Endocrine Abstracts

Beclere first described the use of pituitary radiotherapy in 1909. Despite this long history of use, there is debate surrounding its role in the modern management of patients with pituitary disease. Whilst treatment with conventionally fractionated external beam radiotherapy (RT) is used infrequently as primary therapy in patients with pituitary adenomas, it is commonly administered following non-curative pituitary surgery. In acromegaly, Cushing's disease/Nelson's syndrome, a...

Focussed radiotherapy or radiosurgery has been a disappointing alternativeto surgery as a primary treatment for pituitary adenomas. Our departmenthas delivered stereotactic multiple arc radiotherapy (SMART) through anadapted conventional linear accelerator (LINAC) for pituitary adenomas notcured by conventional therapy. We have treated 21 patients with biochemicaland/or radiological evidence of persisting disease despite maximalconventional therapy: all patients had undergone ...

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