Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Symposia

Endocrine disrupting chemicals (Endorsed by Endocrine Connections)

ea0063s7.1 | Endocrine disrupting chemicals (Endorsed by Endocrine Connections) | ECE2019

Mixtures measured in human, disrupt thyroid hormone signaling and behavior in Xenopus laevis

Fini Jean-Baptiste

Endocrine disrupting chemicals (EDCs) harm human health both as single molecules and as mixtures. Most research on EDCs is done on individual chemicals whereas we are exposed to mixtures of numerous and possibly interacting molecules. This discrepancy presents a dilemma for risk assessment and legislation. Thyroid hormones are essential for normal brain development where they influence, through specific embryonic and post-natal periods all the steps of brain development. In ad...

ea0063s7.2 | Endocrine disrupting chemicals (Endorsed by Endocrine Connections) | ECE2019

Actions of endocrine disrupting chemicals on pancreatic beta cells and risk of diabetes mellitus

Nadal Angel

Type 2 diabetes (T2D), results from a deficiency in insulin action on peripheral tissues together with a lack of compensatory insulin production and release by pancreatic beta cells. The etiology of T2D involves both, genetic predisposition and environmental factors. Bisphenol-A (BPA) is a widespread endocrine disrupting chemical that modify pancreatic beta cell function and induce insulin resistance in rodents after treatment during different timing of exposure, including pre...

ea0063s7.3 | Endocrine disrupting chemicals (Endorsed by Endocrine Connections) | ECE2019

Prenatal obesogen exposure leads to a transgenerational thrifty phenotype in mice

Blumberg Bruce

Obesity is commonly ascribed to an imbalance between caloric intake and energy expenditure, but a growing body of evidence underscores the contributions of other factors in the obesity epidemic. We found that exposure of F0 animals to TBT throughout pregnancy and lactation predisposed male F4 descendants of TBT-treated animals to obesity when challenged with a higher fat diet. The TBT group showed impaired ability to mobilize fat during fasting and elevated serum leptin levels...