD11b on human neutrophils

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    • Adrenomedullin stimulation of cytokines and growth factor release in endothelial cells and skin fibroblasts: A possible role in wound healing

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    • Growth hormone treatment does not decrease homocysteine levels

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    • Bacterial lipopolysaccharide directly stimulates cortisol secretion by human adrenal cells

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    • IGFBP-5 regulates IGF-I mediated signaling and survival in the mouse mammary gland

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  • Diabetes & Metabolism
  • • Effects of growth hormone replacement (GHR) on VLDL and LDL APOB100 kinetics in growth hormone deficient (GHD) subjects

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    • The effect of growth hormone replacement (GHR) on lipoprotein composition in growth hormone deficient (GHD) hypopituitary adults

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    • Demonstration of diurnal variation of plasma glycated insulin in type 2 diabetes

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    • Increased red cell folate subsequent to folic acid supplementation in type II diabetes results in a reduction in microalbumin excretion but an increased atherogenic lipid profile

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    • Changes in anthropometric, metabolic and insulin resistance indices among offspring of caribbean patients with type 2 diabetes mellitus

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    • Insulin secretion and metabolic control in Caribbean type 2 diabetic patients commonly treated with sulphonylurea drugs

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    • Abnormalities of vascular function and fibrinolysis in young women with polycystic ovary syndrome

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    • Insulin resistance and metabolic syndrome in obese children

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    • Thioland and steriod levels in polycystic ovary syndrome

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    • Acanthosis nigricans: A valid clinical marker of insulin resistance in obesity

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    • Effects of ACE inhibitors on myocardial infarction, cerebrovascular death, stroke, diabetic nephropathy and insulin sensitivity in patients with diabetes mellitus type 2

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    • Screening strategy and cost analysis of gestational diabetes mellitus in Iranian pregnant women

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    • Incidence of hypertension in patients with gestational diabetes mellitus and non diabetic pregnant women

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    • Effectiveness of a weight management programme in a hospital staff setting

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    • The expression of resistin mRNA in human adipose tissue

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    • Expression of adiponectin mRNA in human adipose tissue depots in non-diabetic and diabetic patients

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    • Expression of purinergic receptors in human insulin-secreting cells in health and disease

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    • A novel gender dimorphism in the response of the gonadal axis to critical illness

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    • Weight gain is not inevitable in the management of type 2 diabetes mellitus

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    • Comparison of effect of insulin in hypothyroidism and after the thyroid hormone therapy

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    • The utility of the HOMA model for identifying women with polycystic ovarian syndrome (PCOS) who are insulin resistant

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    • Paradoxical variability of SHBG and insulin resistance in PCOS patients and controls

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    • Islet amyloid polypeptide (IAPP) accumulates in lysosomes of human beta-cells by crinophagy but does not form fibrils

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    • Audit on lipid management in diabetes

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    • Single nucleotide polymorphisms in the ghrelin gene in tall obese children

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    • Paediatric diabetes survey shows type 2 diabetes prevalence 0.4%, distinct from type 1, and associated with overweight, puberty, female sex and ethnic minority status

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    • ACTH stimulates insulin secretion by MIN6 mouse insulinoma cells

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    • Intensive insulin therapy in diabetic pregnancy

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    • Counterregulatory hormone responses to hypoglycaemia in type 2 diabetes mellitus - comparison of metformin and sulphonylurea treated subjects

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    • Complication in acute myocardial infarction and admission hyperglycaemia

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    • Serum lipoprotein (a) and other lipid parameters in patients with liver cirrhosis and chronic active hepatitis

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    • Lectin binding of serum hCG in pregnancy and type 1 diabetes

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    • Atorvastatin decreases LDL oxidation in glucocorticoid excess state

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    • A pilot study of metformin for the treatment of hirsutism in patients without diabetes

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    • Ultrasound features of polycystic ovaries (PCO) and metabolic syndrome X

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  • Endocrine Tumours and Neoplasia
  • • Outcome of transphenoidal surgery by one surgeon for acute acromegaly

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    • Identification of novel epigenetically silenced sequences in pituitary tumours

