Workshop E: Disorders of the gonads

32 year old female presented to her GP following a first trimester miscarriage which consequently resulted in her experiencing secondary amenorrhoea for more than 9 months. Secondary amenorrhoea is defined as cessation of regular menses for 3-6 months or the cessation of irregular menses for 6-12 months. Her main concern was around her subfertility and dry skin. She started menarche at the age of 10 with regular monthly menses until her copper coil insertion 4 years ago. She h...

0 shares

ea0082we2 | Workshop E: Disorders of the gonads | SFEEU2022

47, XYY syndrome: hypogonadism and osteoporosis

Srinivasan Ramalingam , Ramalingam Satheekshan , Wahid Alam , TunYee LainLai , Thomas Joegi , Makkuni Damodar

A male, born in 1957, with history of familial spinocerebellar ataxia, Type 2 diabetes (diagnosed in 1999), asthma, learning difficulties, chronic pancreatitis, recurrent falls, multiple low trauma fractures and osteoporosis was referred to Endocrinology Department in 2019. He sustained a right radial fracture at the age of 34 (1992), followed by comminuted right distal radius and Ulna styloid process fracture in 2002, Left and right Neck of Femur fractures in 2013 and 2014 re...

0 shares

ea0082we3 | Workshop E: Disorders of the gonads | SFEEU2022

Polycythaemia related to exogenous testosterone administration

Page Tristan , Hazlehurst Jonathan

This 60-year-old male was reviewed remotely for follow up in the general endocrine outpatient clinic having originally been referred for erectile dysfunction and low libido. He had a past medical history of hypertension and dyslipidaemia and was prescribed amlodipine and atorvastatin. On previous clinical assessments, he had increased muscle bulk, normal secondary sexual characteristics with testes measuring 15mls and 12mls. There had been no evidence of gynaecomastia. He work...

0 shares

ea0082we4 | Workshop E: Disorders of the gonads | SFEEU2022

Secondary Amenorrhea: Hypothalamic Amenorrhea an important cause to consider

Shaikh Sheeba , Lewis Alexander

Hypothalamic amenorrhea is a diagnosis of exclusion. It accounts for 30% of cases of secondary amenorrhoea in women of reproductive age. It is caused by abnormal signalling between the hypothalamus and the pituitary gland due to deficient pulsatile secretion of GnRH. This reduced secretion of GnRH leads to levels of LH and FSH that are insufficient to maintain full folliculogenesis and normal ovulatory ovarian function, with consequent oestrogen deficiency. There are many caus...

0 shares

ea0082we5 | Workshop E: Disorders of the gonads | SFEEU2022

A challenging case of hypogonadism

Lei Yin Win , Witczak Justyna , Taylor Peter

Gonadal dysgenesis with DAX1 duplication as the cause of XY disorder of sexual development is a rare condition. Duplication of this causes male to female sex reversal while mutation or deletion can cause adrenal hypoplasia congenita with hypogonadotropic hypogonadism. We present a case of 37-year-old lady who was referred to endocrine clinic with ongoing symptoms of fatigue. She was diagnosed with 46 XY gonadal dysgenesis when she presented with groin swelling at the ...

0 shares

ea0082we6 | Workshop E: Disorders of the gonads | SFEEU2022

Role of sonography in the diagnosis of primary amenorrhea - benefits vs pitfalls

Ali Rashid Razan , Iqbal Khan Irfan

A 17 year-old female was referred to Endocrinology with primary amenorrhoea and arrested puberty (B4 PH4 AH2). She reported breast development in line with her peer group and had experienced a single show of vaginal spotting aged 15 years. Although guidelines recommend baseline pelvic USS in the investigation of primary amenorrhoea, it generally only adds value in females with high LH+FSH and abnormal karyotype; indeed, it may raise undue concerns of uterine (Mulle...

0 shares

ea0082we7 | Workshop E: Disorders of the gonads | SFEEU2022

Isolated Hypogonadotropic Hypogonadism

Ni Aung Nwe , Bujanova Jana

17 year old male was referred by GP with short stature and delayed development of secondary sex characteristics. History: He was born at full term with a bodyweight of eight pounds and normal development till adolescence. He is the second out of three children and as his parents and siblings entered puberty at expected ages and he has not suffered from the chronic illness make constitutional delay of puberty or functional hypothalamic hypogonadism less l...

