Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Symposia

New genetics of pituitary tumours (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>)

ea0037s18.1 | New genetics of pituitary tumours (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2015

A novel role for stem cells in the regulation of turnover in the postnatal pituitary

Andoniadou Cynthia

Dysfunction in the mechanisms that regulate cell numbers in the pituitary gland can underlie hypopituitarism as well as the generation of tumours. Investigations into how these conditions arise has led to an interest in identifying mechanisms for correct maintenance of endocrine cells throughout life. Currently, the source and identity of signals promoting this maintenance in the postnatal pituitary are not known. We have previously shown that pituitary-specific disruptions in...

ea0037s18.3 | New genetics of pituitary tumours (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2015

Genetics of Cushings Disease

Reincke Martin

Cushing’s disease is caused by corticotroph adenomas of the pituitary. To explore molecular mechanisms of endocrine autonomy, we recently performed exome sequencing of 10 corticotroph adenomas1 identifying somatic mutations in the USP8 deubiquitinase gene in 4 of 10 adenomas. The mutations clustered in the 14-3-3 protein binding motif enhancing proteolytic cleavage and catalytic activity of USP8. Cleaved USP8 led to increased EGF receptor deubiquitination impai...