Searchable abstracts of presentations at key conferences in endocrinology
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NANETS 2023

Abstracts

Population Science

ea0098p1 | Population Science | NANETS2023

Rising incidence of bronchopulmonary neuroendocrine tumors

Paciorek Alan , Moon Farhana , Khuong Le Bryan , Zhang1, Li , Steiding Paige , Bergsland Emily , Mulvey Claire

Background: The epidemiology of typical (TC) and atypical carcinoid (AC) bronchopulmonary neuroendocrine tumors (pulmNETs) is not well understood. We aim to describe the incidence of pulmNETs and differences by sex and race and ethnicity (R&E) in the diverse state of California.Methods: All patients with malignant pulmNETs diagnosed from 1992-2019 in the population-based California Cancer Registry were identified by histology (ICD-O-3 code 8240 for T...

ea0098p2 | Population Science | NANETS2023

Renal neuroendocrine tumors: a single center clinicopathologic and molecular analysis

J Pegna Guillaume , Mittra Erik , Mallak Nadine , Kardosh Adel , Chen Emerson , Lopez Charles , Pommier Rodney

Background: Renal neuroendocrine tumors (NETs) are a particularly rare subset of NETs, with fewer than 100 cases described in the literature. Of these, next generation sequencing (NGS) findings have been described in fewer than 10 cases, all but one of which had grade 1 disease.Methods: A single-center, IRB-approved retrospective analysis of patients with grade 2 or 3 well-differentiated renal NETs treated at our institution from 2016-2023 for whom NGS d...

ea0098p3 | Population Science | NANETS2023

Factors affecting patient knowledge and awareness about neuroendocrine tumors

Sonti Sahithi , Advani Shailesh , Iyer Renuka

Background: Neuroendocrine Tumor (NET) patients are the fastest growing population of cancer patients, hence we wanted to assess if there are gaps in patient knowledge and awareness of their disease. To improve our understanding of the factors affecting patient knowledgeability, we looked at their educational level, satisfaction with educational materials provided at initial diagnosis, other sources used for awareness, and their level of accessibility to education materials ab...

ea0098p4 | Population Science | NANETS2023

Determinants of financial distress in patients with neuroendocrine tumors

Sonti Sahithi , Advani Shailesh , Iyer Renuka

Background: Neuroendocrine tumors are a rare group of cancers. The median overall survival of these patients is ~10 years, presenting a unique issue of accrued financial distress over a long period of time. We attempted to look at the potential determinants of financial distress in NET patients, focusing on their demographics, comorbidity burden, educational status and tumor symptoms.Methods: A total of 155 patients have been enrolled in the Roswell Park...

ea0098p5 | Population Science | NANETS2023

Higher serotonin levels from ileum neuroendocrine tumors are associated with mesenteric mass progression

Yogo Akitada , Paciorek Alan , Moon Farhan , Bergsland Emily K. , Alseidi Adnan , Adam Mohamed , Maker Ajay , Corvera Carlos , Hirose Kenzo , Nakakura Eric K.

Background: Serotonin produced by ileum neuroendocrine tumors (i-NETs) promotes development of the mesenteric mass (MM) associated with lymph node metastases. We previously reported that more extensive MM progression along the superior mesenteric vessels predicts a lower rate of complete surgical resection. In this study, we hypothesized that tumoral serotonin production is associated not only with the development of MM but also its progression, and we examined serotonin level...

ea0098p6 | Population Science | NANETS2023

The use of antidepressants is associated with mesenteric mass formation of ileum neuroendocrine tumors

Yogo Akitada , Paciorek Alan , Moon Farhan , Bergsland Emily K. , Alseidi Adnan , Adam Mohamed , Maker Ajay , Corvera Carlos , Hirose Kenzo , Nakakura Eric K.

Background: Serotonin production by ileum neuroendocrine tumors (i-NETs) is considered a critical mediator of the fibrotic reaction in mesenteric mass (MM)/ lymph node metastasis. Antidepressants modify serotonin dynamics: however, their role in MM formation is uncertain. We hypothesized that histories of antidepressant use affect MM formation. This study examined the correlation between antidepressant use and MM formation.Methods: One hundred eighty-two...

ea0098p7 | Population Science | NANETS2023

Validity of geographic-level social determinant of health metrics in pancreatic neuroendocrine tumors

Gillis Andrea , Herring Brendon , Guenter Rachael , Chen Weisheng , Chen Dai , Chen Herbert , Bart Rose J. , Manne Upender , Bhatia Smita

Background: Various social determinant of health (SDOH) metrics and indices are utilized to evaluate access to cancer care and to explain disparities in outcome in pancreatic neuroendocrine tumors (PNETs). Little prior work has compared the validity of various geographic metrics. Therefore we aimed to examine different geographic metrics validity (from smallest to largest: census block group< census tract< zip code< county) utilizing single institutional data in a ...

ea0098p8 | Population Science | NANETS2023

Influence of social determinants of health on pancreatic neuroendocrine tumor stage at presentation

Gillis Andrea , Herring Brendon , Guenter Rachael , Chen Weisheng , Chen Dai , Chen Herbert , Bart Rose J. , Manne Upender , Bhatia Smita

Background: Tumor size and lymph node involvement (stage) have been utilized to prognosticate pancreatic neuroendocrine tumors (PNETs) but the influence of race and social vulnerability on these factors remains unexplored. Therefore we sought to explore this in a racially and socioeconomically diverse cohort.Methods: We reviewed records of all patients who underwent surgical resection for PNETs from 2006-2022 at a single NCI-designated cancer center in t...

ea0098p9 | Population Science | NANETS2023

Contemporary incidence and survival of lung neuroendocrine neoplasms: a population-based study

Rousseau Mathieu , Wakeam Elliott , Singh Simron , Myrehaug Sten , Law Calvin , Barabash Victoria , C Chan Wing , Hallet Julie

Background: While the epidemiology of overall and gastrointestinal neuroendocrine neoplasms (NENs) has been reported, data specific to lung NENs remain scarce. Such understanding is crucial in designing tailored strategies to improve care and outcomes. We examined the incidence, overall survival (OS), and disease-specific death (DS-deaths) for lung NENs.Methods: We conducted a population-based retrospective cohort study of adult patients with incident lu...

ea0098p10 | Population Science | NANETS2023

Quality of life differs by age and sex for participants with advanced neuroendocrine neoplasms in the eNET study

Mulvey Claire K. , Paciorek Alan , Steiding Paige , Moon Farhana , Zhang Li , Bergsland Emily K.

Background: Patients with neuroendocrine neoplasms (NENs) have a high burden of chronic symptoms. We assessed symptom burden and overall quality of life (QOL) for eNET study participants and analyzed differences by age, sex, and NEN primary site.Methods: eNET is a prospective, cohort study on the Eureka digital health platform enrolling individuals with advanced NENs. Participants completed validated surveys on an internet-supported device at baseline an...

ea0098p11 | Population Science | NANETS2023

Sex differences during hospital stay among patients with neuroendocrine neoplasms

Ying Tan Wan , Cramer Laura D. , Vijayvergia Namrata , Lustberg Maryam , Kunz Pamela L.

Background: On the basis of prior large epidemiologic and retrospective studies on treatment-related side effects, it appears that there are sex-based differences in the epidemiology of NENs and treatment-related side effects. The purpose of this study was to examine sex differences in incidence, diagnoses present during hospital stay, and mortality among patients with NENs.Methods: The NIS database was used to define an unweighted sample of patients wit...