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    • Expression of the F-box protein Skp-2 in normal and tumorous human pituitary

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    • High resolution allelotyping of adenomas identifies novel regions of genetic loss

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    • Cushing's syndrome due to apparently autonomous adrenal hyperplasia in a patient with multiple endocrine neoplasia type I

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    • An evalution of endocrine assessment of patients with pituitary tumours prior to tertiary referral

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    • Hereditary multiple exostosis due to an acceptor splice site mutation in the EXT1 gene

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    • Approaches to evaluating the role of vitamin D receptor polymorphisms in breast and prostatic carcinoma

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    • Treatment options for refractory hypercalcaemia in a patient with PTHrP-secreting neuroendocrine tumour and primary hyperparathyroidism

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    • Multiple endocrine neoplasia type 1 (MEN-1) with two different pancreatic tumours

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    • Cigarette smoking exposure, serum insulin-like growth factors, and cancer risk: A population-based study

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    • Hypercalcaemia associated with clear cell carcinoma of the ovary

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    • pound31,474 saved with shared care

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    • The pathogenesis of pancreatic beta-cell adenoma does not involve defects in ATP-sensitive potassium channels

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    • Do symptoms and signs of acromegaly correlate with GH during medical treatment?

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    • Alterations in expression levels of ER subtypes and their coregulators in endocrine resistant breast cancer

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    • A role for co-regulators in estrogen receptor function

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    • Experience with cabergoline therapy in 34 patients with acromegaly

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    • Expression of somatostatin receptor subtypes 1, 2, 3, and 5 in the hyperplastic and neoplastic endometrium

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    • Do non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than other non-functioning adenomas?

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    • Chronic lymphoedema improved by the diagnosis and treatment of underlying acromegaly

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    • The destruction box of pituitary tumor transforming gene (PTTG) mediates cell transformation

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    • Growth hormone receptor and type 1 IGF receptor in human somatotroph tumours

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    • Hunting for oncogenes in pituitary adenomas - a cautionary tale of new technology

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    • Diagnostic accuracy of ultrasound in preoperative assessment of primary hyperparathyroidism

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    • Choice of calcitonin assay

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    • The incidence of colorectal neoplasia in acromegaly

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    • Clinical and biochemical findings in paragangliomas

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    • Inhibition of 11beta-HSD2 has an anti-proliferative effect on pituitary tumour cells

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    • Reference ranges for urinary metadrenalines in patient populations

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    • Primary medical management of macroprolactinomas with cabergoline(CAB)

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    • Routine calcitonin measurement in management of thyroid nodules: A decision analysis approach

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    • Patterns and mechanisms of hypercortisolism in association with phaeochromocytoma

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    • Ghrelin, but not GHRP-6 or hexarelin increases proliferation of colonic epithelium via effects on c-myc mRNA

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  • Genetics
  • • No association of a 3' UTR polymorphism of the interleukin-12 P40 (IL12B) gene with Grave's disease in a UK population

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    • Lack of association of the insulin gene region with Grave's disease in the UK

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    • The angiotensin II response to an acute exercise stimulus and the angiotensin converting enzyme (ACE) genotype

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    • A nonsense mutation in exon two of the DNASE1 gene is not present in UK subjects with SLE and autoimmune thyroid disease

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    • Seven novel mutations in the androgen receptor gene associated with complete androgen insensitivity syndrome

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    • Compound heterozygous AIRE-1 mutations in autoimmune polyendocrinopathy type 1

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    • Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

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    • Single nucleotide polymorphisms of the beta2-adrenergic receptor (ADRB2) gene and hypertension

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    • Independent Y chromosome markers associated with blood pressure and testosterone levels

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  • Growth and Development
  • • Increased heights and weights of Isfahani male children and adolescents in Iran

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    • Androgen receptors are expressed in the developing antler tip and velvet skin of the red deer (Cervus elaphus )

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    • Gender variation in leptin circadian rhythm and pulsatility in adult growth hormone deficiency; effects of growth hormone replacement