0 shares

ea0082we8 | Workshop E: Disorders of the gonads | SFEEU2022

Central hypogonadism in a man with a Rathke’s cleft cyst

Issuree Kiran

A 57 year old man presented with a 2 year history of erectile dysfunction and loss of libido. He was able to achieve erections but could not maintain them for intercourse. This was causing considerable strain on his marital life. He also complained of lethargy and general fatigue. His past medical history included diet-controlled type 2 diabetes and hypertension. He was an ex-smoker with a 40 pack year history and drank socially. He was an office worker. He had 3 grown up chil...

1 shares

ea0082we9 | Workshop E: Disorders of the gonads | SFEEU2022

Primary female hypogonadism

Razi Ahmed Shaikh , Ali Mudassir , Devine Kerri , Iqbal Khan Irfan

Female with primary hypogonadism have inadequate function of the ovaries, with impaired production of germ cells (eggs) and sex hormones (oestrogen and progesterone). We recently came across a 22-year old female with short stature in childhood and adulthood she received growth hormone treatment (due to arrested puberty) between 3-5 years of age and further treatment at age of 10 years. She had history of IUGR, primary amenorrhoea, sensorineural deafness, congenitally missing t...

1 shares

ea0082we10 | Workshop E: Disorders of the gonads | SFEEU2022

A rare case of male hypogonadism

Musharraf Adeel , Criseno Sherwin , Elhassan Yasir , Gleeson Helena

A 29 year old gentleman presented to Urology with scrotal pain. He had renal calculi but examination also revealed small testicles for which he was referred to Endocrinology. He achieved normal developmental milestones. He had no history of mumps or testicular torsion or surgery. He had no history of hypospadias or undescended testicles. He was not on any regular medication and denied anabolic steroids use. He reported a normal sense of smell. His body weight was 72 Kg with he...

0 shares

ea0082we11 | Workshop E: Disorders of the gonads | SFEEU2022

Anabolic steroid induced hypogonadism: Challenge to endocrinologists with expanding anabolic steroid users’ websites

Thayyil Sheena , Kong Marie-France

40year old bodybuilder was re-referred to clinic with low mood, reduced libido, poor morning erections and fatigue. His past medical history included hypogonadal hypogonadism secondary to anabolic androgen abuse, mental health disease and personality disorders. He had undergone breast reconstruction surgery for bilateral gynaecomastia secondary to anabolic steroid use despite taking precautionary tamoxifen injections as per peer groups advice. Previously, he was lost for...

0 shares

ea0082we12 | Workshop E: Disorders of the gonads | SFEEU2022

"Is there a right time to stop hormone replacement therapy?"

Iqbal Khan Irfan , Ali Rashid Razan , Razi Ahmed Shaikh

A 59-year-old woman with 46XY complete androgen insensitivity syndrome was referred back to our service. She also has history of hypertension and migraines. She was gonadectomised at the age of 15 years and treated with Ethinylestradiol. She married and was able to have enjoyable sex without the need for vaginoplasty or dilators. However, at 54 years she was firmly advised to stop Ethinylestradiol due to satisfactory bone density and risks of HRT outweighing benefits&#14...

0 shares

ea0082we13 | Workshop E: Disorders of the gonads | SFEEU2022

Reversible hypopituitarism in a young male athlete

Lam George , Kurera Isuri

Negative caloric balance and low body weight can impair pituitary function. This syndrome is well recognised in women, but it is less often diagnosed or considered in men. We present the case of a 16-year-old male who presented with increasing tiredness, bloating and inability to focus over a period of 3 months. He had been involved in regular sporting activities over last few years recently increased the physical activity focusing on fitness with a calorie deficit diet leadin...

0 shares

ea0082we14 | Workshop E: Disorders of the gonads | SFEEU2022

Abstract Withdrawn...

0 shares

Endocrine Abstracts

Society for Endocrinology Endocrine Update 2022

Society for Endocrinology Clinical Update 2022

How to solve the Rubik’s cube? A case of functional hypothalamic amenorrhoea in a low BMI female

47, XYY syndrome: hypogonadism and osteoporosis

Polycythaemia related to exogenous testosterone administration

Secondary Amenorrhea: Hypothalamic Amenorrhea an important cause to consider

A challenging case of hypogonadism

Role of sonography in the diagnosis of primary amenorrhea - benefits vs pitfalls

Isolated Hypogonadotropic Hypogonadism

Central hypogonadism in a man with a Rathke’s cleft cyst

Primary female hypogonadism

A rare case of male hypogonadism

Anabolic steroid induced hypogonadism: Challenge to endocrinologists with expanding anabolic steroid users’ websites

"Is there a right time to stop hormone replacement therapy?"

Reversible hypopituitarism in a young male athlete

BiosciAbstracts