Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Symposia

Hormones and immunity in pregnancy

ea0037s28.1 | Hormones and immunity in pregnancy | ECE2015

Hormonal modulation of immune responses during pregnancy

Zenclussen Ana Claudia

Pregnancy is a puzzling phenomenon for researches as it defies the rules of immunology. The immune system of a pregnant woman is able to both tolerate the foreign while being alert to possible harm. It is now known that paternal antigens expressed by the fetus are not ignored but actively tolerated by the maternal immune system. Pregnancy hormones may have a pivotal role on the modulation of immune cell functions. We have described the important participation of the pregnancy ...

ea0037s28.2 | Hormones and immunity in pregnancy | ECE2015

Sex hormones and B cells in pregnancy

Jensen Federico

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...

ea0037s28.3 | Hormones and immunity in pregnancy | ECE2015

Vitamin D and pregnancy outcome

Harvey Nicholas

Low concentrations of 25-hydroxyvitamin D, the major circulating storage form, are common in the general population. Over recent decades, there has been increasing evidence for a role of vitamin D in disease pathogenesis far beyond the musculoskeletal system. Thus, many studies have investigated whether low levels of circulating 25-hydroxyvitamin D have a detrimental effect on pregnancy outcomes, for both mother and offspring, and whether supplementation with vitamin D might a...