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    • Monitoring insulin-like growth factor-I and IGF binding protein-3 in children and adolescents on GH treatment using filter paper blood spots

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    • Serum Ghrelin concentrations in healthy children and adolescents

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    • BMI corresponds to oestradiol levels and delayed puberty in boys

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    • An audit of paediatric to adult transition of childhood onset growth hormone deficiency

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    • Factors affecting insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults

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    • Familial combined pituitary hormone deficiency by PROP1 gene mutation, in a Portuguese family

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    • A survey of the investigation of short stature in Wales

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    • Accelerated aortic root dilatation in Turner syndrome

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    • Cellular proliferation in the adrenal cortex in vitro

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    • Developmental regulation of the mt1 melatonin receptor gene in the rat pituitary gland

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    • Growth hormone therapy decreases LDL oxidation in oestrogen deficiency

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    • Abnormal collagen morphology and decreased bone strength in growth hormone deficient rats

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    • Growth hormone replacement: Patients' views

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  • Neuroendocrinology
  • • Growth hormone deficient patients over 60 years require a low dose of GH and short titration phase to achieve normal serum IGF-I levels

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    • A relationship between interleukin-1 and interleukin-6 secretion by human pituitary adenomas in culture

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    • Time dependency of somatotroph dysfunction following radiation damage of the hypothalamic-pituitary axis

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    • Ghrelin is acutely regulated by insulin but not glucose

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    • Gender differences in the relationship between leptin and the autonomic nervous system

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    • Magnetic resonance perfusion enables assessment of blood supply to pituitary gland

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    • Long term treatment of adult growth hormone deficiency does not normalise quality of life compared to control subjects: A need for a different strategy?

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    • Expression and purification of histidine-tagged anosmin-1 by drosophila S2 cells and Ni-NTA agarose chromatography

      ea0003p184
    • Cardiac sympathovagal balance correlates positively with age in growth hormone deficient (GHD) patients

      ea0003p185
    • The pattern of green fluorescent protein (GFP) expression following intrahypothalamic injection of adeno-associated virus-GFP

      ea0003p186
    • The effect of serotonin on the GH, T3, T4, milk production and composition

      ea0003p187
    • Diet-induced obesity in the Sprague-Dawley (SD) rat

      ea0003p188
    • The correlation between serum insulin-like growth factor 1 levels and creatinine clearance in adults with growth hormone deficiency

      ea0003p189
    • Functional neurosecretory GnRH deficiency in a man with adult onset hypogonadotrophic hypogonadism: an unrecognised entity?

      ea0003p190
    • Precipitating factors and surgical outcome in pituitary apoplexy

      ea0003p191
    • Single centre audit of surgical outcome in Cushing's disease

      ea0003p192
    • Leptin and leptin receptors are developmentally regulated in rat pituitary

      ea0003p193
    • Influence of age on the vulnerability of the hypothalamic-pituitary axis to radiation damage

      ea0003p194
    • Weight gain and obesity in patients with hypothalamic damage

      ea0003p195
    • Urinary catecholamines and catecholamine-metabolites in the immediate post-operative period following coronary revascularization surgery

      ea0003p196
    • The effect of bombesin on the Gh, T3, T4 and milk production and compositions

      ea0003p197
    • Functional complement C3a receptors in the rat pituitary gland

      ea0003p198
    • Serum IGF-I levels and correlation with functional activity in the elderly

      ea0003p199
    • Disease activity in acromegaly may be assessed four weeks after discontinuation of pegvisomant

      ea0003p200
    • Outcome of treatment for Cushing's disease in Birmingham; the experience of a single surgeon

      ea0003p201
    • Beta-adrenergic input exerts both acute and chronic effects on steroid production in H295R human adrenocortical cells

      ea0003p202
    • Neuropeptides and adrenocortical proliferation in vitro

      ea0003p203
    • Growth hormone (GH) deficiency in adults treated for acute lymphoblastic leukaemia (ALL) in childhood

      ea0003p204
    • Outcomes in the management of pituitary apoplexy; a conservative approach may be prudent

      ea0003p205
    • Prolactin releasing peptide does not have a significant role in the control of growth hormone secretion either in vitro or in vivo in freely moving male rats

      ea0003p206
    • Measures of cardiovascular parameters in patients with acromegaly switched from SC octreotide to Sandostatin-LAR

      ea0003p207
  • Reproduction
  • • Is the antidiuretic effect of recombinant prolactin mediated by changes in the glomerular filtration rate?

