Endocrine Abstracts

The gut microbiota is now the subject of considerable investigation and our knowledge of its composition and understanding of functions are rapidly growing.Gut microbiota has profound impact on host physiology and it is now well-established that dysbiosis is associated with altered glycemic control and type 2 diabetes development. Targeting microbiota appears therefore as a promising strategy for the treatment of diabetic patients. Using probiotics in order to modulate blood g...

Alterations in (small) intestinal microbiota are associated with aberrant insulin secretion. We previously showed that fecal transplantation (infusing intestinal microbiota from lean donors) in insulin resistant subjects has beneficial effects on the recipients’ microbiota composition and glucose metabolism via altering fecal SCFA producers levels (Vrieze, Gastroenterology 2012). Followup studies suggest that this beneficial effect can be divided in responders and non res...

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