Endocrine Abstracts

‘European Young Endocrine Scientists’ (EYES), founded in 2011, is a committee under the patronage of the European Society of Endocrinology (ESE). Our primary goal is to increase the mutual exchange of ideas and knowledge between early career researchers (ECR’s) across Europe, in both basic and clinical endocrinology. EYES enables ECR’s from all ESE member societies to actively contribute to the society’s activities and help them fully develop into the ...

Background: Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass in healthy humans and further increases during caloric restriction (CR). However, BMAT function during CR and other conditions remains poorly understood. Circulating glucocorticoids also increase during CR, and glucocorticoid therapy increases BMAT; thus, we hypothesise that glucocorticoid excess mediates BMAT expansion during CR. Many effects of endogenous glucocor...

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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated prevalence of 25–30% worldwide, rising to 90% in morbidly obese patients and to 60% in patients with type 2 diabetes (T2D). The mortality related to NAFLD, attributed to hepatic and extra-hepatic diseases, continues to increase. Moreover, T2D is an aggravating factor for NAFLD, as it increases the risk of developing non-alcoholic steatohepatitis (NASH), liver f...

Background: HNF1B-MODY is a rare autosomal dominant monogenic form of diabetes coexisting with kidney abnormalities.Objectives: Identification of altered serum metabolites among HNF1B-MODY patients and investigating its function in syndrome pathogenesis.Methods: We recruited patients with HNF1B-MODY (N=10), HNF1A-MODY (N=10), polycystic kidney disease: non-dialyzed and dialyzed ...

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