      ea0003p208
    • Cardiovascular risk profiles in women with polycystic ovarian syndrome (PCOS)

      ea0003p209
    • Weight change and androgen levels during contraceptive treatment of women affected by polycystic ovary syndrome (PCOS)

      ea0003p210
    • Parathyroid polyhormone action on motility of pregnant mouse uterus in vitro: Role of nitric oxide

      ea0003p211
    • Phenotype and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians (SA) and Caucasians (C): Is there a difference?

      ea0003p212
    • Detection of bio-inactive prolactin (macroprolactin) is analyser dependant

      ea0003p213
    • Awareness of Libyan women of the menopause and their attitudes to hormone replacement therapy

      ea0003p214
    • The mRNA expression and regulation of natural antimicrobials in human fetal membranes and placenta

      ea0003p215
    • Activation of supraoptic nucleus (SON) oxytocin neurones during mouse parturition

      ea0003p216
    • Residual ovarian function after cytotoxic chemotherapy and possible predictors of ovarian recovery

      ea0003p217
    • A randomised controlled trial comparing the use of metformin and dianette in hirsutism associated with PCOS

      ea0003p218
    • Testicular Leydig cell tumour presenting as primary infertility

      ea0003p219
    • Phytoestrogens as inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 in luteinized human granulosa cells

      ea0003p220
    • Oxygen tension regulates placental 11 beta-hydroxysteroid dehydrogenase type 2

      ea0003p221
    • Androgen status and female sexual dysfunction in healthy pre-menopausal women

      ea0003p222
    • A novel sensitive radioimmunoassay for the measurement of soluble Flt-1 (soluble vascular endothelial growth factor receptor-1)

      ea0003p223
    • Improvement of hyperandrogenism and insulin resistance in females with severe obesity after weight loss through bariatric surgery

      ea0003p224
    • Oral clatharate-DHEA as a potential form of androgen replacement in hypogonadal men. A phase 2, open label, placebo controlled, parallel group pharmacokinetic study

      ea0003p225
    • Significant ethnic variation in circulating total bound and free testosterone

      ea0003p226
    • Increased HOXA10 expression in late gestation: A novel target for hormonal regulation in placenta and decidua

      ea0003p227
    • Efficacy of metformin for ovulation induction in polycystic ovary syndrome

      ea0003p228
    • Expression of mRNA for IGF-1, IGF-2, type 1-IGF receptor, type 2-IGF receptor and insulin receptor in isolated, human preantral follicles

      ea0003p229
    • FSH alters metabolism and increases chromosomal abnormalities in mouse cumulus-oocyte-complexes matured in vitro

      ea0003p230
    • Engineering of single chain antibodies selected from a phage display library into human IgGs that recognise gonadotrophin surge-attenuating factor (GnSAF) bioactivity

      ea0003p231
    • 1,25-dihydroxyvitamin D3 receptors (VDR) are present on human granulosa cells and cells of the corpus luteum

      ea0003p232
    • Semen profile, hormonal analysis and physiological activity of Pakistani men with varying degrees of sperm concentrations

      ea0003p233
    • Effectiveness of antioxidant vitamin therapy in improving semen quality

      ea0003p234
    • Regulation of expression and activity of lysyl oxidase in developing ovarian follicles

      ea0003p235
  • Signalling
  • • Do inhibitors of NAD(P)H oxidase improve endothelial function in rat and human arteries?

