Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2022

Harrogate, United Kingdom
14 Nov 2022 - 16 Nov 2022

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SfE BES is returning to Harrogate in 2022. Join with endocrine specialists from across the UK and beyond for the Society for Endocrinology's flagship meeting.

Symposia

Old hormones, new tricks: new approaches for treating reproductive diseases

ea0086s4.1 | Old hormones, new tricks: new approaches for treating reproductive diseases | SFEBES2022

Size matters. Small molecule targeting of gonadotrophin hormone receptors

Hanyroup Sharika , Anderson Ross , Nataraja Selvaraj , Yu Henry , Kreuchwig Annika , Krause Gerd , Katz Arieh , Millar Robert , Newton Claire

G protein-coupled receptors (GPCRs) are critical for signal transduction within neuroendocrine signalling pathways, and genetic mutations in G protein-coupled GPCRs underlie numerous diseases. Inactivating GPCR mutations can impede ligand interactions or signal transduction, or can result in misfolding of nascent receptor proteins and subsequent retention in the endoplasmic reticulum (ER) and thus failure to traffic to the cell surface. Examination of the functionality and cel...