      ea0003p236
    • Analysis of GR/NFkB interactions in living cells

      ea0003p237
    • Interactions of vitamin D analogues with downstream effectors of insulin-like growth factor 1 (IGF-I) signalling

      ea0003p238
    • Dexamethasone blocks mitochondrial targeting-induced apoptosis

      ea0003p239
    • Expression and function of voltage-gated calcium channels in human pancreatic B-cells in health and disease

      ea0003p240
    • Mutations in the growth hormone receptor (GHR) may differentially affect signalling and receptor trafficking

      ea0003p241
    • Essential role of p38 mitogen-activated protein kinase in adipogenesis

      ea0003p242
  • Steroids
  • • Free cortisol index in suspected HPA axis pathology

      ea0003p243
    • Expression and corticosteroid regulation of serum and glucocorticoid regulated kinase, and epithelial sodium channel subunits in human ocular ciliary epithelium

      ea0003p244
    • Carbenoxolone, an inhibitor of 11 beta hydroxysteroid dehydrogenase type 1, reduces intraocular pressure in patients with ocular hypertension

      ea0003p245
    • Comparison of the efficacy of long-term self-administration of subcutaneous human chorionic gonadotrophin with intramuscular exogenous testosterone (Sustanon) in male hypogonadism

      ea0003p246
    • The prevalence and morbidity of long-term oral corticosteroid therapy

      ea0003p247
    • The relationship between smoking, statin therapy and testosterone in men with coronary artery disease

      ea0003p248
    • Androgens and diabetes mellitus in men with coronary artery disease

      ea0003p249
    • Testosterone and pro-inflammatory cytokines in men with chronic heart failure

      ea0003p250
    • Testosterone therapy improves depressive symptoms in men with chronic heart failure

      ea0003p251
    • Testosterone increases interleukin 10, an anti-inflammatory cytokine, in whole blood from hypogonadal men

      ea0003p252
    • Testosterone and skeletal muscle parameters in men with chronic heart failure

      ea0003p253
    • Hypoglycaemia and Addison's disease - cause or association?

      ea0003p254
    • Intermittent hyponatraemia due to isolated ACTH deficiency

      ea0003p255
    • Expression of adipose 11 beta-hydroxysteroid dehydrogenase type 1 in human obesity

      ea0003p256
    • Enhanced hepatic A-ring reduction of glucocorticoids in obesity: Regulation by glucocorticoids and insulin

      ea0003p257
    • In vitro expression of catalytically active human aldosterone synthase

      ea0003p258
    • Reduced glucocorticoid receptor expression in obese Zucker rats: Protection from the metabolic consequences of obesity?

      ea0003p259
    • Assessment of mineralocorticoid status by urinary corticosteroid profiling using gas chromatography-mass spectrometry (GCMS)

      ea0003p260
    • Angiotensin II and ACTH differentially regulate adrenal steroid production through key steroidogenic enzymes

      ea0003p261
    • A role for nur-77 in the regulation of adrenal steroid production

      ea0003p262
    • Growth hormone increases fat mass in patients with simple obesity

      ea0003p263
    • Cortisone reductase (11 beta-hydroxysteroid dehydrogenase type 1) deficiency presenting with features of late onset congenital adrenal hyperplasia

      ea0003p264
    • Phytoestrogen dietary supplementation does not alter serum IGF-1 levels in postmenopausal women

      ea0003p265
    • Testosterone exhibits a calcium antagonistic action upon store operated calcium channels in cultured vascular smooth muscle cells

      ea0003p266
    • Testosterone does not increase the production of cyclic AMP (cAMP) in cultured vascular smooth muscle cells

      ea0003p267
    • Circulating steroid levels in the testicular feminised (Tfm) mouse

      ea0003p268
    • Size at birth, gestational age and cortisol secretion in adult life: Do multiple mechanisms underlie fetal programming of the hypothalamic-pituitary-adrenal axis?

      ea0003p269
    • Roles of K-Ras and Gadd153 in 17beta-oestradiol-induced apoptosis in colo205 cells

      ea0003p270
    • Fetal and maternal regulation of aldosterone synthase and 11 beta hydroxylase

      ea0003p271
    • Quantification of aldosterone synthase (CYP11B2 ) gene expression in the adrenal gland and central nervous system following dietary sodium manipulation

      ea0003p272
    • Long-term overall success after transsphenoidal surgery for Cushing's disease: Time for a reappraisal of therapy?

      ea0003p273
    • What value do cortisol measurements provide in monitoring metyrapone therapy?

      ea0003p274
  • Thyroid
  • • Atrial fibrillation predicts mortality in thyrotoxicosis

      ea0003p275
    • Increased force/unit cross sectional area as well as increased bulk causes recovery in proximal strength in hyper/hypothyroidism

      ea0003p276
    • Influence of pre-treatment factors on outcomes following the use of high fixed dose radioiodine treatment for hyperthyroidism

      ea0003p277
    • The female preponderance to autoimmune thyroid disease is reduced in multiplex type 1 diabetes families

      ea0003p278
    • Analysis of a clinical workstation thyrotoxicosis share-care scheme

      ea0003p279
    • Thyrotoxic heart failure in a previously fit 40 year old woman

      ea0003p280
    • Delayed resolution of endothelial dysfunction despite biochemical correction of thyrotoxicosis

      ea0003p281
    • Thyroid function in paediatric patients with malignancy after radiotherapy in Isfahan, Iran

      ea0003p282
    • Thyroid hormone (TH) regulation of iodothyronine deiodinase and thyroid hormone receptor (TR) expression in placental trophoblast cells

      ea0003p283
    • Pituitary tumor transforming gene and basic fibroblast growth factor-2 - novel potential molecular indicators for thyroid cancer

      ea0003p284
    • Outcome at two years of fixed dose radioiodine treatment for thyrotoxicosis

      ea0003p285
    • Effect of blood exchange transfusion on neonatal thyroid function

      ea0003p286
    • Provision of a new strength thyroxine tablet would facilitate tight control of TSH concentrations in primary hypothyroidism

      ea0003p287
    • The follow-up status of patients 10 years after treatment with radioactive iodine(RI) for hyperthyroidism

      ea0003p288
    • A cluster of cases of subacute thyroiditis in North East England

      ea0003p289
    • Audit of the management of maternal hypothyroidism in pregnancy: Implications for service provision

      ea0003p290
    • Lithium associated thyrotoxicosis

      ea0003p291
    • Thyroid dysfunction in diabetes: Can we justify routine screening?

      ea0003p292
    • Clinical assessment of two methods for measuring thyrotropin binding inhibiting immunoglobulin (TBII)

      ea0003p293
    • Thyroid peroxidase antibodies are not a surrogate for thyroid stimulating antibodies in the investigation of the etiology of thyrotoxicosis

      ea0003p294
    • Molecular characterisation of congenital hypothyroidism

      ea0003p295
    • Pyrimidine and purine metabolism in human leukocytes in autoimmunological thyroid diseases - RNA expression of some enzymes

      ea0003p296
    • Protein kinase C delta interacts with the sodium iodide symporter (NIS) to increase its activity in human thyrocytes

      ea0003p297
    • Profile of the thyroid function in a population with type-2 diabetes mellitus

      ea0003p298
    • Thyroid function in early pregnancy. A prospective study

      ea0003p299
    • Determining the molecular causes of hyperthyroidism

      ea0003p300
    • Telephone follow-up following radioiodine therapy for thyrotoxicosis improves outcome

      ea0003p301
    • Environmental factors produce variation within a model of thyroid eye disease

      ea0003p302
    • The use of lithium as an adjunct to radioiodine therapy for thyrotoxicosis

      ea0003p303
    • Adenoviral expression of secreted Tie-2 reduces thyroid follicular cell growth and adhesion

      ea0003p304
    • Primary hypothyroidism and unilateral thyroid eye disease: A case report

      ea0003p305
    • Plasma total and free tissue factor pathway inhibitor, tissue plasminogen activator antigen, and plasminogen activator inhibitor antigen levels in various thyriod disorders

      ea0003p306
    • High thyroglobulin autoantibodies in Sri Lankan tamil tea workers exhibit an epitope-recognition pattern distinct from healthy subjects and autoimmune thyroid disease (AITD) patients

      ea0003p307
    • Thyroid disease in patients with genetic haemochromatosis - A prospective study

      ea0003p308